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The map label for this gene is ywqF [H]

Identifier: 23100384

GI number: 23100384

Start: 3028811

End: 3030133

Strand: Reverse

Name: ywqF [H]

Synonym: OB2929

Alternate gene names: 23100384

Gene position: 3030133-3028811 (Counterclockwise)

Preceding gene: 23100385

Following gene: 23100383

Centisome position: 83.46

GC content: 35.6

Gene sequence:

>1323_bases
GTGATTGAAATGGATGTAGCAGTAATTGGTACAGGTTATGTTGGGTTAGTTACAGGTGCCTGCTTAGCGGAAAAGGGTCA
CCGAGTTCATTGTATTGATATTGATGAATCAAGAGTTCAGCAACTTAACAATGCAATAAGCCCCATATACGAAGAAGGAA
TTGAGGAACTCTTAAAAAATGGAATAAATAATGATAATCTGTTTTTTACAACAGACTATAAAGAAGGACTACATCAGAAA
GACATTGTATTTCTTGCTGTAGGTACCCCTGAATCAGAAGACGGTTCTGCGGATTTATCTTATTTATACAAAGCAAGTGA
AACCATGGCTTCTTATGTAGATCGTGATGTTACAGTAGTAATAAAAAGTACCGTACCTGTAGGAACTGGTGAACAAATTG
GTGACAAATTAAATTCATTAGTAAGCCCAGGTGTGAATATAAGAATGGCTTCCAACCCAGAATTTTTAAGGCAGGGGACG
GCGGTATACGATACATTTCACGCAGATAGGATTGTTGTCGGAGCAAATCATCCAGACGCCCAAAAACAATTAGAAGAATT
ATATCATTCTTTTCAACTTCCTATTGTAGTGACTGACATTCGAAGTGCAGAAATGATTAAATATACAGCTAACTCCTTCT
TAGCAATGAAAATCAGTTTTATTAATGAAGTAGCTAACTTATCTGAAAAGTTAGGTGCGAATATAGAATCCGTAACTGAA
GGAATTGGTATGGATAAACGTATTGGCTCTTCATTTTTAAATGCGGGCATCGGATTTGGTGGGTCTTGCTTTCCGAAAGA
TACAAAAGCAATGGTTCAGATTGCTGAATCAGTTAACATGCCACTTTCTCTTATTGAAAAGGTAATTAGCGTAAACGAGA
AGCAACGAGAAATTCTTGTTGATAAAGTTAAAAGTCGATTTACCTCTTTAAAGGGATTAGAAGTAGCAATACTTGGATTG
TCGTTTAAGCCAAATACTGATGACATGAGAGAAGCAGCTTCTATCTCTATAATCCGTAAATTAGTTGATGATGGTGTGAA
AGTGACAGCTTACGACCCTGTAGCTATGGAACGAGCGAAGCAAATATTACCTGAACAGGTGAACTATACTAATAGTATAG
AGGAAGCAATTAAAGGAAAACAAGCAACATTAATTGTTACGGAATGGGATCAAATCAAAGATTTCCCGCTTGATAAATAT
GTTGAGTTAATGACTTCTCCTGTTATTATGGACGGAAGAAACTGCTTTGATATGAAAGAAGTTCAAAAACACAAAATTGA
ATATCATTCTATTGGTAGAAAAACAATTAATAACTTATCATAA

Upstream 100 bases:

>100_bases
TAGAAGCGACGATAGATTTTGCTTTGAATAGAAATGATTTGCATAACGATGTAAAGCATCTGTTGAAGAAAAAATTAGAT
TCAATGGAGTAGAACTAGGA

Downstream 100 bases:

>100_bases
AAATCTACAAAATTGTTTTATTTACTGGTTGGCTATCGAGCCTCCGTGTGTTCAACAGGCATTACGGAGGCTCGTTTTAG
CACTGCCTTCTACAGTGATT

Product: NDP-sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MIEMDVAVIGTGYVGLVTGACLAEKGHRVHCIDIDESRVQQLNNAISPIYEEGIEELLKNGINNDNLFFTTDYKEGLHQK
DIVFLAVGTPESEDGSADLSYLYKASETMASYVDRDVTVVIKSTVPVGTGEQIGDKLNSLVSPGVNIRMASNPEFLRQGT
AVYDTFHADRIVVGANHPDAQKQLEELYHSFQLPIVVTDIRSAEMIKYTANSFLAMKISFINEVANLSEKLGANIESVTE
GIGMDKRIGSSFLNAGIGFGGSCFPKDTKAMVQIAESVNMPLSLIEKVISVNEKQREILVDKVKSRFTSLKGLEVAILGL
SFKPNTDDMREAASISIIRKLVDDGVKVTAYDPVAMERAKQILPEQVNYTNSIEEAIKGKQATLIVTEWDQIKDFPLDKY
VELMTSPVIMDGRNCFDMKEVQKHKIEYHSIGRKTINNLS

Sequences:

