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The map label for this gene is lpxB [H]

Identifier: 23502027

GI number: 23502027

Start: 1128836

End: 1130023

Strand: Reverse

Name: lpxB [H]

Synonym: BR1149

Alternate gene names: 23502027

Gene position: 1130023-1128836 (Counterclockwise)

Preceding gene: 23502028

Following gene: 23502024

Centisome position: 53.61

GC content: 57.91

Gene sequence:

>1188_bases
GTGAACGAAACGAGCCGGCCATTAAAAATAGCGATTGTGGCCGGAGAAGAATCCGGCGACTTGCTGGGCGCTGATCTGAT
TGATGCGTTAAGGGCGCAAACGGATCGACTGGTTGATATTGTCGGGGTTGGCGGCGATCACCTTGCCGAACGGGGGCTCA
AGAGTTTTTTCGACCCGCATGAGATTGCGCTCATGGGGCTGGGGGCGATCCTGAAAAACCTGCCCGGGCTGATGCTGCGT
ATCCGCCAGACAGCGCGGCAGATCGTGGTCGAAAAGCCCGATTGTGTGCTGTTGATCGACAGCCCCGAATTCACCCATCG
TGTGGCGAAGAAAATCAGGGCTTCGGCGCCCTCCATTCCCATCGTCAAATATATTGCGCCCAGTGTCTGGGCTTGGCGGC
CACAGCGCGCGCGCGCCATGCGCGCCTCTATCGACCACGTGCTGACTGTCCTGCCGTTTGAGGTGGAAGTCATGGAAAGG
TTGAACGGGCCGCAGGCAACCTATGTTGGCCATCGCCTGACAAGTCATGAGCCGATCCTGCAGGCACGTGCGTCGCAACT
GGTTCTGGAAGCGCAGCGGTTTAATGCCGACAAACAGACATTGCTATTGCTGCCGGGATCACGGCGCACGGAAATCCAGA
TGTTGATGGAGCCGTTCGGCAAGGCTGTCGAGCAACTGGCGGCGCGTATCGAGAAGCTGGAGGTTGTTCTGCCAACCTTG
CCGCGTATCGAAGCCATGGTGCGCGATCTTTCCAGGGACTGGACCGTAAAACCGCTGATCGTGACGGGGGACGAGGAAAA
GTGGAAAGCTTTTTCCCGCGCCGATGCGGCTTTGGCTGCTTCGGGCACCGTCTCGCTTGAACTTGCTCTTGCACGTATCC
CCAGTGTGCTTTCCTACAAGGCCGATTGGTTCGCCCGCAAATTTCTGATGCCGAAGATCACGATCTGGAGCGCGGCCTTG
CCGAACATCATTGTGGATGAGCCTGTCGTGCCGGAATATTTCAATGAATTTGTGCGGCCCGGAATGCTTGCCCGCAATCT
GGAGCGGATCATGCGGCCCGGTTCGGCGCGGCAGGCACAACTCGACGGTTTTGACGAGGTCGCATCCGTCATGAAAACCG
AAAAACCTTCCGGTGAGATCGGTGCGCGTGTTCTGCTTGCCCTTGCCGAAGGAAGAAGCGCATTCTAG

Upstream 100 bases:

>100_bases
GGCGAACCTTTATTCTTGGTTTCGGAGAAACGCTTGCAGCGGCCAATAAAAAAGGTCTTTTTATCGAAACCATCAGTCGA
GACGGGAAAGGCAAGACAGG

Downstream 100 bases:

>100_bases
AGCATTTCCAGCAAAAGTGCGAAGCGGTTTTGCGTAGGATAATGCGACAAAACAAATGGTTAGAGCGCATCCCGAAAACC
GGTTCCCACTTTCGGGAGGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MNETSRPLKIAIVAGEESGDLLGADLIDALRAQTDRLVDIVGVGGDHLAERGLKSFFDPHEIALMGLGAILKNLPGLMLR
IRQTARQIVVEKPDCVLLIDSPEFTHRVAKKIRASAPSIPIVKYIAPSVWAWRPQRARAMRASIDHVLTVLPFEVEVMER
LNGPQATYVGHRLTSHEPILQARASQLVLEAQRFNADKQTLLLLPGSRRTEIQMLMEPFGKAVEQLAARIEKLEVVLPTL
PRIEAMVRDLSRDWTVKPLIVTGDEEKWKAFSRADAALAASGTVSLELALARIPSVLSYKADWFARKFLMPKITIWSAAL
PNIIVDEPVVPEYFNEFVRPGMLARNLERIMRPGSARQAQLDGFDEVASVMKTEKPSGEIGARVLLALAEGRSAF

Sequences:

>Translated_395_residues
MNETSRPLKIAIVAGEESGDLLGADLIDALRAQTDRLVDIVGVGGDHLAERGLKSFFDPHEIALMGLGAILKNLPGLMLR
IRQTARQIVVEKPDCVLLIDSPEFTHRVAKKIRASAPSIPIVKYIAPSVWAWRPQRARAMRASIDHVLTVLPFEVEVMER
LNGPQATYVGHRLTSHEPILQARASQLVLEAQRFNADKQTLLLLPGSRRTEIQMLMEPFGKAVEQLAARIEKLEVVLPTL
PRIEAMVRDLSRDWTVKPLIVTGDEEKWKAFSRADAALAASGTVSLELALARIPSVLSYKADWFARKFLMPKITIWSAAL
PNIIVDEPVVPEYFNEFVRPGMLARNLERIMRPGSARQAQLDGFDEVASVMKTEKPSGEIGARVLLALAEGRSAF
>Mature_395_residues
MNETSRPLKIAIVAGEESGDLLGADLIDALRAQTDRLVDIVGVGGDHLAERGLKSFFDPHEIALMGLGAILKNLPGLMLR
IRQTARQIVVEKPDCVLLIDSPEFTHRVAKKIRASAPSIPIVKYIAPSVWAWRPQRARAMRASIDHVLTVLPFEVEVMER
LNGPQATYVGHRLTSHEPILQARASQLVLEAQRFNADKQTLLLLPGSRRTEIQMLMEPFGKAVEQLAARIEKLEVVLPTL
PRIEAMVRDLSRDWTVKPLIVTGDEEKWKAFSRADAALAASGTVSLELALARIPSVLSYKADWFARKFLMPKITIWSAAL
PNIIVDEPVVPEYFNEFVRPGMLARNLERIMRPGSARQAQLDGFDEVASVMKTEKPSGEIGARVLLALAEGRSAF

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=397, Percent_Identity=32.4937027707809, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43778; Mature: 43778

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNETSRPLKIAIVAGEESGDLLGADLIDALRAQTDRLVDIVGVGGDHLAERGLKSFFDPH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCHH
EIALMGLGAILKNLPGLMLRIRQTARQIVVEKPDCVLLIDSPEFTHRVAKKIRASAPSIP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCC
IVKYIAPSVWAWRPQRARAMRASIDHVLTVLPFEVEVMERLNGPQATYVGHRLTSHEPIL
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHCCCCCCCCHHH
QARASQLVLEAQRFNADKQTLLLLPGSRRTEIQMLMEPFGKAVEQLAARIEKLEVVLPTL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRIEAMVRDLSRDWTVKPLIVTGDEEKWKAFSRADAALAASGTVSLELALARIPSVLSYK
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHH
ADWFARKFLMPKITIWSAALPNIIVDEPVVPEYFNEFVRPGMLARNLERIMRPGSARQAQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
LDGFDEVASVMKTEKPSGEIGARVLLALAEGRSAF
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNETSRPLKIAIVAGEESGDLLGADLIDALRAQTDRLVDIVGVGGDHLAERGLKSFFDPH
CCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCHH
EIALMGLGAILKNLPGLMLRIRQTARQIVVEKPDCVLLIDSPEFTHRVAKKIRASAPSIP
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCC
IVKYIAPSVWAWRPQRARAMRASIDHVLTVLPFEVEVMERLNGPQATYVGHRLTSHEPIL
HHHHHCCCHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHCCCCCCCCHHH
QARASQLVLEAQRFNADKQTLLLLPGSRRTEIQMLMEPFGKAVEQLAARIEKLEVVLPTL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PRIEAMVRDLSRDWTVKPLIVTGDEEKWKAFSRADAALAASGTVSLELALARIPSVLSYK
HHHHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHH
ADWFARKFLMPKITIWSAALPNIIVDEPVVPEYFNEFVRPGMLARNLERIMRPGSARQAQ
HHHHHHHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
LDGFDEVASVMKTEKPSGEIGARVLLALAEGRSAF
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA