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The map label for this gene is serA [H]

Identifier: 23100081

GI number: 23100081

Start: 2692136

End: 2693722

Strand: Direct

Name: serA [H]

Synonym: OB2626

Alternate gene names: 23100081

Gene position: 2692136-2693722 (Clockwise)

Preceding gene: 23100080

Following gene: 23100083

Centisome position: 74.15

GC content: 39.26

Gene sequence:

>1587_bases
ATGACTTTTCACGTACTTATTAGTGATCCATTAAGCGAAGAGGGACTCAAACCGCTTCAAGAAGCTGAAAATATTGAGGT
TGTGATTAACCCAGGATGGAATGAACAAGAATTATCAGATCAAATAGATTCATTTGATGCCATTTTAGTTCGAAGTCAGA
CCCAAGTAACACGTGCCTTAATTGAAAAAGCAAGCAATTTAAAAATCATTGGTCGAGCTGGAGTTGGTGTTGATAATATA
GATCTTGAAGCTGCTACAGAAAATGGAGTTATTGTTGTCAATGCGCCAAATGGGAATACAAACTCTGCAGCAGAGCATAC
GATGGCAATGATTATGGCATTATCAAGAAATATCCCACAAGCTTATCACGCGTTAAAACAAAAACAATGGGATCGAAAAC
GTTTTGTAGGCGTTGAGTTAAAACAAAAGACACTGGGCATTGTCGGATTAGGAAGGATCGGTGCTGAAGTAGCTGCTCGA
GCAAAAGGTCAACGTATGAATGTCATTGCCTACGATCCTTTCTTCACAGAAGAAAAAGCAGAACAAATGGGTGTTCAATA
TGGGACACTAGAAGACGTATTACGTGCAGGTGATTTTATCACTGTCCATACCCCACTGCTTAAGGAAACAAAGCATTTAA
TTAACAAAGATGCTTTTGACCTGATGAAAGATGGTGTACAAATTGTTAATTGCGCTCGGGGCGGAATTATTGATGAAGAT
GCATTATACGATGCAATACAGTCTGGAAAAGTAGCAGGTGCCGCACTTGATGTGTTCGAACAAGAACCTTTTACAGAGCA
TAAGTTGTTAACACTTCCCGAAGTTGTAGCCACACCGCACTTAGGTGCGAGTACTGTAGAAGCTCAAGAAGTAGTCGCTA
TTGATGTGAGTCATGATGTCCTCAGGTTCTCTCAAGGAGAAGCAGTTCGTAATCCTGTTAATATGCCATCAGTTCCAAGC
GAGATCATGTATAAAATTGAGCCGTACTTCCACCTTGCTGAAAAGCTCGGTACATTTATTACAGATTTAACAAAAGAAGT
GGTAAGCGAAGTAAAAATTACGTATGCTGGTGATTTAGCAGATATTGAAATTGCACCATTAACTCGGAATGCGGTTAAAG
GTCTCTTAAAACGTTACTTAGGAAGTAGAATCAATGATGTAAACGCATTGTTTCTAGCTGACCGCAAAGGAATTGAGGTC
AGTGAAAGTAAAACGTCGTCTAAAAAAGGGTTCACAAACTTAATCACAATTGAGGTTTCAGGAAAATTTGGAACTAGAAA
AGTAGCAGGAACATTATTAAATGGTTTAGGTCCACGTTTAGTTCGTGTCGATGAGTACCGCGTAGATATAACACCAGAAG
GTCATATGGTTGTAATCCAACATCGTGATCAGCCAGGGGTTATTGGTCGAATGGGAAGTACTATCGCAAAACATGATATT
AATATTGCTACGATGCAAGTGGATCGCTCAGATATTGGTGGAGACGCTATTATGATTCTAACCATAGATCGACACCTAGC
AGATGAAGCATTAAACGAAATCGAAAGCCTAGATGAAATTAAATCAGTTACTGCGATTGATTTATAA

Upstream 100 bases:

>100_bases
AATTGAGATTGGTTTACAACTAATCGGGAAGAACATTGAATTAGGAAAAGGGACAGCTGCAGCTCAGCAAATTTATATAC
AGCAGGAGGTAAAATAAACG

Downstream 100 bases:

