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The map label for this gene is panC

Identifier: 23100730

GI number: 23100730

Start: 3411568

End: 3412419

Strand: Direct

Name: panC

Synonym: OB3275

Alternate gene names: 23100730

Gene position: 3411568-3412419 (Clockwise)

Preceding gene: 23100729

Following gene: 23100733

Centisome position: 93.97

GC content: 41.55

Gene sequence:

>852_bases
ATGACAAAACGAATTACGACCATAAAAGAAATGCAACACCTTAGTCGAACACGGAAAGCACATAATAAACAAATTGGATT
TGTACCAACGATGGGGGCATTGCATGACGGGCATTTACAAATGGTGAAGCAATCAATAGCGGACAATGACTATACCGTGG
TCAGCGTCTTTGTAAACCCACTGCAATTTGGGCCAAATGAGGATTTCGATGCTTATCCACGAACCATTGAAGAGGACGAG
GCACAGCTAGATGCATTAGGTGCCGATTATGTCTTCTACCCGAGCGTGGAAGAAATGTACCCTAAGCCACTCGAGCTTTC
GATCAACGTCCATCGAATGGCGGAAGTATTAGAAGGAGCAAAGCGTCCGGGTCATTTTGACGGTGTGGTAACCGTCGTCA
ATAAGTTATTTAATATTATCCGTCCTGATATCGCCTATTTTGGAAAAAAAGACGCGCAGCAACTGGCAATCATTGAAAAG
ATGGTCGAGGAATTTAATCATCCGATTACCATTCGAGGCATGGATACGATACGTGAATTAGATGGATTAGCAAAAAGCTC
GCGCAACATTTACTTAACAGACAACGAGCGACAAGAAGCCGTTCAATTATATCAAAGTCTATTAAAAGCAAAACAGTTAT
ATGATGCGGGTGAACGAAGCAGCGATGTTATCATCGATGAAATCCACACCCATTTAACCACACATACATCCGGAACGATT
GAAGAGATTGCGATTTACAGCTACCCAGAACTGATAGAACAAACACAGATTACTGGCCGGATTTTTATATCGTTAGCCGT
GAAATTTTCACAAGCGAGATTGATCGATAATATTATTGTAGAAAAAAGTTGA

Upstream 100 bases:

>100_bases
GTGTAGAATCCATAAAAAACTTTCATGACGAGGTGAAGCGACAAGCGTTTCCTACTGAAGAATACACATACAAGAAACAA
ATTATGAACGAGGTAGACGA

Downstream 100 bases:

>100_bases
AAGTAGTTGTCCAGCTCTTTATCGTAGGCCGATTTCCTAGTTTCTGACTACCTGAGATGTTCGTTACAAGCATAAAAAAA
TAGTGGGTATTCCCCACTAT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTKRITTIKEMQHLSRTRKAHNKQIGFVPTMGALHDGHLQMVKQSIADNDYTVVSVFVNPLQFGPNEDFDAYPRTIEEDE
AQLDALGADYVFYPSVEEMYPKPLELSINVHRMAEVLEGAKRPGHFDGVVTVVNKLFNIIRPDIAYFGKKDAQQLAIIEK
MVEEFNHPITIRGMDTIRELDGLAKSSRNIYLTDNERQEAVQLYQSLLKAKQLYDAGERSSDVIIDEIHTHLTTHTSGTI
EEIAIYSYPELIEQTQITGRIFISLAVKFSQARLIDNIIVEKS

Sequences:

>Translated_283_residues
MTKRITTIKEMQHLSRTRKAHNKQIGFVPTMGALHDGHLQMVKQSIADNDYTVVSVFVNPLQFGPNEDFDAYPRTIEEDE
AQLDALGADYVFYPSVEEMYPKPLELSINVHRMAEVLEGAKRPGHFDGVVTVVNKLFNIIRPDIAYFGKKDAQQLAIIEK
MVEEFNHPITIRGMDTIRELDGLAKSSRNIYLTDNERQEAVQLYQSLLKAKQLYDAGERSSDVIIDEIHTHLTTHTSGTI
EEIAIYSYPELIEQTQITGRIFISLAVKFSQARLIDNIIVEKS
>Mature_282_residues
TKRITTIKEMQHLSRTRKAHNKQIGFVPTMGALHDGHLQMVKQSIADNDYTVVSVFVNPLQFGPNEDFDAYPRTIEEDEA
QLDALGADYVFYPSVEEMYPKPLELSINVHRMAEVLEGAKRPGHFDGVVTVVNKLFNIIRPDIAYFGKKDAQQLAIIEKM
VEEFNHPITIRGMDTIRELDGLAKSSRNIYLTDNERQEAVQLYQSLLKAKQLYDAGERSSDVIIDEIHTHLTTHTSGTIE
EIAIYSYPELIEQTQITGRIFISLAVKFSQARLIDNIIVEKS

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=279, Percent_Identity=43.7275985663082, Blast_Score=218, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322046, Length=296, Percent_Identity=38.8513513513513, Blast_Score=189, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_OCEIH (Q8CX59)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_694197.1
- ProteinModelPortal:   Q8CX59
- SMR:   Q8CX59
- GeneID:   1016461
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB3275
- NMPDR:   fig|221109.1.peg.3277
- HOGENOM:   HBG428839
- OMA:   ASSKENH
- ProtClustDB:   PRK00380
- BioCyc:   OIHE221109:OB3275-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32194; Mature: 32063

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: ACT_SITE 38-38 BINDING 62-62 BINDING 62-62 BINDING 154-154 BINDING 177-177

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRITTIKEMQHLSRTRKAHNKQIGFVPTMGALHDGHLQMVKQSIADNDYTVVSVFVNP
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHH
LQFGPNEDFDAYPRTIEEDEAQLDALGADYVFYPSVEEMYPKPLELSINVHRMAEVLEGA
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCHHHHCCCCEEEEECHHHHHHHHHHC
KRPGHFDGVVTVVNKLFNIIRPDIAYFGKKDAQQLAIIEKMVEEFNHPITIRGMDTIREL
CCCCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHH
DGLAKSSRNIYLTDNERQEAVQLYQSLLKAKQLYDAGERSSDVIIDEIHTHLTTHTSGTI
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCH
EEIAIYSYPELIEQTQITGRIFISLAVKFSQARLIDNIIVEKS
HHHHHHCCHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKRITTIKEMQHLSRTRKAHNKQIGFVPTMGALHDGHLQMVKQSIADNDYTVVSVFVNP
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHH
LQFGPNEDFDAYPRTIEEDEAQLDALGADYVFYPSVEEMYPKPLELSINVHRMAEVLEGA
HHCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCHHHHCCCCEEEEECHHHHHHHHHHC
KRPGHFDGVVTVVNKLFNIIRPDIAYFGKKDAQQLAIIEKMVEEFNHPITIRGMDTIREL
CCCCCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECHHHHHHH
DGLAKSSRNIYLTDNERQEAVQLYQSLLKAKQLYDAGERSSDVIIDEIHTHLTTHTSGTI
HHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCH
EEIAIYSYPELIEQTQITGRIFISLAVKFSQARLIDNIIVEKS
HHHHHHCCHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376