Click here to switch to the map view.

The map label for this gene is vraS [H]

Identifier: 23100278

GI number: 23100278

Start: 2902588

End: 2903640

Strand: Reverse

Name: vraS [H]

Synonym: OB2823

Alternate gene names: 23100278

Gene position: 2903640-2902588 (Counterclockwise)

Preceding gene: 23100279

Following gene: 23100277

Centisome position: 79.98

GC content: 37.99

Gene sequence:

>1053_bases
ATGAATACCATTATTCGATATGTTCTCTTGTCAATTACCTGTAGTTTTGTCTTAGGGATTACATTTGTCGTCATGACTTT
TCTTACCTTTTCTTTAAATGATTCGATCGGATGGAGTGCATTATGGGAAGTCAAAATTGGAGATGTGTCTTTCTTATTAA
CGTTATTCGCTTTGACGATTATCTTCGGAACAGTCATTGGTACGATTATCGGCTGGTATTGGAAAGAAAACCTAAAACAA
ATTGAAAAAATGTTAACCGGGATTATTCAGGGGGATAGACATCCTGAAAAAGAAGAAATTCCAAAAGAAATGGATGCTAT
TTCGAACCGCATGAATCAGCTTCAAGAGAAATTAAGGGCGCAAACAGAACATGCGCAGCGAATTGCGACAGAACGTGCAA
ATGAACGTGAACAAAGCTTACAAGAAGTAGTAGTTCAAGAAAGAAATCGTCTTGCAAGAGAATTACATGATTCTGTGAGT
CAACAGCTCTTTGCCGCGTCGATGATGATGTCAGCAATTAATGAAGCAGAGACCGCTGAAGATCCAACATTAAATAAGCA
ATTAAATATGGTTGAAAAAATGATCCACCAATCCCAACTCGAAATGCGTGCATTATTACTCCATTTGCGCCCAGTAGCTT
TAAAAGGGAAGTCATTGCAAGAGGGAGTGGAGGAGCTCTTACATGAATTAACACAAAAAGTACCTCTAGAAATTGATGCA
AAAGTAGAGGATTTCAACACAGATAAAGGTGTAGAAGATCAGCTATTTCGTATTTTCCAAGAGTCGATATCGAATACACT
ACGCCATGCGAAAGCTACTACGTTACAAGTTCTCCTAATTGAGCGAGATGAAAATATTATCTTGCGTGTGTCGGATGATG
GTATTGGATTTCAAACTGAAGATGTTAAAACAAGTTCTTATGGGATGCAAAATATGCGTGAACGCGCGTATGAAGTTGGC
GGTACATTGAAGGTTATAAGTGTACCAAATGAAGGTACACGGCTTGAAGTAAAAGTCCCTATCTTAAGAAAGGAAGATAC
ATCCAATGATTAA

Upstream 100 bases:

>100_bases
ATAAATCGATTCATTATGAAACCGAATCCTATAGTACAACGTATCCAAGAGTGAAAATCATTACCTCAATATTTTCTGGA
GACATTGAGGTGAAACGCGT

Downstream 100 bases:

>100_bases
AGTTTTATTTGTCGATGATCATGAAATGGTACGAATAGGCGTATCTGCATATCTTTCTTCGCAACCAGATATTGATGTAA
TAGCAGAGGCAGATGATGGT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MNTIIRYVLLSITCSFVLGITFVVMTFLTFSLNDSIGWSALWEVKIGDVSFLLTLFALTIIFGTVIGTIIGWYWKENLKQ
IEKMLTGIIQGDRHPEKEEIPKEMDAISNRMNQLQEKLRAQTEHAQRIATERANEREQSLQEVVVQERNRLARELHDSVS
QQLFAASMMMSAINEAETAEDPTLNKQLNMVEKMIHQSQLEMRALLLHLRPVALKGKSLQEGVEELLHELTQKVPLEIDA
KVEDFNTDKGVEDQLFRIFQESISNTLRHAKATTLQVLLIERDENIILRVSDDGIGFQTEDVKTSSYGMQNMRERAYEVG
GTLKVISVPNEGTRLEVKVPILRKEDTSND

Sequences:

>Translated_350_residues
MNTIIRYVLLSITCSFVLGITFVVMTFLTFSLNDSIGWSALWEVKIGDVSFLLTLFALTIIFGTVIGTIIGWYWKENLKQ
IEKMLTGIIQGDRHPEKEEIPKEMDAISNRMNQLQEKLRAQTEHAQRIATERANEREQSLQEVVVQERNRLARELHDSVS
QQLFAASMMMSAINEAETAEDPTLNKQLNMVEKMIHQSQLEMRALLLHLRPVALKGKSLQEGVEELLHELTQKVPLEIDA
KVEDFNTDKGVEDQLFRIFQESISNTLRHAKATTLQVLLIERDENIILRVSDDGIGFQTEDVKTSSYGMQNMRERAYEVG
GTLKVISVPNEGTRLEVKVPILRKEDTSND
>Mature_350_residues
MNTIIRYVLLSITCSFVLGITFVVMTFLTFSLNDSIGWSALWEVKIGDVSFLLTLFALTIIFGTVIGTIIGWYWKENLKQ
IEKMLTGIIQGDRHPEKEEIPKEMDAISNRMNQLQEKLRAQTEHAQRIATERANEREQSLQEVVVQERNRLARELHDSVS
QQLFAASMMMSAINEAETAEDPTLNKQLNMVEKMIHQSQLEMRALLLHLRPVALKGKSLQEGVEELLHELTQKVPLEIDA
KVEDFNTDKGVEDQLFRIFQESISNTLRHAKATTLQVLLIERDENIILRVSDDGIGFQTEDVKTSSYGMQNMRERAYEVG
GTLKVISVPNEGTRLEVKVPILRKEDTSND

Specific function: Member of the two-component regulatory system vraS/vraR involved in the control of the cell wall peptidoglycan biosynthesis. Probably activates vraR by phosphorylation [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787474, Length=273, Percent_Identity=27.4725274725275, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=26.6990291262136, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082311, Length=234, Percent_Identity=26.4957264957265, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR017202 [H]

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39945; Mature: 39945

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50109 HIS_KIN ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIIRYVLLSITCSFVLGITFVVMTFLTFSLNDSIGWSALWEVKIGDVSFLLTLFALTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHH
IFGTVIGTIIGWYWKENLKQIEKMLTGIIQGDRHPEKEEIPKEMDAISNRMNQLQEKLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QTEHAQRIATERANEREQSLQEVVVQERNRLARELHDSVSQQLFAASMMMSAINEAETAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPTLNKQLNMVEKMIHQSQLEMRALLLHLRPVALKGKSLQEGVEELLHELTQKVPLEIDA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEC
KVEDFNTDKGVEDQLFRIFQESISNTLRHAKATTLQVLLIERDENIILRVSDDGIGFQTE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCC
DVKTSSYGMQNMRERAYEVGGTLKVISVPNEGTRLEVKVPILRKEDTSND
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECEEECCCCCCC
>Mature Secondary Structure
MNTIIRYVLLSITCSFVLGITFVVMTFLTFSLNDSIGWSALWEVKIGDVSFLLTLFALTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHH
IFGTVIGTIIGWYWKENLKQIEKMLTGIIQGDRHPEKEEIPKEMDAISNRMNQLQEKLRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QTEHAQRIATERANEREQSLQEVVVQERNRLARELHDSVSQQLFAASMMMSAINEAETAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DPTLNKQLNMVEKMIHQSQLEMRALLLHLRPVALKGKSLQEGVEELLHELTQKVPLEIDA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEC
KVEDFNTDKGVEDQLFRIFQESISNTLRHAKATTLQVLLIERDENIILRVSDDGIGFQTE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCEEEEECCCCCCCCCC
DVKTSSYGMQNMRERAYEVGGTLKVISVPNEGTRLEVKVPILRKEDTSND
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA