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The map label for this gene is fghA [H]

Identifier: 23501041

GI number: 23501041

Start: 142777

End: 143532

Strand: Reverse

Name: fghA [H]

Synonym: BR0127

Alternate gene names: 23501041

Gene position: 143532-142777 (Counterclockwise)

Preceding gene: 23501042

Following gene: 23501040

Centisome position: 6.81

GC content: 58.2

Gene sequence:

>756_bases
ATGACCTTCGCGCTTTTCCTGCCGCCGCAGGCAAAAGACGGGCCGGTGCCGGTGCTTTGGTATCTTTCCGGCCTCACCTG
CACACATCAGAACGTCATGGACAAAGGCGAATATCGCCAATTGGCCTCAGAACTTGGAATTGCCGTTATTTGCCCAGATA
CCAGCCCGCGTGGCGACAGTATTGCGGACGAGCCCGATAATTGGCAATTCGGCAAGGGGGCTGGCTTCTATGTCGATGCC
ATGCAAGCGCCTTTCGCGCAGAACTATCGGATGTACAGCTATATCACGCAGGAACTGTCCGCTCTCGTTGCCAGGCAATT
TCCGCTCGATATGGAGCGGCAGGCCATCACCGGGCACTCCATGGGCGGGCATGGCGCACTGACGATCGCACTGAAGAACC
CCGATCGTTTCAAATCCGTCTCCGCTTTCGCTCCCATCGTGCAGCCTTCGACGGCGGGATGGTCGAGGCCGGCGCTCGAA
AAATATCTGGGACCGGACGAACAGGCATGGCGCGCCTATGATGCGACACTTCTCATTGAAGACGGCCATCGCTTCCCGGA
AATCCTTGTCGATCAGGGAACGGCAGATGGCTTCCTTGATGACGGCCTGCGGCCATGGCTGCTGGAGGAGGCTTGCAGGA
AAGCGGGCATTGCGCTCACGCTCAACATGCGCGAGGGCTATGACCATTCCTATTTCTTCATCTCAACCTTCATGGGCGAC
CATCTGCGCTGGCATTCGGAACGGCTGCGCAGCTAG

Upstream 100 bases:

>100_bases
CTTGGGAGTTAGAAATTTCATGGAAACGATCTCAACCGCCCGGTGTTTTGACGGCACACAAGGCGTCTATCGCCACAAGA
GCGAAGCCTGCCAATGCGAT

Downstream 100 bases:

>100_bases
AGCATACTTGAACAAAGACCTGGAGCGTGATGACGACCTGACTTAAAGTCATCACGCTCCAACGTATGCGCTTCCCCCCC
CCCGGCATAGAATCAGTTGC

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTFALFLPPQAKDGPVPVLWYLSGLTCTHQNVMDKGEYRQLASELGIAVICPDTSPRGDSIADEPDNWQFGKGAGFYVDA
MQAPFAQNYRMYSYITQELSALVARQFPLDMERQAITGHSMGGHGALTIALKNPDRFKSVSAFAPIVQPSTAGWSRPALE
KYLGPDEQAWRAYDATLLIEDGHRFPEILVDQGTADGFLDDGLRPWLLEEACRKAGIALTLNMREGYDHSYFFISTFMGD
HLRWHSERLRS

Sequences:

>Translated_251_residues
MTFALFLPPQAKDGPVPVLWYLSGLTCTHQNVMDKGEYRQLASELGIAVICPDTSPRGDSIADEPDNWQFGKGAGFYVDA
MQAPFAQNYRMYSYITQELSALVARQFPLDMERQAITGHSMGGHGALTIALKNPDRFKSVSAFAPIVQPSTAGWSRPALE
KYLGPDEQAWRAYDATLLIEDGHRFPEILVDQGTADGFLDDGLRPWLLEEACRKAGIALTLNMREGYDHSYFFISTFMGD
HLRWHSERLRS
>Mature_250_residues
TFALFLPPQAKDGPVPVLWYLSGLTCTHQNVMDKGEYRQLASELGIAVICPDTSPRGDSIADEPDNWQFGKGAGFYVDAM
QAPFAQNYRMYSYITQELSALVARQFPLDMERQAITGHSMGGHGALTIALKNPDRFKSVSAFAPIVQPSTAGWSRPALEK
YLGPDEQAWRAYDATLLIEDGHRFPEILVDQGTADGFLDDGLRPWLLEEACRKAGIALTLNMREGYDHSYFFISTFMGDH
LRWHSERLRS

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=254, Percent_Identity=53.1496062992126, Blast_Score=276, Evalue=9e-75,
Organism=Escherichia coli, GI1786551, Length=250, Percent_Identity=46.8, Blast_Score=248, Evalue=3e-67,
Organism=Escherichia coli, GI1788477, Length=251, Percent_Identity=49.800796812749, Blast_Score=238, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17510185, Length=254, Percent_Identity=46.8503937007874, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322393, Length=269, Percent_Identity=42.3791821561338, Blast_Score=206, Evalue=2e-54,
Organism=Drosophila melanogaster, GI45551932, Length=255, Percent_Identity=47.843137254902, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24648347, Length=255, Percent_Identity=47.843137254902, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 28112; Mature: 27981

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFALFLPPQAKDGPVPVLWYLSGLTCTHQNVMDKGEYRQLASELGIAVICPDTSPRGDS
CEEEEEECCCCCCCCEEEEEEECCCEECHHHHHCCHHHHHHHHHCCEEEEECCCCCCCCC
IADEPDNWQFGKGAGFYVDAMQAPFAQNYRMYSYITQELSALVARQFPLDMERQAITGHS
CCCCCCCCCCCCCCCEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
MGGHGALTIALKNPDRFKSVSAFAPIVQPSTAGWSRPALEKYLGPDEQAWRAYDATLLIE
CCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHEECEEEEEE
DGHRFPEILVDQGTADGFLDDGLRPWLLEEACRKAGIALTLNMREGYDHSYFFISTFMGD
CCCCCCHHEEECCCCCCCHHCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEHHHHH
HLRWHSERLRS
HHHHHHHHHCC
>Mature Secondary Structure 
TFALFLPPQAKDGPVPVLWYLSGLTCTHQNVMDKGEYRQLASELGIAVICPDTSPRGDS
EEEEEECCCCCCCCEEEEEEECCCEECHHHHHCCHHHHHHHHHCCEEEEECCCCCCCCC
IADEPDNWQFGKGAGFYVDAMQAPFAQNYRMYSYITQELSALVARQFPLDMERQAITGHS
CCCCCCCCCCCCCCCEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCC
MGGHGALTIALKNPDRFKSVSAFAPIVQPSTAGWSRPALEKYLGPDEQAWRAYDATLLIE
CCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCHHHHHEECEEEEEE
DGHRFPEILVDQGTADGFLDDGLRPWLLEEACRKAGIALTLNMREGYDHSYFFISTFMGD
CCCCCCHHEEECCCCCCCHHCCCCHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEHHHHH
HLRWHSERLRS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]