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The map label for this gene is pyrR

Identifier: 23098942

GI number: 23098942

Start: 1527163

End: 1527705

Strand: Direct

Name: pyrR

Synonym: OB1487

Alternate gene names: 23098942

Gene position: 1527163-1527705 (Clockwise)

Preceding gene: 23098941

Following gene: 23098943

Centisome position: 42.06

GC content: 37.57

Gene sequence:

>543_bases
ATGAAAAAGAAAACGGAAATACTGGATGCAGCATCCATACAACGAGCACTAACAAGAATGTCTCATGAAATATTGGAAAA
AAATAAAGGTGGAGAAAATCTCGTCTTGATTGGAATAAAAACAAGAGGTGTTCCACTAGCAAAGCGTATCCAGCAGAAAA
TTAAGCAAATCGAATCTATTGAGGTTCCTTTAGGTGAATTAGATATTACCATGTATCGAGATGATCTTGACAAAGTATCT
GAACAAGAGGACCCGAAGATTAACTCTGTTTCAATTGGAATGGATATAACCGATAAACATGTTATTTTGATAGATGATGT
ATTATTTACTGGAAGAACGGTTCGAGCAGCAATGGATGCTGTTATGGACGTTGGTCGCCCCTCTACAATCCAGCTTGGTT
CACTCGTGGATAGAGGGCATCGTGAGTTACCTATCCGTGCTGATTATGTTGGGAAGAACATACCAACATCGGATCGAGAA
ATTGTTGTTGTTCAACTAAGTGAACAAGATCAAGAAGATCGTGTATCTTTATATGAAAAATAA

Upstream 100 bases:

>100_bases
AGTCCAGAGAGGCTAGAAAGGGATCGTATGTTACATGTAAAAGTATGCCCTTTTTCCTTTCTTGGAAAAGGGCATTTTTA
GATTGAGGTGAGATACGCAA

Downstream 100 bases:

>100_bases
ATATGTTCAGCTTTTAATCAAATCCTGAGAGGTTTGGAAGGTTGTTTTTGGCTACGTATATCTTTGGATACCTATATATT
CCAGGATACGTATAGCTCTC

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MKKKTEILDAASIQRALTRMSHEILEKNKGGENLVLIGIKTRGVPLAKRIQQKIKQIESIEVPLGELDITMYRDDLDKVS
EQEDPKINSVSIGMDITDKHVILIDDVLFTGRTVRAAMDAVMDVGRPSTIQLGSLVDRGHRELPIRADYVGKNIPTSDRE
IVVVQLSEQDQEDRVSLYEK

Sequences:

>Translated_180_residues
MKKKTEILDAASIQRALTRMSHEILEKNKGGENLVLIGIKTRGVPLAKRIQQKIKQIESIEVPLGELDITMYRDDLDKVS
EQEDPKINSVSIGMDITDKHVILIDDVLFTGRTVRAAMDAVMDVGRPSTIQLGSLVDRGHRELPIRADYVGKNIPTSDRE
IVVVQLSEQDQEDRVSLYEK
>Mature_180_residues
MKKKTEILDAASIQRALTRMSHEILEKNKGGENLVLIGIKTRGVPLAKRIQQKIKQIESIEVPLGELDITMYRDDLDKVS
EQEDPKINSVSIGMDITDKHVILIDDVLFTGRTVRAAMDAVMDVGRPSTIQLGSLVDRGHRELPIRADYVGKNIPTSDRE
IVVVQLSEQDQEDRVSLYEK

Specific function: Displays also a weak uracil phosphoribosyltransferase activity which is not physiologically significant

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRR_OCEIH (Q8CXH9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692408.1
- HSSP:   P41007
- ProteinModelPortal:   Q8CXH9
- SMR:   Q8CXH9
- GeneID:   1017742
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1487
- NMPDR:   fig|221109.1.peg.1489
- HOGENOM:   HBG641958
- OMA:   PNVVGAT
- ProtClustDB:   PRK05205
- BioCyc:   OIHE221109:OB1487-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01219
- InterPro:   IPR000836
- InterPro:   IPR023050

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 20246; Mature: 20246

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKTEILDAASIQRALTRMSHEILEKNKGGENLVLIGIKTRGVPLAKRIQQKIKQIESI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHC
EVPLGELDITMYRDDLDKVSEQEDPKINSVSIGMDITDKHVILIDDVLFTGRTVRAAMDA
CCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECHHHCCCHHHHHHHH
VMDVGRPSTIQLGSLVDRGHRELPIRADYVGKNIPTSDREIVVVQLSEQDQEDRVSLYEK
HHHCCCCCEEEHHHHHHCCCCCCCEEHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHCCC
>Mature Secondary Structure
MKKKTEILDAASIQRALTRMSHEILEKNKGGENLVLIGIKTRGVPLAKRIQQKIKQIESI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHC
EVPLGELDITMYRDDLDKVSEQEDPKINSVSIGMDITDKHVILIDDVLFTGRTVRAAMDA
CCCCCCEEEEEEHHHHHHHCCCCCCCCCEEEECCCCCCCEEEEEECHHHCCCHHHHHHHH
VMDVGRPSTIQLGSLVDRGHRELPIRADYVGKNIPTSDREIVVVQLSEQDQEDRVSLYEK
HHHCCCCCEEEHHHHHHCCCCCCCEEHHHCCCCCCCCCCEEEEEEECCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376