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The map label for this gene is rocC [H]

Identifier: 23100388

GI number: 23100388

Start: 3036674

End: 3038128

Strand: Reverse

Name: rocC [H]

Synonym: OB2933

Alternate gene names: 23100388

Gene position: 3038128-3036674 (Counterclockwise)

Preceding gene: 23100389

Following gene: 23100387

Centisome position: 83.68

GC content: 38.14

Gene sequence:

>1455_bases
ATGGAAAAACGTACCACCTTAAAGAAGACGCTAAAGCCACATTGGGTTTGGGCAATTGCGTTAGGATCCTCGATTGGTTG
GGGGGCTTTTGTACAGCCTGCAGCATGGATGGGGACAGCTGGACCTTTGGGAGCAATGATTGGATTTGGTATTGGTGGAC
TTCTAATGATGCTGATTGCAGTTAGCTACGGGTTCCTTATTAAAAGCTTTCCGGTATCAGGCGGTGAATTTGCATACGCA
TTTATTAGCTTAGGAAGGACTCATGCCTTTATTAGCGGTTGGTTTCTTACGTTAGGTTACATTTGTATTGTTGCATTAAA
TGCTTCTGCTCTCGCACTAATGTTTAAATTCGTCTTTCCATCTGTATTAGAGAATTTCTATATGTACCAAATTGCTGATT
GGGATGTATATGGTATGGAAATTATCATTGCATCGATCGCACTTATCATTTTTGGATATTTAAATATACGAGGTGGAGGA
TTTACAGGAAGTGCGCAATTTATTTTTTGTATTATTATGGTTGGCGGAGTATTACTACTAACAACACTAGTAGGAATCAA
TCCATCCGCTGATATTAGTAATGTAGCACCACTATTTCCATCAGACAAAACTGCTATAGCGGCAATTTTATCGATAGTAG
CAATTGCACCGTGGGCTTTTGTTGGTTTTGACAATATTCCACAAGCCGCTGAAGAATTTAATTTTTCCTCGAAAAAAGCA
TTCCGGTTAATTATTTTAGCAATCTTGTTTGCGACCATACTTTATTGCCTCATGATATTTGCAACGGCAATGGCCCAACC
TTGGGAAGGATTAGTTGCAGCTGGCCATAACTGGGGAACTGCTGAAGCATTACAAGACATACTAGGCACGGTAGGAGTAG
CTATATTAGCTATAGCATTGTTAATGGGGATTTTCACAGGACTGAATGGTTTTATTATTTCTACAAGTCGTTTACTATTC
GCAATGTCTCGTGCAAAATTCATCCCAAGATCTTTCTCAAAACTTGGTAAAAATGAAACACCATATATCAGCATTATCTT
TACAGTTATTGTCGCAATGGTGGCTCCATGGTTTGGGAGACAAGCATTAACTTGGGTCGTGGATATGTCATCAGTGGGTG
TAACAATCGCATATTTCTACACTTGTTATACAGCTTTTTCATTATTTAAATGGAATGACAACCATGGATTTAATACGAAT
AAGCATGTTGTAGCCCCAGGCAAGAAGATATTTGCTTTACTAGGAATGGTTGCTAGTATCTCCTTCCTCGGTTTATTGCT
CATTCCAGGGTCACCTGCATTTCTTGGCCTGGAATCACGCATTGCATTAGTTGTATGGATTGTACTAGGAATCATTTTCT
ACATCATGAAATATAAAGATTATAAAAATCTCGACAAAGAAGAAATGAACTATCTTATTTTAGGATCTAAAGAAATTAAA
GTGAAAAAGGATTAA

Upstream 100 bases:

>100_bases
TGGTAGAGTGTTTTTTGTACTTTTTTGTAACTTTGTTCATATGTAGGAAAATTAATTAGAGCTTAAGTTACAAATACAAA
ATAGAAGGAGTATTCATTAT

Downstream 100 bases:

>100_bases
TGAAGAAGTAGACTAGCTATTGTTATAAATAGCTAGTCTTTTTTTACCTTTAATCGAATCTTCCATCTGAATTTTCCGAT
AGAATAGAACTATGACTTTG

Product: cationic amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MEKRTTLKKTLKPHWVWAIALGSSIGWGAFVQPAAWMGTAGPLGAMIGFGIGGLLMMLIAVSYGFLIKSFPVSGGEFAYA
FISLGRTHAFISGWFLTLGYICIVALNASALALMFKFVFPSVLENFYMYQIADWDVYGMEIIIASIALIIFGYLNIRGGG
FTGSAQFIFCIIMVGGVLLLTTLVGINPSADISNVAPLFPSDKTAIAAILSIVAIAPWAFVGFDNIPQAAEEFNFSSKKA
FRLIILAILFATILYCLMIFATAMAQPWEGLVAAGHNWGTAEALQDILGTVGVAILAIALLMGIFTGLNGFIISTSRLLF
AMSRAKFIPRSFSKLGKNETPYISIIFTVIVAMVAPWFGRQALTWVVDMSSVGVTIAYFYTCYTAFSLFKWNDNHGFNTN
KHVVAPGKKIFALLGMVASISFLGLLLIPGSPAFLGLESRIALVVWIVLGIIFYIMKYKDYKNLDKEEMNYLILGSKEIK
VKKD

Sequences:

