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The map label for this gene is atpA [H]

Identifier: 23502654

GI number: 23502654

Start: 1728988

End: 1730517

Strand: Reverse

Name: atpA [H]

Synonym: BR1801

Alternate gene names: 23502654

Gene position: 1730517-1728988 (Counterclockwise)

Preceding gene: 23502655

Following gene: 23502653

Centisome position: 82.1

GC content: 59.8

Gene sequence:

>1530_bases
ATGGACATCCGCGCCGCGGAAATTTCCGCTATCCTGAAAGAGCAAATCAAGAACTTCGGCAAGGAGGCTGAGGTCTCCGA
GGTCGGTCAGGTTCTGTCCGTTGGCGACGGTATCGCCCGCGTCTATGGTCTGGATAATGTTCAGGCCGGTGAAATGGTCG
AATTCCCCGGTGGCATTCGCGGCATGGCGCTGAACCTTGAAAGCGACAATGTCGGCGTCGTTATCTTCGGTGCCGACCGT
GACATCAAGGAAGGCGATGTCGTCAAGCGCACCGGCGCAATCGTCGACGTTCCGGTTGGTCCCGAACTGCTTGGCCGCGT
GGTCGATGCTCTCGGCAATCCGATTGACGGCAAGGGCCCGATCAAGGCCAAGGAACGCCGCCGCGTGGACGTCAAGGCGC
CCGGCATTATTCCGCGCAAGTCGGTCCATGAGCCGATGTCGACCGGCCTCAAGGCCATCGACGCGCTGATCCCGGTTGGC
CGCGGCCAGCGCGAGCTGGTCATCGGCGACCGCCAGACCGGCAAGACCGCGATCATTCTCGACACCTTCCTCAACCAGAA
GCCGATCCACGACAATGGCCCGGACAAGGACAAGCTTTATTGCGTCTATGTCGCCGTTGGCCAGAAGCGTTCGACCGTTG
CCCAGTTCGTGAAGGTTCTCGAAGAACGCGGCGCACTCGAATATTCGATCGTCGTTGCGGCCACCGCATCCGATCCGGCC
CCGATGCAGTATCTCGCTCCGTTTGCGGGCTGCGCCATGGGTGAATATTTCCGTGACAACGGCCAGCACGCCCTCATCGG
CTATGACGATCTGTCGAAGCAGGCTGTCGCTTATCGCCAGATGTCGCTTCTGCTGCGTCGTCCTCCGGGCCGTGAAGCTT
ATCCGGGCGACGTTTTCTACCTGCACTCCCGTCTTCTCGAACGCGCTGCAAAGCTCAACGACGAAAACGGCGCTGGCTCG
CTGACGGCTCTGCCGGTCATCGAAACGCAGGGCAACGACGTTTCGGCCTTCATTCCGACCAATGTGATCTCGATCACCGA
CGGCCAGATCTTCCTCGAAACCAACCTGTTCTATCAGGGTATCCGCCCGGCTGTGAACGTCGGCCTGTCGGTTTCGCGCG
TTGGTTCTTCGGCCCAGATCAAGGCCATGAAGCAGGTTGCCGGTTCGATCAAGGGCGAGCTTGCCCAGCATCGTGAAATG
GCTGCCTTCGCACAGTTCGGTTCCGATCTTGACGCTGCAACGCAGCGCCTTCTCAACCGCGGTGCGCGCCTGACCGAACT
CCTGAAGCAGCCGCAGTTCTCGCCGCTGAAGACGGAAGAGCAGGTTGCCGTGATCTATGCCGGTGTTAACGGCTATCTCG
ACAAGCTTGCTGTCAACCAGGTCGGCAAGTTTGAAGAAGGCCTTCTCGCTTCGCTTCGCACCGAGCACAAGGATGTGCTT
GAGGGCATTCGCAACGAGAAAGCCCTTACCGATGACCTCAAGGCCAAGCTCAAGGCAGCGATCGACGCGTTCGCCAAGTC
TTTCGCTTGA

Upstream 100 bases:

>100_bases
TCCTCGGCGGTCTTATCGTCAAGATGGGTTCGCGTCAGATCGACACGTCCCTTCGCACCAAACTTTCTTCTCTTAAGCTT
GCACTGAAAGAGGTCGGCTG

Downstream 100 bases:

