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The map label for this gene is clpP [H]

Identifier: 23501987

GI number: 23501987

Start: 1085634

End: 1086263

Strand: Reverse

Name: clpP [H]

Synonym: BR1109

Alternate gene names: 23501987

Gene position: 1086263-1085634 (Counterclockwise)

Preceding gene: 23501988

Following gene: 23501986

Centisome position: 51.54

GC content: 56.35

Gene sequence:

>630_bases
ATGAGAGATCCGATCGAAACCGTCATGAACCTCGTGCCGATGGTGGTCGAGCAGACCAACCGTGGCGAACGGGCCTATGA
TATCTTCTCGCGTCTTCTGAAAGAACGCATCATTTTCGTCAATGGACCCGTCGAAGACGGCATGTCCATGCTGGTCTGCG
CGCAGCTTCTCTTTCTTGAAGCGGAAAATCCGAAGAAAGAGATCAACATGTATATCAACTCGCCCGGCGGCGTCGTGACG
TCCGGCATGGCGATCTATGATACGATGCAGTTTATCCGCCCGCCGGTTTCCACGCTTTGCATGGGGCAGGCCGCTTCGAT
GGGGTCCCTGTTGCTGACCGCTGGCGCTACCGGCCATCGTTATGCGCTGCCCAATGCGCGCATCATGGTTCACCAGCCTT
CGGGCGGCTTCCAGGGCCAGGCTTCGGATATTGAGCGCCACGCGCAGGATATCATCAAGATGAAGCGCCGCCTGAATGAA
ATCTACGTCAAGCACACGGGCCGCGACTACGACACCATTGAACGCACGCTCGATCGTGACCATTTCATGACTGCCCAGGA
GGCGCTTGAATTCGGTCTCATCGACAAGGTGGTCGAAGTGCGCGATGTAAGCGCAGACGAATCGAAATAA

Upstream 100 bases:

>100_bases
ATATTTCGCGCCACTTGCGGAACAGGGGCGCAACGCCCTATGTATGGAAGTCCGACGATTCAACCTAGTCATATCGCCAT
TAATATATCAGAGGCCCATA

Downstream 100 bases:

>100_bases
GGTCGAAATCTTCGGTGCGCTCCCTTTTTCGTGCCTTTTGCCACAAAAGGGGCCCAATTCTTGGTCGTACGTGATGGTTA
ATGCGTCACGTTAAGTATCT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLEAENPKKEINMYINSPGGVVT
SGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHRYALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNE
IYVKHTGRDYDTIERTLDRDHFMTAQEALEFGLIDKVVEVRDVSADESK

Sequences:

>Translated_209_residues
MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLEAENPKKEINMYINSPGGVVT
SGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHRYALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNE
IYVKHTGRDYDTIERTLDRDHFMTAQEALEFGLIDKVVEVRDVSADESK
>Mature_209_residues
MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLEAENPKKEINMYINSPGGVVT
SGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHRYALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNE
IYVKHTGRDYDTIERTLDRDHFMTAQEALEFGLIDKVVEVRDVSADESK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=61.0526315789474, Blast_Score=254, Evalue=4e-68,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=62.6865671641791, Blast_Score=280, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=61.8279569892473, Blast_Score=247, Evalue=4e-66,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=65.4450261780105, Blast_Score=270, Evalue=6e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23452; Mature: 23452

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEINMYINSPGGVVTSGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHR
CCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHCCCHHHHHHCCHHCCCCEEEECCCCCCE
YALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNEIYVKHTGRDYDTIERTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMTAQEALEFGLIDKVVEVRDVSADESK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRDPIETVMNLVPMVVEQTNRGERAYDIFSRLLKERIIFVNGPVEDGMSMLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEINMYINSPGGVVTSGMAIYDTMQFIRPPVSTLCMGQAASMGSLLLTAGATGHR
CCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHCCCHHHHHHCCHHCCCCEEEECCCCCCE
YALPNARIMVHQPSGGFQGQASDIERHAQDIIKMKRRLNEIYVKHTGRDYDTIERTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
HFMTAQEALEFGLIDKVVEVRDVSADESK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA