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The map label for this gene is panF [H]

Identifier: 23100232

GI number: 23100232

Start: 2852740

End: 2854260

Strand: Reverse

Name: panF [H]

Synonym: OB2777

Alternate gene names: 23100232

Gene position: 2854260-2852740 (Counterclockwise)

Preceding gene: 23100233

Following gene: 23100230

Centisome position: 78.62

GC content: 38.92

Gene sequence:

>1521_bases
ATGTTGACTGATAATCAAGCGACGCTTGCGTGGATCATCGGAGCGTGTCTCTTCGTCTACTTTTTGCTCATTGTTTGGCT
AGGGAAGCGGGGAGCAAAATATAGCCGTTCGATGAAGGGCTTTTCCATTGCTAAAGGAAAGGTGAGTCCTTGGCTAATTG
GTATCAGCTTTGGAGCAACCTATTCTAGTGCTAATTTATTTATTGGTGTACCTGGTTGGGCATACATGTATGGTACACCT
GTACTTTGGTATACATTAGGATGTTTTGGAATCACCTGGGTTGGCTTATTACTTGTTACCAAAAAGTTTTGGGAACACGG
ACAAAAGAATGAAGGTAGTTTAACGCTTCCGCAATGGCTAGGTAATCGCTATAATAGTAAAGCATTACAAGTCATCGTAG
CGTTATTGATTCTATTTAATATCTACTATATTGTTGCTCAAAATGTGGGTTTAGCTACCATGTTTGAAACAATTATAGGA
ATTCCTTATTATTGGGGGATTCTTTTTGGAGTCACATTAACGATTTTATATATTAGTATGGGCGGAGCATATGCACAATT
GATTACAGATGGAATTCAAGGCATTGTAATGTCCGTTATTTCAGTTCTGTTATTCCTCTCTCTTTTTTGGACAATCGGTG
GAGGATGGGGAACTCTAGGGAATTTAACCGGACAATTACATAATGCAGACCCTGCTTTAACAGCTTCTACAGCTGCAGGT
AGTCCATTTTATAGCGGGTTCGCCATTATGGCAATTCAATGGTTCTTACTTAGTTTCGTCCTTCTTCCCCAATTAATGAA
TAAAGTATTATCAGTAGGGAAGAAAGAGGATCTTCGTAAATTTACATTATCTGCTGGAGCAACCCTGTTTTTCTTATCTA
CATTCTCTGTGTTTGCTGGGTTAGCGGCAAGAGTTCTGATACCGGGATTAACTTCGTCTGATAGTGCAGTTCCAGCATAT
GTATTGGAGTATTTTCCAACGGTATTAATTGTCCTAATTGTGATGGGGATTGTATCAGCAATACTATCGACAACCGATAG
CTTGTATCTTGGTATGACAGCAAGTATAGGAAACGATATCTATAAAGTAGTAGTCGCTCCTTTTCTGTATAAGAATAAAA
ATGTATCTGCAAAGCAAATAGATCGAAAAGCCGTCCGAGTAGCTCGAATTGCATTATTTATTATCGGACTAATTTCGTTA
TATATGTCATTTAACCGTCCGGAATCACTATCATTACTGCTGCAGTTTGGGACATCGGCAATCATTAGTGGAGTAGTAGC
CCCGCTTACACTAAGTTATTTTTGGAAAAAAGCAAATCGTGTAGGTGCGATAGCTTCTGTGATTGTAGGAGCGGCTTGCT
TTATGATTCTTACTGGTTTTGGGGTTCAAGATCATGTATTTACAGCATTGCTATATAGTTCCATGCTAGGCTATGGGGTT
ATGATTGCTGGTAGTCTATGGGCAGAACATGTAACTAGTCATCGAAAAGTTAAACAAATTGAACAACAGCAAGTATTGTA
A

Upstream 100 bases:

>100_bases
CAGATGATCACATTTTATTTTATTGGAGTTGTCGTTTTCTGGATAATTGGTTTGATTGTCTGGAATAAAATATACCCAAA
AGGAACGGAGGAGAATACGA

Downstream 100 bases:

>100_bases
ATGCGTGTTCAAAGGGATGGAAAGAATCGAGAAGACCGGGGGTTTTGAATACCGGGACTTATGGAAGAGTTAGACATGAA
GAGTGGAAACTATAAATAAT

Product: sodium:pantothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MLTDNQATLAWIIGACLFVYFLLIVWLGKRGAKYSRSMKGFSIAKGKVSPWLIGISFGATYSSANLFIGVPGWAYMYGTP
VLWYTLGCFGITWVGLLLVTKKFWEHGQKNEGSLTLPQWLGNRYNSKALQVIVALLILFNIYYIVAQNVGLATMFETIIG
IPYYWGILFGVTLTILYISMGGAYAQLITDGIQGIVMSVISVLLFLSLFWTIGGGWGTLGNLTGQLHNADPALTASTAAG
SPFYSGFAIMAIQWFLLSFVLLPQLMNKVLSVGKKEDLRKFTLSAGATLFFLSTFSVFAGLAARVLIPGLTSSDSAVPAY
VLEYFPTVLIVLIVMGIVSAILSTTDSLYLGMTASIGNDIYKVVVAPFLYKNKNVSAKQIDRKAVRVARIALFIIGLISL
YMSFNRPESLSLLLQFGTSAIISGVVAPLTLSYFWKKANRVGAIASVIVGAACFMILTGFGVQDHVFTALLYSSMLGYGV
MIAGSLWAEHVTSHRKVKQIEQQQVL

