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The map label for this gene is clpA [C]

Identifier: 23502047

GI number: 23502047

Start: 1147163

End: 1149637

Strand: Reverse

Name: clpA [C]

Synonym: BR1169

Alternate gene names: 23502047

Gene position: 1149637-1147163 (Counterclockwise)

Preceding gene: 23502048

Following gene: 23502042

Centisome position: 54.54

GC content: 57.62

Gene sequence:

>2475_bases
ATGCCATCGTTCTCCCCCAGCCTTGAAAGGGCGCTGCATCAGGCCCTCACCATCGCAAACGAGCGGCACCACGAATATGC
CACCCTCGAACATCTTTTGCTTGCGCTGATCGACGATCAGGACGCTGGCGCCGTGATGCGCGCCTGCAATGTTGATCTGG
ATTATCTCAAGCATATCGTTACTGACTATATTGACCGCGAGCTGGACAATCTCATCACCGGCTATGATGAGGATTCCAAA
CCGACAGCCGCTTTCCAGCGGGTGATCCAGCGTGCTGTGATCCATGTTCAGTCTTCCAACCGTGACGAAGTGACGGGCGC
GAATGTGCTTGTCGCCATCTTTGCGGAACGGGAAAGCCATGCTGCCTACTTCCTTCAGGAGCAGCAGATGACCCGTTACG
ACGCCGTCAACTATATCTCCCACGGCATTTCCAAGCGCCCGCAGGGCAGTGAGCCGCGCACGCCACGCGGCGTGGAAAGC
GCCAGTGAGGAGCGGACAGGCATCGAGCAGGAGGAAGCTCCCAAGAAGAAGCAGGATGCTCTTTCGGCCTATTGCATCAA
TCTCAACGAAAAGGCCAAGGCGGGCCGGATCGACCCGCTTATCGGCCGGGACAGCGAGATAAACCGCACGATTCAGGTTC
TGTGCCGCCGCTCCAAGAACAATCCGCTTTATGTGGGCGATCCCGGTGTCGGCAAAACGGCGATTGCCGAAGGGCTGGCT
AAACGCATCGTTGAGGGGCAGGTGCCGGACGCACTTGCGGATGCGACCATCTTCTCGCTCGACATGGGCACGCTGTTGGC
CGGCACCCGCTATCGCGGCGATTTTGAAGAACGTTTGAAGCAGGTCGTGAAGGAACTGGAGGAATTTCCGGGCGCGGTGC
TTTTCATCGATGAAATTCATACGGTTATCGGCGCGGGCGCGACTTCGGGCGGTGCAATGGATGCATCAAACCTTTTGAAG
CCGGCGCTCTCTTCCGGCGCGATCCGCTGCATCGGCTCGACCACCTATAAGGAATATCGCCAGTTCTTCGAGAAGGACAG
GGCCCTGGTGCGCCGCTTCCAGAAGATCGACGTGAACGAGCCTTCGATCCCGGATACGATCGAGATCATGAAAGGCTTGA
AGCCGTATTTTGAAGACTTTCACAAGGTCAAATATACGGTTGATGCCATCAAATCGGCTGTCGAGCTGTCGGCACGTTAT
ATTTCGGATCGCAAATTGCCGGACAAGGCAATCGATGTGATAGACGAAACGGGTGCAAGCCAGATGCTTCTGCCTGAAAA
CAAGCGCAAGAAGACCATCGGCGTGAAGGAAATCGAGGCAACCATCGCCACGATGGCCCGCATCCCGCCCAAGTCCGTTT
CCAAGGACGATGAAGAAGTGCTTTCGCATCTGGAAGCCGAATTGAAGCGCGTTGTCTATGGGCAGGATCTGGCTATCGAT
GCGCTGTCGGCTTCGATCAAGCTGGCCCGTGCGGGGCTGCGCGAGCCGGACAAGCCGATCGGTTCCTATCTGTTTTCCGG
CCCCACCGGCGTCGGCAAGACGGAAGTGGCCAAGCAACTGGCAAGCTCGCTCGGCGTGGAGCTGCTGCGCTTTGATATGT
CGGAATATATGGAGCGTCACACCGTTTCCCGGTTGATTGGCGCGCCTCCCGGCTATGTCGGCTTCGATCAGGGTGGTCTT
CTGACCGACGGCGTGGACCAGCATCCGCATTGTGTGCTGTTGCTCGACGAAATCGAGAAGGCGCATCCCGACCTGTTCAA
CATTTTGTTGCAGGTGATGGATCATGGGGCGCTGACCGACCATAACGGCAAGAAGATCGACTTCCGCAATGTCATTCTCA
TCATGACGACCAATGCGGGCGCGTCGGATATGGCGAAAGCTGCTATCGGCTTCGGCTCGACGCGGCGCGAAGGCGACGAC
ATGGAAGCGATCAACCGGCTGTTTACGCCGGAATTCCGCAACCGTCTGGATGCCATCATTCCGTTTGGCCCGCTGCCGGT
GCCGGTCATTCATCAGGTCGTGCAGAAGTTCGTGCTGCAACTTGAAGCCCAGCTTGCCGAACGCGGCGTGACCTTTGAAC
TGACCGATGCGGCCATCGCATGGCTGGCCGACAAGGGCTATGACGAGCGCATGGGCGCGCGTCCGCTTGCCCGTGTCATT
CAGGAACATATCAAGAAGCCGCTGGCCGATGAGGTGCTCTTCGGCAAGCTCAAGCATGGTGGAACCGTCCGTGTGGATGT
GACCACCAAGGAAGATGGCAATACCGACCTGATGCTGGAAAGCATCGCCGAAAAGCCGGTAAAGCCGAAGAAGGACATTC
CGCCGGAAAAGAAGTTGCCGCAGCGCAGGAAGGCTGCGCCGAAGAAGGCGGAAAAGGAAAAGGTGCTGGCTGGCAAGGAT
GAGCCTGCGCCGAAGCCCACCACAAAGGCAACGCCGATAAAATCCTCGGTGCCCAAAGTGCCGCGCAAGAAATAA

Upstream 100 bases:

>100_bases
CACTTACGAGGTTGCCGAAACCAAAGTCAGTCAGGTCATGGATTTCGCCCGTCAAAACCAGCATCCGCTGCAATGCGTGA
TGGAGAAAAAGTGAGGTCAT

Downstream 100 bases:

>100_bases
ACGCATAAAAACGGCCCTTCGGGGCCGTTTTTATTAAACTACCATCTGCCGTCAGCAAAATGGTGCTGCCATGGCAGTGA
ATACTAATCGCAAAAAATAT

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 824; Mature: 823

Protein sequence:

>824_residues
MPSFSPSLERALHQALTIANERHHEYATLEHLLLALIDDQDAGAVMRACNVDLDYLKHIVTDYIDRELDNLITGYDEDSK
PTAAFQRVIQRAVIHVQSSNRDEVTGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGISKRPQGSEPRTPRGVES
ASEERTGIEQEEAPKKKQDALSAYCINLNEKAKAGRIDPLIGRDSEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGLA
KRIVEGQVPDALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDASNLLK
PALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIPDTIEIMKGLKPYFEDFHKVKYTVDAIKSAVELSARY
ISDRKLPDKAIDVIDETGASQMLLPENKRKKTIGVKEIEATIATMARIPPKSVSKDDEEVLSHLEAELKRVVYGQDLAID
ALSASIKLARAGLREPDKPIGSYLFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGL
LTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGALTDHNGKKIDFRNVILIMTTNAGASDMAKAAIGFGSTRREGDD
MEAINRLFTPEFRNRLDAIIPFGPLPVPVIHQVVQKFVLQLEAQLAERGVTFELTDAAIAWLADKGYDERMGARPLARVI
QEHIKKPLADEVLFGKLKHGGTVRVDVTTKEDGNTDLMLESIAEKPVKPKKDIPPEKKLPQRRKAAPKKAEKEKVLAGKD
EPAPKPTTKATPIKSSVPKVPRKK

Sequences:

>Translated_824_residues
MPSFSPSLERALHQALTIANERHHEYATLEHLLLALIDDQDAGAVMRACNVDLDYLKHIVTDYIDRELDNLITGYDEDSK
PTAAFQRVIQRAVIHVQSSNRDEVTGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGISKRPQGSEPRTPRGVES
ASEERTGIEQEEAPKKKQDALSAYCINLNEKAKAGRIDPLIGRDSEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGLA
KRIVEGQVPDALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDASNLLK
PALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIPDTIEIMKGLKPYFEDFHKVKYTVDAIKSAVELSARY
ISDRKLPDKAIDVIDETGASQMLLPENKRKKTIGVKEIEATIATMARIPPKSVSKDDEEVLSHLEAELKRVVYGQDLAID
ALSASIKLARAGLREPDKPIGSYLFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGL
LTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGALTDHNGKKIDFRNVILIMTTNAGASDMAKAAIGFGSTRREGDD
MEAINRLFTPEFRNRLDAIIPFGPLPVPVIHQVVQKFVLQLEAQLAERGVTFELTDAAIAWLADKGYDERMGARPLARVI
QEHIKKPLADEVLFGKLKHGGTVRVDVTTKEDGNTDLMLESIAEKPVKPKKDIPPEKKLPQRRKAAPKKAEKEKVLAGKD
EPAPKPTTKATPIKSSVPKVPRKK
>Mature_823_residues
PSFSPSLERALHQALTIANERHHEYATLEHLLLALIDDQDAGAVMRACNVDLDYLKHIVTDYIDRELDNLITGYDEDSKP
TAAFQRVIQRAVIHVQSSNRDEVTGANVLVAIFAERESHAAYFLQEQQMTRYDAVNYISHGISKRPQGSEPRTPRGVESA
SEERTGIEQEEAPKKKQDALSAYCINLNEKAKAGRIDPLIGRDSEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGLAK
RIVEGQVPDALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIHTVIGAGATSGGAMDASNLLKP
ALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNEPSIPDTIEIMKGLKPYFEDFHKVKYTVDAIKSAVELSARYI
SDRKLPDKAIDVIDETGASQMLLPENKRKKTIGVKEIEATIATMARIPPKSVSKDDEEVLSHLEAELKRVVYGQDLAIDA
LSASIKLARAGLREPDKPIGSYLFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLL
TDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGALTDHNGKKIDFRNVILIMTTNAGASDMAKAAIGFGSTRREGDDM
EAINRLFTPEFRNRLDAIIPFGPLPVPVIHQVVQKFVLQLEAQLAERGVTFELTDAAIAWLADKGYDERMGARPLARVIQ
EHIKKPLADEVLFGKLKHGGTVRVDVTTKEDGNTDLMLESIAEKPVKPKKDIPPEKKLPQRRKAAPKKAEKEKVLAGKDE
PAPKPTTKATPIKSSVPKVPRKK

