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The map label for this gene is murA

Identifier: 23100427

GI number: 23100427

Start: 3081719

End: 3083050

Strand: Reverse

Name: murA

Synonym: OB2972

Alternate gene names: 23100427

Gene position: 3083050-3081719 (Counterclockwise)

Preceding gene: 23100428

Following gene: 23100426

Centisome position: 84.92

GC content: 40.62

Gene sequence:

>1332_bases
ATGGAAAAAATCATCGTAAGTGGCGGACACCAATTGAATGGCACCGTACGGCTTGAAGGTGCTAAAAACGCTGTACTACC
TGTTTTAGCTGCAAGTTTAATTGCGAGTGAAGGGGAAAGCGTTATTAAAGAAGTACCAGTTTTAGCAGACGTGTACACAA
TTAATGAAGTATTACGTAATCTAAACGCAGAAGTTGAATTTGATTCAACAACAAAGACAGTGAATATTAATGCATCACAA
CAATTAGAGACAGAAGCCCCATTTGAATATGTAAGAAAAATGCGTGCATCTGTACTTGTTTTGGGACCACTTTTGGCCCG
TTATGGACACGCGAAAGTTGCTATGCCAGGAGGATGTGCGATTGGTTCTCGACCAATTGATTTACACCTTAAAGGTTTCG
AAGCAATGGGAGCAGAAATCCATGTAGGTAACGGCTATGTGGAAGCAAATGTGAATGGCAGATTACAAGGTGCGAAGATT
TATCTTGATATGCCAAGTGTAGGTGCGACGGAAAACATTATGATGGCTGCAGCACTTGCAGAGGGTAAGACAGTAATTGA
AAATGCAGCAAAAGAACCAGAAATAGTTGATTTAGCAAATTATCTTAATAAGATGGGTGCGAATATCGTTGGAGCAGGTA
CGGAAACAATCCGTATTATTGGTGTAGAAAAACTTCGCGGTACGGAGCACATGATTATACCTGATCGTATTGAAGCTGGT
ACCTTTATGGTTGCCTCTGCAATTACTGGAGGTAATGTATTCATTGAGAATGCAATGCGTGAACATTTACGCTCTGTAAT
TTCAAAGTTAGAAGAAATGAATGTTGATGTAATTGATGAGAATGGCGGTCTACGAATCATAGGGCCAGAGAAATTAAAAT
CAACAGATATTAAAACATTACCGCATCCTGGTTTTCCTACAGATATGCAATCACAAATGATGTCATTAATGCTTCGTGCA
GAAGGCACAGGTGTGATTACGGAGACTGTTTTCGAAAATCGTTTTATGCATGTAGAAGAATTTCGACGCATGAATGCGAA
TATCAAAATTGAAGGACGCAGTGTGATTATTGAAGGTATTTCAGAGTTGCAAGGCGCTGAAGTAGCAGCAACAGATCTTC
GTGCGGCAGCGGCACTTATTTTAGCAGGTCTTGTAAGCGATGGATACACACGTGTGACGGAGCTTAAGCATCTAGACCGT
GGCTATGTTGATATTGTTGATAAGTTAGCGGCACTTGGTGCAGATATCAAGAGAGTGGATGAGAACGGAGTAGTTGTACA
ACCACTCTACGTAACTGCTGCAAAAGAATCAAATGAAATAGCAGCGGATTAA

Upstream 100 bases:

>100_bases
ATAGAAGACGAAGCAGGAAATGAGAAATACACGATAGGAACACCTATCCTAATACATGAATATTAATATAGGGAAATTGG
ATCTGAAGGGGATTTATAAC

Downstream 100 bases:

>100_bases
TAAAAATTTTATAATAGTTATTTCTAAGGTAGATGTGTTATTACGCATCTACCTTTTCGTGTTTCAAGAAAAATTTTCCT
TATGAAAAGCAGGCCTTATA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEKIIVSGGHQLNGTVRLEGAKNAVLPVLAASLIASEGESVIKEVPVLADVYTINEVLRNLNAEVEFDSTTKTVNINASQ
QLETEAPFEYVRKMRASVLVLGPLLARYGHAKVAMPGGCAIGSRPIDLHLKGFEAMGAEIHVGNGYVEANVNGRLQGAKI
YLDMPSVGATENIMMAAALAEGKTVIENAAKEPEIVDLANYLNKMGANIVGAGTETIRIIGVEKLRGTEHMIIPDRIEAG
TFMVASAITGGNVFIENAMREHLRSVISKLEEMNVDVIDENGGLRIIGPEKLKSTDIKTLPHPGFPTDMQSQMMSLMLRA
EGTGVITETVFENRFMHVEEFRRMNANIKIEGRSVIIEGISELQGAEVAATDLRAAAALILAGLVSDGYTRVTELKHLDR
GYVDIVDKLAALGADIKRVDENGVVVQPLYVTAAKESNEIAAD

Sequences:

