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The map label for this gene is vipB [H]

Identifier: 23099537

GI number: 23099537

Start: 2112313

End: 2113242

Strand: Direct

Name: vipB [H]

Synonym: OB2082

Alternate gene names: 23099537

Gene position: 2112313-2113242 (Clockwise)

Preceding gene: 23099536

Following gene: 23099547

Centisome position: 58.18

GC content: 34.52

Gene sequence:

>930_bases
TTGACAAAATATTTAGTTACTGGCGGCGCAGGATTCGTAGGATCAAATATCGTAAGGAAGCTTATTTCAAACGGGGAATC
GGTTAGATTGCTAGATAATTTCAGTACAGGAAACAAGAACAATATAGCAGATATTAACGATCAAGTAGAGATAATTAGCG
GAGACTTTACAAATAAAGCAGTAGTTAAAGAAGCTATGAAAGGTGTAGATATTATCTTACATCAAGGGGCTATTCCTTCT
GTTCCTAAATCAATCGACAATCCAATATTATCTAATTATGCAAATGTGAACGGTACACTTACTCTTTTAAACGCTGCCGT
TGAGGAAGGTGTCAGTCGATTTGTATACGCAGCTTCTTCTTCCGCTTATGGCAATAATAAAAGGTTACCGAAACAAGAAG
ATATGATTGCTAATCCTATGTCACCTTATGCAGTTAGTAAATATACGGGTGAACTATATTGTAAAGTTTTTTATGAAATA
TACGGATTAGAAACGATTTCCTTACGTTATTTTAATGTATTCGGCCCAAGACAAAATCCACATTCAAAATATGCTGCGGT
CATTCCAGCATTTATAGAATCAATCATTCAAAATCAATCACCTATTATATACGGTGATGGTACACAATCAAGAGATTTCA
CTTATATCGATAATGTTGTATCTGCTAATCTACTTGCCGCTACCGCGAAAAATTTAAAAGGGGAAGTAGTTAATATCGGT
ACTGGAACCCAAATACAGCTAAATGATTTGGTGGATCGTATTAACAATATTTTAGGAAAAAACATTTCTGCTATCCATAC
GAAGGATCGTGCAGGTGACGTTAAACATTCCTTAGCTGACATACAGCGCGCTAAAGATATAATAAACTATGAACCAATAA
CTACATTTGATGATGGTTTAATAAAAACAGTAGAATGGTTTGACAAATAA

Upstream 100 bases:

>100_bases
TGCCTATTTTGTTAAATCAATTATATTCCCCCTATACGTATATTTATAACTTTCATAGTATATCAAGATCTAACTAACAA
ACGAAAAAGGGGAATGAAAT

Downstream 100 bases:

>100_bases
ATTATGAAGCAGATGAAATAAAAGAAAGAACAGTTTTTTCTAATTTAATTAATTAGGACTGTTAATGTTAAAATATAATC
TAAATTTCATCTGCTTTACG

Product: UDP-glucose 4-epimerase

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTKYLVTGGAGFVGSNIVRKLISNGESVRLLDNFSTGNKNNIADINDQVEIISGDFTNKAVVKEAMKGVDIILHQGAIPS
VPKSIDNPILSNYANVNGTLTLLNAAVEEGVSRFVYAASSSAYGNNKRLPKQEDMIANPMSPYAVSKYTGELYCKVFYEI
YGLETISLRYFNVFGPRQNPHSKYAAVIPAFIESIIQNQSPIIYGDGTQSRDFTYIDNVVSANLLAATAKNLKGEVVNIG
TGTQIQLNDLVDRINNILGKNISAIHTKDRAGDVKHSLADIQRAKDIINYEPITTFDDGLIKTVEWFDK

Sequences:

>Translated_309_residues
MTKYLVTGGAGFVGSNIVRKLISNGESVRLLDNFSTGNKNNIADINDQVEIISGDFTNKAVVKEAMKGVDIILHQGAIPS
VPKSIDNPILSNYANVNGTLTLLNAAVEEGVSRFVYAASSSAYGNNKRLPKQEDMIANPMSPYAVSKYTGELYCKVFYEI
YGLETISLRYFNVFGPRQNPHSKYAAVIPAFIESIIQNQSPIIYGDGTQSRDFTYIDNVVSANLLAATAKNLKGEVVNIG
TGTQIQLNDLVDRINNILGKNISAIHTKDRAGDVKHSLADIQRAKDIINYEPITTFDDGLIKTVEWFDK
>Mature_308_residues
TKYLVTGGAGFVGSNIVRKLISNGESVRLLDNFSTGNKNNIADINDQVEIISGDFTNKAVVKEAMKGVDIILHQGAIPSV
PKSIDNPILSNYANVNGTLTLLNAAVEEGVSRFVYAASSSAYGNNKRLPKQEDMIANPMSPYAVSKYTGELYCKVFYEIY
GLETISLRYFNVFGPRQNPHSKYAAVIPAFIESIIQNQSPIIYGDGTQSRDFTYIDNVVSANLLAATAKNLKGEVVNIGT
GTQIQLNDLVDRINNILGKNISAIHTKDRAGDVKHSLADIQRAKDIINYEPITTFDDGLIKTVEWFDK

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=314, Percent_Identity=31.8471337579618, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7657641, Length=320, Percent_Identity=29.0625, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=23.9644970414201, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=23.9644970414201, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=23.9644970414201, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI193211614, Length=349, Percent_Identity=24.6418338108883, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI8393516, Length=349, Percent_Identity=24.6418338108883, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788353, Length=338, Percent_Identity=29.2899408284024, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1786974, Length=327, Percent_Identity=26.2996941896024, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI48994969, Length=340, Percent_Identity=27.9411764705882, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790049, Length=311, Percent_Identity=26.3665594855305, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788365, Length=327, Percent_Identity=23.5474006116208, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788366, Length=269, Percent_Identity=25.6505576208178, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539532, Length=313, Percent_Identity=29.7124600638978, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17568069, Length=329, Percent_Identity=25.8358662613982, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI115532424, Length=320, Percent_Identity=25.625, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982038, Length=340, Percent_Identity=25.5882352941176, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71982035, Length=338, Percent_Identity=25.4437869822485, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319493, Length=336, Percent_Identity=25, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356223, Length=312, Percent_Identity=28.2051282051282, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI19923002, Length=336, Percent_Identity=27.6785714285714, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 33849; Mature: 33718

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYLVTGGAGFVGSNIVRKLISNGESVRLLDNFSTGNKNNIADINDQVEIISGDFTNKA
CCEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHH
VVKEAMKGVDIILHQGAIPSVPKSIDNPILSNYANVNGTLTLLNAAVEEGVSRFVYAASS
HHHHHHCCCEEEEECCCCCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCC
SAYGNNKRLPKQEDMIANPMSPYAVSKYTGELYCKVFYEIYGLETISLRYFNVFGPRQNP
CCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCC
HSKYAAVIPAFIESIIQNQSPIIYGDGTQSRDFTYIDNVVSANLLAATAKNLKGEVVNIG
CHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
TGTQIQLNDLVDRINNILGKNISAIHTKDRAGDVKHSLADIQRAKDIINYEPITTFDDGL
CCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IKTVEWFDK
HHHHHHHCC
>Mature Secondary Structure 
TKYLVTGGAGFVGSNIVRKLISNGESVRLLDNFSTGNKNNIADINDQVEIISGDFTNKA
CEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHH
VVKEAMKGVDIILHQGAIPSVPKSIDNPILSNYANVNGTLTLLNAAVEEGVSRFVYAASS
HHHHHHCCCEEEEECCCCCCCCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHEEECCC
SAYGNNKRLPKQEDMIANPMSPYAVSKYTGELYCKVFYEIYGLETISLRYFNVFGPRQNP
CCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCC
HSKYAAVIPAFIESIIQNQSPIIYGDGTQSRDFTYIDNVVSANLLAATAKNLKGEVVNIG
CHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEC
TGTQIQLNDLVDRINNILGKNISAIHTKDRAGDVKHSLADIQRAKDIINYEPITTFDDGL
CCCEEEHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHH
IKTVEWFDK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]