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The map label for this gene is hxlA [H]

Identifier: 23100261

GI number: 23100261

Start: 2886608

End: 2887240

Strand: Direct

Name: hxlA [H]

Synonym: OB2806

Alternate gene names: 23100261

Gene position: 2886608-2887240 (Clockwise)

Preceding gene: 23100260

Following gene: 23100262

Centisome position: 79.51

GC content: 38.55

Gene sequence:

>633_bases
ATGAAATTACAACTAGCACTAGACCTTGTCAACATACCGGAAGCAATCGAATTAGTGAAGGAAGTTGAACCATATATTGA
TGTCGTAGAAATTGGTACACCCGTCGTTATTAATGAAGGACTTAAAGCAGTAAAAGAAATGAAAGCTGCTTTCCCAGACT
TAACGGTATTAGCTGACCTTAAAATTATGGATGCAGCAGGATATGAAGTAAGTCAGGCTTCTCAAGCAGGAGCTGATATT
ATTACCATTCTTGGTACAGCCGAAGATCAATCAATCCAAGGAGCCGTCGAAGAAGCTAAAAAACATAACAAAAAGATTCT
TGTCGATATGATTGCCGTAAAAGATATTGAGACACGCGCAAAAGAATTAGATGAACTAGGCGTAGATTATATTTGCGTAC
ACACTGGCTATGATTTACAAGCGGTAGGGAAGAACTCTTTTGAAGATCTCGCAACTATTAAAAGTGTTGTTAAACAAGCC
CAAACGGCTATCGCAGGTGGGATCAAACAAGAAACACTACCAGAAGTAATTAAGCACCAACCGGACCTTATCATTGTAGG
TGGTGGAATCACAAGCAAAGAAGATAAACAAACTGTTGCTCGTGAAATGAAAGAATTAATCCAATTAGGATAG

Upstream 100 bases:

>100_bases
TACTTTTTGTCACTATATGTGTTGAAAGTGCGTACTTCCGTTCATGATAGTTAGAACTTATAATGGACATCATACTTTAA
AAAAGAAAGGGAGAGTCAAC

Downstream 100 bases:

>100_bases
TGATACAGTGATGAAAACAACACAATATGCATTTGAAATCGTACAGGAATTAACTCAATCACTCCAATTAATTTCTGAAA
ATGAAGCAGAAAAATTAATG

Product: 3-hexulose-6-phosphate synthase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKLQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVKEMKAAFPDLTVLADLKIMDAAGYEVSQASQAGADI
ITILGTAEDQSIQGAVEEAKKHNKKILVDMIAVKDIETRAKELDELGVDYICVHTGYDLQAVGKNSFEDLATIKSVVKQA
QTAIAGGIKQETLPEVIKHQPDLIIVGGGITSKEDKQTVAREMKELIQLG

Sequences:

>Translated_210_residues
MKLQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVKEMKAAFPDLTVLADLKIMDAAGYEVSQASQAGADI
ITILGTAEDQSIQGAVEEAKKHNKKILVDMIAVKDIETRAKELDELGVDYICVHTGYDLQAVGKNSFEDLATIKSVVKQA
QTAIAGGIKQETLPEVIKHQPDLIIVGGGITSKEDKQTVAREMKELIQLG
>Mature_210_residues
MKLQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVKEMKAAFPDLTVLADLKIMDAAGYEVSQASQAGADI
ITILGTAEDQSIQGAVEEAKKHNKKILVDMIAVKDIETRAKELDELGVDYICVHTGYDLQAVGKNSFEDLATIKSVVKQA
QTAIAGGIKQETLPEVIKHQPDLIIVGGGITSKEDKQTVAREMKELIQLG

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790640, Length=208, Percent_Identity=29.8076923076923, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790006, Length=174, Percent_Identity=32.7586206896552, Blast_Score=80, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 22673; Mature: 22673

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVKEMKAAFPDLTVLADL
CEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCEEHHHH
KIMDAAGYEVSQASQAGADIITILGTAEDQSIQGAVEEAKKHNKKILVDMIAVKDIETRA
HHCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KELDELGVDYICVHTGYDLQAVGKNSFEDLATIKSVVKQAQTAIAGGIKQETLPEVIKHQ
HHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PDLIIVGGGITSKEDKQTVAREMKELIQLG
CCEEEEECCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLQLALDLVNIPEAIELVKEVEPYIDVVEIGTPVVINEGLKAVKEMKAAFPDLTVLADL
CEEEEEEEHHCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCEEHHHH
KIMDAAGYEVSQASQAGADIITILGTAEDQSIQGAVEEAKKHNKKILVDMIAVKDIETRA
HHCCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
KELDELGVDYICVHTGYDLQAVGKNSFEDLATIKSVVKQAQTAIAGGIKQETLPEVIKHQ
HHHHHCCCCEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PDLIIVGGGITSKEDKQTVAREMKELIQLG
CCEEEEECCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377 [H]