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The map label for this gene is cobA [H]

Identifier: 23502173

GI number: 23502173

Start: 1257845

End: 1258693

Strand: Reverse

Name: cobA [H]

Synonym: BR1297

Alternate gene names: 23502173

Gene position: 1258693-1257845 (Counterclockwise)

Preceding gene: 23502176

Following gene: 23502172

Centisome position: 59.72

GC content: 62.19

Gene sequence:

>849_bases
GTGATCGCGAAAAGCAAAGTGGCTTTGCCCGTGATGGAGCCCGGCCATGTCTGGCTTGTCGGGGCCGGTCCGGGCGATCC
CGGTCTTTTGACCCTCCATGCGGTGAACGCTTTGCAACAGGCGGATGTGATCGTCTATGACGCGCTGGTCGATGATTCCT
GTCTTTCGCTGAAGAATGCGACCGCCACGTTGGAATATGCCGGCAAGCGCGGCGGCAAACCATCGCCCAGGCAACGCGAC
ATCTCGCTGCGGCTGGTGGAGCTTGCACGGCAAGGCAAGAAGGTGCTGCGGCTCAAGGGTGGCGATCCTTTCGTGTTCGG
GCGCGGGGCGGAAGAGGCGCTCACGCTTGTTGAGTATCATGTTCCGTTTCGCATCGTGCCGGGGGTCACAGCCGGGGTTG
GCGGGCTTGCCTATGCGGGAATTGCCGCCACGCATCGCGATATCAATCAGGCGGTAACGTTTCTGACCGGGCATGACGCA
ACCGGCGCCATGCCCGATGGCGTCGATTGGGCGGGTATTGCCCGATCGTCGCCGGTCATCGTCATGTATATGGCGATGAA
ACATATCGGCCTCATAGCCGGGCGGCTGATCGAGGCTGGACGTTCGCCAGATGAGCCGGTGGCCTTCGTCTGCAATGCCA
GCCTGCCGGACCAGACCGTGCTTGAAACAACGTTGGGCCGGGCTGCAATCGAGGTGGAAGCAGCCGGGCTGCAACCGCCA
GCCATTGTGGTTGTGGGTGAGGTGGTGCGCTTGCGTGCCGGGCTGGACTGGATCGGCGCAATGGCGGGAAAAAGCCTTGT
CAGCGATCCGCTGGGCAAGAGAACGCAACAGGGAGTGCAGAGCGCATGA

Upstream 100 bases:

>100_bases
CGTCGTTCATGGACGACTTATAATGTATCTGATAGCTGTGCGGCTAGTAAATTGAACGTGGTTGTAGAGTATGAGCAAAG
CTGACGAAGCGGCTGCCTGT

Downstream 100 bases:

>100_bases
AGGGATTCATGATTGCCGCACCGGCCTCCGGGTCGGGCAAGACGACCGTGACCTTGGGTTTGTTGCGCGCCCTGAAACGC
AGGGGCGAGGTGCTTGCGCC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRGGKPSPRQRD
ISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDA
TGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPP
AIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA

Sequences:

>Translated_282_residues
MIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRGGKPSPRQRD
ISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDA
TGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPP
AIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
>Mature_282_residues
MIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRGGKPSPRQRD
ISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDA
TGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPP
AIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA

Specific function: Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=249, Percent_Identity=43.7751004016064, Blast_Score=196, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322922, Length=256, Percent_Identity=32.8125, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 29461; Mature: 29461

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNA
CCCCCCEECEEECCCCEEEEECCCCCCCEEEEHHHHHHHHCCEEEEEEHHCCHHHHHCCC
TATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYH
EEEEEEHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHEEEC
VPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDWAGIARSSPVI
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEE
VMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPP
EHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCC
AIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
EEEEHHHHHHHHHCHHHHHHHHCHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNA
CCCCCCEECEEECCCCEEEEECCCCCCCEEEEHHHHHHHHCCEEEEEEHHCCHHHHHCCC
TATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYH
EEEEEEHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCHHHHHHHEEEC
VPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDWAGIARSSPVI
CCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCCCEE
VMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIEVEAAGLQPP
EHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEEEEEECCCCCC
AIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
EEEEHHHHHHHHHCHHHHHHHHCHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520; 2546914 [H]