Click here to switch to the map view.

The map label for this gene is sipS [H]

Identifier: 23098845

GI number: 23098845

Start: 1435033

End: 1435557

Strand: Reverse

Name: sipS [H]

Synonym: OB1390

Alternate gene names: 23098845

Gene position: 1435557-1435033 (Counterclockwise)

Preceding gene: 23098846

Following gene: 23098844

Centisome position: 39.54

GC content: 33.71

Gene sequence:

>525_bases
GTGACTAACAAAAAAGATAGGAATGAATGGGTCAGTGGCATTAAAGCAATTGTATTAGCTATCATTATCGCCCTTTTTTT
GCGAACATTTATATTTGCAACTTCTATTGTAGAAGGTGAAAGCATGGCCCCTACACTTGAAAACGGTGAAAGAGTTATTT
TTAATAAAGTAGTTTATATGCTTGATGAGCCTGACCGTGGAGATATTGTAATTATTCGTCAACCTCCTAAAAATTATGTA
AAACGTATCATTGGCTTACCCGGTGAAGAGATAGAAATAAAAGATCATCAATTGTATATTAATGGTGATGCTTATACTCA
ATCCTTCCTATCCAAAGATGCCTTATATTCTACAAGCAACTTCGGGCCAATCATTATCCCTGAAGAAAATTATTTTGTTA
TGGGAGATAATCGACTTATTAGTAAGGATAGTCGAAACGGGCTTGGATATATACCGAAAGAAGATATTATCGGTAAATCA
GAATTAATAATTTATCCTTTTAACGAGCTAGGACTAACTCATTAA

Upstream 100 bases:

>100_bases
CAGTAAAAATATTGAGAAATTTTTAGATAATTAATCTCGAAATATAATATAAATTATGCTACGATTAGTATAACCTTTTA
TCATCGGAGGATGGTCCATT

Downstream 100 bases:

>100_bases
AAAAGACAGATTCGATTTTAAACGAATCTGTCTTTTTATTATTCATTATCCATTAAGCAGTACCCGATATTTAGTACGAT
AATTCCAAAACAAACAACAC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTNKKDRNEWVSGIKAIVLAIIIALFLRTFIFATSIVEGESMAPTLENGERVIFNKVVYMLDEPDRGDIVIIRQPPKNYV
KRIIGLPGEEIEIKDHQLYINGDAYTQSFLSKDALYSTSNFGPIIIPEENYFVMGDNRLISKDSRNGLGYIPKEDIIGKS
ELIIYPFNELGLTH

Sequences:

>Translated_174_residues
MTNKKDRNEWVSGIKAIVLAIIIALFLRTFIFATSIVEGESMAPTLENGERVIFNKVVYMLDEPDRGDIVIIRQPPKNYV
KRIIGLPGEEIEIKDHQLYINGDAYTQSFLSKDALYSTSNFGPIIIPEENYFVMGDNRLISKDSRNGLGYIPKEDIIGKS
ELIIYPFNELGLTH
>Mature_173_residues
TNKKDRNEWVSGIKAIVLAIIIALFLRTFIFATSIVEGESMAPTLENGERVIFNKVVYMLDEPDRGDIVIIRQPPKNYVK
RIIGLPGEEIEIKDHQLYINGDAYTQSFLSKDALYSTSNFGPIIIPEENYFVMGDNRLISKDSRNGLGYIPKEDIIGKSE
LIIYPFNELGLTH

Specific function: Not essential for cell viability, but required for efficient secretion of many proteins [H]

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 19741; Mature: 19610

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS50003 PH_DOMAIN ; PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKKDRNEWVSGIKAIVLAIIIALFLRTFIFATSIVEGESMAPTLENGERVIFNKVVYM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEE
LDEPDRGDIVIIRQPPKNYVKRIIGLPGEEIEIKDHQLYINGDAYTQSFLSKDALYSTSN
ECCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCC
FGPIIIPEENYFVMGDNRLISKDSRNGLGYIPKEDIIGKSELIIYPFNELGLTH
CCCEEEECCCEEEEECCEEECCCCCCCCCCCCCHHCCCCCCEEEEEHHHCCCCC
>Mature Secondary Structure 
TNKKDRNEWVSGIKAIVLAIIIALFLRTFIFATSIVEGESMAPTLENGERVIFNKVVYM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEE
LDEPDRGDIVIIRQPPKNYVKRIIGLPGEEIEIKDHQLYINGDAYTQSFLSKDALYSTSN
ECCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCC
FGPIIIPEENYFVMGDNRLISKDSRNGLGYIPKEDIIGKSELIIYPFNELGLTH
CCCEEEECCCEEEEECCEEECCCCCCCCCCCCCHHCCCCCCEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1639057; 7934829; 7876097; 9384377; 8951809; 9823656 [H]