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The map label for this gene is ywqF [H]

Identifier: 23100339

GI number: 23100339

Start: 2971004

End: 2972362

Strand: Reverse

Name: ywqF [H]

Synonym: OB2884

Alternate gene names: 23100339

Gene position: 2972362-2971004 (Counterclockwise)

Preceding gene: 23100340

Following gene: 23100338

Centisome position: 81.87

GC content: 39.44

Gene sequence:

>1359_bases
ATGAAAAAAATTTCAGTAGCCGGAACAGGCTACGTCGGACTAGTAACCGGCGTGTGTATGGCAGAGAACGGGCATAATGT
CACTTGCGTAGATATAGACGAACAAAAGGTTCAGATGATGCGTGATGGGAGATCTCCTATCTACGAAACTGGTTTAGAAG
CGTTAATGGTAAAGAACATAGAAGCTGGACGTTTACATTTTACTACGGATTATCAATCTGCATATAAAGATGCGGAAGCA
GTATTTATAGGAGTAGGTACTCCTGAAAGGGAAGATGGATCTGCGAATCTATCGTACTTAGCTACTGTTGCAAGACAAGT
TGCAGAGTCTATCAAGAATGATTGTTTAGTAGTGGTGAAATCTACCGTACCTGTAGGAACGAATGATAAGGTAGAACAGT
TCATTAAAGATTTCCTTATAAAAGATGTTCGAGTTGAAATAGCTTCTAACCCTGAGTTTCTTGCACAAGGTTCTGCGGTG
AAAGATACATTAGAGGCGGATCGTATTGTCATTGGAACAGAAACTGAATGGGCGGAGAAGATACTAACAGATATCTACGA
GCCATTCGGTCTTCCAATTGTTTCGGTAAATAGAAAATCAGCAGAAATGATTAAATATGCATCCAATGACTTTCTTGCAT
TAAAGATTTCTTATATGAATGATATTGCAAATCTTTGTGAGTTGGTAGGGGCAGATGTTCAGGACGTAGCTAGAGGAATG
AGTTTTGATGACAGAATAGGGAGTAAATTCTTAAATGCGGGGATTGGATATGGTGGTTCTTGTTTCCCGAAAGATACGAA
AGCCCTTGAATACATTGCTCGTCAAAATGGCTATGAACTAAAAACAGTGAAGGCAGCCATTGATGTAAATAACCAGCAGA
AGTCAATGCTTTATAAAAAAGCAAGTAAACGTTTAATTACATTTAGCGGACTTAAAGTCGCTGTACTAGGATTAACTTTT
AAACCGGGTACCGATGATTTACGCGAAGCACCTTCCTTAGAGAATATTCCAATGTTGTTGTCTGAAGGAGCGGATATTTA
TGCGTACGATCCAGTTGGAGCAGAGAACTTTGCTAAGGTGCATCCAGAAGGGAAACATGGAAATGGAAGTATTACGTATG
TTTCTAATCCAGAACATGCACTAGAAGATGCTAATGTGTGCTTTATCTTTACAGAATGGGGAGAGATAAAAGAAGTATCT
CCTCAAAAATTTGCAGACTTAATGCGCACTCCACTTGTTTACGATGGCAGAAATATTCATCCAGTCAAAGAAATGGTAGA
GGCTAGTGTTGAGTACTATTCAGTGGGAAGACCGTCGACTGTTGATACTCGAGTAAAGGAGATGGAAATCGTTGACTAA

Upstream 100 bases:

>100_bases
TCTATTAGGAATTTAAATAAGATATGCTTACTAATACCTTTAATTTTGAGATTGAACTAAGTAAATAAATATAACTGCTT
CATTAGAGGAGATTATTGAT

Downstream 100 bases:

>100_bases
AGAAAACAAGGTTTACTTAATAACCGGAGCAGCGGGATTTATCGGACATTTCTTATCTCGAAGACTATTAGATCAAGGGT
TTAACGTAATCGGATTAGAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKKISVAGTGYVGLVTGVCMAENGHNVTCVDIDEQKVQMMRDGRSPIYETGLEALMVKNIEAGRLHFTTDYQSAYKDAEA
VFIGVGTPEREDGSANLSYLATVARQVAESIKNDCLVVVKSTVPVGTNDKVEQFIKDFLIKDVRVEIASNPEFLAQGSAV
KDTLEADRIVIGTETEWAEKILTDIYEPFGLPIVSVNRKSAEMIKYASNDFLALKISYMNDIANLCELVGADVQDVARGM
SFDDRIGSKFLNAGIGYGGSCFPKDTKALEYIARQNGYELKTVKAAIDVNNQQKSMLYKKASKRLITFSGLKVAVLGLTF
KPGTDDLREAPSLENIPMLLSEGADIYAYDPVGAENFAKVHPEGKHGNGSITYVSNPEHALEDANVCFIFTEWGEIKEVS
PQKFADLMRTPLVYDGRNIHPVKEMVEASVEYYSVGRPSTVDTRVKEMEIVD

Sequences:

>Translated_452_residues
MKKISVAGTGYVGLVTGVCMAENGHNVTCVDIDEQKVQMMRDGRSPIYETGLEALMVKNIEAGRLHFTTDYQSAYKDAEA
VFIGVGTPEREDGSANLSYLATVARQVAESIKNDCLVVVKSTVPVGTNDKVEQFIKDFLIKDVRVEIASNPEFLAQGSAV
KDTLEADRIVIGTETEWAEKILTDIYEPFGLPIVSVNRKSAEMIKYASNDFLALKISYMNDIANLCELVGADVQDVARGM
SFDDRIGSKFLNAGIGYGGSCFPKDTKALEYIARQNGYELKTVKAAIDVNNQQKSMLYKKASKRLITFSGLKVAVLGLTF
KPGTDDLREAPSLENIPMLLSEGADIYAYDPVGAENFAKVHPEGKHGNGSITYVSNPEHALEDANVCFIFTEWGEIKEVS
PQKFADLMRTPLVYDGRNIHPVKEMVEASVEYYSVGRPSTVDTRVKEMEIVD
>Mature_452_residues
MKKISVAGTGYVGLVTGVCMAENGHNVTCVDIDEQKVQMMRDGRSPIYETGLEALMVKNIEAGRLHFTTDYQSAYKDAEA
VFIGVGTPEREDGSANLSYLATVARQVAESIKNDCLVVVKSTVPVGTNDKVEQFIKDFLIKDVRVEIASNPEFLAQGSAV
KDTLEADRIVIGTETEWAEKILTDIYEPFGLPIVSVNRKSAEMIKYASNDFLALKISYMNDIANLCELVGADVQDVARGM
SFDDRIGSKFLNAGIGYGGSCFPKDTKALEYIARQNGYELKTVKAAIDVNNQQKSMLYKKASKRLITFSGLKVAVLGLTF
KPGTDDLREAPSLENIPMLLSEGADIYAYDPVGAENFAKVHPEGKHGNGSITYVSNPEHALEDANVCFIFTEWGEIKEVS
PQKFADLMRTPLVYDGRNIHPVKEMVEASVEYYSVGRPSTVDTRVKEMEIVD

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=443, Percent_Identity=34.9887133182844, Blast_Score=228, Evalue=6e-60,
Organism=Homo sapiens, GI296040438, Length=343, Percent_Identity=34.9854227405248, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI296040443, Length=294, Percent_Identity=37.0748299319728, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1788340, Length=364, Percent_Identity=32.4175824175824, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI48994968, Length=350, Percent_Identity=29.1428571428571, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17560350, Length=464, Percent_Identity=32.7586206896552, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=34.8484848484849, Blast_Score=238, Evalue=7e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49714; Mature: 49714

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKISVAGTGYVGLVTGVCMAENGHNVTCVDIDEQKVQMMRDGRSPIYETGLEALMVKNI
CCEEEECCCCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHCCC
EAGRLHFTTDYQSAYKDAEAVFIGVGTPEREDGSANLSYLATVARQVAESIKNDCLVVVK
CCCEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
STVPVGTNDKVEQFIKDFLIKDVRVEIASNPEFLAQGSAVKDTLEADRIVIGTETEWAEK
CCCCCCCCHHHHHHHHHHHHHHHEEEECCCCHHHHCCCHHHHHHCCCEEEEECCHHHHHH
ILTDIYEPFGLPIVSVNRKSAEMIKYASNDFLALKISYMNDIANLCELVGADVQDVARGM
HHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHCCC
SFDDRIGSKFLNAGIGYGGSCFPKDTKALEYIARQNGYELKTVKAAIDVNNQQKSMLYKK
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
ASKRLITFSGLKVAVLGLTFKPGTDDLREAPSLENIPMLLSEGADIYAYDPVGAENFAKV
HHCCEEEECCCEEEEEEEEECCCCHHHHHCCCCCCCCHHHHCCCCEEEECCCCCCCHHCC
HPEGKHGNGSITYVSNPEHALEDANVCFIFTEWGEIKEVSPQKFADLMRTPLVYDGRNIH
CCCCCCCCCEEEEECCCHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEECCCCCC
PVKEMVEASVEYYSVGRPSTVDTRVKEMEIVD
HHHHHHHHHHHHEECCCCCCHHHHHHHEECCC
>Mature Secondary Structure
MKKISVAGTGYVGLVTGVCMAENGHNVTCVDIDEQKVQMMRDGRSPIYETGLEALMVKNI
CCEEEECCCCHHHHHHHHEEECCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHHCCC
EAGRLHFTTDYQSAYKDAEAVFIGVGTPEREDGSANLSYLATVARQVAESIKNDCLVVVK
CCCEEEEEECHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEE
STVPVGTNDKVEQFIKDFLIKDVRVEIASNPEFLAQGSAVKDTLEADRIVIGTETEWAEK
CCCCCCCCHHHHHHHHHHHHHHHEEEECCCCHHHHCCCHHHHHHCCCEEEEECCHHHHHH
ILTDIYEPFGLPIVSVNRKSAEMIKYASNDFLALKISYMNDIANLCELVGADVQDVARGM
HHHHHHHHHCCCEEEECCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHHCCC
SFDDRIGSKFLNAGIGYGGSCFPKDTKALEYIARQNGYELKTVKAAIDVNNQQKSMLYKK
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHH
ASKRLITFSGLKVAVLGLTFKPGTDDLREAPSLENIPMLLSEGADIYAYDPVGAENFAKV
HHCCEEEECCCEEEEEEEEECCCCHHHHHCCCCCCCCHHHHCCCCEEEECCCCCCCHHCC
HPEGKHGNGSITYVSNPEHALEDANVCFIFTEWGEIKEVSPQKFADLMRTPLVYDGRNIH
CCCCCCCCCEEEEECCCHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEECCCCCC
PVKEMVEASVEYYSVGRPSTVDTRVKEMEIVD
HHHHHHHHHHHHEECCCCCCHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]