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=352, Percent_Identity=32.9545454545455, Blast_Score=163, Evalue=5e-40,
Organism=Escherichia coli, GI1787109, Length=745, Percent_Identity=59.4630872483221, Blast_Score=903, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=270, Percent_Identity=54.8148148148148, Blast_Score=296, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6320464, Length=318, Percent_Identity=45.5974842767296, Blast_Score=274, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6323002, Length=429, Percent_Identity=38.2284382284382, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 91068; Mature: 90937

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSPSLERALHQALTIANERHHEYATLEHLLLALIDDQDAGAVMRACNVDLDYLKHIV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
TDYIDRELDNLITGYDEDSKPTAAFQRVIQRAVIHVQSSNRDEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGISKRPQGSEPRTPRGVESASEERTGIEQEEAPKKKQDA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHCCCHHHHH
LSAYCINLNEKAKAGRIDPLIGRDSEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGLA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
KRIVEGQVPDALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIH
HHHHCCCCCHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHH
TVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSIPDTIEIMKGLKPYFEDFHKVKYTVDAIKSAVELSARYISDRKLPDKAIDVIDETGAS
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QMLLPENKRKKTIGVKEIEATIATMARIPPKSVSKDDEEVLSHLEAELKRVVYGQDLAID
CCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
ALSASIKLARAGLREPDKPIGSYLFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERH
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGALTD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCC
HNGKKIDFRNVILIMTTNAGASDMAKAAIGFGSTRREGDDMEAINRLFTPEFRNRLDAII
CCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCC
PFGPLPVPVIHQVVQKFVLQLEAQLAERGVTFELTDAAIAWLADKGYDERMGARPLARVI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHCCCHHHHHHH
QEHIKKPLADEVLFGKLKHGGTVRVDVTTKEDGNTDLMLESIAEKPVKPKKDIPPEKKLP
HHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
QRRKAAPKKAEKEKVLAGKDEPAPKPTTKATPIKSSVPKVPRKK
HHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure 
PSFSPSLERALHQALTIANERHHEYATLEHLLLALIDDQDAGAVMRACNVDLDYLKHIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHH
TDYIDRELDNLITGYDEDSKPTAAFQRVIQRAVIHVQSSNRDEVTGANVLVAIFAERESH
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCH
AAYFLQEQQMTRYDAVNYISHGISKRPQGSEPRTPRGVESASEERTGIEQEEAPKKKQDA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHCCCHHHHH
LSAYCINLNEKAKAGRIDPLIGRDSEINRTIQVLCRRSKNNPLYVGDPGVGKTAIAEGLA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHH
KRIVEGQVPDALADATIFSLDMGTLLAGTRYRGDFEERLKQVVKELEEFPGAVLFIDEIH
HHHHCCCCCHHHHHHHHHEECHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHH
TVIGAGATSGGAMDASNLLKPALSSGAIRCIGSTTYKEYRQFFEKDRALVRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSIPDTIEIMKGLKPYFEDFHKVKYTVDAIKSAVELSARYISDRKLPDKAIDVIDETGAS
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QMLLPENKRKKTIGVKEIEATIATMARIPPKSVSKDDEEVLSHLEAELKRVVYGQDLAID
CCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHH
ALSASIKLARAGLREPDKPIGSYLFSGPTGVGKTEVAKQLASSLGVELLRFDMSEYMERH
HHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSRLIGAPPGYVGFDQGGLLTDGVDQHPHCVLLLDEIEKAHPDLFNILLQVMDHGALTD
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCCC
HNGKKIDFRNVILIMTTNAGASDMAKAAIGFGSTRREGDDMEAINRLFTPEFRNRLDAII
CCCCEEEECCEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHCC
PFGPLPVPVIHQVVQKFVLQLEAQLAERGVTFELTDAAIAWLADKGYDERMGARPLARVI
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCHHHCCCHHHHHHH
QEHIKKPLADEVLFGKLKHGGTVRVDVTTKEDGNTDLMLESIAEKPVKPKKDIPPEKKLP
HHHHHCCHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
QRRKAAPKKAEKEKVLAGKDEPAPKPTTKATPIKSSVPKVPRKK
HHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]