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The map label for this gene is pdhA [H]

Identifier: 23502007

GI number: 23502007

Start: 1106984

End: 1108024

Strand: Reverse

Name: pdhA [H]

Synonym: BR1129

Alternate gene names: 23502007

Gene position: 1108024-1106984 (Counterclockwise)

Preceding gene: 23502008

Following gene: 23502006

Centisome position: 52.57

GC content: 55.81

Gene sequence:

>1041_bases
ATGGCACCGAGGGCTAAAAAGGCGCCTGCTGGCAAAACGCAGGCGTCTTCCGTGAATGCACCCAAGGCACCTTCGCCTGC
GAATTTCGACAAGAAGCAGGAGTTGGAAGCTTATCGCGAAATGCTGCTGATCCGGCGTTTTGAAGAAAAGGCCGGCCAAC
TTTATGGCATGAGTTTTATTGGCGGCTTCTGCCACCTTTATATCGGCCAGGAGGCCGTGGTGGTTGGCATGCAGATGGCG
TTGCAGGAAGGCGATCAGGTTATCACCGGCTATCGCGACCATGGTCATATGCTGGCCGTGGGCATGAGTGCGCGTGGCGT
GATGGCCGAACTGACCGGACGCCGCGGCGGCCTTTCCAAGGGCAAGGGCGGCTCCATGCACATGTTCTCCAAGGAAAAGA
ATTTTTATGGTGGCCATGGCATTGTCGGCGCGCAGGTTTCGCTCGGTACGGGGTTGGCCTTCGCCAATCACTATCGTGAG
AATAAATCCGTTTCGCTGACCTATTTCGGCGATGGTGCGGCGAATCAGGGTCAGGTTTATGAAAGCTTTAACATGGCCTC
GCTGTGGAAGCTTCCGGTGATCTACGTCATCGAAAACAACCGTTATGCGATGGGGACGGCGGTTTCGCGTTCTTCCGCTG
AAACCGATTTTTCCAAGCGCGGCCTTTCCTTCAATATCCCCGGCATTCAGGTCGATGGCATGGATGTGCGCGCGGTAAAG
GCGGCAGCCGATCTTGCGACCGAATGGGCGCGTTCCGGCAAGGGGCCGATCATTCTGGAAATGCTTACCTACCGCTATCG
CGGCCACTCCATGTCCGATCCGGCCAAGTACCGCTCGAAGGAAGAAGTGCAGAAAATGCGCTCCGAACATGATCCGATCG
AGCAGGTCAAAAACCGCCTGATCGAAAAGGGCTGGGCAACCGAAGAAGAGCTGAAGGAAATCGACAGGGAAGTTCGGGAC
ATTGTCGCTGATGCTGCCGATTTTGCCGAACATGATCCGGAGCCGGATGCGTCCGAGCTCTATACGGATATTCTGCTCTA
A

Upstream 100 bases:

>100_bases
AAGAGTTTGGTGGCATAGCAGCTATGCTCTGGGCGCATATTGTATCTTGTAATATGCCCGTATACCCTCACACTAGAACG
ACAATTTTAGGGAGCGAGAT

Downstream 100 bases:

>100_bases
TTCGAGGAAGGTGTTGCTATGCCCATAGAAATTCTCATGCCCGCACTTTCCCCGACCATGGAGGAGGGCAAGCTCTCCAA
ATGGCTCAAGAAAGAAGGCG

Product: pyruvate dehydrogenase complex, E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MAPRAKKAPAGKTQASSVNAPKAPSPANFDKKQELEAYREMLLIRRFEEKAGQLYGMSFIGGFCHLYIGQEAVVVGMQMA
LQEGDQVITGYRDHGHMLAVGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKNFYGGHGIVGAQVSLGTGLAFANHYRE
NKSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYVIENNRYAMGTAVSRSSAETDFSKRGLSFNIPGIQVDGMDVRAVK
AAADLATEWARSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKNRLIEKGWATEEELKEIDREVRD
IVADAADFAEHDPEPDASELYTDILL

Sequences:

