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The map label for this gene is ywlC [H]

Identifier: 23100449

GI number: 23100449

Start: 3102764

End: 3103783

Strand: Reverse

Name: ywlC [H]

Synonym: OB2994

Alternate gene names: 23100449

Gene position: 3103783-3102764 (Counterclockwise)

Preceding gene: 23100450

Following gene: 23100448

Centisome position: 85.49

GC content: 41.08

Gene sequence:

>1020_bases
ATGACTACGAAACGATGGAATATGAATGATATAGACAAGAATCAAAGTTATATAAAGGAAGCTGCAGGTATTCTGCAAGC
TGGTCAAACAGTCGCTTTTCCAACAGAAACAGTCTATGGATTAGGAGCCGATGCTACAAATCCACAAGCCGTTTCTAAAA
TTTTTCAAGCAAAAGGCCGACCGGAAGATAATCCACTGATAGCTCATGTGGCTACAAAAGAACAACTACAACGCTTAGTT
ACTTCTATACCTGGCTATGTGGATAAATTAATTGCGGCTTTCTCTCCTGGACCGCTGACGTTTATTTTACCGAGTAACGG
GATATGTGCTTCAAATGTAACAGCAGGACTTGATACCATTGGTGTACGTATACCGAACCATCCTGTAGCATTACAATTAT
TAAAGGAAGTAGATATCCCGATCGCAGCACCAAGTGCAAATATTTCTGGAAAACCTAGCCCAACAACAGCTGATCATGTC
TTTAACGATCTCGAAGGTAGAATTGCAGGGCTTGTAGATGGTGGGCCAACAGGGGTTGGATTAGAATCCACCGTTATAGA
TTGTACACAAGAGATTCCGGTGATACTTCGTCCGGGTGGAGTTACGAAAGAGAATTTAGAAAGTGTAATCGGGCATGTTT
TGGTAGACCCTGGGATTATTGATGGGGAAGGGAAACCAAAATCCCCAGGAATGAAGTATAAACACTATGCACCTGAAGTC
CCCTTGTGGATTTTCGAAGGTGATAGTAATGGATTCCAAGAGTTGATCGAGAAAGAACAACAAAGCAATCATAGAGTAGG
TGTATTATGCTCCAATCAATTTGCGGTTCAGTTATCTCATGATAATATCTATCAGTTAGGAGACTCGATGGAAGAGATTG
CATCAAGTCTTTACGACGGCTTGCGTTATTTTAAGCAACAGGCAGTAGATGTTATTATTTGTGAGTCTTTCCCGGAGAGT
GGAATTGGACAGGCAATTATGAATCGATTACGTAAAGCTTCTGACTCAACAATTACGTAA

Upstream 100 bases:

>100_bases
AATTATATGTGGAAAAGTGGATAATCATGACGGATTATCCACTTTTTTGCGTTTCTAGTCGGCTTCTACTAAAATAGAAA
CGTAGAAAAGAGGTTACAGA

Downstream 100 bases:

>100_bases
AGTTAATAGAATATCTAAAAATGTAAGCAACAGGCATTCATAAGACTTCTTATTCATGCATATAGTTTATTAGCATGTCC
TAGGAGGAAGTTGAATGCCT

Product: hypothetical protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTTKRWNMNDIDKNQSYIKEAAGILQAGQTVAFPTETVYGLGADATNPQAVSKIFQAKGRPEDNPLIAHVATKEQLQRLV
TSIPGYVDKLIAAFSPGPLTFILPSNGICASNVTAGLDTIGVRIPNHPVALQLLKEVDIPIAAPSANISGKPSPTTADHV
FNDLEGRIAGLVDGGPTGVGLESTVIDCTQEIPVILRPGGVTKENLESVIGHVLVDPGIIDGEGKPKSPGMKYKHYAPEV
PLWIFEGDSNGFQELIEKEQQSNHRVGVLCSNQFAVQLSHDNIYQLGDSMEEIASSLYDGLRYFKQQAVDVIICESFPES
GIGQAIMNRLRKASDSTIT

Sequences:

>Translated_339_residues
MTTKRWNMNDIDKNQSYIKEAAGILQAGQTVAFPTETVYGLGADATNPQAVSKIFQAKGRPEDNPLIAHVATKEQLQRLV
TSIPGYVDKLIAAFSPGPLTFILPSNGICASNVTAGLDTIGVRIPNHPVALQLLKEVDIPIAAPSANISGKPSPTTADHV
FNDLEGRIAGLVDGGPTGVGLESTVIDCTQEIPVILRPGGVTKENLESVIGHVLVDPGIIDGEGKPKSPGMKYKHYAPEV
PLWIFEGDSNGFQELIEKEQQSNHRVGVLCSNQFAVQLSHDNIYQLGDSMEEIASSLYDGLRYFKQQAVDVIICESFPES
GIGQAIMNRLRKASDSTIT
>Mature_338_residues
TTKRWNMNDIDKNQSYIKEAAGILQAGQTVAFPTETVYGLGADATNPQAVSKIFQAKGRPEDNPLIAHVATKEQLQRLVT
SIPGYVDKLIAAFSPGPLTFILPSNGICASNVTAGLDTIGVRIPNHPVALQLLKEVDIPIAAPSANISGKPSPTTADHVF
NDLEGRIAGLVDGGPTGVGLESTVIDCTQEIPVILRPGGVTKENLESVIGHVLVDPGIIDGEGKPKSPGMKYKHYAPEVP
LWIFEGDSNGFQELIEKEQQSNHRVGVLCSNQFAVQLSHDNIYQLGDSMEEIASSLYDGLRYFKQQAVDVIICESFPESG
IGQAIMNRLRKASDSTIT

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI2367210, Length=155, Percent_Identity=32.258064516129, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87081864, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17537239, Length=201, Percent_Identity=28.8557213930348, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6321269, Length=373, Percent_Identity=37.8016085790885, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI78707274, Length=180, Percent_Identity=31.1111111111111, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 36428; Mature: 36297

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKRWNMNDIDKNQSYIKEAAGILQAGQTVAFPTETVYGLGADATNPQAVSKIFQAKGR
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHEECCCCCCCHHHHHHHHHHCCC
PEDNPLIAHVATKEQLQRLVTSIPGYVDKLIAAFSPGPLTFILPSNGICASNVTAGLDTI
CCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHH
GVRIPNHPVALQLLKEVDIPIAAPSANISGKPSPTTADHVFNDLEGRIAGLVDGGPTGVG
EEECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCC
LESTVIDCTQEIPVILRPGGVTKENLESVIGHVLVDPGIIDGEGKPKSPGMKYKHYAPEV
CCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC
PLWIFEGDSNGFQELIEKEQQSNHRVGVLCSNQFAVQLSHDNIYQLGDSMEEIASSLYDG
CEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHCCHHHHHHHHHHHH
LRYFKQQAVDVIICESFPESGIGQAIMNRLRKASDSTIT
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTKRWNMNDIDKNQSYIKEAAGILQAGQTVAFPTETVYGLGADATNPQAVSKIFQAKGR
CCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHEECCCCCCCHHHHHHHHHHCCC
PEDNPLIAHVATKEQLQRLVTSIPGYVDKLIAAFSPGPLTFILPSNGICASNVTAGLDTI
CCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCHHHH
GVRIPNHPVALQLLKEVDIPIAAPSANISGKPSPTTADHVFNDLEGRIAGLVDGGPTGVG
EEECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCCC
LESTVIDCTQEIPVILRPGGVTKENLESVIGHVLVDPGIIDGEGKPKSPGMKYKHYAPEV
CCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCC
PLWIFEGDSNGFQELIEKEQQSNHRVGVLCSNQFAVQLSHDNIYQLGDSMEEIASSLYDG
CEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCHHHHCCHHHHHHHHHHHH
LRYFKQQAVDVIICESFPESGIGQAIMNRLRKASDSTIT
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]