>100_bases
ATTTTGTGACGGGATGAACGGATGCCTTCACTAAAGGATCTGAGAAACCGTATCGCCTCGGTCAAGGCGACGCAGAAAAT
CACCAAGGCGATGCAGATGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGADR
DIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPIKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPA
PMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDENGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQHREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVL
EGIRNEKALTDDLKAKLKAAIDAFAKSFA

Sequences:

>Translated_509_residues
MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGADR
DIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPIKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPA
PMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDENGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQHREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVL
EGIRNEKALTDDLKAKLKAAIDAFAKSFA
>Mature_509_residues
MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIRGMALNLESDNVGVVIFGADR
DIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGPIKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVG
RGQRELVIGDRQTGKTAIILDTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPA
PMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDENGAGS
LTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQGIRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQHREM
AAFAQFGSDLDAATQRLLNRGARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVL
EGIRNEKALTDDLKAKLKAAIDAFAKSFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=503, Percent_Identity=71.3717693836978, Blast_Score=740, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=503, Percent_Identity=71.3717693836978, Blast_Score=740, Evalue=0.0,
Organism=Homo sapiens, GI19913426, Length=355, Percent_Identity=27.887323943662, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI32189394, Length=441, Percent_Identity=25.1700680272109, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI19913428, Length=295, Percent_Identity=28.135593220339, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19913424, Length=250, Percent_Identity=26.8, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=55.3398058252427, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1788251, Length=346, Percent_Identity=28.0346820809249, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1790170, Length=408, Percent_Identity=24.5098039215686, Blast_Score=105, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=70.9741550695825, Blast_Score=732, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=70.9741550695825, Blast_Score=730, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=65.4075546719682, Blast_Score=661, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17570191, Length=336, Percent_Identity=27.0833333333333, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=295, Percent_Identity=28.135593220339, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=382, Percent_Identity=24.869109947644, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988068, Length=76, Percent_Identity=59.2105263157895, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=66, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=69.5219123505976, Blast_Score=734, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=373, Percent_Identity=28.9544235924933, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6322581, Length=404, Percent_Identity=25.4950495049505, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=70.0990099009901, Blast_Score=729, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=340, Percent_Identity=28.2352941176471, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24646341, Length=340, Percent_Identity=28.2352941176471, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17136796, Length=340, Percent_Identity=28.2352941176471, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24638766, Length=428, Percent_Identity=24.5327102803738, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI28574560, Length=427, Percent_Identity=24.824355971897, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 54917; Mature: 54917

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLESDNVGVVIFGADRDIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPA
EHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDENGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEEECHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQHREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EGIRNEKALTDDLKAKLKAAIDAFAKSFA
HHHCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIRAAEISAILKEQIKNFGKEAEVSEVGQVLSVGDGIARVYGLDNVQAGEMVEFPGGIR
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCEEECCCCCC
GMALNLESDNVGVVIFGADRDIKEGDVVKRTGAIVDVPVGPELLGRVVDALGNPIDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCEEECCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IKAKERRRVDVKAPGIIPRKSVHEPMSTGLKAIDALIPVGRGQRELVIGDRQTGKTAIIL
CCHHHCCEEECCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTFLNQKPIHDNGPDKDKLYCVYVAVGQKRSTVAQFVKVLEERGALEYSIVVAATASDPA
EHHCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCC
PMQYLAPFAGCAMGEYFRDNGQHALIGYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFY
CHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
LHSRLLERAAKLNDENGAGSLTALPVIETQGNDVSAFIPTNVISITDGQIFLETNLFYQG
HHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEEECCCEEEEECCEEEEEECHHHHC
IRPAVNVGLSVSRVGSSAQIKAMKQVAGSIKGELAQHREMAAFAQFGSDLDAATQRLLNR
CCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
GARLTELLKQPQFSPLKTEEQVAVIYAGVNGYLDKLAVNQVGKFEEGLLASLRTEHKDVL
CHHHHHHHHCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EGIRNEKALTDDLKAKLKAAIDAFAKSFA
HHHCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]