>100_bases
ATAAAGTTCCATCGAGATCAGTTATAACAACCATTAATAGATGTTTTGATTTTCATTACAGACGGCGCTTTCCGCAGGCA
CCGGTTTTTAGCTAACTTGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTFHVLISDPLSEEGLKPLQEAENIEVVINPGWNEQELSDQIDSFDAILVRSQTQVTRALIEKASNLKIIGRAGVGVDNI
DLEAATENGVIVVNAPNGNTNSAAEHTMAMIMALSRNIPQAYHALKQKQWDRKRFVGVELKQKTLGIVGLGRIGAEVAAR
AKGQRMNVIAYDPFFTEEKAEQMGVQYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQIVNCARGGIIDED
ALYDAIQSGKVAGAALDVFEQEPFTEHKLLTLPEVVATPHLGASTVEAQEVVAIDVSHDVLRFSQGEAVRNPVNMPSVPS
EIMYKIEPYFHLAEKLGTFITDLTKEVVSEVKITYAGDLADIEIAPLTRNAVKGLLKRYLGSRINDVNALFLADRKGIEV
SESKTSSKKGFTNLITIEVSGKFGTRKVAGTLLNGLGPRLVRVDEYRVDITPEGHMVVIQHRDQPGVIGRMGSTIAKHDI
NIATMQVDRSDIGGDAIMILTIDRHLADEALNEIESLDEIKSVTAIDL

Sequences:

>Translated_528_residues
MTFHVLISDPLSEEGLKPLQEAENIEVVINPGWNEQELSDQIDSFDAILVRSQTQVTRALIEKASNLKIIGRAGVGVDNI
DLEAATENGVIVVNAPNGNTNSAAEHTMAMIMALSRNIPQAYHALKQKQWDRKRFVGVELKQKTLGIVGLGRIGAEVAAR
AKGQRMNVIAYDPFFTEEKAEQMGVQYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQIVNCARGGIIDED
ALYDAIQSGKVAGAALDVFEQEPFTEHKLLTLPEVVATPHLGASTVEAQEVVAIDVSHDVLRFSQGEAVRNPVNMPSVPS
EIMYKIEPYFHLAEKLGTFITDLTKEVVSEVKITYAGDLADIEIAPLTRNAVKGLLKRYLGSRINDVNALFLADRKGIEV
SESKTSSKKGFTNLITIEVSGKFGTRKVAGTLLNGLGPRLVRVDEYRVDITPEGHMVVIQHRDQPGVIGRMGSTIAKHDI
NIATMQVDRSDIGGDAIMILTIDRHLADEALNEIESLDEIKSVTAIDL
>Mature_527_residues
TFHVLISDPLSEEGLKPLQEAENIEVVINPGWNEQELSDQIDSFDAILVRSQTQVTRALIEKASNLKIIGRAGVGVDNID
LEAATENGVIVVNAPNGNTNSAAEHTMAMIMALSRNIPQAYHALKQKQWDRKRFVGVELKQKTLGIVGLGRIGAEVAARA
KGQRMNVIAYDPFFTEEKAEQMGVQYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQIVNCARGGIIDEDA
LYDAIQSGKVAGAALDVFEQEPFTEHKLLTLPEVVATPHLGASTVEAQEVVAIDVSHDVLRFSQGEAVRNPVNMPSVPSE
IMYKIEPYFHLAEKLGTFITDLTKEVVSEVKITYAGDLADIEIAPLTRNAVKGLLKRYLGSRINDVNALFLADRKGIEVS
ESKTSSKKGFTNLITIEVSGKFGTRKVAGTLLNGLGPRLVRVDEYRVDITPEGHMVVIQHRDQPGVIGRMGSTIAKHDIN
IATMQVDRSDIGGDAIMILTIDRHLADEALNEIESLDEIKSVTAIDL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=407, Percent_Identity=42.2604422604423, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI4557497, Length=294, Percent_Identity=34.0136054421769, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI61743967, Length=294, Percent_Identity=34.0136054421769, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=34.4594594594595, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=34.4594594594595, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI145580575, Length=297, Percent_Identity=34.6801346801347, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI6912396, Length=329, Percent_Identity=30.0911854103343, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789279, Length=346, Percent_Identity=31.5028901734104, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87082289, Length=315, Percent_Identity=32.0634920634921, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1787645, Length=282, Percent_Identity=31.2056737588652, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788660, Length=253, Percent_Identity=26.4822134387352, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87081824, Length=171, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=303, Percent_Identity=44.5544554455446, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=332, Percent_Identity=28.9156626506024, Blast_Score=137, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=298, Percent_Identity=34.2281879194631, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6322116, Length=298, Percent_Identity=33.5570469798658, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324055, Length=231, Percent_Identity=34.6320346320346, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324964, Length=292, Percent_Identity=30.8219178082192, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6325144, Length=169, Percent_Identity=31.3609467455621, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=204, Percent_Identity=27.9411764705882, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=297, Percent_Identity=26.5993265993266, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=304, Percent_Identity=45.3947368421053, Blast_Score=261, Evalue=6e-70,
Organism=Drosophila melanogaster, GI24646446, Length=277, Percent_Identity=35.3790613718412, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646448, Length=277, Percent_Identity=35.3790613718412, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646452, Length=277, Percent_Identity=35.3790613718412, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646450, Length=277, Percent_Identity=35.3790613718412, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=35.3790613718412, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574286, Length=319, Percent_Identity=29.4670846394984, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=27.9874213836478, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=27.9874213836478, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=27.9874213836478, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=27.9874213836478, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=27.9874213836478, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=25.2365930599369, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28571528, Length=313, Percent_Identity=29.7124600638978, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57769; Mature: 57638

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFHVLISDPLSEEGLKPLQEAENIEVVINPGWNEQELSDQIDSFDAILVRSQTQVTRAL
CEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHCHHEEEEECHHHHHHHH
IEKASNLKIIGRAGVGVDNIDLEAATENGVIVVNAPNGNTNSAAEHTMAMIMALSRNIPQ
HHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHH
AYHALKQKQWDRKRFVGVELKQKTLGIVGLGRIGAEVAARAKGQRMNVIAYDPFFTEEKA
HHHHHHHHHCHHHHEECEEEHHHHCCEEEECHHHHHHHHHCCCCEEEEEEECCCCCHHHH
EQMGVQYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQIVNCARGGIIDED
HHHCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHCCHHHHHHHCCHHEEHHHCCCCCCHH
ALYDAIQSGKVAGAALDVFEQEPFTEHKLLTLPEVVATPHLGASTVEAQEVVAIDVSHDV
HHHHHHHCCCCCHHHHHHHHCCCCCCCCEEECCHHHHCCCCCCCCCCCCEEEEEECCHHH
LRFSQGEAVRNPVNMPSVPSEIMYKIEPYFHLAEKLGTFITDLTKEVVSEVKITYAGDLA
HHCCCCCHHCCCCCCCCCCHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
DIEIAPLTRNAVKGLLKRYLGSRINDVNALFLADRKGIEVSESKTSSKKGFTNLITIEVS
CEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEEEC
GKFGTRKVAGTLLNGLGPRLVRVDEYRVDITPEGHMVVIQHRDQPGVIGRMGSTIAKHDI
CCCCCHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCHHHCCCHHHHCCC
NIATMQVDRSDIGGDAIMILTIDRHLADEALNEIESLDEIKSVTAIDL
EEEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TFHVLISDPLSEEGLKPLQEAENIEVVINPGWNEQELSDQIDSFDAILVRSQTQVTRAL
EEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCHHHHHHHHHCHHEEEEECHHHHHHHH
IEKASNLKIIGRAGVGVDNIDLEAATENGVIVVNAPNGNTNSAAEHTMAMIMALSRNIPQ
HHCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCHH
AYHALKQKQWDRKRFVGVELKQKTLGIVGLGRIGAEVAARAKGQRMNVIAYDPFFTEEKA
HHHHHHHHHCHHHHEECEEEHHHHCCEEEECHHHHHHHHHCCCCEEEEEEECCCCCHHHH
EQMGVQYGTLEDVLRAGDFITVHTPLLKETKHLINKDAFDLMKDGVQIVNCARGGIIDED
HHHCCCCCCHHHHHHCCCEEEEECHHHHHHHHHHCCHHHHHHHCCHHEEHHHCCCCCCHH
ALYDAIQSGKVAGAALDVFEQEPFTEHKLLTLPEVVATPHLGASTVEAQEVVAIDVSHDV
HHHHHHHCCCCCHHHHHHHHCCCCCCCCEEECCHHHHCCCCCCCCCCCCEEEEEECCHHH
LRFSQGEAVRNPVNMPSVPSEIMYKIEPYFHLAEKLGTFITDLTKEVVSEVKITYAGDLA
HHCCCCCHHCCCCCCCCCCHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
DIEIAPLTRNAVKGLLKRYLGSRINDVNALFLADRKGIEVSESKTSSKKGFTNLITIEVS
CEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEEEC
GKFGTRKVAGTLLNGLGPRLVRVDEYRVDITPEGHMVVIQHRDQPGVIGRMGSTIAKHDI
CCCCCHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEECCCCCCHHHCCCHHHHCCC
NIATMQVDRSDIGGDAIMILTIDRHLADEALNEIESLDEIKSVTAIDL
EEEEEEEECCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 7934829 [H]