Click here to switch to the map view.

The map label for this gene is panF [H]

Identifier: 23099697

GI number: 23099697

Start: 2280673

End: 2282145

Strand: Direct

Name: panF [H]

Synonym: OB2242

Alternate gene names: 23099697

Gene position: 2280673-2282145 (Clockwise)

Preceding gene: 23099696

Following gene: 23099698

Centisome position: 62.82

GC content: 35.17

Gene sequence:

>1473_bases
ATGAATACAACAATGATTTGGACTGGAATAGTTATCTATATTGTTATTGCAATCATTATTGCATTACTTTCTCGACAAGG
AAAACAATCCAATATGACCTCTTATTTTTTAGGAGATAGAAAGCTAGGCGGATTTGTTTCTGCTCTTAGTTATAGTGCAA
CTACATATAGTGCCTTTATGTTAGTCGGACTAGCAGGTTTAACTTACAGTGGTGGTGTAGGAGCTTTAGGGTTTGAATTA
ATTTATTTAATGGGGGTTTCCCTCGTTGCTTTTTTCGGCCCTCGATATTGGCTCGTTGGAAAAAAATACGGATATGTTAC
ACCATCACAGATGCTCGGTGATCGGTATCAACATAGAGGTGTTGCCATTGCTGTTGCTATCGCTAATGGATTATTTCTAA
TTCCTTATAGTGCTGTTCAACTAGCAGGGATTGGATATTTACTACAAGGCGTGTCAAATCAAGCAATTACATTTAGCACT
GGAGTAATTATCGCAACACTTTTAGCTATTGTCTTTTCATATATAGCCGGTATACGTTCAGTTGCTTGGACAGACTCATT
ACAATCTTTATTTATGATTATCGGTTCTACACTGGTTGTTATATTCTTGGTTAATAAATTAGGTGGTATCAGTGGATTCT
TTAGCCAATTAGAAACTCACAGTCCAGAGATGTTAACCGTTCCAGGTAATGGATTTTTTAGCTTTTGGACATTTTTAGGG
TTAACCATTCCTTGGTTTTTCTTTAGTATTTCCAATCCGCAAGTTAGTCAGCGATTGTTTATGCCTGCTTCTTTAAAAAG
TATGCGTCAAATGTTAATTGGTTTTATGATATTTGGATTTATTTATACGATTGTTGCAATTACGTGGGGATTCACTGCTT
TTATCTTAAATCCAGGTATGGAAAATGCTGATCTCGCAACACCGTTCATTCTGTCATCAGACGCTATCCCTTCTGTATTA
GCAGTCATCGTAATGATTGGTATTATGGCAGCAGCTATTTCAACAATTGACTCTATTTTACTTACCGTGTCATCTTTGTT
TGCAAAAGACGTCTATGGTAACATTCGAAAAAATAGTAATGATCAAACTCAATTAAAAGTAGGAAAAATCGTAATTCCTA
TTATTGCTATTCTTGCATTTTTATTTGCAGAGTTACAATTAAATCTCATCGCAGTTTTATCAGTGGCATCATCAGCGGGA
CTTATCGTTGTAGTTCCAGCAATTATAGGATGTTTCTTCTGGAAAAAAGGAACTGCTGCAGGTGTTCTATCCAGTGTGAT
TATTGCTGGATTACTTGTTTGTATTTTAGAGATTTTTCAGTTAAATCCATTAGGGATAGCTTCTGGTCTTTGGGGATTAT
CCGTATCGACCATATTATTTATCGTTATTAGTTTACTAACGAAAGCTCCTAAACAAAAAGCTGATGAATTTATCGACTAT
ATTAAAAATGAAATGAAAAGAATCAATGCCTAA

Upstream 100 bases:

>100_bases
ATATTGATAAATGGTATGGTAGTTTTTTTATTTGGATTGTTCTAGCATTAATCGTTGTTATCTGTAATATCACTTTGACA
AAGAATTGGGGTAAATTTAA

Downstream 100 bases:

>100_bases
TAAAAATATCCTATTCAAGGGGGGTACTTGTTCTTTTCCTACATAATGTTAGCATCTCAAGGCATAACGTAAAGCTCTTA
AAACCAACAGGCATCTTTGA

Product: pantothenate permease

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNTTMIWTGIVIYIVIAIIIALLSRQGKQSNMTSYFLGDRKLGGFVSALSYSATTYSAFMLVGLAGLTYSGGVGALGFEL
IYLMGVSLVAFFGPRYWLVGKKYGYVTPSQMLGDRYQHRGVAIAVAIANGLFLIPYSAVQLAGIGYLLQGVSNQAITFST
GVIIATLLAIVFSYIAGIRSVAWTDSLQSLFMIIGSTLVVIFLVNKLGGISGFFSQLETHSPEMLTVPGNGFFSFWTFLG
LTIPWFFFSISNPQVSQRLFMPASLKSMRQMLIGFMIFGFIYTIVAITWGFTAFILNPGMENADLATPFILSSDAIPSVL
AVIVMIGIMAAAISTIDSILLTVSSLFAKDVYGNIRKNSNDQTQLKVGKIVIPIIAILAFLFAELQLNLIAVLSVASSAG
LIVVVPAIIGCFFWKKGTAAGVLSSVIIAGLLVCILEIFQLNPLGIASGLWGLSVSTILFIVISLLTKAPKQKADEFIDY
IKNEMKRINA

Sequences:

>Translated_490_residues
MNTTMIWTGIVIYIVIAIIIALLSRQGKQSNMTSYFLGDRKLGGFVSALSYSATTYSAFMLVGLAGLTYSGGVGALGFEL
IYLMGVSLVAFFGPRYWLVGKKYGYVTPSQMLGDRYQHRGVAIAVAIANGLFLIPYSAVQLAGIGYLLQGVSNQAITFST
GVIIATLLAIVFSYIAGIRSVAWTDSLQSLFMIIGSTLVVIFLVNKLGGISGFFSQLETHSPEMLTVPGNGFFSFWTFLG
LTIPWFFFSISNPQVSQRLFMPASLKSMRQMLIGFMIFGFIYTIVAITWGFTAFILNPGMENADLATPFILSSDAIPSVL
AVIVMIGIMAAAISTIDSILLTVSSLFAKDVYGNIRKNSNDQTQLKVGKIVIPIIAILAFLFAELQLNLIAVLSVASSAG
LIVVVPAIIGCFFWKKGTAAGVLSSVIIAGLLVCILEIFQLNPLGIASGLWGLSVSTILFIVISLLTKAPKQKADEFIDY
IKNEMKRINA
>Mature_490_residues
MNTTMIWTGIVIYIVIAIIIALLSRQGKQSNMTSYFLGDRKLGGFVSALSYSATTYSAFMLVGLAGLTYSGGVGALGFEL
IYLMGVSLVAFFGPRYWLVGKKYGYVTPSQMLGDRYQHRGVAIAVAIANGLFLIPYSAVQLAGIGYLLQGVSNQAITFST
GVIIATLLAIVFSYIAGIRSVAWTDSLQSLFMIIGSTLVVIFLVNKLGGISGFFSQLETHSPEMLTVPGNGFFSFWTFLG
LTIPWFFFSISNPQVSQRLFMPASLKSMRQMLIGFMIFGFIYTIVAITWGFTAFILNPGMENADLATPFILSSDAIPSVL
AVIVMIGIMAAAISTIDSILLTVSSLFAKDVYGNIRKNSNDQTQLKVGKIVIPIIAILAFLFAELQLNLIAVLSVASSAG
LIVVVPAIIGCFFWKKGTAAGVLSSVIIAGLLVCILEIFQLNPLGIASGLWGLSVSTILFIVISLLTKAPKQKADEFIDY
IKNEMKRINA

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=507, Percent_Identity=26.0355029585799, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI87082237, Length=451, Percent_Identity=27.0509977827051, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1790113, Length=403, Percent_Identity=27.2952853598015, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787251, Length=500, Percent_Identity=24.8, Blast_Score=85, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52824; Mature: 52824

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTMIWTGIVIYIVIAIIIALLSRQGKQSNMTSYFLGDRKLGGFVSALSYSATTYSAFM
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVGLAGLTYSGGVGALGFELIYLMGVSLVAFFGPRYWLVGKKYGYVTPSQMLGDRYQHRG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCC
VAIAVAIANGLFLIPYSAVQLAGIGYLLQGVSNQAITFSTGVIIATLLAIVFSYIAGIRS
CEEEEEECCCEEEECHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
VAWTDSLQSLFMIIGSTLVVIFLVNKLGGISGFFSQLETHSPEMLTVPGNGFFSFWTFLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
LTIPWFFFSISNPQVSQRLFMPASLKSMRQMLIGFMIFGFIYTIVAITWGFTAFILNPGM
HHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENADLATPFILSSDAIPSVLAVIVMIGIMAAAISTIDSILLTVSSLFAKDVYGNIRKNSN
CCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DQTQLKVGKIVIPIIAILAFLFAELQLNLIAVLSVASSAGLIVVVPAIIGCFFWKKGTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCHH
GVLSSVIIAGLLVCILEIFQLNPLGIASGLWGLSVSTILFIVISLLTKAPKQKADEFIDY
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKNEMKRINA
HHHHHHHCCC
>Mature Secondary Structure
MNTTMIWTGIVIYIVIAIIIALLSRQGKQSNMTSYFLGDRKLGGFVSALSYSATTYSAFM
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
LVGLAGLTYSGGVGALGFELIYLMGVSLVAFFGPRYWLVGKKYGYVTPSQMLGDRYQHRG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCC
VAIAVAIANGLFLIPYSAVQLAGIGYLLQGVSNQAITFSTGVIIATLLAIVFSYIAGIRS
CEEEEEECCCEEEECHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
VAWTDSLQSLFMIIGSTLVVIFLVNKLGGISGFFSQLETHSPEMLTVPGNGFFSFWTFLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
LTIPWFFFSISNPQVSQRLFMPASLKSMRQMLIGFMIFGFIYTIVAITWGFTAFILNPGM
HHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENADLATPFILSSDAIPSVLAVIVMIGIMAAAISTIDSILLTVSSLFAKDVYGNIRKNSN
CCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DQTQLKVGKIVIPIIAILAFLFAELQLNLIAVLSVASSAGLIVVVPAIIGCFFWKKGTAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCHH
GVLSSVIIAGLLVCILEIFQLNPLGIASGLWGLSVSTILFIVISLLTKAPKQKADEFIDY
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IKNEMKRINA
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]