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The map label for this gene is dnaC [H]

Identifier: 23100915

GI number: 23100915

Start: 3597383

End: 3598747

Strand: Reverse

Name: dnaC [H]

Synonym: OB3460

Alternate gene names: 23100915

Gene position: 3598747-3597383 (Counterclockwise)

Preceding gene: 23100916

Following gene: 23100913

Centisome position: 99.12

GC content: 40.66

Gene sequence:

>1365_bases
ATGAGTGCATCGTGGAATGATCGTACGCCGCCACATAATATCGAAGCAGAGCAATCGGTACTAGGTGCGGTTTTTTTAGA
GCCGCAAGCCTACGTAACCGCATCAGAGACGTTGATTGCCGAAGACTTTTACCGGGCCAGTCACCAGCGAATATTTGCAG
CAATGATGAGTTTATCCGATAAAGGTGAACCTATTGATGTTATAACAGTGACAACATTTTTAAATGATCGGAAGCAATTG
GAAGAAGCTGGTGGTGTTACTTATTTAACCCAGCTAGCAGAAAGTGTTCCAACAGCTGCAAATATAGAGTACTATAGTAA
GATTGTAGAAGAGAAGTCTACTTTACGCAGTTTAATTCGTAAAGCAACAGACATTGTGACCTCTTCGTTTGAAAAAGAGG
ACGAAGTAGAAGATGTATTAAATGACGCAGAGAAAAGTATTTTGGAAGTGTCTGGGAGAAAAAACTCTGGTGCTTTTAAA
AATATCAAAGATGTCTTAATCGATGTGTATGATAATATAGAACAATTGCATCAACAAAACGGAGATGTAACCGGAGTACC
GACAGGATTTCAGGACTTAGATCGTATTACATCTGGTTTCCAGCGAAATGATTTAATTATTATTGCTGCTCGTCCTTCGG
TTGGTAAGACGGCATTCGCCCTGAACGTAGCCCAAAACGTTGCAGTAAAAACGGATCAGAATGTGGCCATCTTCAGTCTT
GAGATGGGAGCTGACCAATTAGTGCAACGTATGCTTTGTGCAGAAGGGAATATTGATGCACAACGTCTTCGAAATGGACA
ACTCCAAGCAGATGATTGGGGCAAGCTAACCATGGCCATGGGCTCCCTATCCAATGCGGGAATTTATATAGATGATACAC
CAGGCGTACGGGTGAATGAGATTCGTTCTAAATGTCGTCGTCTTAAGCAGGAGCATGGACTTGGTATGATCTTAATCGAT
TATTTGCAATTGATTCAAGGAAGTGGAAGTTCGAAAGAGAATCGACAGCAAGAGGTATCTGAGATTTCACGTGCATTAAA
AGCATTAGCAAGAGAATTAGAAGTCCCTCTTATCGCTCTTTCTCAGTTATCTCGTGGTGTAGAATCACGACAAGATAAAC
GACCGATGATGTCTGATATTCGTGAGTCTGGAAGTATTGAGCAGGATGCAGATATTGTAGGCTTCCTTTATCGTGATGAT
TATTATGATCAGGAGACAGAAAAACAAAATATTATAGAAATTATAATTGCAAAACAACGTAATGGCCCAACAGGAACGGT
AGAACTAGCCTTTGTAAAAGAATATAATAAATTCGTTGATTTGGACCATCGATACCAGGAAGGAGATATCCCTCCAGCGA
TGTAA

Upstream 100 bases:

>100_bases
TTGGTGAAGTGTGCGTAAACGATCGAAATATTTCATGCGGACACTACTTGCCATATCGTTTTTTAGCGATGGTTTTAATT
GTTATTAGGAGGAGAATGCG

Downstream 100 bases:

>100_bases
TTATCCGTGTAAGTTGAGGCTCGGAACCTGGTCAAAAGCCGAATGAAAGTTAGAATAAGCGCAGTATATTTCTGAAGTGG
TTTTTCAAAGCTAATCATTC

Product: replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSASWNDRTPPHNIEAEQSVLGAVFLEPQAYVTASETLIAEDFYRASHQRIFAAMMSLSDKGEPIDVITVTTFLNDRKQL
EEAGGVTYLTQLAESVPTAANIEYYSKIVEEKSTLRSLIRKATDIVTSSFEKEDEVEDVLNDAEKSILEVSGRKNSGAFK
NIKDVLIDVYDNIEQLHQQNGDVTGVPTGFQDLDRITSGFQRNDLIIIAARPSVGKTAFALNVAQNVAVKTDQNVAIFSL
EMGADQLVQRMLCAEGNIDAQRLRNGQLQADDWGKLTMAMGSLSNAGIYIDDTPGVRVNEIRSKCRRLKQEHGLGMILID
YLQLIQGSGSSKENRQQEVSEISRALKALARELEVPLIALSQLSRGVESRQDKRPMMSDIRESGSIEQDADIVGFLYRDD
YYDQETEKQNIIEIIIAKQRNGPTGTVELAFVKEYNKFVDLDHRYQEGDIPPAM

