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The map label for this gene is menA [H]

Identifier: 23099782

GI number: 23099782

Start: 2378587

End: 2379522

Strand: Direct

Name: menA [H]

Synonym: OB2327

Alternate gene names: 23099782

Gene position: 2378587-2379522 (Clockwise)

Preceding gene: 23099773

Following gene: 23099783

Centisome position: 65.52

GC content: 33.65

Gene sequence:

>936_bases
ATGCAATCAAAAGATACATCAAACATAAAACAATTATTAAATGAACGTGAAGGATTTCATGTTTGGTGGCGACTACTTCG
ACCACACACTTTAACCGCATCATTTGTCCCAGTTTTTGTAGGTACAATGATTGCATTTAATGAAGGTGCCATTAACTGGT
GGATTTTTACAGCGATGTTAATAGCTTCTCTATTAATTCAATCAGCAACTAATATGTTTAATGAGTATTATGACTTTGTT
CGAGGATTAGATAATGACCAATCTGTGGGAATTGGGGGATCAATTGTACGAGATGGGCTAAAACCAAAACATATTCGAAA
TTTAGCATTTTTATTTTACGGAATATCAGTTTTACTTGGAATATACATTTGCATGATGTCTAGTTGGTGGATTGCAATTA
TTGGTTTATTTTGTATGTTAATTGGTTATTTATATACTGGAGGCCCTATTCCAATTTCATATACTCCATTTGGAGAATTA
TTTTCAGGAGTATTAATGGGATCAGTAATCATCGGTATTACTTATTATATCCAAACTGAAACGATATCTACAGAAATGAT
TTGGATTTCAATCCCAATTACAATATTTATTGGCTGTATAAATTTTGCTAATAATATCCGAGATCGTGAAGGGGATAAAC
GTGGTGGCAGAAAAACGATTGCAGTATTGATTGGAAAAGAAAGATCGGTTGCGCTACTTGGAACTTTAATCGCGTTGGCG
TACATTATGACCTTATTGTATATCTTAATTGGATTCCTTCCAATTTGGTCTTTCATCACTTTCTTGAGTATTCCAAAAGC
ATATGGAATAATTAAGAAATTCCAAGGGAAGAAAACATCACTTGAAATGATGCCGGCGATGGGTGCTACTGCAAAAACAA
ACACTATGTATGGAATGTTATTAGGGCTGTCACTACTTATAACAGCATTGTTATAA

Upstream 100 bases:

>100_bases
CTATTATTTCTATAAAATTCCTGCTAGTAACATACATTGACACCTTCTTAACCTTTCCATAAAATTAATATGATATAGAA
AAATCAGGAGGATACGCTCA

Downstream 100 bases:

>100_bases
CTTTGAAAGGATGGAACTATGACAAATAAATTAAGTAAAGATAAGCTAAATTATTTTAAAGAGAAATTACAACAAATGAA
AGAGGAATTAGAAGATAAAC

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQSKDTSNIKQLLNEREGFHVWWRLLRPHTLTASFVPVFVGTMIAFNEGAINWWIFTAMLIASLLIQSATNMFNEYYDFV
RGLDNDQSVGIGGSIVRDGLKPKHIRNLAFLFYGISVLLGIYICMMSSWWIAIIGLFCMLIGYLYTGGPIPISYTPFGEL
FSGVLMGSVIIGITYYIQTETISTEMIWISIPITIFIGCINFANNIRDREGDKRGGRKTIAVLIGKERSVALLGTLIALA
YIMTLLYILIGFLPIWSFITFLSIPKAYGIIKKFQGKKTSLEMMPAMGATAKTNTMYGMLLGLSLLITALL

Sequences:

>Translated_311_residues
MQSKDTSNIKQLLNEREGFHVWWRLLRPHTLTASFVPVFVGTMIAFNEGAINWWIFTAMLIASLLIQSATNMFNEYYDFV
RGLDNDQSVGIGGSIVRDGLKPKHIRNLAFLFYGISVLLGIYICMMSSWWIAIIGLFCMLIGYLYTGGPIPISYTPFGEL
FSGVLMGSVIIGITYYIQTETISTEMIWISIPITIFIGCINFANNIRDREGDKRGGRKTIAVLIGKERSVALLGTLIALA
YIMTLLYILIGFLPIWSFITFLSIPKAYGIIKKFQGKKTSLEMMPAMGATAKTNTMYGMLLGLSLLITALL
>Mature_311_residues
MQSKDTSNIKQLLNEREGFHVWWRLLRPHTLTASFVPVFVGTMIAFNEGAINWWIFTAMLIASLLIQSATNMFNEYYDFV
RGLDNDQSVGIGGSIVRDGLKPKHIRNLAFLFYGISVLLGIYICMMSSWWIAIIGLFCMLIGYLYTGGPIPISYTPFGEL
FSGVLMGSVIIGITYYIQTETISTEMIWISIPITIFIGCINFANNIRDREGDKRGGRKTIAVLIGKERSVALLGTLIALA
YIMTLLYILIGFLPIWSFITFLSIPKAYGIIKKFQGKKTSLEMMPAMGATAKTNTMYGMLLGLSLLITALL

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=288, Percent_Identity=27.7777777777778, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=22, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737429, Length=284, Percent_Identity=27.8169014084507, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34757; Mature: 34757

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSKDTSNIKQLLNEREGFHVWWRLLRPHTLTASFVPVFVGTMIAFNEGAINWWIFTAML
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IASLLIQSATNMFNEYYDFVRGLDNDQSVGIGGSIVRDGLKPKHIRNLAFLFYGISVLLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IYICMMSSWWIAIIGLFCMLIGYLYTGGPIPISYTPFGELFSGVLMGSVIIGITYYIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
TISTEMIWISIPITIFIGCINFANNIRDREGDKRGGRKTIAVLIGKERSVALLGTLIALA
EECEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
YIMTLLYILIGFLPIWSFITFLSIPKAYGIIKKFQGKKTSLEMMPAMGATAKTNTMYGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
LGLSLLITALL
HHHHHHHHHHC
>Mature Secondary Structure
MQSKDTSNIKQLLNEREGFHVWWRLLRPHTLTASFVPVFVGTMIAFNEGAINWWIFTAML
CCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IASLLIQSATNMFNEYYDFVRGLDNDQSVGIGGSIVRDGLKPKHIRNLAFLFYGISVLLG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
IYICMMSSWWIAIIGLFCMLIGYLYTGGPIPISYTPFGELFSGVLMGSVIIGITYYIQTE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEE
TISTEMIWISIPITIFIGCINFANNIRDREGDKRGGRKTIAVLIGKERSVALLGTLIALA
EECEEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHH
YIMTLLYILIGFLPIWSFITFLSIPKAYGIIKKFQGKKTSLEMMPAMGATAKTNTMYGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHH
LGLSLLITALL
HHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]