>Translated_484_residues
MEKRTTLKKTLKPHWVWAIALGSSIGWGAFVQPAAWMGTAGPLGAMIGFGIGGLLMMLIAVSYGFLIKSFPVSGGEFAYA
FISLGRTHAFISGWFLTLGYICIVALNASALALMFKFVFPSVLENFYMYQIADWDVYGMEIIIASIALIIFGYLNIRGGG
FTGSAQFIFCIIMVGGVLLLTTLVGINPSADISNVAPLFPSDKTAIAAILSIVAIAPWAFVGFDNIPQAAEEFNFSSKKA
FRLIILAILFATILYCLMIFATAMAQPWEGLVAAGHNWGTAEALQDILGTVGVAILAIALLMGIFTGLNGFIISTSRLLF
AMSRAKFIPRSFSKLGKNETPYISIIFTVIVAMVAPWFGRQALTWVVDMSSVGVTIAYFYTCYTAFSLFKWNDNHGFNTN
KHVVAPGKKIFALLGMVASISFLGLLLIPGSPAFLGLESRIALVVWIVLGIIFYIMKYKDYKNLDKEEMNYLILGSKEIK
VKKD
>Mature_484_residues
MEKRTTLKKTLKPHWVWAIALGSSIGWGAFVQPAAWMGTAGPLGAMIGFGIGGLLMMLIAVSYGFLIKSFPVSGGEFAYA
FISLGRTHAFISGWFLTLGYICIVALNASALALMFKFVFPSVLENFYMYQIADWDVYGMEIIIASIALIIFGYLNIRGGG
FTGSAQFIFCIIMVGGVLLLTTLVGINPSADISNVAPLFPSDKTAIAAILSIVAIAPWAFVGFDNIPQAAEEFNFSSKKA
FRLIILAILFATILYCLMIFATAMAQPWEGLVAAGHNWGTAEALQDILGTVGVAILAIALLMGIFTGLNGFIISTSRLLF
AMSRAKFIPRSFSKLGKNETPYISIIFTVIVAMVAPWFGRQALTWVVDMSSVGVTIAYFYTCYTAFSLFKWNDNHGFNTN
KHVVAPGKKIFALLGMVASISFLGLLLIPGSPAFLGLESRIALVVWIVLGIIFYIMKYKDYKNLDKEEMNYLILGSKEIK
VKKD

Specific function: Putative transport protein involved in arginine degradative pathway. Probably transports arginine or ornithine [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=370, Percent_Identity=22.972972972973, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789017, Length=365, Percent_Identity=22.7397260273973, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788480, Length=426, Percent_Identity=22.5352112676056, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319824, Length=406, Percent_Identity=23.3990147783251, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322892, Length=370, Percent_Identity=21.6216216216216, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52774; Mature: 52774

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRTTLKKTLKPHWVWAIALGSSIGWGAFVQPAAWMGTAGPLGAMIGFGIGGLLMMLIA
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
VSYGFLIKSFPVSGGEFAYAFISLGRTHAFISGWFLTLGYICIVALNASALALMFKFVFP
HHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SVLENFYMYQIADWDVYGMEIIIASIALIIFGYLNIRGGGFTGSAQFIFCIIMVGGVLLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TTLVGINPSADISNVAPLFPSDKTAIAAILSIVAIAPWAFVGFDNIPQAAEEFNFSSKKA
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHH
FRLIILAILFATILYCLMIFATAMAQPWEGLVAAGHNWGTAEALQDILGTVGVAILAIAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LMGIFTGLNGFIISTSRLLFAMSRAKFIPRSFSKLGKNETPYISIIFTVIVAMVAPWFGR
HHHHHHCCCCCEEHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
QALTWVVDMSSVGVTIAYFYTCYTAFSLFKWNDNHGFNTNKHVVAPGKKIFALLGMVASI
CHHHHEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCHHHHHHHHHHHHH
SFLGLLLIPGSPAFLGLESRIALVVWIVLGIIFYIMKYKDYKNLDKEEMNYLILGSKEIK
HHHHHHEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCCEE
VKKD
EECC
>Mature Secondary Structure
MEKRTTLKKTLKPHWVWAIALGSSIGWGAFVQPAAWMGTAGPLGAMIGFGIGGLLMMLIA
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHH
VSYGFLIKSFPVSGGEFAYAFISLGRTHAFISGWFLTLGYICIVALNASALALMFKFVFP
HHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SVLENFYMYQIADWDVYGMEIIIASIALIIFGYLNIRGGGFTGSAQFIFCIIMVGGVLLL
HHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
TTLVGINPSADISNVAPLFPSDKTAIAAILSIVAIAPWAFVGFDNIPQAAEEFNFSSKKA
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHH
FRLIILAILFATILYCLMIFATAMAQPWEGLVAAGHNWGTAEALQDILGTVGVAILAIAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LMGIFTGLNGFIISTSRLLFAMSRAKFIPRSFSKLGKNETPYISIIFTVIVAMVAPWFGR
HHHHHHCCCCCEEHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
QALTWVVDMSSVGVTIAYFYTCYTAFSLFKWNDNHGFNTNKHVVAPGKKIFALLGMVASI
CHHHHEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCHHHHHHHHHHHHH
SFLGLLLIPGSPAFLGLESRIALVVWIVLGIIFYIMKYKDYKNLDKEEMNYLILGSKEIK
HHHHHHEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEEEECCCCEE
VKKD
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]