>Translated_440_residues
MIEMDVAVIGTGYVGLVTGACLAEKGHRVHCIDIDESRVQQLNNAISPIYEEGIEELLKNGINNDNLFFTTDYKEGLHQK
DIVFLAVGTPESEDGSADLSYLYKASETMASYVDRDVTVVIKSTVPVGTGEQIGDKLNSLVSPGVNIRMASNPEFLRQGT
AVYDTFHADRIVVGANHPDAQKQLEELYHSFQLPIVVTDIRSAEMIKYTANSFLAMKISFINEVANLSEKLGANIESVTE
GIGMDKRIGSSFLNAGIGFGGSCFPKDTKAMVQIAESVNMPLSLIEKVISVNEKQREILVDKVKSRFTSLKGLEVAILGL
SFKPNTDDMREAASISIIRKLVDDGVKVTAYDPVAMERAKQILPEQVNYTNSIEEAIKGKQATLIVTEWDQIKDFPLDKY
VELMTSPVIMDGRNCFDMKEVQKHKIEYHSIGRKTINNLS
>Mature_440_residues
MIEMDVAVIGTGYVGLVTGACLAEKGHRVHCIDIDESRVQQLNNAISPIYEEGIEELLKNGINNDNLFFTTDYKEGLHQK
DIVFLAVGTPESEDGSADLSYLYKASETMASYVDRDVTVVIKSTVPVGTGEQIGDKLNSLVSPGVNIRMASNPEFLRQGT
AVYDTFHADRIVVGANHPDAQKQLEELYHSFQLPIVVTDIRSAEMIKYTANSFLAMKISFINEVANLSEKLGANIESVTE
GIGMDKRIGSSFLNAGIGFGGSCFPKDTKAMVQIAESVNMPLSLIEKVISVNEKQREILVDKVKSRFTSLKGLEVAILGL
SFKPNTDDMREAASISIIRKLVDDGVKVTAYDPVAMERAKQILPEQVNYTNSIEEAIKGKQATLIVTEWDQIKDFPLDKY
VELMTSPVIMDGRNCFDMKEVQKHKIEYHSIGRKTINNLS

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=460, Percent_Identity=34.7826086956522, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI296040438, Length=363, Percent_Identity=34.9862258953168, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI296040443, Length=314, Percent_Identity=36.3057324840764, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1788340, Length=364, Percent_Identity=33.5164835164835, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI48994968, Length=350, Percent_Identity=28.8571428571429, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17560350, Length=458, Percent_Identity=33.6244541484716, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=35.6371490280778, Blast_Score=275, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48613; Mature: 48613

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMDVAVIGTGYVGLVTGACLAEKGHRVHCIDIDESRVQQLNNAISPIYEEGIEELLKN
CEEEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
GINNDNLFFTTDYKEGLHQKDIVFLAVGTPESEDGSADLSYLYKASETMASYVDRDVTVV
CCCCCCEEEEECHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
IKSTVPVGTGEQIGDKLNSLVSPGVNIRMASNPEFLRQGTAVYDTFHADRIVVGANHPDA
EECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHCCCHHEEEECCCEEEEECCCCHH
QKQLEELYHSFQLPIVVTDIRSAEMIKYTANSFLAMKISFINEVANLSEKLGANIESVTE
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGMDKRIGSSFLNAGIGFGGSCFPKDTKAMVQIAESVNMPLSLIEKVISVNEKQREILV
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
DKVKSRFTSLKGLEVAILGLSFKPNTDDMREAASISIIRKLVDDGVKVTAYDPVAMERAK
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
QILPEQVNYTNSIEEAIKGKQATLIVTEWDQIKDFPLDKYVELMTSPVIMDGRNCFDMKE
HHCHHHCCCHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHCCCEEECCCCCCCHHH
VQKHKIEYHSIGRKTINNLS
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIEMDVAVIGTGYVGLVTGACLAEKGHRVHCIDIDESRVQQLNNAISPIYEEGIEELLKN
CEEEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
GINNDNLFFTTDYKEGLHQKDIVFLAVGTPESEDGSADLSYLYKASETMASYVDRDVTVV
CCCCCCEEEEECHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEE
IKSTVPVGTGEQIGDKLNSLVSPGVNIRMASNPEFLRQGTAVYDTFHADRIVVGANHPDA
EECCCCCCCCHHHHHHHHHHHCCCCEEEECCCHHHHHCCCHHEEEECCCEEEEECCCCHH
QKQLEELYHSFQLPIVVTDIRSAEMIKYTANSFLAMKISFINEVANLSEKLGANIESVTE
HHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIGMDKRIGSSFLNAGIGFGGSCFPKDTKAMVQIAESVNMPLSLIEKVISVNEKQREILV
CCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
DKVKSRFTSLKGLEVAILGLSFKPNTDDMREAASISIIRKLVDDGVKVTAYDPVAMERAK
HHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHH
QILPEQVNYTNSIEEAIKGKQATLIVTEWDQIKDFPLDKYVELMTSPVIMDGRNCFDMKE
HHCHHHCCCHHHHHHHHCCCCEEEEEEEHHHHCCCCHHHHHHHHCCCEEECCCCCCCHHH
VQKHKIEYHSIGRKTINNLS
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]