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The map label for this gene is caiT [H]

Identifier: 23100229

GI number: 23100229

Start: 2847473

End: 2849065

Strand: Reverse

Name: caiT [H]

Synonym: OB2774

Alternate gene names: 23100229

Gene position: 2849065-2847473 (Counterclockwise)

Preceding gene: 23100230

Following gene: 23100228

Centisome position: 78.48

GC content: 35.97

Gene sequence:

>1593_bases
GTGAGTATAGATAAAAGTTCAAAGAAAGGACTTATTGATTATAAAATTTTTCTACCAGCTTTGATTATTATAGTAGGAAT
TAGTATTCCGCTTTCATTATATGAAGAAGAATCTTTAGCAATTTTAAATTCTATATTTAATGGAGTAGTAGATTCATTTA
GTTGGGGTTACATATGGTATGGAATCATATTACTTGTAGCTGGTTTGTATTTTTCATTTTCTAAATATGGAAAAGTTGTA
TTAGGAGATCCGATGGAAAAGCCGCGATTTACATTATTTGAATATGCTTCTATTTTAGTTGCGATGGGCTTAGGGTCAAC
GATTATGCGTACCGCAATGATAGAATGGGGCAATGTGGCGGTGAATCCTCCGTTTGGTGCAGAAGCTGGTTCAGATGCTG
CGATTTTATGGGGAAGCGCGTATAGTATGTTTCTTTGGGGCTTCCAAGTGTTTGCAGTATTTGTTATGGCTGCGCCAGCG
ATGGGCTATATTCTACATGTGAAAAAGCGACCAATGATGCGTATATCTGAAGCATGTCGAATTCTATTCGGTGACCGTTT
TACTGATGGAATTGGTGGTATAGTTCTAGATGTTCTATTCTTAATTAGTATCTTGTCTGGTGCTGCGGTTACATTAGGTT
TAGGGGCACCAATCGTTACCTATAATTTAGCAGAATTACTCAATATAGAGCTATCATTTGGTTTAACATTGATTGTAACC
GTTATTTGGGTATTGCTATTCTCTATTAGTGCCTACCTCGGTATAGAAAAAGGAATAAAGCGATTAAGTACATTAAATAT
GTATTTGGCTGGAGCATTTGCATTATTTATTATGGTTATCGGTCCAGGAGTATTTATTCTCAATTACTTTACGGATACGG
TTGGATTTCTGATTTCAAATTATGCCGATATTTCTTTGCATACAAATGCTTTGGGAAGCGGAGAGGCAACACATATTGAA
AGTAATACGATCTTCTGGTTTGCGTATAATGCTACGTGGGCGATGTTGCACAGTGTATTTGCTGCAAAAATTTCTAGAGG
ACGCACAATCAAAGAAATGATATTGACGTACCTTCTTGCACCAACGATGATTTCTTGGATTGCATCAGGTGTATTAGGCG
GACTAGGTGTATATAAATATTTAAATGGTGAAGTTGCGGTATTGGATATTATATCTAACCAAGACCCGATGGCCGCGATA
CCTGCAATTTTATCTTCCTTACCATTAGGGAATTTAGTATTGATTGTATTTATCATAATCGCTATGATTTTCTTAACGAC
AACACTTGATTCAACAACGTACACGATTGCATCTTATGCAGGAACAGAAAATATGAGTAAAGCTGAGCCTTCAAGGAATT
TACGTATTATCATTGCAGCTATTATTACAATTGTAGCTCTTATCTTAATGCGAATTGGTGGTTTAGCACCGTTAGAGGTT
GTTTCTGGATTAATGGGACTACCGATCATCTTTATTCAGTTCTTGACGATTTACGCTGCTAAAAAAATGATGGATAAGGA
TCGAGCATGGATTACAAATGTTAGAGAAGAAGATAAGAAATATTATAATAAGAGCAAGGGTAAAAGGTTATAA

Upstream 100 bases:

>100_bases
TAACAAATCTATACTTCCTGCTTATTGCCTATTGATTATGTTTATTCGGTTGATCTATGTGGTAAACACAGTTGAATTCG
ATTTAGTAGGAGGTACTACT

Downstream 100 bases:

>100_bases
CTAGACTTTAAGATGAGAAATATAAATCCGAACGAATGCGTTTATCAATATGCTTCGTTCGGATTTTTATGTTTTATAGG
TCCTTAATTATAAAGAAATA

Product: choline transporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSIDKSSKKGLIDYKIFLPALIIIVGISIPLSLYEEESLAILNSIFNGVVDSFSWGYIWYGIILLVAGLYFSFSKYGKVV
LGDPMEKPRFTLFEYASILVAMGLGSTIMRTAMIEWGNVAVNPPFGAEAGSDAAILWGSAYSMFLWGFQVFAVFVMAAPA
MGYILHVKKRPMMRISEACRILFGDRFTDGIGGIVLDVLFLISILSGAAVTLGLGAPIVTYNLAELLNIELSFGLTLIVT
VIWVLLFSISAYLGIEKGIKRLSTLNMYLAGAFALFIMVIGPGVFILNYFTDTVGFLISNYADISLHTNALGSGEATHIE
SNTIFWFAYNATWAMLHSVFAAKISRGRTIKEMILTYLLAPTMISWIASGVLGGLGVYKYLNGEVAVLDIISNQDPMAAI
PAILSSLPLGNLVLIVFIIIAMIFLTTTLDSTTYTIASYAGTENMSKAEPSRNLRIIIAAIITIVALILMRIGGLAPLEV
VSGLMGLPIIFIQFLTIYAAKKMMDKDRAWITNVREEDKKYYNKSKGKRL

