Click here to switch to the map view.

The map label for this gene is mrpD [H]

Identifier: 23099449

GI number: 23099449

Start: 2019674

End: 2021158

Strand: Direct

Name: mrpD [H]

Synonym: OB1994

Alternate gene names: 23099449

Gene position: 2019674-2021158 (Clockwise)

Preceding gene: 23099448

Following gene: 23099450

Centisome position: 55.63

GC content: 35.08

Gene sequence:

>1485_bases
ATGAGTAATTTAGTTATTTTGCCGATTATAATACCATTTATAATAGGTGCTATATTATTAATGTTTGCAAAGCACCATAA
AGTACAGCGTATAATTAGTAGTATTTCCATAATTATATTATTAGCTCTAGCTATATATCTTGCTATTTATGCATACCAAC
ATGGTACTCTAGTATTAGAACTAGGTAATTGGGATGCCCCATTCGGTATTGTGCTAGTTGCTGACTTACTGTCAACATTT
ATGGTATTACTCGCTACCCTTGTTGGAGCGGTATGTTTATTCTTTGCTTTTAAAACAATAAGTCCGGATAGAGAAAAGTA
TTATTTCTATCCACTTTATTTCTTTTTACTAATCGGTGTAAATGGAGCATTTTTAACCGGTGATCTATTTAATTTATTTG
TATTTTTTGAGGTAATGTTAATTGCCTCATACGGATTAATTGTCCATGGTGGTACAGGCTATCAGTTACGAGAATCATTT
AAATATGTGATTATCAATGTTTTTGCTTCCGGGTTATTTATAGTAGCAATTGCGTGGATTTACTCTATTACTGGTACAAT
GAATATGGCTCATATAGGAGAAAGAGTTGCAGAACTTGACCAAGCAGGTGCATTAAATGTGGTAGCTATCCTCTTATTTA
TTGTATTTGCTTCAAAAGGTGCCCTATTCCCTCTTTATTTTTGGTTACCAAAATCCTATTTTGGTCCTCCAGCTGCAATT
GCAGCATTATTTGGTGGATTACTTACCAAGGTCGGGATATATGCGATCATTCGCACTTTTACAGTTATTTTCAATCATGA
TCCTGGATTCACTCATAAAGGAATTATTGTCACCATCGCTGGTTTTACAATGTTATTTGGCGTGTTAGGAGCTGTATCTC
AATTTGATTTCAAACGTATCCTTTCCTACCATATTATTAGTCAGGTTGGATATATGGTTATGGGACTAGGAATCTTCACG
CCATTAGCTATGGCGGGCGCTATCTATTATATAGCACATCATATGATTGTAAAAACTGCATTATTCTTATTCGCTGGTGT
AACAGAGAAAATAACAGGAACAACTGATTTAAAGAAAATGGGAGGACTACTTGGAAGTCATCCTGCCCTAGCATGGATGT
TCTTTATTACCGCTGTCTCATTAGCTGGAATACCTCCTTTAAGTGGATTCTTCAGTAAATTCCCGATCATCTTGGCAGGT
TTTGAAGAAGGACAATATGTGATTTCTGGAGTAGCATTACTTGTAGGTTTATTAACACTATTTTCGATGATGAAAATATT
CAGTTATGCCTTTTGGGGTAAGCAAAAGCATACAGAAGAACAAGCAAATATCCCTATCGGTAAATTATTGTTACCAGTGG
TACCATTAGTTGCATTAACGATAATTTTAGGATTCGCAGCTGAGCCAATCTTCACTTACTCATTAGATGTTGCTGAACAG
ATTATGGATCCTTCAAATTATATTGAATCTGTCCTTAAGGAGTAG

Upstream 100 bases:

>100_bases
GTTATTAGTTTTGCAGTAACTTCTCTATTGCTTGTTATGGCATATCGCACATATAAAGTGCATCAAACGGATGATTTAGA
AGAGTTAAGGGGTTCTGCTG

Downstream 100 bases:

>100_bases
TGATTATGCCTTTTCAAATTTTATTAAATGTATTAATTGCATTTTTATGGATGTTTTTACAGAATGATTATACCGCAATT
ACTTTCGTAGTAGGTTACCT

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSNLVILPIIIPFIIGAILLMFAKHHKVQRIISSISIIILLALAIYLAIYAYQHGTLVLELGNWDAPFGIVLVADLLSTF
MVLLATLVGAVCLFFAFKTISPDREKYYFYPLYFFLLIGVNGAFLTGDLFNLFVFFEVMLIASYGLIVHGGTGYQLRESF
KYVIINVFASGLFIVAIAWIYSITGTMNMAHIGERVAELDQAGALNVVAILLFIVFASKGALFPLYFWLPKSYFGPPAAI
AALFGGLLTKVGIYAIIRTFTVIFNHDPGFTHKGIIVTIAGFTMLFGVLGAVSQFDFKRILSYHIISQVGYMVMGLGIFT
PLAMAGAIYYIAHHMIVKTALFLFAGVTEKITGTTDLKKMGGLLGSHPALAWMFFITAVSLAGIPPLSGFFSKFPIILAG
FEEGQYVISGVALLVGLLTLFSMMKIFSYAFWGKQKHTEEQANIPIGKLLLPVVPLVALTIILGFAAEPIFTYSLDVAEQ
IMDPSNYIESVLKE

Sequences:

>Translated_494_residues
MSNLVILPIIIPFIIGAILLMFAKHHKVQRIISSISIIILLALAIYLAIYAYQHGTLVLELGNWDAPFGIVLVADLLSTF
MVLLATLVGAVCLFFAFKTISPDREKYYFYPLYFFLLIGVNGAFLTGDLFNLFVFFEVMLIASYGLIVHGGTGYQLRESF
KYVIINVFASGLFIVAIAWIYSITGTMNMAHIGERVAELDQAGALNVVAILLFIVFASKGALFPLYFWLPKSYFGPPAAI
AALFGGLLTKVGIYAIIRTFTVIFNHDPGFTHKGIIVTIAGFTMLFGVLGAVSQFDFKRILSYHIISQVGYMVMGLGIFT
PLAMAGAIYYIAHHMIVKTALFLFAGVTEKITGTTDLKKMGGLLGSHPALAWMFFITAVSLAGIPPLSGFFSKFPIILAG
FEEGQYVISGVALLVGLLTLFSMMKIFSYAFWGKQKHTEEQANIPIGKLLLPVVPLVALTIILGFAAEPIFTYSLDVAEQ
IMDPSNYIESVLKE
>Mature_493_residues
SNLVILPIIIPFIIGAILLMFAKHHKVQRIISSISIIILLALAIYLAIYAYQHGTLVLELGNWDAPFGIVLVADLLSTFM
VLLATLVGAVCLFFAFKTISPDREKYYFYPLYFFLLIGVNGAFLTGDLFNLFVFFEVMLIASYGLIVHGGTGYQLRESFK
YVIINVFASGLFIVAIAWIYSITGTMNMAHIGERVAELDQAGALNVVAILLFIVFASKGALFPLYFWLPKSYFGPPAAIA
ALFGGLLTKVGIYAIIRTFTVIFNHDPGFTHKGIIVTIAGFTMLFGVLGAVSQFDFKRILSYHIISQVGYMVMGLGIFTP
LAMAGAIYYIAHHMIVKTALFLFAGVTEKITGTTDLKKMGGLLGSHPALAWMFFITAVSLAGIPPLSGFFSKFPIILAGF
EEGQYVISGVALLVGLLTLFSMMKIFSYAFWGKQKHTEEQANIPIGKLLLPVVPLVALTIILGFAAEPIFTYSLDVAEQI
MDPSNYIESVLKE

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=301, Percent_Identity=28.2392026578073, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI251831116, Length=342, Percent_Identity=22.5146198830409, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1788829, Length=419, Percent_Identity=29.5942720763723, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788827, Length=428, Percent_Identity=26.4018691588785, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788613, Length=422, Percent_Identity=28.9099526066351, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788831, Length=314, Percent_Identity=28.9808917197452, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788614, Length=455, Percent_Identity=27.9120879120879, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI2367154, Length=346, Percent_Identity=26.5895953757225, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI145693160, Length=363, Percent_Identity=25.6198347107438, Blast_Score=82, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54177; Mature: 54045

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLVILPIIIPFIIGAILLMFAKHHKVQRIISSISIIILLALAIYLAIYAYQHGTLVLE
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
LGNWDAPFGIVLVADLLSTFMVLLATLVGAVCLFFAFKTISPDREKYYFYPLYFFLLIGV
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHC
NGAFLTGDLFNLFVFFEVMLIASYGLIVHGGTGYQLRESFKYVIINVFASGLFIVAIAWI
CCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSITGTMNMAHIGERVAELDQAGALNVVAILLFIVFASKGALFPLYFWLPKSYFGPPAAI
HHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCHHCCCCHHHH
AALFGGLLTKVGIYAIIRTFTVIFNHDPGFTHKGIIVTIAGFTMLFGVLGAVSQFDFKRI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LSYHIISQVGYMVMGLGIFTPLAMAGAIYYIAHHMIVKTALFLFAGVTEKITGTTDLKKM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHH
GGLLGSHPALAWMFFITAVSLAGIPPLSGFFSKFPIILAGFEEGQYVISGVALLVGLLTL
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHH
FSMMKIFSYAFWGKQKHTEEQANIPIGKLLLPVVPLVALTIILGFAAEPIFTYSLDVAEQ
HHHHHHHHHHHHCCHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEHHHHHHH
IMDPSNYIESVLKE
HCCHHHHHHHHHCC
>Mature Secondary Structure 
SNLVILPIIIPFIIGAILLMFAKHHKVQRIISSISIIILLALAIYLAIYAYQHGTLVLE
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE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HCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]