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The map label for this gene is spoIIAB

Identifier: 23099295

GI number: 23099295

Start: 1872688

End: 1873128

Strand: Reverse

Name: spoIIAB

Synonym: OB1840

Alternate gene names: 23099295

Gene position: 1873128-1872688 (Counterclockwise)

Preceding gene: 23099296

Following gene: 23099294

Centisome position: 51.59

GC content: 35.37

Gene sequence:

>441_bases
ATGAAAAATGAAATGTCCCTCGCATTTGCAAGTGTCAGTGAAAATGAAGCATTTGCTCGTGTAGCAGTAGCTTCTTTTAT
AACACAGTTAGATCCGACTATGGATGAGTTGACGGAAATTAAGACCGTTGTATCTGAAGCAGTAACCAATTCAATCATTC
ATGGATATCATAATGAACCTCACCATAAAGTTTACATTGAATGCGTGCTTCAGGATGATGAAATTGAAATAACCATTCGT
GATGAAGGAGTTGGTATAAAGGATATTGATGAAGCAAGAGAACCTTTGTATACTTCGAAGCCAGAACTAGAACGATCTGG
AATGGGATTTACAATTATTGAAAACTTTATGGATTCTGTGGAAGTTATTTCTGCTCCCGAAAAAGGTACTTCCGTATATA
TGACCAAACAACTTTCGAAATCAAAAACTGTTTATAATTAA

Upstream 100 bases:

>100_bases
CTCCTCCAATACAACGGTTATTTGAAATGTCAGGGCTATTTAAAATAGTTCGTAAAGCGGAAAATGAACGTTATGCATTA
GAGGCATTGGGGGTGGCATC

Downstream 100 bases:

>100_bases
GGTCTAATCATGAATGTGAATAAAACACGGGAGCGGGAGCAGCTTTCCGATGAGCAGGTAAAAGAACTTATACGTTTGAG
CCAGCAAGGGGACCAATCAG

Product: anti-sigma F factor

Products: NA

Alternate protein names: Stage II sporulation protein AB

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKNEMSLAFASVSENEAFARVAVASFITQLDPTMDELTEIKTVVSEAVTNSIIHGYHNEPHHKVYIECVLQDDEIEITIR
DEGVGIKDIDEAREPLYTSKPELERSGMGFTIIENFMDSVEVISAPEKGTSVYMTKQLSKSKTVYN

Sequences:

>Translated_146_residues
MKNEMSLAFASVSENEAFARVAVASFITQLDPTMDELTEIKTVVSEAVTNSIIHGYHNEPHHKVYIECVLQDDEIEITIR
DEGVGIKDIDEAREPLYTSKPELERSGMGFTIIENFMDSVEVISAPEKGTSVYMTKQLSKSKTVYN
>Mature_146_residues
MKNEMSLAFASVSENEAFARVAVASFITQLDPTMDELTEIKTVVSEAVTNSIIHGYHNEPHHKVYIECVLQDDEIEITIR
DEGVGIKDIDEAREPLYTSKPELERSGMGFTIIENFMDSVEVISAPEKGTSVYMTKQLSKSKTVYN

Specific function: Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases si

COG id: COG2172

COG function: function code T; Anti-sigma regulatory factor (Ser/Thr protein kinase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-factor family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SP2AB_OCEIH (Q8EQ73)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692761.1
- ProteinModelPortal:   Q8EQ73
- SMR:   Q8EQ73
- GeneID:   1018332
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1840
- NMPDR:   fig|221109.1.peg.1839
- HOGENOM:   HBG425195
- OMA:   KSKALCN
- ProtClustDB:   PRK03660
- BioCyc:   OIHE221109:OB1840-MONOMER
- BRENDA:   2.7.11.1
- HAMAP:   MF_00637
- InterPro:   IPR010194
- InterPro:   IPR003594
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387
- TIGRFAMs:   TIGR01925

Pfam domain/function: PF02518 HATPase_c; SSF55874 ATP_bd_ATPase

EC number: =2.7.11.1

Molecular weight: Translated: 16365; Mature: 16365

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEMSLAFASVSENEAFARVAVASFITQLDPTMDELTEIKTVVSEAVTNSIIHGYHNEP
CCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
HHKVYIECVLQDDEIEITIRDEGVGIKDIDEAREPLYTSKPELERSGMGFTIIENFMDSV
CCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHH
EVISAPEKGTSVYMTKQLSKSKTVYN
HHHCCCCCCCEEEEEHHHHCCCCCCC
>Mature Secondary Structure
MKNEMSLAFASVSENEAFARVAVASFITQLDPTMDELTEIKTVVSEAVTNSIIHGYHNEP
CCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
HHKVYIECVLQDDEIEITIRDEGVGIKDIDEAREPLYTSKPELERSGMGFTIIENFMDSV
CCEEEEEEEEECCEEEEEEECCCCCCCCHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHH
EVISAPEKGTSVYMTKQLSKSKTVYN
HHHCCCCCCCEEEEEHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376