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The map label for this gene is hisD [H]

Identifier: 23501159

GI number: 23501159

Start: 261359

End: 262651

Strand: Reverse

Name: hisD [H]

Synonym: BR0252

Alternate gene names: 23501159

Gene position: 262651-261359 (Counterclockwise)

Preceding gene: 23501160

Following gene: 23501158

Centisome position: 12.46

GC content: 61.87

Gene sequence:

>1293_bases
ATGGTCACAACGCTCAGACAGACCGACCCTGATTTTGAACAGAAGTTTGCGGCCTTCCTCTCCGGCAAGCGCGAGGTTTC
GGAAGATGTGGACCGCGCCGTGCGGGAAATCGTGGATCGTGTACGCCGCGAGGGTGACAGCGCGCTGCTCGATTATTCAC
GCCGCTTCGACCGGATCGATCTGGAAAAGACCGGCATTGCCGTCACCGAGGCCGAGATCGATGCCGCATTCGATGCCGCT
CCCGCCTCCACCGTCGAAGCATTGAAGCTTGCGCGCGACCGTATCGAAAAGCACCATGCTCGCCAGTTGCCGAAGGACGA
CCGCTATACGGATGCGCTTGGCGTCGAGCTTGGCTCGCGCTGGACGGCCATCGAGGCTGTCGGCCTCTATGTGCCTGGCG
GCACGGCCAGCTATCCAAGTTCCGTTCTGATGAATGCGATGCCCGCCAAGGTCGCAGGCGTGGACCGCATCGTCATGGTG
GTGCCCGCACCCGATGGCAATCTCAATCCGCTGGTGCTGGTGGCAGCCCGCCTTGCAGGCGTGTCGGAGATTTACCGCGT
CGGCGGCGCGCAGGCCATTGCCGCCCTTGCCTATGGCACCGAAACGATCCGTCCCGTCGCCAAGATCGTCGGCCCCGGCA
ATGCCTATGTGGCAGCGGCAAAGCGCATCGTATTCGGAACGGTCGGCATCGACATGATCGCCGGGCCATCCGAAGTGCTG
ATCGTGGCCGACAAGGACAATAACCCGGACTGGATCGCCGCCGATCTTCTGGCACAGGCCGAGCACGATACGGCCGCGCA
ATCCATCCTGATGACCAATGACGAGGCCTTTGCCCACGCGGTGGAAGAAGCGGTCGAACGGCAGCTTCACACCCTGGCGC
GCACTGAAACGGCTTCCGCAAGCTGGCGCGATTTCGGTGCGGTCATTCTGGTCAAGGATTTCGAGGACGCAATTCCGCTT
GCCAACCGTATTGCGGCCGAGCATCTGGAAATCGCCGTGGCCGATGCGGAGGCGTTCGTACCGCGCATCCGCAATGCCGG
TTCCATATTCATTGGCGGTTATACACCGGAAGTGATCGGCGATTATGTGGGGGGCTGCAACCATGTGCTGCCAACGGCGC
GCTCTGCCCGTTTCTCCTCCGGCCTTTCGGTGCTCGATTATATGAAGCGCACCTCGCTTCTCAAGCTGGGCTCCGAGCAG
CTTCGCGCACTTGGACCGGCTGCGATCGAGATTGCACGCGCCGAGGGTCTCGATGCCCATGCCCAATCCGTCGCCATTCG
TCTGAACCTATGA

Upstream 100 bases:

>100_bases
AATCTCTTCCGCGCCATAACGTATGAGAACGCCCTCCCGCCTCATGCGCCTTGCGCTTTTGGGCTGCAAGCCCGCTTGAA
ATATTTGAAGGAGTGTCCGC

Downstream 100 bases:

>100_bases
GGGACCATGACTGCCGACGTTCCCAATGCCCGTCTTGTTGACGTCGAGCTCGATGAATCCATCGGGCGCTCGACGCCTGA
TGTCGAGCATGAACGCGCAG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAA
PASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMV
VPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPL
ANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQ
LRALGPAAIEIARAEGLDAHAQSVAIRLNL

Sequences:

>Translated_430_residues
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAA
PASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMV
VPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPL
ANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQ
LRALGPAAIEIARAEGLDAHAQSVAIRLNL
>Mature_430_residues
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAA
PASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMV
VPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPL
ANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQ
LRALGPAAIEIARAEGLDAHAQSVAIRLNL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=421, Percent_Identity=41.3301662707838, Blast_Score=289, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=40.0479616306954, Blast_Score=276, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46073; Mature: 46073

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR
CHHCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCC
WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG
EEEEEEEEEEECCCCCCCCHHHHHHCCCHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHEEEECCHHEECCCCEEE
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASA
EEEECCCCCCHHHHHHHHHCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIG
CHHCCCEEEEEECCHHHHHHHHHHHHHHHHEEEECHHHHHHHHCCCCEEEECCCCHHHHH
DYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAH
HHHCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHEEHHHCCCCCC
AQSVAIRLNL
CCEEEEEEEC
>Mature Secondary Structure
MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR
CHHCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCC
WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG
EEEEEEEEEEECCCCCCCCHHHHHHCCCHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHH
VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHEEEECCHHEECCCCEEE
IVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASA
EEEECCCCCCHHHHHHHHHCCCHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
SWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIG
CHHCCCEEEEEECCHHHHHHHHHHHHHHHHEEEECHHHHHHHHCCCCEEEECCCCHHHHH
DYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAH
HHHCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHCCHHHHEEHHHCCCCCC
AQSVAIRLNL
CCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA