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The map label for this gene is rnc

Identifier: 23098981

GI number: 23098981

Start: 1569826

End: 1570512

Strand: Direct

Name: rnc

Synonym: OB1526

Alternate gene names: 23098981

Gene position: 1569826-1570512 (Clockwise)

Preceding gene: 23098980

Following gene: 23098983

Centisome position: 43.24

GC content: 38.86

Gene sequence:

>687_bases
ATGGATATACGTCCATTGGAGGAACACTTAGGTATCTCTTTTCAACAAAAAGCATTGTTAAAGGAAGCCTTTACCCATTC
ATCGTATGTGAATGAGCATCGGAAACAACGACTATCCGATAATGAGCGTCTGGAATTTTTAGGGGACGCAGTTTTGGAAT
TAGCTGTATCACAGTATTTATATCGTAATAATAAAGATATGCCAGAAGGAGAAATGACAAAGCTTCGAGCGGCCATTGTA
TGTGAACCTTCCTTGAAAAACTTTGCAGAAGAGTTGGAATTTGGCAAATTCCTGCGATTAGGTAAAGGCGAACAGCAAAC
AGGAGGAAGAGAGAGACCTGCTATTTTGGCGGATGCTTTCGAAGCATTTCTAGGGGCCCTCTATTTAGATCAGGGCTTTG
ATAATGTGCTGGATTTCTTAAATATCCATGTTTTTCCTAAGTTAACAACGGGTGCTTTTTCGCATGCGATGGATTATAAA
AGTCAATTACAAGAATTTGTTCAACAACATAAAGATCAAAAGATTGAATATAGGATCATCGAGGAAAAGGGACCATCACA
TAATAAGGAATTTGTTGCCGAAGTAGTCATTCAAGAAAAAGCTGCTGGGATTGGTACAGGTCGCACTAAAAAAGAAGCGG
AACAACGAGCTGCAAAAAATGCGCTAGATAGTATCAATAACAGTTAA

Upstream 100 bases:

>100_bases
ATTGTAAAAGTCTTGAGAAGCTTTAACTAGATTTGATCTTGTTTTATTCTTCTTAGCCAATCACAAGTGTAAGTTTCATT
TTATTATAGGAGGTGTCTAA

Downstream 100 bases:

>100_bases
TAAAAAATCTCAAGGTTAAAATTATCCTTGAGATTTTGTGTATTATTTACGTATGCTTGATAGTTCTTGGATGAATGCTT
GTTTTTCCAATGCGCTTAAC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MDIRPLEEHLGISFQQKALLKEAFTHSSYVNEHRKQRLSDNERLEFLGDAVLELAVSQYLYRNNKDMPEGEMTKLRAAIV
CEPSLKNFAEELEFGKFLRLGKGEQQTGGRERPAILADAFEAFLGALYLDQGFDNVLDFLNIHVFPKLTTGAFSHAMDYK
SQLQEFVQQHKDQKIEYRIIEEKGPSHNKEFVAEVVIQEKAAGIGTGRTKKEAEQRAAKNALDSINNS

Sequences:

>Translated_228_residues
MDIRPLEEHLGISFQQKALLKEAFTHSSYVNEHRKQRLSDNERLEFLGDAVLELAVSQYLYRNNKDMPEGEMTKLRAAIV
CEPSLKNFAEELEFGKFLRLGKGEQQTGGRERPAILADAFEAFLGALYLDQGFDNVLDFLNIHVFPKLTTGAFSHAMDYK
SQLQEFVQQHKDQKIEYRIIEEKGPSHNKEFVAEVVIQEKAAGIGTGRTKKEAEQRAAKNALDSINNS
>Mature_228_residues
MDIRPLEEHLGISFQQKALLKEAFTHSSYVNEHRKQRLSDNERLEFLGDAVLELAVSQYLYRNNKDMPEGEMTKLRAAIV
CEPSLKNFAEELEFGKFLRLGKGEQQTGGRERPAILADAFEAFLGALYLDQGFDNVLDFLNIHVFPKLTTGAFSHAMDYK
SQLQEFVQQHKDQKIEYRIIEEKGPSHNKEFVAEVVIQEKAAGIGTGRTKKEAEQRAAKNALDSINNS

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=228, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI155030234, Length=228, Percent_Identity=31.5789473684211, Blast_Score=107, Evalue=7e-24,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=33.9622641509434, Blast_Score=118, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193202651, Length=228, Percent_Identity=32.4561403508772, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17506883, Length=228, Percent_Identity=32.4561403508772, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17552834, Length=255, Percent_Identity=29.0196078431373, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137682, Length=226, Percent_Identity=31.4159292035398, Blast_Score=106, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_OCEIH (Q8ER05)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692447.1
- ProteinModelPortal:   Q8ER05
- SMR:   Q8ER05
- GeneID:   1017802
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1526
- NMPDR:   fig|221109.1.peg.1528
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- BioCyc:   OIHE221109:OB1526-MONOMER
- BRENDA:   3.1.26.3
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25919; Mature: 25919

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRPLEEHLGISFQQKALLKEAFTHSSYVNEHRKQRLSDNERLEFLGDAVLELAVSQYL
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YRNNKDMPEGEMTKLRAAIVCEPSLKNFAEELEFGKFLRLGKGEQQTGGRERPAILADAF
HHCCCCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EAFLGALYLDQGFDNVLDFLNIHVFPKLTTGAFSHAMDYKSQLQEFVQQHKDQKIEYRII
HHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
EEKGPSHNKEFVAEVVIQEKAAGIGTGRTKKEAEQRAAKNALDSINNS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIRPLEEHLGISFQQKALLKEAFTHSSYVNEHRKQRLSDNERLEFLGDAVLELAVSQYL
CCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YRNNKDMPEGEMTKLRAAIVCEPSLKNFAEELEFGKFLRLGKGEQQTGGRERPAILADAF
HHCCCCCCCHHHHHHHHHHEECHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EAFLGALYLDQGFDNVLDFLNIHVFPKLTTGAFSHAMDYKSQLQEFVQQHKDQKIEYRII
HHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
EEKGPSHNKEFVAEVVIQEKAAGIGTGRTKKEAEQRAAKNALDSINNS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376