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The map label for this gene is menB [H]

Identifier: 23099778

GI number: 23099778

Start: 2373625

End: 2374443

Strand: Reverse

Name: menB [H]

Synonym: OB2323

Alternate gene names: 23099778

Gene position: 2374443-2373625 (Counterclockwise)

Preceding gene: 23099779

Following gene: 23099777

Centisome position: 65.4

GC content: 39.44

Gene sequence:

>819_bases
ATGTCTGTAGAATGGCAAAAGGTAAACAGCTATGAAGAAATAATTTATGAAAAATATAATGGGATTGCAAAAGTTACCAT
TAATCGTCCTGAAAAACGTAATGCATTTACACCACTAACGGTAAAAGAAATGATTGATGCATTTATTGATGCTCGCGATG
ATTCTTCTATCGGTGTAATTGTTTTAGCTGGAGAAGGTGAAAAAGCTTTCTGTTCAGGTGGAGACCAATCTGTGCGCGGG
CACGGGGGTTATGTTGGTACGGACGAGGTTCCTCGTTTAAATGTATTAGATTTACAACGTCTTATCCGCACGATACCAAA
ACCAGTAATTGCAATGGTTTCCGGTTACGCTATTGGTGGAGGTCATGTACTACATGTAGTTTGCGACTTAACAATTGCTG
CTGATAATGCCATCTTTGGTCAAACAGGTCCAAAAGTGGGTAGCTTTGATGCGGGTTACGGAGCTGGATATTTAGCACGT
CTAGTTGGTCATAAACGCGCACGTGAAATCTGGTATTTATGTCGTCAATACAATGCGGATGAAGCATATGAAATGGGACT
TGTAAATACGGTTGTACCACTAGATAAACTTGAGGAAGAAACTATCCAATGGTGTGAAGAAATTTTAGAAAAATCGCCAA
CAGCTTTACGTTTCTTAAAAGCTTCCTTTAATGCGGATACAGATGGATTAGCTGGACTGCAACAATTAGGTGGAGACGCT
ACATTATTGTATTATACAACGGATGAAGCTAAAGAAGGACGCGATGCGTTTAAAGAAAAAAGAAAACCTGACTTTAAACA
ATTCCCTCGCTTCCCTTAA

Upstream 100 bases:

>100_bases
TTCATGTGGAAAATCCTCAAATCTTTGGTAAAATAGTAGAAGAGTTTCTAATTAGAAACCCAATAACTACATAATTTTGT
TGCTTGAAAGGAGCATATAT

Downstream 100 bases:

>100_bases
GATGTGATAGAATGGAGAAAAACCTTTGTCCCGTGTGGACAAAGGTTTCTTTTATCGTATAGTGTACTAGAATGGAGAGA
TTATCATGAGTGAAACAACT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSVEWQKVNSYEEIIYEKYNGIAKVTINRPEKRNAFTPLTVKEMIDAFIDARDDSSIGVIVLAGEGEKAFCSGGDQSVRG
HGGYVGTDEVPRLNVLDLQRLIRTIPKPVIAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGAGYLAR
LVGHKRAREIWYLCRQYNADEAYEMGLVNTVVPLDKLEEETIQWCEEILEKSPTALRFLKASFNADTDGLAGLQQLGGDA
TLLYYTTDEAKEGRDAFKEKRKPDFKQFPRFP

Sequences:

>Translated_272_residues
MSVEWQKVNSYEEIIYEKYNGIAKVTINRPEKRNAFTPLTVKEMIDAFIDARDDSSIGVIVLAGEGEKAFCSGGDQSVRG
HGGYVGTDEVPRLNVLDLQRLIRTIPKPVIAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGAGYLAR
LVGHKRAREIWYLCRQYNADEAYEMGLVNTVVPLDKLEEETIQWCEEILEKSPTALRFLKASFNADTDGLAGLQQLGGDA
TLLYYTTDEAKEGRDAFKEKRKPDFKQFPRFP
>Mature_271_residues
SVEWQKVNSYEEIIYEKYNGIAKVTINRPEKRNAFTPLTVKEMIDAFIDARDDSSIGVIVLAGEGEKAFCSGGDQSVRGH
GGYVGTDEVPRLNVLDLQRLIRTIPKPVIAMVSGYAIGGGHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGAGYLARL
VGHKRAREIWYLCRQYNADEAYEMGLVNTVVPLDKLEEETIQWCEEILEKSPTALRFLKASFNADTDGLAGLQQLGGDAT
LLYYTTDEAKEGRDAFKEKRKPDFKQFPRFP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=262, Percent_Identity=33.587786259542, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31542718, Length=263, Percent_Identity=31.1787072243346, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI45643119, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI260275230, Length=218, Percent_Identity=27.9816513761468, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI260274832, Length=218, Percent_Identity=27.9816513761468, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=31.6239316239316, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=28.4615384615385, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI157694516, Length=207, Percent_Identity=23.6714975845411, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI213417737, Length=207, Percent_Identity=23.6714975845411, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4757966, Length=226, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538581, Length=226, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI25453481, Length=226, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI51538573, Length=226, Percent_Identity=25.6637168141593, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI37594471, Length=160, Percent_Identity=26.875, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI37594469, Length=160, Percent_Identity=26.875, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=273, Percent_Identity=67.3992673992674, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1787659, Length=260, Percent_Identity=32.3076923076923, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=28.6792452830189, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI221142681, Length=270, Percent_Identity=30, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=29.3893129770992, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17554946, Length=256, Percent_Identity=31.640625, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI25145438, Length=249, Percent_Identity=32.9317269076305, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=237, Percent_Identity=27.4261603375527, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17549921, Length=216, Percent_Identity=28.2407407407407, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=238, Percent_Identity=29.8319327731092, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560910, Length=181, Percent_Identity=33.1491712707182, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17534483, Length=290, Percent_Identity=27.5862068965517, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535521, Length=211, Percent_Identity=26.5402843601896, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=203, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI25144157, Length=203, Percent_Identity=27.5862068965517, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI20129971, Length=265, Percent_Identity=33.9622641509434, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=265, Percent_Identity=33.9622641509434, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653139, Length=267, Percent_Identity=29.5880149812734, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357171, Length=189, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI19922422, Length=272, Percent_Identity=24.6323529411765, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650670, Length=194, Percent_Identity=29.3814432989691, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24654903, Length=197, Percent_Identity=24.8730964467005, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30122; Mature: 29990

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEWQKVNSYEEIIYEKYNGIAKVTINRPEKRNAFTPLTVKEMIDAFIDARDDSSIGVI
CCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
VLAGEGEKAFCSGGDQSVRGHGGYVGTDEVPRLNVLDLQRLIRTIPKPVIAMVSGYAIGG
EEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCEECC
GHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGAGYLARLVGHKRAREIWYLCRQYNAD
CCEEEEEEHEEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EAYEMGLVNTVVPLDKLEEETIQWCEEILEKSPTALRFLKASFNADTDGLAGLQQLGGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCE
TLLYYTTDEAKEGRDAFKEKRKPDFKQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC
>Mature Secondary Structure 
SVEWQKVNSYEEIIYEKYNGIAKVTINRPEKRNAFTPLTVKEMIDAFIDARDDSSIGVI
CCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
VLAGEGEKAFCSGGDQSVRGHGGYVGTDEVPRLNVLDLQRLIRTIPKPVIAMVSGYAIGG
EEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCEECC
GHVLHVVCDLTIAADNAIFGQTGPKVGSFDAGYGAGYLARLVGHKRAREIWYLCRQYNAD
CCEEEEEEHEEEECCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
EAYEMGLVNTVVPLDKLEEETIQWCEEILEKSPTALRFLKASFNADTDGLAGLQQLGGDA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCE
TLLYYTTDEAKEGRDAFKEKRKPDFKQFPRFP
EEEEEECCCHHHHHHHHHHHCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]