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The map label for this gene is msrAB [H]

Identifier: 23099189

GI number: 23099189

Start: 1776471

End: 1777430

Strand: Reverse

Name: msrAB [H]

Synonym: OB1734

Alternate gene names: 23099189

Gene position: 1777430-1776471 (Counterclockwise)

Preceding gene: 23099190

Following gene: 28563931

Centisome position: 48.96

GC content: 36.56

Gene sequence:

>960_bases
ATGTCTAAACAAACAGAAATAGCTACATTTGCAGGAGGTTGCTTCTGGTGTATGGTAGAGCCATTTGATCAACGACCAGG
TGTTATCGATATTCGTTCTGGTTATACAGGGGGACATGTAGAAAATCCAACCTATGAACAAGTGTGCACGAATACAACAG
GTCATGTCGAAGCAGTACAAATTACATTTGATCCTGAAATAATGCCATATAAAGAATTGGTAGAGACATTTTGGCAACAA
ATTGACCCTACAGATGCTGGTGGCCAATTTAATGACCGTGGCGAGTCATACCAAACAGCTATCTTTTATCATACAGAAGA
ACAGAAAAAGATAGCTGAGGATTCTAAAAAAGCATTAGATGAGAGCAATCGTTTTAAGATGCCCATAGTGACTCCGGTTC
TCCCAGCAAAACCTTTTTATGAAGCTGAAGAAGGTCACCAAGATTATTATAAAAAACGGAGCTTTCATTACAGAATGTAT
AAAAAAGGATCAGGAAGACAAGATTTTATTAAAAACAATTGGCAGAATACAATTGATAAAAATGAATTAAAAGAGAAGCT
AACTCCGATTCAATATCATGTTACTCAGGAAAATGGAACTGAACGCCCATTTGACAATGAATACTGGAACAACACACAAG
AAGGTATTTATGTTGATATTATAAAAGGAAATGTTTTATTCTCATCTAAAGAACAGTATGATGCTGGATGCGGTTGGCCA
AGCTTCACGAAACCCGTTGACCCTTATCAAATAGAAGATAAGGTAGATAAAACACATGGAATGGTACGTACAGAAATTCG
AAGCAAGCAATCAGATTCACACTTAGGACATGTTTTTGAAGATGGGCCACAAGATAAAGGTGGACTTAGATATTGCATGA
ACTCTGCCGCGATGCGTTTTATTCCAAAAGAAAAAATGGAAGAAGAGGGCTATAGCAAATATCTGTATCTATTTAATTAA

Upstream 100 bases:

>100_bases
ACTCCTAAGTTATTTATATAATGCTTCGTGCTTGATTTTTTTTATCAAAAAGGGAAAAATAGGGATAAATCGATATATTA
AATACGATTGGAGGAATTAC

Downstream 100 bases:

>100_bases
CCATAATAATAATATGTAAACTAGAGAGGGCGAAACTTGATGATTCACTTAAATTGGGAAGACAGACCAACAATGAAACA
AATTGAATGTGTGCATGCGG

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSKQTEIATFAGGCFWCMVEPFDQRPGVIDIRSGYTGGHVENPTYEQVCTNTTGHVEAVQITFDPEIMPYKELVETFWQQ
IDPTDAGGQFNDRGESYQTAIFYHTEEQKKIAEDSKKALDESNRFKMPIVTPVLPAKPFYEAEEGHQDYYKKRSFHYRMY
KKGSGRQDFIKNNWQNTIDKNELKEKLTPIQYHVTQENGTERPFDNEYWNNTQEGIYVDIIKGNVLFSSKEQYDAGCGWP
SFTKPVDPYQIEDKVDKTHGMVRTEIRSKQSDSHLGHVFEDGPQDKGGLRYCMNSAAMRFIPKEKMEEEGYSKYLYLFN

Sequences:

>Translated_319_residues
MSKQTEIATFAGGCFWCMVEPFDQRPGVIDIRSGYTGGHVENPTYEQVCTNTTGHVEAVQITFDPEIMPYKELVETFWQQ
IDPTDAGGQFNDRGESYQTAIFYHTEEQKKIAEDSKKALDESNRFKMPIVTPVLPAKPFYEAEEGHQDYYKKRSFHYRMY
KKGSGRQDFIKNNWQNTIDKNELKEKLTPIQYHVTQENGTERPFDNEYWNNTQEGIYVDIIKGNVLFSSKEQYDAGCGWP
SFTKPVDPYQIEDKVDKTHGMVRTEIRSKQSDSHLGHVFEDGPQDKGGLRYCMNSAAMRFIPKEKMEEEGYSKYLYLFN
>Mature_318_residues
SKQTEIATFAGGCFWCMVEPFDQRPGVIDIRSGYTGGHVENPTYEQVCTNTTGHVEAVQITFDPEIMPYKELVETFWQQI
DPTDAGGQFNDRGESYQTAIFYHTEEQKKIAEDSKKALDESNRFKMPIVTPVLPAKPFYEAEEGHQDYYKKRSFHYRMYK
KGSGRQDFIKNNWQNTIDKNELKEKLTPIQYHVTQENGTERPFDNEYWNNTQEGIYVDIIKGNVLFSSKEQYDAGCGWPS
FTKPVDPYQIEDKVDKTHGMVRTEIRSKQSDSHLGHVFEDGPQDKGGLRYCMNSAAMRFIPKEKMEEEGYSKYLYLFN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=134, Percent_Identity=44.0298507462687, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI301336162, Length=134, Percent_Identity=44.0298507462687, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI73089054, Length=134, Percent_Identity=44.0298507462687, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI37620216, Length=134, Percent_Identity=44.0298507462687, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI117606353, Length=134, Percent_Identity=43.2835820895522, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=38.8157894736842, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=38.8157894736842, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=39.4230769230769, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788077, Length=133, Percent_Identity=48.1203007518797, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790665, Length=151, Percent_Identity=43.046357615894, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17553450, Length=149, Percent_Identity=40.2684563758389, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI115532676, Length=128, Percent_Identity=42.96875, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=35.8620689655172, Blast_Score=87, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6319816, Length=151, Percent_Identity=33.112582781457, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221378662, Length=133, Percent_Identity=45.8646616541353, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221378664, Length=126, Percent_Identity=46.8253968253968, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645799, Length=126, Percent_Identity=45.2380952380952, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45553335, Length=126, Percent_Identity=45.2380952380952, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21356369, Length=126, Percent_Identity=45.2380952380952, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24645801, Length=137, Percent_Identity=41.6058394160584, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24645804, Length=137, Percent_Identity=41.6058394160584, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24664627, Length=143, Percent_Identity=35.6643356643357, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=34.965034965035, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45553131, Length=138, Percent_Identity=34.7826086956522, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 37068; Mature: 36936

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQTEIATFAGGCFWCMVEPFDQRPGVIDIRSGYTGGHVENPTYEQVCTNTTGHVEAVQ
CCCCCCEEEECCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEE
ITFDPEIMPYKELVETFWQQIDPTDAGGQFNDRGESYQTAIFYHTEEQKKIAEDSKKALD
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHC
ESNRFKMPIVTPVLPAKPFYEAEEGHQDYYKKRSFHYRMYKKGSGRQDFIKNNWQNTIDK
CCCCEECCEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHCCHHCCCCH
NELKEKLTPIQYHVTQENGTERPFDNEYWNNTQEGIYVDIIKGNVLFSSKEQYDAGCGWP
HHHHHHCCCEEEEEECCCCCCCCCCCHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCC
SFTKPVDPYQIEDKVDKTHGMVRTEIRSKQSDSHLGHVFEDGPQDKGGLRYCMNSAAMRF
CCCCCCCCEEHHHHHHHHHCHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
IPKEKMEEEGYSKYLYLFN
CCHHHHHHCCCEEEEEEEC
>Mature Secondary Structure 
SKQTEIATFAGGCFWCMVEPFDQRPGVIDIRSGYTGGHVENPTYEQVCTNTTGHVEAVQ
CCCCCEEEECCCEEEEEECCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCCEEEEE
ITFDPEIMPYKELVETFWQQIDPTDAGGQFNDRGESYQTAIFYHTEEQKKIAEDSKKALD
EEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHHHC
ESNRFKMPIVTPVLPAKPFYEAEEGHQDYYKKRSFHYRMYKKGSGRQDFIKNNWQNTIDK
CCCCEECCEECCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCHHHHHCCHHCCCCH
NELKEKLTPIQYHVTQENGTERPFDNEYWNNTQEGIYVDIIKGNVLFSSKEQYDAGCGWP
HHHHHHCCCEEEEEECCCCCCCCCCCHHCCCCCCCEEEEEEECCEEECCCCCCCCCCCCC
SFTKPVDPYQIEDKVDKTHGMVRTEIRSKQSDSHLGHVFEDGPQDKGGLRYCMNSAAMRF
CCCCCCCCEEHHHHHHHHHCHHHHHHHHCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHH
IPKEKMEEEGYSKYLYLFN
CCHHHHHHCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]