>Translated_346_residues
MAPRAKKAPAGKTQASSVNAPKAPSPANFDKKQELEAYREMLLIRRFEEKAGQLYGMSFIGGFCHLYIGQEAVVVGMQMA
LQEGDQVITGYRDHGHMLAVGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKNFYGGHGIVGAQVSLGTGLAFANHYRE
NKSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYVIENNRYAMGTAVSRSSAETDFSKRGLSFNIPGIQVDGMDVRAVK
AAADLATEWARSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKNRLIEKGWATEEELKEIDREVRD
IVADAADFAEHDPEPDASELYTDILL
>Mature_345_residues
APRAKKAPAGKTQASSVNAPKAPSPANFDKKQELEAYREMLLIRRFEEKAGQLYGMSFIGGFCHLYIGQEAVVVGMQMAL
QEGDQVITGYRDHGHMLAVGMSARGVMAELTGRRGGLSKGKGGSMHMFSKEKNFYGGHGIVGAQVSLGTGLAFANHYREN
KSVSLTYFGDGAANQGQVYESFNMASLWKLPVIYVIENNRYAMGTAVSRSSAETDFSKRGLSFNIPGIQVDGMDVRAVKA
AADLATEWARSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKNRLIEKGWATEEELKEIDREVRDI
VADAADFAEHDPEPDASELYTDILL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=54.7169811320755, Blast_Score=358, Evalue=3e-99,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=54.7169811320755, Blast_Score=335, Evalue=2e-92,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=54.7169811320755, Blast_Score=335, Evalue=3e-92,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=53.5384615384615, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=49.3710691823899, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI11386135, Length=332, Percent_Identity=29.8192771084337, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI258645172, Length=332, Percent_Identity=30.1204819277108, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17536047, Length=327, Percent_Identity=53.2110091743119, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI32564172, Length=327, Percent_Identity=53.2110091743119, Blast_Score=339, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI86563355, Length=327, Percent_Identity=31.1926605504587, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI86563357, Length=327, Percent_Identity=31.1926605504587, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17542494, Length=181, Percent_Identity=23.7569060773481, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321026, Length=319, Percent_Identity=51.7241379310345, Blast_Score=335, Evalue=7e-93,
Organism=Drosophila melanogaster, GI24639744, Length=317, Percent_Identity=51.7350157728707, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI28571106, Length=317, Percent_Identity=51.7350157728707, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639740, Length=317, Percent_Identity=51.7350157728707, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=52.4590163934426, Blast_Score=320, Evalue=9e-88,
Organism=Drosophila melanogaster, GI24639748, Length=317, Percent_Identity=52.3659305993691, Blast_Score=311, Evalue=5e-85,
Organism=Drosophila melanogaster, GI21355903, Length=277, Percent_Identity=29.9638989169675, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38146; Mature: 38015

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPRAKKAPAGKTQASSVNAPKAPSPANFDKKQELEAYREMLLIRRFEEKAGQLYGMSFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHH
GGFCHLYIGQEAVVVGMQMALQEGDQVITGYRDHGHMLAVGMSARGVMAELTGRRGGLSK
HHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCHHHHHCCCCCCCCC
GKGGSMHMFSKEKNFYGGHGIVGAQVSLGTGLAFANHYRENKSVSLTYFGDGAANQGQVY
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHH
ESFNMASLWKLPVIYVIENNRYAMGTAVSRSSAETDFSKRGLSFNIPGIQVDGMDVRAVK
HCCCHHHEECCCEEEEEECCCEEEEEHHCCCCCCCHHHHCCCEECCCCEEECCCCHHHHH
AAADLATEWARSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKNRL
HHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHH
IEKGWATEEELKEIDREVRDIVADAADFAEHDPEPDASELYTDILL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
APRAKKAPAGKTQASSVNAPKAPSPANFDKKQELEAYREMLLIRRFEEKAGQLYGMSFI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHH
GGFCHLYIGQEAVVVGMQMALQEGDQVITGYRDHGHMLAVGMSARGVMAELTGRRGGLSK
HHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCHHHHHCCCCCCCCC
GKGGSMHMFSKEKNFYGGHGIVGAQVSLGTGLAFANHYRENKSVSLTYFGDGAANQGQVY
CCCCCEEEEECCCCCCCCCCEEEEEEECCCCHHHHHHHCCCCCEEEEEECCCCCCCCCHH
ESFNMASLWKLPVIYVIENNRYAMGTAVSRSSAETDFSKRGLSFNIPGIQVDGMDVRAVK
HCCCHHHEECCCEEEEEECCCEEEEEHHCCCCCCCHHHHCCCEECCCCEEECCCCHHHHH
AAADLATEWARSGKGPIILEMLTYRYRGHSMSDPAKYRSKEEVQKMRSEHDPIEQVKNRL
HHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHH
IEKGWATEEELKEIDREVRDIVADAADFAEHDPEPDASELYTDILL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]