Sequences:

>Translated_454_residues
MSASWNDRTPPHNIEAEQSVLGAVFLEPQAYVTASETLIAEDFYRASHQRIFAAMMSLSDKGEPIDVITVTTFLNDRKQL
EEAGGVTYLTQLAESVPTAANIEYYSKIVEEKSTLRSLIRKATDIVTSSFEKEDEVEDVLNDAEKSILEVSGRKNSGAFK
NIKDVLIDVYDNIEQLHQQNGDVTGVPTGFQDLDRITSGFQRNDLIIIAARPSVGKTAFALNVAQNVAVKTDQNVAIFSL
EMGADQLVQRMLCAEGNIDAQRLRNGQLQADDWGKLTMAMGSLSNAGIYIDDTPGVRVNEIRSKCRRLKQEHGLGMILID
YLQLIQGSGSSKENRQQEVSEISRALKALARELEVPLIALSQLSRGVESRQDKRPMMSDIRESGSIEQDADIVGFLYRDD
YYDQETEKQNIIEIIIAKQRNGPTGTVELAFVKEYNKFVDLDHRYQEGDIPPAM
>Mature_453_residues
SASWNDRTPPHNIEAEQSVLGAVFLEPQAYVTASETLIAEDFYRASHQRIFAAMMSLSDKGEPIDVITVTTFLNDRKQLE
EAGGVTYLTQLAESVPTAANIEYYSKIVEEKSTLRSLIRKATDIVTSSFEKEDEVEDVLNDAEKSILEVSGRKNSGAFKN
IKDVLIDVYDNIEQLHQQNGDVTGVPTGFQDLDRITSGFQRNDLIIIAARPSVGKTAFALNVAQNVAVKTDQNVAIFSLE
MGADQLVQRMLCAEGNIDAQRLRNGQLQADDWGKLTMAMGSLSNAGIYIDDTPGVRVNEIRSKCRRLKQEHGLGMILIDY
LQLIQGSGSSKENRQQEVSEISRALKALARELEVPLIALSQLSRGVESRQDKRPMMSDIRESGSIEQDADIVGFLYRDDY
YDQETEKQNIIEIIIAKQRNGPTGTVELAFVKEYNKFVDLDHRYQEGDIPPAM

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=438, Percent_Identity=47.0319634703196, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 50635; Mature: 50503

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASWNDRTPPHNIEAEQSVLGAVFLEPQAYVTASETLIAEDFYRASHQRIFAAMMSLSD
CCCCCCCCCCCCCCCHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGEPIDVITVTTFLNDRKQLEEAGGVTYLTQLAESVPTAANIEYYSKIVEEKSTLRSLIR
CCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KATDIVTSSFEKEDEVEDVLNDAEKSILEVSGRKNSGAFKNIKDVLIDVYDNIEQLHQQN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GDVTGVPTGFQDLDRITSGFQRNDLIIIAARPSVGKTAFALNVAQNVAVKTDQNVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEEHHHCCEEECCCCEEEEEE
EMGADQLVQRMLCAEGNIDAQRLRNGQLQADDWGKLTMAMGSLSNAGIYIDDTPGVRVNE
ECCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCHHH
IRSKCRRLKQEHGLGMILIDYLQLIQGSGSSKENRQQEVSEISRALKALARELEVPLIAL
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SQLSRGVESRQDKRPMMSDIRESGSIEQDADIVGFLYRDDYYDQETEKQNIIEIIIAKQR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEEEECCCCCCCHHHHHHHEEEEEEECC
NGPTGTVELAFVKEYNKFVDLDHRYQEGDIPPAM
CCCCCEEEEEEEHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SASWNDRTPPHNIEAEQSVLGAVFLEPQAYVTASETLIAEDFYRASHQRIFAAMMSLSD
CCCCCCCCCCCCCCHHHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
KGEPIDVITVTTFLNDRKQLEEAGGVTYLTQLAESVPTAANIEYYSKIVEEKSTLRSLIR
CCCCEEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
KATDIVTSSFEKEDEVEDVLNDAEKSILEVSGRKNSGAFKNIKDVLIDVYDNIEQLHQQN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GDVTGVPTGFQDLDRITSGFQRNDLIIIAARPSVGKTAFALNVAQNVAVKTDQNVAIFSL
CCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCHHHEEEHHHCCEEECCCCEEEEEE
EMGADQLVQRMLCAEGNIDAQRLRNGQLQADDWGKLTMAMGSLSNAGIYIDDTPGVRVNE
ECCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCCHHH
IRSKCRRLKQEHGLGMILIDYLQLIQGSGSSKENRQQEVSEISRALKALARELEVPLIAL
HHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SQLSRGVESRQDKRPMMSDIRESGSIEQDADIVGFLYRDDYYDQETEKQNIIEIIIAKQR
HHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHEEEEECCCCCCCHHHHHHHEEEEEEECC
NGPTGTVELAFVKEYNKFVDLDHRYQEGDIPPAM
CCCCCEEEEEEEHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]