>Translated_443_residues
MEKIIVSGGHQLNGTVRLEGAKNAVLPVLAASLIASEGESVIKEVPVLADVYTINEVLRNLNAEVEFDSTTKTVNINASQ
QLETEAPFEYVRKMRASVLVLGPLLARYGHAKVAMPGGCAIGSRPIDLHLKGFEAMGAEIHVGNGYVEANVNGRLQGAKI
YLDMPSVGATENIMMAAALAEGKTVIENAAKEPEIVDLANYLNKMGANIVGAGTETIRIIGVEKLRGTEHMIIPDRIEAG
TFMVASAITGGNVFIENAMREHLRSVISKLEEMNVDVIDENGGLRIIGPEKLKSTDIKTLPHPGFPTDMQSQMMSLMLRA
EGTGVITETVFENRFMHVEEFRRMNANIKIEGRSVIIEGISELQGAEVAATDLRAAAALILAGLVSDGYTRVTELKHLDR
GYVDIVDKLAALGADIKRVDENGVVVQPLYVTAAKESNEIAAD
>Mature_443_residues
MEKIIVSGGHQLNGTVRLEGAKNAVLPVLAASLIASEGESVIKEVPVLADVYTINEVLRNLNAEVEFDSTTKTVNINASQ
QLETEAPFEYVRKMRASVLVLGPLLARYGHAKVAMPGGCAIGSRPIDLHLKGFEAMGAEIHVGNGYVEANVNGRLQGAKI
YLDMPSVGATENIMMAAALAEGKTVIENAAKEPEIVDLANYLNKMGANIVGAGTETIRIIGVEKLRGTEHMIIPDRIEAG
TFMVASAITGGNVFIENAMREHLRSVISKLEEMNVDVIDENGGLRIIGPEKLKSTDIKTLPHPGFPTDMQSQMMSLMLRA
EGTGVITETVFENRFMHVEEFRRMNANIKIEGRSVIIEGISELQGAEVAATDLRAAAALILAGLVSDGYTRVTELKHLDR
GYVDIVDKLAALGADIKRVDENGVVVQPLYVTAAKESNEIAAD

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=50.9523809523809, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_OCEIH (Q8EM86)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693894.1
- ProteinModelPortal:   Q8EM86
- GeneID:   1016743
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2972
- NMPDR:   fig|221109.1.peg.2975
- HOGENOM:   HBG482701
- OMA:   NRFMHLE
- ProtClustDB:   PRK09369
- BioCyc:   OIHE221109:OB2972-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 47652; Mature: 47652

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: ACT_SITE 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKIIVSGGHQLNGTVRLEGAKNAVLPVLAASLIASEGESVIKEVPVLADVYTINEVLRN
CCEEEEECCCEECCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHH
LNAEVEFDSTTKTVNINASQQLETEAPFEYVRKMRASVLVLGPLLARYGHAKVAMPGGCA
CCCEEEECCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
IGSRPIDLHLKGFEAMGAEIHVGNGYVEANVNGRLQGAKIYLDMPSVGATENIMMAAALA
CCCCCEEEEEECHHHCCCEEEECCCEEEECCCCEEEEEEEEEECCCCCCCCHHHEEHHHH
EGKTVIENAAKEPEIVDLANYLNKMGANIVGAGTETIRIIGVEKLRGTEHMIIPDRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEEEHHHCCCCEEEECCCCCCC
TFMVASAITGGNVFIENAMREHLRSVISKLEEMNVDVIDENGGLRIIGPEKLKSTDIKTL
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHHCCCCCCCC
PHPGFPTDMQSQMMSLMLRAEGTGVITETVFENRFMHVEEFRRMNANIKIEGRSVIIEGI
CCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHCCCCEEECCCEEEEECH
SELQGAEVAATDLRAAAALILAGLVSDGYTRVTELKHLDRGYVDIVDKLAALGADIKRVD
HHHCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEC
ENGVVVQPLYVTAAKESNEIAAD
CCCEEEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MEKIIVSGGHQLNGTVRLEGAKNAVLPVLAASLIASEGESVIKEVPVLADVYTINEVLRN
CCEEEEECCCEECCEEEECCCCCHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHH
LNAEVEFDSTTKTVNINASQQLETEAPFEYVRKMRASVLVLGPLLARYGHAKVAMPGGCA
CCCEEEECCCEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
IGSRPIDLHLKGFEAMGAEIHVGNGYVEANVNGRLQGAKIYLDMPSVGATENIMMAAALA
CCCCCEEEEEECHHHCCCEEEECCCEEEECCCCEEEEEEEEEECCCCCCCCHHHEEHHHH
EGKTVIENAAKEPEIVDLANYLNKMGANIVGAGTETIRIIGVEKLRGTEHMIIPDRIEAG
CCHHHHHHCCCCCCHHHHHHHHHHHCCCEEECCCCEEEEEEEHHHCCCCEEEECCCCCCC
TFMVASAITGGNVFIENAMREHLRSVISKLEEMNVDVIDENGGLRIIGPEKLKSTDIKTL
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEECHHHHCCCCCCCC
PHPGFPTDMQSQMMSLMLRAEGTGVITETVFENRFMHVEEFRRMNANIKIEGRSVIIEGI
CCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHCCCCEEECCCEEEEECH
SELQGAEVAATDLRAAAALILAGLVSDGYTRVTELKHLDRGYVDIVDKLAALGADIKRVD
HHHCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEC
ENGVVVQPLYVTAAKESNEIAAD
CCCEEEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376