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The map label for this gene is lspA

Identifier: 23098940

GI number: 23098940

Start: 1525621

End: 1526094

Strand: Direct

Name: lspA

Synonym: OB1485

Alternate gene names: 23098940

Gene position: 1525621-1526094 (Clockwise)

Preceding gene: 23098939

Following gene: 23098941

Centisome position: 42.02

GC content: 31.86

Gene sequence:

>474_bases
ATGATTATGTATTATTTAATAGCTATTGCGCTTGTCATTATTGACCAACTAACGAAATGGTTGGTAGTTTCACGTATGGA
GTTAGGGGAATCTATATCTGTTATTGATAACTTTTTCTATATAACTTCACACCGAAACACAGGAGCAGCTTGGGGAATAT
TAGAAGGACAAATGCTCTTATTTTATATAATCACTACTATAGTCATAATCGGTATTATTTATTTTTTACATACACATGCG
AAAGGTGACAAATTACTATCCGTTGCACTTGTGGTAATTTTAGGAGGAGCAATAGGTAATTTTATTGATCGTATATTTAG
ACAAGAAGTAGTTGATTTTGCAAACTTTTACATCTTTGATTATAACTTTCCGATTTTTAATGTTGCTGACTCATCATTAA
CCATCGGTGTAATTCTATTTCTCATAGCTACGATTCTGGAAGAAAAGCGTCAGAAAGGAAAATCAAAATCATGA

Upstream 100 bases:

>100_bases
CCAAAGATACATTATGATTTGGAATCACGTTTGTTCTTGAAAATGTTTGAGCACCGGTATAAGATAGAAAGAGTTCGATT
AGAATCGAGGGGTATAATAA

Downstream 100 bases:

>100_bases
CAAAGAGTCAACACATCGTGACAGAACAACAAGGAAAAACAAGAGTAGATAAACTATTAACACAATTGCTTGCGGATCAA
TCACGTTCACAAATACAAGG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MIMYYLIAIALVIIDQLTKWLVVSRMELGESISVIDNFFYITSHRNTGAAWGILEGQMLLFYIITTIVIIGIIYFLHTHA
KGDKLLSVALVVILGGAIGNFIDRIFRQEVVDFANFYIFDYNFPIFNVADSSLTIGVILFLIATILEEKRQKGKSKS

Sequences:

>Translated_157_residues
MIMYYLIAIALVIIDQLTKWLVVSRMELGESISVIDNFFYITSHRNTGAAWGILEGQMLLFYIITTIVIIGIIYFLHTHA
KGDKLLSVALVVILGGAIGNFIDRIFRQEVVDFANFYIFDYNFPIFNVADSSLTIGVILFLIATILEEKRQKGKSKS
>Mature_157_residues
MIMYYLIAIALVIIDQLTKWLVVSRMELGESISVIDNFFYITSHRNTGAAWGILEGQMLLFYIITTIVIIGIIYFLHTHA
KGDKLLSVALVVILGGAIGNFIDRIFRQEVVDFANFYIFDYNFPIFNVADSSLTIGVILFLIATILEEKRQKGKSKS

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=157, Percent_Identity=29.9363057324841, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_OCEIH (Q8ER40)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692406.1
- MEROPS:   A08.001
- GeneID:   1017740
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1485
- NMPDR:   fig|221109.1.peg.1487
- HOGENOM:   HBG724422
- OMA:   FFYITSH
- ProtClustDB:   PRK00376
- BioCyc:   OIHE221109:OB1485-MONOMER
- BRENDA:   3.4.23.36
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17774; Mature: 17774

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 103-103 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

HASH(0xe807380)-; HASH(0xc6a269c)-; HASH(0xe46e84c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMYYLIAIALVIIDQLTKWLVVSRMELGESISVIDNFFYITSHRNTGAAWGILEGQMLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
FYIITTIVIIGIIYFLHTHAKGDKLLSVALVVILGGAIGNFIDRIFRQEVVDFANFYIFD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YNFPIFNVADSSLTIGVILFLIATILEEKRQKGKSKS
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
>Mature Secondary Structure
MIMYYLIAIALVIIDQLTKWLVVSRMELGESISVIDNFFYITSHRNTGAAWGILEGQMLL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCHHHHHHHHH
FYIITTIVIIGIIYFLHTHAKGDKLLSVALVVILGGAIGNFIDRIFRQEVVDFANFYIFD
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YNFPIFNVADSSLTIGVILFLIATILEEKRQKGKSKS
CCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376