Sequences:

>Translated_506_residues
MLTDNQATLAWIIGACLFVYFLLIVWLGKRGAKYSRSMKGFSIAKGKVSPWLIGISFGATYSSANLFIGVPGWAYMYGTP
VLWYTLGCFGITWVGLLLVTKKFWEHGQKNEGSLTLPQWLGNRYNSKALQVIVALLILFNIYYIVAQNVGLATMFETIIG
IPYYWGILFGVTLTILYISMGGAYAQLITDGIQGIVMSVISVLLFLSLFWTIGGGWGTLGNLTGQLHNADPALTASTAAG
SPFYSGFAIMAIQWFLLSFVLLPQLMNKVLSVGKKEDLRKFTLSAGATLFFLSTFSVFAGLAARVLIPGLTSSDSAVPAY
VLEYFPTVLIVLIVMGIVSAILSTTDSLYLGMTASIGNDIYKVVVAPFLYKNKNVSAKQIDRKAVRVARIALFIIGLISL
YMSFNRPESLSLLLQFGTSAIISGVVAPLTLSYFWKKANRVGAIASVIVGAACFMILTGFGVQDHVFTALLYSSMLGYGV
MIAGSLWAEHVTSHRKVKQIEQQQVL
>Mature_506_residues
MLTDNQATLAWIIGACLFVYFLLIVWLGKRGAKYSRSMKGFSIAKGKVSPWLIGISFGATYSSANLFIGVPGWAYMYGTP
VLWYTLGCFGITWVGLLLVTKKFWEHGQKNEGSLTLPQWLGNRYNSKALQVIVALLILFNIYYIVAQNVGLATMFETIIG
IPYYWGILFGVTLTILYISMGGAYAQLITDGIQGIVMSVISVLLFLSLFWTIGGGWGTLGNLTGQLHNADPALTASTAAG
SPFYSGFAIMAIQWFLLSFVLLPQLMNKVLSVGKKEDLRKFTLSAGATLFFLSTFSVFAGLAARVLIPGLTSSDSAVPAY
VLEYFPTVLIVLIVMGIVSAILSTTDSLYLGMTASIGNDIYKVVVAPFLYKNKNVSAKQIDRKAVRVARIALFIIGLISL
YMSFNRPESLSLLLQFGTSAIISGVVAPLTLSYFWKKANRVGAIASVIVGAACFMILTGFGVQDHVFTALLYSSMLGYGV
MIAGSLWAEHVTSHRKVKQIEQQQVL

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=463, Percent_Identity=23.3261339092873, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082237, Length=446, Percent_Identity=28.0269058295964, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787251, Length=463, Percent_Identity=23.5421166306695, Blast_Score=82, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 55117; Mature: 55117

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDNQATLAWIIGACLFVYFLLIVWLGKRGAKYSRSMKGFSIAKGKVSPWLIGISFGAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCEEEEEEECCC
YSSANLFIGVPGWAYMYGTPVLWYTLGCFGITWVGLLLVTKKFWEHGQKNEGSLTLPQWL
CCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHH
GNRYNSKALQVIVALLILFNIYYIVAQNVGLATMFETIIGIPYYWGILFGVTLTILYISM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GGAYAQLITDGIQGIVMSVISVLLFLSLFWTIGGGWGTLGNLTGQLHNADPALTASTAAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCEECCCCC
SPFYSGFAIMAIQWFLLSFVLLPQLMNKVLSVGKKEDLRKFTLSAGATLFFLSTFSVFAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
LAARVLIPGLTSSDSAVPAYVLEYFPTVLIVLIVMGIVSAILSTTDSLYLGMTASIGNDI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHHHH
YKVVVAPFLYKNKNVSAKQIDRKAVRVARIALFIIGLISLYMSFNRPESLSLLLQFGTSA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IISGVVAPLTLSYFWKKANRVGAIASVIVGAACFMILTGFGVQDHVFTALLYSSMLGYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MIAGSLWAEHVTSHRKVKQIEQQQVL
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTDNQATLAWIIGACLFVYFLLIVWLGKRGAKYSRSMKGFSIAKGKVSPWLIGISFGAT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCCCEEEEEEECCC
YSSANLFIGVPGWAYMYGTPVLWYTLGCFGITWVGLLLVTKKFWEHGQKNEGSLTLPQWL
CCCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHH
GNRYNSKALQVIVALLILFNIYYIVAQNVGLATMFETIIGIPYYWGILFGVTLTILYISM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GGAYAQLITDGIQGIVMSVISVLLFLSLFWTIGGGWGTLGNLTGQLHNADPALTASTAAG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCEECCCCC
SPFYSGFAIMAIQWFLLSFVLLPQLMNKVLSVGKKEDLRKFTLSAGATLFFLSTFSVFAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHH
LAARVLIPGLTSSDSAVPAYVLEYFPTVLIVLIVMGIVSAILSTTDSLYLGMTASIGNDI
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEHHHHHHH
YKVVVAPFLYKNKNVSAKQIDRKAVRVARIALFIIGLISLYMSFNRPESLSLLLQFGTSA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
IISGVVAPLTLSYFWKKANRVGAIASVIVGAACFMILTGFGVQDHVFTALLYSSMLGYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
MIAGSLWAEHVTSHRKVKQIEQQQVL
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]