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The map label for this gene is hisC

Identifier: 23099237

GI number: 23099237

Start: 1819782

End: 1820876

Strand: Reverse

Name: hisC

Synonym: OB1782

Alternate gene names: 23099237

Gene position: 1820876-1819782 (Counterclockwise)

Preceding gene: 23099238

Following gene: 23099236

Centisome position: 50.15

GC content: 35.25

Gene sequence:

>1095_bases
ATGCAAGGTAAAGAGATTCTAAAACAGTTAAGTCCATATAAACAAGGGAAACAGATAAAAGATATCCAAAAAGACTATCA
ATTAGATTACATTGTAAAATTGGCATCGAACGAAAATCCATATGGATATTCTAAACAGGTTAATGAAGCGTTAAGCACAG
AAAATTTCGACTTCCATATTTATCCTGATGGTTACACTTCTGATTTACGTACTGACCTAACACAAAAATTAAACATTGAT
GAATCAGAAATTATTTTTGGGAGCGGTTCTGAGGAAATTATTCAACTATTATGTCGCTCTTATATTATCCCTGGATCTAA
TGTTGTCATGGCTACTCCAACATTTCCACAGTATAAACATTACTCGCTTATTGAGAATGCAGAAATAAAAGAAATCCCAA
CAGACAAGGAAGGTTATCATCAATTAGACAAAATGCTAGGTTCGATTGATGATCATACAGCGATTGTTTGGCTATGTACA
CCTAATAATCCGACAGGTGCTGCTTTCTCAAAAGAGGAGCTTATCACATTCTTAGATAATTGTCCTAAGGAAGTCCTAGT
CGTCTTAGATGAAGCATACTACGAATATTTACATTCGGATAAAGATTTAGATGCATTACAGTTGCGTTTTACCTACAGTA
ATGTAATTGTGCTTCGTACGTTTTCAAAAGCATATGGATTAGCAGGCTTACGTATTGGGTACGGTATCGCCAACTCAACT
ATTATCGAGACACTGGATAAGGTTCGTGGACCTTTTAACACGAATTCAGTAGCTCAAAAAGCAGCTTCATATGCACTAAA
AGATCAAGAATTCATTCAACATACAAATCAAGAAAATTATAAAAACCTAACTGAATTCCAACACTTTCTTCAAAGGTTAG
GATGGGGTTACTACGATTCAGAAGCGAACTTCCTGTTGGTTAAGACACCGATCAGTGGCATGGACGTCTACGAATATTTG
CTCCGATTTGGTTTTATCGTCCGACCAGGAGAATTATTAGGTATACCAAAAACCGTTCGAGTAACAATTGGTAAAGAACA
AGATATGAAAGAATTACAAAAAGTATTAGAACAATTTGATCATGAACTAGGATAG

Upstream 100 bases:

>100_bases
TAATTCGGACAGATAAAACTCAACAAGAAATTAATCATGTATTTCATAACAATGCAGTAAAACTCAGACCAGATTTGCTA
CAAAAGGATGGCGAGTAGAT

Downstream 100 bases:

>100_bases
GTGTATGCATGAAACAACAAACGATATTAATAGCAGGATTAGGTTTAATTGGAGGCTCTATAGCAAGAGCAATCCGAAAT
TTTTCAGACCATAAATTAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MQGKEILKQLSPYKQGKQIKDIQKDYQLDYIVKLASNENPYGYSKQVNEALSTENFDFHIYPDGYTSDLRTDLTQKLNID
ESEIIFGSGSEEIIQLLCRSYIIPGSNVVMATPTFPQYKHYSLIENAEIKEIPTDKEGYHQLDKMLGSIDDHTAIVWLCT
PNNPTGAAFSKEELITFLDNCPKEVLVVLDEAYYEYLHSDKDLDALQLRFTYSNVIVLRTFSKAYGLAGLRIGYGIANST
IIETLDKVRGPFNTNSVAQKAASYALKDQEFIQHTNQENYKNLTEFQHFLQRLGWGYYDSEANFLLVKTPISGMDVYEYL
LRFGFIVRPGELLGIPKTVRVTIGKEQDMKELQKVLEQFDHELG

Sequences:

>Translated_364_residues
MQGKEILKQLSPYKQGKQIKDIQKDYQLDYIVKLASNENPYGYSKQVNEALSTENFDFHIYPDGYTSDLRTDLTQKLNID
ESEIIFGSGSEEIIQLLCRSYIIPGSNVVMATPTFPQYKHYSLIENAEIKEIPTDKEGYHQLDKMLGSIDDHTAIVWLCT
PNNPTGAAFSKEELITFLDNCPKEVLVVLDEAYYEYLHSDKDLDALQLRFTYSNVIVLRTFSKAYGLAGLRIGYGIANST
IIETLDKVRGPFNTNSVAQKAASYALKDQEFIQHTNQENYKNLTEFQHFLQRLGWGYYDSEANFLLVKTPISGMDVYEYL
LRFGFIVRPGELLGIPKTVRVTIGKEQDMKELQKVLEQFDHELG
>Mature_364_residues
MQGKEILKQLSPYKQGKQIKDIQKDYQLDYIVKLASNENPYGYSKQVNEALSTENFDFHIYPDGYTSDLRTDLTQKLNID
ESEIIFGSGSEEIIQLLCRSYIIPGSNVVMATPTFPQYKHYSLIENAEIKEIPTDKEGYHQLDKMLGSIDDHTAIVWLCT
PNNPTGAAFSKEELITFLDNCPKEVLVVLDEAYYEYLHSDKDLDALQLRFTYSNVIVLRTFSKAYGLAGLRIGYGIANST
IIETLDKVRGPFNTNSVAQKAASYALKDQEFIQHTNQENYKNLTEFQHFLQRLGWGYYDSEANFLLVKTPISGMDVYEYL
LRFGFIVRPGELLGIPKTVRVTIGKEQDMKELQKVLEQFDHELG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=371, Percent_Identity=26.1455525606469, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788722, Length=245, Percent_Identity=24.4897959183673, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=391, Percent_Identity=25.5754475703325, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS82_OCEIH (Q8EQB9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692703.1
- ProteinModelPortal:   Q8EQB9
- SMR:   Q8EQB9
- GeneID:   1018276
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1782
- NMPDR:   fig|221109.1.peg.1783
- HOGENOM:   HBG646350
- OMA:   YAFELRT
- BioCyc:   OIHE221109:OB1782-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41661; Mature: 41661

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGKEILKQLSPYKQGKQIKDIQKDYQLDYIVKLASNENPYGYSKQVNEALSTENFDFHI
CCHHHHHHHHCCHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCEEEE
YPDGYTSDLRTDLTQKLNIDESEIIFGSGSEEIIQLLCRSYIIPGSNVVMATPTFPQYKH
CCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
YSLIENAEIKEIPTDKEGYHQLDKMLGSIDDHTAIVWLCTPNNPTGAAFSKEELITFLDN
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHC
CPKEVLVVLDEAYYEYLHSDKDLDALQLRFTYSNVIVLRTFSKAYGLAGLRIGYGIANST
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEHHHHHCCCCCEECCCCCHHH
IIETLDKVRGPFNTNSVAQKAASYALKDQEFIQHTNQENYKNLTEFQHFLQRLGWGYYDS
HHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECC
EANFLLVKTPISGMDVYEYLLRFGFIVRPGELLGIPKTVRVTIGKEQDMKELQKVLEQFD
CCCEEEEECCCCCHHHHHHHHHHCCEECCCHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
HELG
HCCC
>Mature Secondary Structure
MQGKEILKQLSPYKQGKQIKDIQKDYQLDYIVKLASNENPYGYSKQVNEALSTENFDFHI
CCHHHHHHHHCCHHCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCEEEE
YPDGYTSDLRTDLTQKLNIDESEIIFGSGSEEIIQLLCRSYIIPGSNVVMATPTFPQYKH
CCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCC
YSLIENAEIKEIPTDKEGYHQLDKMLGSIDDHTAIVWLCTPNNPTGAAFSKEELITFLDN
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHC
CPKEVLVVLDEAYYEYLHSDKDLDALQLRFTYSNVIVLRTFSKAYGLAGLRIGYGIANST
CCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEHHHHHCCCCCEECCCCCHHH
IIETLDKVRGPFNTNSVAQKAASYALKDQEFIQHTNQENYKNLTEFQHFLQRLGWGYYDS
HHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECC
EANFLLVKTPISGMDVYEYLLRFGFIVRPGELLGIPKTVRVTIGKEQDMKELQKVLEQFD
CCCEEEEECCCCCHHHHHHHHHHCCEECCCHHCCCCCEEEEEECCCHHHHHHHHHHHHHH
HELG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376