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The map label for this gene is lysC [H]

Identifier: 23502724

GI number: 23502724

Start: 1808808

End: 1810079

Strand: Reverse

Name: lysC [H]

Synonym: BR1871

Alternate gene names: 23502724

Gene position: 1810079-1808808 (Counterclockwise)

Preceding gene: 23502726

Following gene: 23502723

Centisome position: 85.88

GC content: 59.04

Gene sequence:

>1272_bases
ATGGCGCGCATCGTGATGAAATTCGGCGGCACTTCGGTGGCCGATCTGGAACGCATCTATAATGTGGCGCGCCACGTCAA
ACGCGAGGTCGAGGCGGGCAATCAGGTTGCCGTGGTCGTTTCGGCCATGTCCGGCAAGACCAATGAGCTGGTCGACTGGG
TGCAGAACATGCCGAAGGTTTGCGGCGCAAGCTCTCCCTTTTATGATGCGCGCGAATATGACACCATCGTCGCCTCCGGT
GAACAGGTGACAAGCGGCCTTCTGGCAATTGCGCTTCAGTCCATCGGCGTGGATGCGCGCTCGTGGCAGGGCTGGCAGAT
CCCCATCCAGACCGACAATGCACATGGTGCAGCCCGCATTCAGGAAATCGACGGTTCGCAAATCATCCGCCGCATGGAAA
TGGGGCAGGTTGCCGTCGTTGCCGGTTTCCAGGGCATTGGCCCGGACAATCGCGTGGCAACGCTTGGTCGCGGTGGTTCG
GATACGTCCGCGGTTGCTGTTGCCGCTGCCGTGAAGGCGGATCGCTGCGACATCTATACGGATGTGGATGGCGTTTACAC
CACCGACCCGCGCATCGAGCCAAAGGCGCGCCGCCTGCCGAAGATTTCCTTTGAGGAAATGCTGGAAATGGCATCGCTGG
GCGCCAAGGTTTTCCAGGTGCGCTCGGTGGAGCTTGCCATGGTGCACAAGGTGCGTACTTTCGTGCGCTCAAGCTTTACG
GATCCCGATGCGCCGGGCATGGGTGATCCGATCAACCCGCCCGGAACGCTTATTTGCGACGAGGAAGAAATCGTGGAACA
GCAGGTCGTCACAGGTATCGCCTTTGCGAAGGATGAGGCACAGATTTCGCTGCGGCGCGTGGCCGACCGGCCGGGCGTGT
CGGCGGCAATTTTCGGGCCGCTTGCCGAAGAGCACATCAATGTCGACATGATCGTGCAGAACGTGTCGGAAGACGGCTCC
AAGACCGACATGACCTTTACCATTCCCACCGGCGACATCGACAAGGCGCTGAAGGTTCTGGACAAGGCCAAGAGCGAAAT
CAGCTTTGACAATATCCAGTCCGAAACCGGCCTTGCGAAAATCTCCGTTATCGGCATCGGCATGCGCAGCCATGCGGGTG
TCGCGGCTACCGCCTTCAAGGCGCTTGCCGAAAAGGGCATCAATATCCGCGCCATCACCACGTCGGAAATCAAGATTTCC
ATTTTGATCGATGGGCCTTATGCGGAATTGGCGGTGCGCACGCTGCATGCCGTCTATGGTCTCGACAAGTAA

Upstream 100 bases:

>100_bases
CCCCATTTTAGCTATGTGACCACAAGTTTGCCTGTCGCAACAATATAAGGTTTGGGCAGGTGAGAGTGTAATTTTTCTAA
AGAGCGGGACGTAACCTTAA

Downstream 100 bases:

>100_bases
TACAAGTGATACGGGGGCTGGAGTTGCCGACGCTCTCCACACCTTGAAATGCTTAATTGCCGCACGGGCTTAACCAGACC
CGATGAGCCAAGCTCATCGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASG
EQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGS
DTSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVFQVRSVELAMVHKVRTFVRSSFT
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGS
KTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHAVYGLDK

Sequences:

>Translated_423_residues
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASG
EQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGS
DTSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVFQVRSVELAMVHKVRTFVRSSFT
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGS
KTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKIS
ILIDGPYAELAVRTLHAVYGLDK
>Mature_422_residues
ARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKVCGASSPFYDAREYDTIVASGE
QVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARIQEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSD
TSAVAVAAAVKADRCDIYTDVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVFQVRSVELAMVHKVRTFVRSSFTD
PDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGPLAEEHINVDMIVQNVSEDGSK
TDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAKISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISI
LIDGPYAELAVRTLHAVYGLDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=473, Percent_Identity=29.5983086680761, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790455, Length=468, Percent_Identity=29.2735042735043, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790376, Length=425, Percent_Identity=24.9411764705882, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320893, Length=398, Percent_Identity=26.6331658291457, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45386; Mature: 45255

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKV
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CGASSPFYDAREYDTIVASGEQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARI
HCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEE
QEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSDTSAVAVAAAVKADRCDIYT
EECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVFQVRSVELAMVHKVRTFVRSSFT
CCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCEEEECC
LAEEHINVDMIVQNVSEDGSKTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAK
HHHHHCCHHHEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEE
ISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHAVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDK
CCC
>Mature Secondary Structure 
ARIVMKFGGTSVADLERIYNVARHVKREVEAGNQVAVVVSAMSGKTNELVDWVQNMPKV
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHH
CGASSPFYDAREYDTIVASGEQVTSGLLAIALQSIGVDARSWQGWQIPIQTDNAHGAARI
HCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCEE
QEIDGSQIIRRMEMGQVAVVAGFQGIGPDNRVATLGRGGSDTSAVAVAAAVKADRCDIYT
EECCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEE
DVDGVYTTDPRIEPKARRLPKISFEEMLEMASLGAKVFQVRSVELAMVHKVRTFVRSSFT
CCCCEEECCCCCCHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DPDAPGMGDPINPPGTLICDEEEIVEQQVVTGIAFAKDEAQISLRRVADRPGVSAAIFGP
CCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCCCEEEECC
LAEEHINVDMIVQNVSEDGSKTDMTFTIPTGDIDKALKVLDKAKSEISFDNIQSETGLAK
HHHHHCCHHHEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCHHHCCCCCCCEE
ISVIGIGMRSHAGVAATAFKALAEKGINIRAITTSEIKISILIDGPYAELAVRTLHAVYG
EEEEEECCCCCCCHHHHHHHHHHHCCCEEEEEEECCEEEEEEECCCHHHHHHHHHHHHHC
LDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]