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The map label for this gene is gyaR [H]

Identifier: 23099812

GI number: 23099812

Start: 2408601

End: 2409569

Strand: Reverse

Name: gyaR [H]

Synonym: OB2357

Alternate gene names: 23099812

Gene position: 2409569-2408601 (Counterclockwise)

Preceding gene: 23099813

Following gene: 23099810

Centisome position: 66.37

GC content: 35.91

Gene sequence:

>969_bases
ATGAGCAAGCCAAAGGTATTTGTTACGAGGAAATTATCAAGTCAATTCGTAAAGGAATATGAAGAAATATTAGATATTCG
TATGTGGGATAAGGAGGAAGAGCCTGTTCCAGAAGAAATATTAAGAAGTCAAGCGAAAGAAGTAGATGCATTATTTACGG
TATTAGGGGATCGTATTGATGAAACATTATTAGCAGAAGCAAAAAATTTAAAAGTGGTAGCAAATATGGCTGTTGGATAT
GACAATATAGATATTGACGCAGCTAGTAAACATGGTATTACAGTTGCGAATACTCCTGATGTACTTTCAGAAACAACAGC
TGATTTAGGTTTTTCACTTTTAGCAGCAACCGCTAGAAGAATCACAGAGGCAAGTACGTATGTAAAGGAAGATAATTGGA
AACAATGGGGCCCTTTCTTATTAGCAGGAACTGATATTCACCACAAAACATTGGGAATTGTTGGAATGGGTAGAATTGGT
GAAGCGTTAGCAAAAAGAGCTACGGGGTTTAATATGAAAATTCAATATCATAACCGTTCCAGAAAACCAGAAGCTGAAGA
AAAACTACAAGCATCCTACGTTAGCTTCGAAGAATTACTCGAAACGTCGGATTTCGTTGTCACTGTTGTTCCTTTTACGA
AAGAGACAGAAGAATTATTTAATGAATCTGCTTTTAAAAAAATGAAAGCATCAGCAATTTTTATTAATATTTCTCGAGGC
AAAGTGGTGGATGAAACAGCGTTGATTGATGCTTTAAATCATGGTGAAATCAAAGCGGCGGGATTGGATGTTTTTTATGA
GGAACCAATTCGTGCAGATCATCCACTAGTTAATATGGATAATGTAGTTTGTTTACCGCATATAGGATCTGCAAGTACTG
AGACACGAACAGAAATGATACATCTATGTATGAAAAATATAGTAGAAGTGACTGCAGGTAGAGTAGCAACTACACCTGTT
AATAACTAA

Upstream 100 bases:

>100_bases
ACAGCTTCGAGATTTTTATCAAATTGTAGGAGTGAATATTTCTGATTGGCAAATACCTGTGGTAAACTGGCTGTAAATAA
ATAAAATGGAGAGATGTTTT

Downstream 100 bases:

>100_bases
CACAAAAATGATCTCTGTACATGAGACAGAGATCATTTTACATATGTTAAATGGAATTAAAATACTTGTTCAATTTCACG
TACGCCAGGAACCTCTGCCA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSKPKVFVTRKLSSQFVKEYEEILDIRMWDKEEEPVPEEILRSQAKEVDALFTVLGDRIDETLLAEAKNLKVVANMAVGY
DNIDIDAASKHGITVANTPDVLSETTADLGFSLLAATARRITEASTYVKEDNWKQWGPFLLAGTDIHHKTLGIVGMGRIG
EALAKRATGFNMKIQYHNRSRKPEAEEKLQASYVSFEELLETSDFVVTVVPFTKETEELFNESAFKKMKASAIFINISRG
KVVDETALIDALNHGEIKAAGLDVFYEEPIRADHPLVNMDNVVCLPHIGSASTETRTEMIHLCMKNIVEVTAGRVATTPV
NN

Sequences:

>Translated_322_residues
MSKPKVFVTRKLSSQFVKEYEEILDIRMWDKEEEPVPEEILRSQAKEVDALFTVLGDRIDETLLAEAKNLKVVANMAVGY
DNIDIDAASKHGITVANTPDVLSETTADLGFSLLAATARRITEASTYVKEDNWKQWGPFLLAGTDIHHKTLGIVGMGRIG
EALAKRATGFNMKIQYHNRSRKPEAEEKLQASYVSFEELLETSDFVVTVVPFTKETEELFNESAFKKMKASAIFINISRG
KVVDETALIDALNHGEIKAAGLDVFYEEPIRADHPLVNMDNVVCLPHIGSASTETRTEMIHLCMKNIVEVTAGRVATTPV
NN
>Mature_321_residues
SKPKVFVTRKLSSQFVKEYEEILDIRMWDKEEEPVPEEILRSQAKEVDALFTVLGDRIDETLLAEAKNLKVVANMAVGYD
NIDIDAASKHGITVANTPDVLSETTADLGFSLLAATARRITEASTYVKEDNWKQWGPFLLAGTDIHHKTLGIVGMGRIGE
ALAKRATGFNMKIQYHNRSRKPEAEEKLQASYVSFEELLETSDFVVTVVPFTKETEELFNESAFKKMKASAIFINISRGK
VVDETALIDALNHGEIKAAGLDVFYEEPIRADHPLVNMDNVVCLPHIGSASTETRTEMIHLCMKNIVEVTAGRVATTPVN
N

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=308, Percent_Identity=42.5324675324675, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=32.0689655172414, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI145580578, Length=258, Percent_Identity=32.1705426356589, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI4557499, Length=258, Percent_Identity=32.1705426356589, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=31.7829457364341, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=31.7829457364341, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI145580575, Length=258, Percent_Identity=32.1705426356589, Blast_Score=127, Evalue=9e-30,
Organism=Escherichia coli, GI87082289, Length=323, Percent_Identity=43.9628482972136, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1789279, Length=255, Percent_Identity=32.156862745098, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787645, Length=226, Percent_Identity=30.9734513274336, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87081824, Length=255, Percent_Identity=23.921568627451, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788660, Length=240, Percent_Identity=27.9166666666667, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=258, Percent_Identity=34.1085271317829, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=242, Percent_Identity=27.6859504132231, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=40, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320925, Length=281, Percent_Identity=30.9608540925267, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=30.4347826086957, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=332, Percent_Identity=25.6024096385542, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321253, Length=286, Percent_Identity=27.972027972028, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=315, Percent_Identity=24.4444444444444, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=164, Percent_Identity=29.8780487804878, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571528, Length=316, Percent_Identity=43.0379746835443, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=40.6130268199234, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=40.6130268199234, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=40.6130268199234, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=40.6130268199234, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=40.6130268199234, Blast_Score=198, Evalue=5e-51,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=39.8467432950192, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24585516, Length=287, Percent_Identity=38.3275261324042, Blast_Score=194, Evalue=5e-50,
Organism=Drosophila melanogaster, GI19921140, Length=268, Percent_Identity=31.3432835820896, Blast_Score=137, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646446, Length=259, Percent_Identity=31.2741312741313, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646448, Length=259, Percent_Identity=31.2741312741313, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646452, Length=259, Percent_Identity=31.2741312741313, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646450, Length=259, Percent_Identity=31.2741312741313, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI62472511, Length=259, Percent_Identity=31.2741312741313, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35829; Mature: 35698

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPKVFVTRKLSSQFVKEYEEILDIRMWDKEEEPVPEEILRSQAKEVDALFTVLGDRID
CCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETLLAEAKNLKVVANMAVGYDNIDIDAASKHGITVANTPDVLSETTADLGFSLLAATARR
HHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
ITEASTYVKEDNWKQWGPFLLAGTDIHHKTLGIVGMGRIGEALAKRATGFNMKIQYHNRS
HHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCEEECCHHHHHHHHHHCCCEEEEEECCCC
RKPEAEEKLQASYVSFEELLETSDFVVTVVPFTKETEELFNESAFKKMKASAIFINISRG
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC
KVVDETALIDALNHGEIKAAGLDVFYEEPIRADHPLVNMDNVVCLPHIGSASTETRTEMI
CEEHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHH
HLCMKNIVEVTAGRVATTPVNN
HHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure 
SKPKVFVTRKLSSQFVKEYEEILDIRMWDKEEEPVPEEILRSQAKEVDALFTVLGDRID
CCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ETLLAEAKNLKVVANMAVGYDNIDIDAASKHGITVANTPDVLSETTADLGFSLLAATARR
HHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHH
ITEASTYVKEDNWKQWGPFLLAGTDIHHKTLGIVGMGRIGEALAKRATGFNMKIQYHNRS
HHHHHHHHCCCCCCCCCCEEEECCCCCHHHCCEEECCHHHHHHHHHHCCCEEEEEECCCC
RKPEAEEKLQASYVSFEELLETSDFVVTVVPFTKETEELFNESAFKKMKASAIFINISRG
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEECCC
KVVDETALIDALNHGEIKAAGLDVFYEEPIRADHPLVNMDNVVCLPHIGSASTETRTEMI
CEEHHHHHHHHCCCCCEEEECCEEEECCCCCCCCCEECCCCEEEECCCCCCCHHHHHHHH
HLCMKNIVEVTAGRVATTPVNN
HHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA