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The map label for this gene is yitG [H]

Identifier: 23099161

GI number: 23099161

Start: 1750808

End: 1752043

Strand: Reverse

Name: yitG [H]

Synonym: OB1706

Alternate gene names: 23099161

Gene position: 1752043-1750808 (Counterclockwise)

Preceding gene: 23099162

Following gene: 23099144

Centisome position: 48.26

GC content: 35.19

Gene sequence:

>1236_bases
ATGGGAAAGAATCATACAAGTACTGCGATCCTATCACTTGGTTCTATACCTTTTATTACCACTCTCGGTAATTCAACATT
AATTCCAATTCTTCCTGAAATGAAAGAAGCATTAGGTATAAGTAATATCCAAGTTAGCTTAACCATCACTCTTTTTTCTA
TAGCAGCCGCTATTTGTATTCCTGTAGCAGGTTATCTATCTGATCGCTTTTCTCGAAAGGCGATTATCGTACCTTCCTTA
GTTATTTTTGGTGCTGGTGGATTGTTAGCCGGAATTGGAGCTGCGTTTTTTTCATCTGCATTTATATGGTTATTAATCGG
TAGAATTATTCAAGGTATAGGAGCTGCGGGGACATTTCCGATTGCTATGGCACTAATCGGAGATCTTTTTAAAGGTAGCG
AGCAGAGCAAAATGTTAGGAATTTATGAAGCTTCTAATGAACTTGGAAAGGTATTATCACCTATTATTGGTGCTGCCTTT
GCACTTATTACATGGTATTTTGTATTTTTTACATTTCCTGTGATTAGTTTTCTCTGTGCAATACTAGTTTTCTTTTTTAT
AAAAGAAAGAAGAAATAGACAAACTCCACCTCCCTTTTATCAATACGTTAAAGGACTGTTTTTAGTGTTTAAACAAGAAG
GACGATGGTTATTCACTGTCTATTTGGCTGGTGGTACGTGTTTATTAACCATTTTTGGAATTCTTTTTTATTTATCTGAC
AAATTAGAAACGGAAAATCATATTATTGGTGTATGGAAAGGACTTATTTTAGCTATTCCACTCCTTATTTTAGTAGCAAC
ATCGTATAGAACCGGTAGTAGAATCGGTAAGAATTTCGTGAAAATGAAACGATTAGCAGTATTTGGTTTTTTACTTATGA
CGCTCTCCTATTTATCACTCATATGGATAGAACCCTTAGTATGGTTTATTTTTGCACTATGCTTTAGCAGTATAGGAGCT
GGCCTAGTCTTGCCTTGTGTCAATACAATGATTGCTGGTGCAGTTGGTAAAGAAAAGCGAGGATTTATTACTTCACTATA
CGGTTCTGTAAGATATATCGGTGTTGCCCTTGGACCTTTATTGTTTGGCTGGTTAATGGATTGGTCTAGAACGGGATTAT
TCTTATCTGTAGCATGCTTCACTTTTTTCGTAGCATTGTTAGTCTTATTTCTACTTCATGTAAATGGTATGGATGGAAGA
GATAAACGAACGAAGATTACGTATAATTATTACTAA

Upstream 100 bases:

>100_bases
TCAACGGTTAGAATATGAACAAAAAATACTTCATGTAATGAAACAAAAAGGATGGCTCGCAATACCACCAATTAATATAA
AATAAAGGGGTACACATAGC

Downstream 100 bases:

>100_bases
TATTATATAAGTAGGAAAAATGATTAAATCTGACTACATTGACCATTCAAAGAAGCTGAGACAAAAGTATTTAATCAAAA
GAAAAAATTCAAAAATCCGC

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MGKNHTSTAILSLGSIPFITTLGNSTLIPILPEMKEALGISNIQVSLTITLFSIAAAICIPVAGYLSDRFSRKAIIVPSL
VIFGAGGLLAGIGAAFFSSAFIWLLIGRIIQGIGAAGTFPIAMALIGDLFKGSEQSKMLGIYEASNELGKVLSPIIGAAF
ALITWYFVFFTFPVISFLCAILVFFFIKERRNRQTPPPFYQYVKGLFLVFKQEGRWLFTVYLAGGTCLLTIFGILFYLSD
KLETENHIIGVWKGLILAIPLLILVATSYRTGSRIGKNFVKMKRLAVFGFLLMTLSYLSLIWIEPLVWFIFALCFSSIGA
GLVLPCVNTMIAGAVGKEKRGFITSLYGSVRYIGVALGPLLFGWLMDWSRTGLFLSVACFTFFVALLVLFLLHVNGMDGR
DKRTKITYNYY

Sequences:

>Translated_411_residues
MGKNHTSTAILSLGSIPFITTLGNSTLIPILPEMKEALGISNIQVSLTITLFSIAAAICIPVAGYLSDRFSRKAIIVPSL
VIFGAGGLLAGIGAAFFSSAFIWLLIGRIIQGIGAAGTFPIAMALIGDLFKGSEQSKMLGIYEASNELGKVLSPIIGAAF
ALITWYFVFFTFPVISFLCAILVFFFIKERRNRQTPPPFYQYVKGLFLVFKQEGRWLFTVYLAGGTCLLTIFGILFYLSD
KLETENHIIGVWKGLILAIPLLILVATSYRTGSRIGKNFVKMKRLAVFGFLLMTLSYLSLIWIEPLVWFIFALCFSSIGA
GLVLPCVNTMIAGAVGKEKRGFITSLYGSVRYIGVALGPLLFGWLMDWSRTGLFLSVACFTFFVALLVLFLLHVNGMDGR
DKRTKITYNYY
>Mature_410_residues
GKNHTSTAILSLGSIPFITTLGNSTLIPILPEMKEALGISNIQVSLTITLFSIAAAICIPVAGYLSDRFSRKAIIVPSLV
IFGAGGLLAGIGAAFFSSAFIWLLIGRIIQGIGAAGTFPIAMALIGDLFKGSEQSKMLGIYEASNELGKVLSPIIGAAFA
LITWYFVFFTFPVISFLCAILVFFFIKERRNRQTPPPFYQYVKGLFLVFKQEGRWLFTVYLAGGTCLLTIFGILFYLSDK
LETENHIIGVWKGLILAIPLLILVATSYRTGSRIGKNFVKMKRLAVFGFLLMTLSYLSLIWIEPLVWFIFALCFSSIGAG
LVLPCVNTMIAGAVGKEKRGFITSLYGSVRYIGVALGPLLFGWLMDWSRTGLFLSVACFTFFVALLVLFLLHVNGMDGRD
KRTKITYNYY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Homo sapiens, GI185136021, Length=189, Percent_Identity=26.984126984127, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790195, Length=154, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24654044, Length=250, Percent_Identity=26.4, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17864456, Length=252, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24654041, Length=252, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24654039, Length=252, Percent_Identity=26.1904761904762, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24654037, Length=252, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45189; Mature: 45058

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNHTSTAILSLGSIPFITTLGNSTLIPILPEMKEALGISNIQVSLTITLFSIAAAICI
CCCCCHHHHHHCCCCCCEEEECCCCCEECCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
PVAGYLSDRFSRKAIIVPSLVIFGAGGLLAGIGAAFFSSAFIWLLIGRIIQGIGAAGTFP
HHHHHHHHHHCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IAMALIGDLFKGSEQSKMLGIYEASNELGKVLSPIIGAAFALITWYFVFFTFPVISFLCA
HHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVFFFIKERRNRQTPPPFYQYVKGLFLVFKQEGRWLFTVYLAGGTCLLTIFGILFYLSD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
KLETENHIIGVWKGLILAIPLLILVATSYRTGSRIGKNFVKMKRLAVFGFLLMTLSYLSL
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWIEPLVWFIFALCFSSIGAGLVLPCVNTMIAGAVGKEKRGFITSLYGSVRYIGVALGPL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFGWLMDWSRTGLFLSVACFTFFVALLVLFLLHVNGMDGRDKRTKITYNYY
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
GKNHTSTAILSLGSIPFITTLGNSTLIPILPEMKEALGISNIQVSLTITLFSIAAAICI
CCCCHHHHHHCCCCCCEEEECCCCCEECCCHHHHHHCCCCCEEEEEHHHHHHHHHHHHH
PVAGYLSDRFSRKAIIVPSLVIFGAGGLLAGIGAAFFSSAFIWLLIGRIIQGIGAAGTFP
HHHHHHHHHHCCCEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IAMALIGDLFKGSEQSKMLGIYEASNELGKVLSPIIGAAFALITWYFVFFTFPVISFLCA
HHHHHHHHHHCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVFFFIKERRNRQTPPPFYQYVKGLFLVFKQEGRWLFTVYLAGGTCLLTIFGILFYLSD
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
KLETENHIIGVWKGLILAIPLLILVATSYRTGSRIGKNFVKMKRLAVFGFLLMTLSYLSL
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWIEPLVWFIFALCFSSIGAGLVLPCVNTMIAGAVGKEKRGFITSLYGSVRYIGVALGPL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
LFGWLMDWSRTGLFLSVACFTFFVALLVLFLLHVNGMDGRDKRTKITYNYY
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]