Click here to switch to the map view.

The map label for this gene is gapA [H]

Identifier: 23099893

GI number: 23099893

Start: 2493545

End: 2494552

Strand: Reverse

Name: gapA [H]

Synonym: OB2438

Alternate gene names: 23099893

Gene position: 2494552-2493545 (Counterclockwise)

Preceding gene: 23099894

Following gene: 23099892

Centisome position: 68.71

GC content: 35.62

Gene sequence:

>1008_bases
ATGGCAGTAAAAATAGGTATTAATGGTTTTGGTAGAATCGGACGTAATGTATTTCGTCAATCTCTAAAAAATAATGAAGT
GGAAGTTGTTGCTATTAATGATTTAACAGATGCTAACATGCTTGCACACTTATTAAAATATGATTCAGTACACGGAAAAT
TACAAGAAGAGGTAACTGTAAATGGTTCTAACCTTGTAATCGATGGTAAAGAAATTAAAGTATTATCAGAGCGTGACCCT
GCTGAACTTGGATGGGGAGATCTTGGTGTTGATATTGTAATTGAATCTACTGGTCGATTCACAAACAAAGAAGATGCTGA
GAAGCATATTCAAGCAGGAGCTAAAAAAGTAATCATCTCTGCACCAGCAAAAGGTGAAGATTTAACAATTGTTATGGGTG
TTAATGATGATCAATATGATCCAAGTGAGCACAATGTAATCTCTAATGCTTCTTGTACGACAAACTGTTTAGCACCATTT
GCAAAAGTATTAAATGATAACTTTGGTATTAAGCGTGGTTTAATGACTACTATCCACTCTTATACAAACGATCAGCAAAT
CTTAGACTTACCACACAAAGATTATCGCCGTGCTCGTGCAGCAGCAGAAAATATCATTCCTACTTCAACAGGAGCTGCAA
AAGCAGTTGGACTTGTATTACCTGAACTTAACGGTAAATTAAATGGTAATGCAGTACGTGTTCCAACTCCAGATGGTTCA
TTAACAGACTTAGTTGCTGAATTAGATAAAAACGTTACTATCGAGGACGTTAATAATGCAATGAAAGAAGCAGCTGAAGG
CCCATTAAAAGGTATCTTAGAGTATTCAGAAGAACCACTTGTATCTTCTGATATCGTAGGTAACAACCATTCTTCTATCT
TCGATGCATTGTCTACAATCGTAATGGAAGATAACATGGTTAAAGTTGTTTCTTGGTATGACAACGAAATGGGTTATTCC
GCTCGTTGTATCGACTTAGCAATCTTTATGAACAATAAAGGACTTTAA

Upstream 100 bases:

>100_bases
AAAGCAATATTCTGATCACTGATCAGGGTGCAGCAGAAGAGATATTAAGAGGATAGCCTCTTTATATATAATTTAATAAA
AATTCTAGGAGGAATTATAC

Downstream 100 bases:

>100_bases
TAGAATTATTCGTTCGAAGAAACATATTGTTTCCTCCGGACGAAAGGATATTGGAGGAGGGAATGGTTTCCTCCTCCATT
TTCCGTTTTAATCAGTATTG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD-dependent glyceraldehyde-3-phosphate dehydrogenase; GAPDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAVKIGINGFGRIGRNVFRQSLKNNEVEVVAINDLTDANMLAHLLKYDSVHGKLQEEVTVNGSNLVIDGKEIKVLSERDP
AELGWGDLGVDIVIESTGRFTNKEDAEKHIQAGAKKVIISAPAKGEDLTIVMGVNDDQYDPSEHNVISNASCTTNCLAPF
AKVLNDNFGIKRGLMTTIHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVGLVLPELNGKLNGNAVRVPTPDGS
LTDLVAELDKNVTIEDVNNAMKEAAEGPLKGILEYSEEPLVSSDIVGNNHSSIFDALSTIVMEDNMVKVVSWYDNEMGYS
ARCIDLAIFMNNKGL

Sequences:

>Translated_335_residues
MAVKIGINGFGRIGRNVFRQSLKNNEVEVVAINDLTDANMLAHLLKYDSVHGKLQEEVTVNGSNLVIDGKEIKVLSERDP
AELGWGDLGVDIVIESTGRFTNKEDAEKHIQAGAKKVIISAPAKGEDLTIVMGVNDDQYDPSEHNVISNASCTTNCLAPF
AKVLNDNFGIKRGLMTTIHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVGLVLPELNGKLNGNAVRVPTPDGS
LTDLVAELDKNVTIEDVNNAMKEAAEGPLKGILEYSEEPLVSSDIVGNNHSSIFDALSTIVMEDNMVKVVSWYDNEMGYS
ARCIDLAIFMNNKGL
>Mature_334_residues
AVKIGINGFGRIGRNVFRQSLKNNEVEVVAINDLTDANMLAHLLKYDSVHGKLQEEVTVNGSNLVIDGKEIKVLSERDPA
ELGWGDLGVDIVIESTGRFTNKEDAEKHIQAGAKKVIISAPAKGEDLTIVMGVNDDQYDPSEHNVISNASCTTNCLAPFA
KVLNDNFGIKRGLMTTIHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVGLVLPELNGKLNGNAVRVPTPDGSL
TDLVAELDKNVTIEDVNNAMKEAAEGPLKGILEYSEEPLVSSDIVGNNHSSIFDALSTIVMEDNMVKVVSWYDNEMGYSA
RCIDLAIFMNNKGL

Specific function: More active in catabolism [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=333, Percent_Identity=53.1531531531532, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI7657116, Length=331, Percent_Identity=49.5468277945619, Blast_Score=335, Evalue=2e-92,
Organism=Escherichia coli, GI1788079, Length=327, Percent_Identity=55.6574923547401, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1789295, Length=334, Percent_Identity=44.9101796407186, Blast_Score=293, Evalue=7e-81,
Organism=Caenorhabditis elegans, GI17534677, Length=337, Percent_Identity=53.7091988130564, Blast_Score=363, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17534679, Length=337, Percent_Identity=53.7091988130564, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI32566163, Length=336, Percent_Identity=52.6785714285714, Blast_Score=350, Evalue=4e-97,
Organism=Caenorhabditis elegans, GI17568413, Length=336, Percent_Identity=52.6785714285714, Blast_Score=350, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6322409, Length=326, Percent_Identity=53.680981595092, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321631, Length=326, Percent_Identity=54.9079754601227, Blast_Score=356, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6322468, Length=326, Percent_Identity=54.2944785276074, Blast_Score=353, Evalue=2e-98,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=52.710843373494, Blast_Score=348, Evalue=2e-96,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=52.710843373494, Blast_Score=348, Evalue=2e-96,
Organism=Drosophila melanogaster, GI17933600, Length=332, Percent_Identity=52.710843373494, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI18110149, Length=332, Percent_Identity=52.710843373494, Blast_Score=348, Evalue=4e-96,
Organism=Drosophila melanogaster, GI19922412, Length=327, Percent_Identity=51.0703363914373, Blast_Score=340, Evalue=6e-94,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1840 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 740 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Min

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 36334; Mature: 36202

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKIGINGFGRIGRNVFRQSLKNNEVEVVAINDLTDANMLAHLLKYDSVHGKLQEEVTV
CEEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEE
NGSNLVIDGKEIKVLSERDPAELGWGDLGVDIVIESTGRFTNKEDAEKHIQAGAKKVIIS
CCCEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEE
APAKGEDLTIVMGVNDDQYDPSEHNVISNASCTTNCLAPFAKVLNDNFGIKRGLMTTIHS
CCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
YTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVGLVLPELNGKLNGNAVRVPTPDGS
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCEEEECCCCCH
LTDLVAELDKNVTIEDVNNAMKEAAEGPLKGILEYSEEPLVSSDIVGNNHSSIFDALSTI
HHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VMEDNMVKVVSWYDNEMGYSARCIDLAIFMNNKGL
HHCCCEEEEEEEECCCCCCCEEEEEEEEEECCCCC
>Mature Secondary Structure 
AVKIGINGFGRIGRNVFRQSLKNNEVEVVAINDLTDANMLAHLLKYDSVHGKLQEEVTV
EEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEE
NGSNLVIDGKEIKVLSERDPAELGWGDLGVDIVIESTGRFTNKEDAEKHIQAGAKKVIIS
CCCEEEEECCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEE
APAKGEDLTIVMGVNDDQYDPSEHNVISNASCTTNCLAPFAKVLNDNFGIKRGLMTTIHS
CCCCCCCEEEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
YTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVGLVLPELNGKLNGNAVRVPTPDGS
CCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCEEEECCCCCH
LTDLVAELDKNVTIEDVNNAMKEAAEGPLKGILEYSEEPLVSSDIVGNNHSSIFDALSTI
HHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VMEDNMVKVVSWYDNEMGYSARCIDLAIFMNNKGL
HHCCCEEEEEEEECCCCCCCEEEEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493629; 9384377; 8755892; 10658653; 10799476 [H]