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The map label for this gene is ilvD [H]

Identifier: 23501013

GI number: 23501013

Start: 103313

End: 105148

Strand: Reverse

Name: ilvD [H]

Synonym: BR0099

Alternate gene names: 23501013

Gene position: 105148-103313 (Counterclockwise)

Preceding gene: 23501015

Following gene: 23501007

Centisome position: 4.99

GC content: 61.0

Gene sequence:

>1836_bases
ATGCCTCCTTATCGTTCGCGTACAACCACCCATGGCCGCAATATGGCCGGCGCGCGCGGCCTATGGCGCGCCACCGGCAT
GAAGGATGAGGATTTCGGCAAGCCGATTATCGCCGTGGTGAACTCGTTCACCCAGTTCGTGCCCGGCCATGTGCATCTGA
AGGATCTCGGCCAGCTCGTCGCGCGCGAAATCGAAAGTGCGGGCGGCGTCGCCAAGGAATTCAATACCATTGCGGTCGAT
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTCCCCTCCCGTGAGCTCATCGCCGACTCGGTCGAATATAT
GGTCAATGCGCATTGCGCCGATGCGATGGTCTGCATCTCCAATTGCGACAAGATCACGCCCGGCATGCTGATGGCGGCGC
TGCGTCTCAATATTCCGGTCGTGTTCGTCTCCGGTGGGCCGATGGAAGCAGGCAAGGTCGTGTGGGAGGATTCTGTCAAG
AAGCTCGACCTCGTGGACGCCATGGTGGCGGCGGCCGACGACCATTATACCGACGAGCAGGTGAAGGCGATTGAGCGTTC
CGCCTGCCCGACCTGTGGGTCGTGTTCGGGCATGTTCACGGCCAATTCGATGAATTGCCTTACCGAAGCGCTCGGCCTGT
CGCTGCCCGGCAATGGTTCGACGCTCGCCACCCATGCAGACCGCAAGCGCCTCTTCGTCGAAGCTGGCCACCTGATCGTC
GATCTCGCCCGCCGCTATTACGAGCAGGATGACGAAAGTGTGCTGCCGCGCTCCATCGCCACTTTCTCGGCTTTCGAGAA
CGCGATGACGCTCGATATCGCCATGGGCGGTTCGACCAATACGGTTCTGCATCTGCTCGCGGCTGCGCAGGAAGCGGAAA
TCGATTTCACCATGGCGGATATAGACCGCCTGTCGCGCCGCGTGCCGGTGCTGTGCAAGGTGGCGCCCGCCGTGTCGTCG
GTTCACATGGAAGACGTGCATCATGCCGGCGGCATCATGGGCATTCTCGGACAGCTCGACAATGCGGGCCTGCTGACCAC
CAGCATCCCGACCGTGCACAGCGAAACGCTCGCTAAGGCGCTTGATCATTGGGATGTAACGCGCACAAACAGCGAAATGG
TGCACAAATTCTATTCCGCCGCTCCCGGCGGCGTGCCGACGCAGGTGGCTTTCAGCCAGGAGCGGCGCTTCGACAAGGTG
GACACCGACCGCGAAAAAGGCGTCATCCGCTCAAAGGAACACGCTTTCAGCCAGGATGGCGGCTTGGCCGTGCTTTACGG
CAATCTGGCGGAAGACGGCTGCATCGTGAAGACGGCAGGCGTGGACGATTCCATCCTGAAATTCTCCGGCCCGGCCCGCA
TTTTTGAAAGCCAGGATTCGGCTGTGCTTGGCATTTTGAACGGCAAGATCAAGCCGGGCGACATCGTGCTGATCCGCTAT
GAAGGCCCGCGCGGCGGCCCCGGAATGCAGGAAATGCTCTACCCGACCAGCTATCTGAAGTCGAAGGGCTTCGGCAAAGC
CTGCGCACTTATCACCGACGGACGTTTCTCGGGCGGTTCATCGGGCCTTTCCATCGGCCATGTTTCGCCGGAAGCAGCCG
AAGGCGGCACGATCGGTCTGGTGCGCGAAGGCGATATCATCGATATCGACATTCCGAACCGCAAGATCCACCTTGCCGTT
GACGACGCCACACTTGCCGAACGCCGCGCCGAGCAGGATGCAGCAGGCTGGAAACCGGCAGAGGAACGCAAGCGTAAAAT
CTCCACTGCGCTGAAAGCCTATGCGGCAATGGCGACAAGTGCCGCCAGGGGCGCGGTGCGAAAGCTGCCGGATTGA

Upstream 100 bases:

>100_bases
ATGGCCCATTTTTTAGCAATATGGGGCAATTTGCGCTTTGCTCGGCGAGAGCGGTTCTGTCATATCGGTGAAGTTAGAAT
AGTTCCTAAAAGGTTTGAAA

Downstream 100 bases:

>100_bases
TCGATAATTAAGAAAAGCAAAAGCCCCGCCCATTGAACTGCCCCCGAAAGTTGGACGACCAACTTCGGGGGAATGCGGGG
CTTTTCATTTTAGAAATTCC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVK
KLDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSS
VHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKV
DTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
EGPRGGPGMQEMLYPTSYLKSKGFGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAV
DDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD

Sequences:

>Translated_611_residues
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVK
KLDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSS
VHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKV
DTDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
EGPRGGPGMQEMLYPTSYLKSKGFGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAV
DDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD
>Mature_610_residues
PPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIESAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKK
LDLVDAMVAAADDHYTDEQVKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIVD
LARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMADIDRLSRRVPVLCKVAPAVSSV
HMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKALDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVD
TDREKGVIRSKEHAFSQDGGLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRYE
GPRGGPGMQEMLYPTSYLKSKGFGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGLVREGDIIDIDIPNRKIHLAVD
DATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATSAARGAVRKLPD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=74.0983606557377, Blast_Score=939, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=533, Percent_Identity=32.0825515947467, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788157, Length=551, Percent_Identity=28.4936479128857, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=32.1223709369025, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322476, Length=609, Percent_Identity=37.2742200328407, Blast_Score=348, Evalue=1e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65345; Mature: 65214

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKKLDLVDAMVAAADDHYTDEQ
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHCHHHHHHHHHHHHHCCCCCCHHH
VKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMAD
HHHHHHHCCCCCHHCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDRLSRRVPVLCKVAPAVSSVHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKA
HHHHHCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVDTDREKGVIRSKEHAFSQDG
HHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHCCCHHCHHHCCCCCC
GLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
CEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGFGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
VREGDIIDIDIPNRKIHLAVDDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATS
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRKLPD
HHHHHHHCCCC
>Mature Secondary Structure 
PPYRSRTTTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIESAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKVVWEDSVKKLDLVDAMVAAADDHYTDEQ
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEEEHHCHHHHHHHHHHHHHCCCCCCHHH
VKAIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKRLFVEAGHLIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHH
DLARRYYEQDDESVLPRSIATFSAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMAD
HHHHHHHCCCCCHHCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHH
IDRLSRRVPVLCKVAPAVSSVHMEDVHHAGGIMGILGQLDNAGLLTTSIPTVHSETLAKA
HHHHHCCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCHHHHHHHHH
LDHWDVTRTNSEMVHKFYSAAPGGVPTQVAFSQERRFDKVDTDREKGVIRSKEHAFSQDG
HHHCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCHHCCCHHCHHHCCCCCC
GLAVLYGNLAEDGCIVKTAGVDDSILKFSGPARIFESQDSAVLGILNGKIKPGDIVLIRY
CEEEEECCCCCCCEEEEECCCCCHHHCCCCCHHHCCCCCCEEEEEECCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGFGKACALITDGRFSGGSSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEE
VREGDIIDIDIPNRKIHLAVDDATLAERRAEQDAAGWKPAEERKRKISTALKAYAAMATS
EECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
AARGAVRKLPD
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA