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The map label for this gene is rnz

Identifier: 23099311

GI number: 23099311

Start: 1885733

End: 1886653

Strand: Direct

Name: rnz

Synonym: OB1856

Alternate gene names: 23099311

Gene position: 1885733-1886653 (Clockwise)

Preceding gene: 23099310

Following gene: 23099312

Centisome position: 51.94

GC content: 32.14

Gene sequence:

>921_bases
ATGGAGCTCGTCTTCCTTGGAACTGGTGCAGGACTTCCATCAAAAACTAGAAACGTTTCTGCTGTTGCTTTAAATATGAC
TCAAGAAATTAATGAAGTTTGGTTATTTGATTGTGGAGAAGCTACACAACATCAAATATTACATACCAACTTAAAACCAA
GAAAAATTACGAAGATATTTATTACACACCTGCACGGAGATCATATTTATGGATTACCTGGATTCTTAAGTAGTCGTTCC
TTTCAGTCAGGTGAAAATCAACCACTTTGTATTTATGGTCCTATAGGAATTAAAGAATTTGTAGAATCCACGTTACGCTT
AAGCCAAACAAATCTTACATATCCAATAACCATCAAAGAAATAACAGAAGACGGGAATTTATTTGAGACAAATGAAATGA
TGGTTGAAACAAAAAAATTGCAGCATGGTATTGATAGTTATGGATATCGGATAAAAGAAAAGGATAAACCAGGAGAACTT
TTAGTAGATAAATTAAAGCAAATTGGCATTGCGCCTGGTCCAATTTATCAGCAAATAAAAGAAAATGAAATCACTACATT
AGATAATGGGTCTATTATTTATCGGAATGATGTACTTGGACCAGCAAAAAAAGGAAAAGTGATATCAATTCTAGGGGATA
CCCGTTATTCAATTGACCATATTCCATTTATCAAGTTCAGTGATATACTTGTACATGAATCAACATTTACGCAAGATAAA
GAATTATTAGCATTTGAATATAATCATTCGACTAATGTACAAGCGGCTAAATTAGCCAAAGAAGCAAACATAAATAAATT
ATATTTAACTCATGTATCTTCTCGTTACCAAGCAGAGGATATAGATTCCATCATTGAAGAAGCAAGAAAAATTTTTCCTA
GTACTTGGTTAGCAAATGATTTTAGTGTTTATGAAATTTAG

Upstream 100 bases:

>100_bases
TTTGTTTTAAATATAATTGTGATAGTGTTTTCACAGATGTTCCAGATATTGCAAAAACTGCCTATCAAACCTATTTATAA
AATAGAAAGTTGGTGAAAAT

Downstream 100 bases:

>100_bases
ATTTTTATAGAAAGAGGAGAGACAAACGTAATGGAATTATTAGAAAGGTATCAATCAATAGTCGAAAATCAACGAGCCTA
TTTTAATCATGGCAATACGG

Product: hypothetical protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MELVFLGTGAGLPSKTRNVSAVALNMTQEINEVWLFDCGEATQHQILHTNLKPRKITKIFITHLHGDHIYGLPGFLSSRS
FQSGENQPLCIYGPIGIKEFVESTLRLSQTNLTYPITIKEITEDGNLFETNEMMVETKKLQHGIDSYGYRIKEKDKPGEL
LVDKLKQIGIAPGPIYQQIKENEITTLDNGSIIYRNDVLGPAKKGKVISILGDTRYSIDHIPFIKFSDILVHESTFTQDK
ELLAFEYNHSTNVQAAKLAKEANINKLYLTHVSSRYQAEDIDSIIEEARKIFPSTWLANDFSVYEI

Sequences:

>Translated_306_residues
MELVFLGTGAGLPSKTRNVSAVALNMTQEINEVWLFDCGEATQHQILHTNLKPRKITKIFITHLHGDHIYGLPGFLSSRS
FQSGENQPLCIYGPIGIKEFVESTLRLSQTNLTYPITIKEITEDGNLFETNEMMVETKKLQHGIDSYGYRIKEKDKPGEL
LVDKLKQIGIAPGPIYQQIKENEITTLDNGSIIYRNDVLGPAKKGKVISILGDTRYSIDHIPFIKFSDILVHESTFTQDK
ELLAFEYNHSTNVQAAKLAKEANINKLYLTHVSSRYQAEDIDSIIEEARKIFPSTWLANDFSVYEI
>Mature_306_residues
MELVFLGTGAGLPSKTRNVSAVALNMTQEINEVWLFDCGEATQHQILHTNLKPRKITKIFITHLHGDHIYGLPGFLSSRS
FQSGENQPLCIYGPIGIKEFVESTLRLSQTNLTYPITIKEITEDGNLFETNEMMVETKKLQHGIDSYGYRIKEKDKPGEL
LVDKLKQIGIAPGPIYQQIKENEITTLDNGSIIYRNDVLGPAKKGKVISILGDTRYSIDHIPFIKFSDILVHESTFTQDK
ELLAFEYNHSTNVQAAKLAKEANINKLYLTHVSSRYQAEDIDSIIEEARKIFPSTWLANDFSVYEI

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=360, Percent_Identity=36.1111111111111, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI87082078, Length=307, Percent_Identity=47.8827361563518, Blast_Score=295, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24652403, Length=293, Percent_Identity=27.3037542662116, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_OCEIH (Q8EQ58)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692777.1
- ProteinModelPortal:   Q8EQ58
- SMR:   Q8EQ58
- GeneID:   1018348
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1856
- NMPDR:   fig|221109.1.peg.1855
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- BioCyc:   OIHE221109:OB1856-MONOMER
- BRENDA:   3.1.26.11
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34607; Mature: 34607

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELVFLGTGAGLPSKTRNVSAVALNMTQEINEVWLFDCGEATQHQILHTNLKPRKITKIF
CEEEEEECCCCCCCCCCCEEEEEEECHHHCCEEEEEECCCCHHHHEEECCCCCCEEEEEE
ITHLHGDHIYGLPGFLSSRSFQSGENQPLCIYGPIGIKEFVESTLRLSQTNLTYPITIKE
EEEECCCEEECCCCHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEE
ITEDGNLFETNEMMVETKKLQHGIDSYGYRIKEKDKPGELLVDKLKQIGIAPGPIYQQIK
ECCCCCEEECCHHHHHHHHHHCCHHHHCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHC
ENEITTLDNGSIIYRNDVLGPAKKGKVISILGDTRYSIDHIPFIKFSDILVHESTFTQDK
CCCCEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCC
ELLAFEYNHSTNVQAAKLAKEANINKLYLTHVSSRYQAEDIDSIIEEARKIFPSTWLAND
EEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCC
FSVYEI
EEEEEC
>Mature Secondary Structure
MELVFLGTGAGLPSKTRNVSAVALNMTQEINEVWLFDCGEATQHQILHTNLKPRKITKIF
CEEEEEECCCCCCCCCCCEEEEEEECHHHCCEEEEEECCCCHHHHEEECCCCCCEEEEEE
ITHLHGDHIYGLPGFLSSRSFQSGENQPLCIYGPIGIKEFVESTLRLSQTNLTYPITIKE
EEEECCCEEECCCCHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEEEEE
ITEDGNLFETNEMMVETKKLQHGIDSYGYRIKEKDKPGELLVDKLKQIGIAPGPIYQQIK
ECCCCCEEECCHHHHHHHHHHCCHHHHCCEEECCCCCHHHHHHHHHHCCCCCCHHHHHHC
ENEITTLDNGSIIYRNDVLGPAKKGKVISILGDTRYSIDHIPFIKFSDILVHESTFTQDK
CCCCEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCC
ELLAFEYNHSTNVQAAKLAKEANINKLYLTHVSSRYQAEDIDSIIEEARKIFPSTWLAND
EEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCC
FSVYEI
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376