Sequences:

>Translated_530_residues
MSIDKSSKKGLIDYKIFLPALIIIVGISIPLSLYEEESLAILNSIFNGVVDSFSWGYIWYGIILLVAGLYFSFSKYGKVV
LGDPMEKPRFTLFEYASILVAMGLGSTIMRTAMIEWGNVAVNPPFGAEAGSDAAILWGSAYSMFLWGFQVFAVFVMAAPA
MGYILHVKKRPMMRISEACRILFGDRFTDGIGGIVLDVLFLISILSGAAVTLGLGAPIVTYNLAELLNIELSFGLTLIVT
VIWVLLFSISAYLGIEKGIKRLSTLNMYLAGAFALFIMVIGPGVFILNYFTDTVGFLISNYADISLHTNALGSGEATHIE
SNTIFWFAYNATWAMLHSVFAAKISRGRTIKEMILTYLLAPTMISWIASGVLGGLGVYKYLNGEVAVLDIISNQDPMAAI
PAILSSLPLGNLVLIVFIIIAMIFLTTTLDSTTYTIASYAGTENMSKAEPSRNLRIIIAAIITIVALILMRIGGLAPLEV
VSGLMGLPIIFIQFLTIYAAKKMMDKDRAWITNVREEDKKYYNKSKGKRL
>Mature_529_residues
SIDKSSKKGLIDYKIFLPALIIIVGISIPLSLYEEESLAILNSIFNGVVDSFSWGYIWYGIILLVAGLYFSFSKYGKVVL
GDPMEKPRFTLFEYASILVAMGLGSTIMRTAMIEWGNVAVNPPFGAEAGSDAAILWGSAYSMFLWGFQVFAVFVMAAPAM
GYILHVKKRPMMRISEACRILFGDRFTDGIGGIVLDVLFLISILSGAAVTLGLGAPIVTYNLAELLNIELSFGLTLIVTV
IWVLLFSISAYLGIEKGIKRLSTLNMYLAGAFALFIMVIGPGVFILNYFTDTVGFLISNYADISLHTNALGSGEATHIES
NTIFWFAYNATWAMLHSVFAAKISRGRTIKEMILTYLLAPTMISWIASGVLGGLGVYKYLNGEVAVLDIISNQDPMAAIP
AILSSLPLGNLVLIVFIIIAMIFLTTTLDSTTYTIASYAGTENMSKAEPSRNLRIIIAAIITIVALILMRIGGLAPLEVV
SGLMGLPIIFIQFLTIYAAKKMMDKDRAWITNVREEDKKYYNKSKGKRL

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=514, Percent_Identity=27.2373540856031, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788102, Length=452, Percent_Identity=27.6548672566372, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786506, Length=514, Percent_Identity=25.6809338521401, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 57988; Mature: 57857

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDKSSKKGLIDYKIFLPALIIIVGISIPLSLYEEESLAILNSIFNGVVDSFSWGYIWY
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIILLVAGLYFSFSKYGKVVLGDPMEKPRFTLFEYASILVAMGLGSTIMRTAMIEWGNVA
HHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEE
VNPPFGAEAGSDAAILWGSAYSMFLWGFQVFAVFVMAAPAMGYILHVKKRPMMRISEACR
ECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHH
ILFGDRFTDGIGGIVLDVLFLISILSGAAVTLGLGAPIVTYNLAELLNIELSFGLTLIVT
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VIWVLLFSISAYLGIEKGIKRLSTLNMYLAGAFALFIMVIGPGVFILNYFTDTVGFLISN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
YADISLHTNALGSGEATHIESNTIFWFAYNATWAMLHSVFAAKISRGRTIKEMILTYLLA
CCCEEEECCCCCCCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
PTMISWIASGVLGGLGVYKYLNGEVAVLDIISNQDPMAAIPAILSSLPLGNLVLIVFIII
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AMIFLTTTLDSTTYTIASYAGTENMSKAEPSRNLRIIIAAIITIVALILMRIGGLAPLEV
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
VSGLMGLPIIFIQFLTIYAAKKMMDKDRAWITNVREEDKKYYNKSKGKRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIDKSSKKGLIDYKIFLPALIIIVGISIPLSLYEEESLAILNSIFNGVVDSFSWGYIWY
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
GIILLVAGLYFSFSKYGKVVLGDPMEKPRFTLFEYASILVAMGLGSTIMRTAMIEWGNVA
HHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEE
VNPPFGAEAGSDAAILWGSAYSMFLWGFQVFAVFVMAAPAMGYILHVKKRPMMRISEACR
ECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHH
ILFGDRFTDGIGGIVLDVLFLISILSGAAVTLGLGAPIVTYNLAELLNIELSFGLTLIVT
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
VIWVLLFSISAYLGIEKGIKRLSTLNMYLAGAFALFIMVIGPGVFILNYFTDTVGFLISN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
YADISLHTNALGSGEATHIESNTIFWFAYNATWAMLHSVFAAKISRGRTIKEMILTYLLA
CCCEEEECCCCCCCCCEEEECCEEEEEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
PTMISWIASGVLGGLGVYKYLNGEVAVLDIISNQDPMAAIPAILSSLPLGNLVLIVFIII
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHH
AMIFLTTTLDSTTYTIASYAGTENMSKAEPSRNLRIIIAAIITIVALILMRIGGLAPLEV
HHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
VSGLMGLPIIFIQFLTIYAAKKMMDKDRAWITNVREEDKKYYNKSKGKRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA