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The map label for this gene is lepB [H]

Identifier: 23098635

GI number: 23098635

Start: 1229786

End: 1230328

Strand: Direct

Name: lepB [H]

Synonym: OB1180

Alternate gene names: 23098635

Gene position: 1229786-1230328 (Clockwise)

Preceding gene: 23098634

Following gene: 23098636

Centisome position: 33.87

GC content: 33.52

Gene sequence:

>543_bases
GTGAAAAAATTCAATATTCGAAGAGTATTGTTACTTTTACTTTTCTTGGTTGGAATTGCAGTTATTTTAAGAACAACTCT
ATTTGCCAATTATGTCGTAGATGGGAAGTCAATGGAACCTACTCTGTTTGACGGGAATTTATTGATGGTGAATAAATTTG
TATATGAATTATCGGATGTAAATCGATTTGATGTTATTGTTTTTCGGGCTTCTAAGGAGGAAGACTATGTTAAACGAGTT
ATTGGAACACCTGGAGATAAGATAGAATATAAGCATGATAAGCTATATATTAATGGAGAATTTATGGAAGAAAGATTTTT
AGAAACTTATAAGGAAGCAAGTTCGGTTGAAAAATTTACAAATGATTTTTCGCTCCAGCAACTAACAGGAGAAAGAGAAG
TTCCTGATGGGAAATTATTCGTATTAGGAGACAATAGACAGGACAGTCTAGATAGTCGATCGTTTGGATTTATAGACGTT
GATCAAATTGTCGGAAAGGTAGACATAACGTATTGGCCACTGACCGGCAAAGTAAATGAATAA

Upstream 100 bases:

>100_bases
AAAAAAATCAGCTGAAAATAATATGTAAATCATGAAAAGGGTTAAAAACTTTCTTCAAGGGTATTATGTATAATAATTAC
TCGATGAAGGATGGAACAAC

Downstream 100 bases:

>100_bases
TAAAAAGTTCTTCGATTAGGACAGAGCTTCTATCTTTGATAAAATAGGTAGAAGCTCTATTTAATTTAGGAGGGGAATAT
ATGGGAATGCGGTTCATATT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MKKFNIRRVLLLLLFLVGIAVILRTTLFANYVVDGKSMEPTLFDGNLLMVNKFVYELSDVNRFDVIVFRASKEEDYVKRV
IGTPGDKIEYKHDKLYINGEFMEERFLETYKEASSVEKFTNDFSLQQLTGEREVPDGKLFVLGDNRQDSLDSRSFGFIDV
DQIVGKVDITYWPLTGKVNE

Sequences:

>Translated_180_residues
MKKFNIRRVLLLLLFLVGIAVILRTTLFANYVVDGKSMEPTLFDGNLLMVNKFVYELSDVNRFDVIVFRASKEEDYVKRV
IGTPGDKIEYKHDKLYINGEFMEERFLETYKEASSVEKFTNDFSLQQLTGEREVPDGKLFVLGDNRQDSLDSRSFGFIDV
DQIVGKVDITYWPLTGKVNE
>Mature_180_residues
MKKFNIRRVLLLLLFLVGIAVILRTTLFANYVVDGKSMEPTLFDGNLLMVNKFVYELSDVNRFDVIVFRASKEEDYVKRV
IGTPGDKIEYKHDKLYINGEFMEERFLETYKEASSVEKFTNDFSLQQLTGEREVPDGKLFVLGDNRQDSLDSRSFGFIDV
DQIVGKVDITYWPLTGKVNE

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 20828; Mature: 20828

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFNIRRVLLLLLFLVGIAVILRTTLFANYVVDGKSMEPTLFDGNLLMVNKFVYELSDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCEEEHHHHHHHHCCC
NRFDVIVFRASKEEDYVKRVIGTPGDKIEYKHDKLYINGEFMEERFLETYKEASSVEKFT
CEEEEEEEECCCCHHHHHHHHCCCCCCEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHH
NDFSLQQLTGEREVPDGKLFVLGDNRQDSLDSRSFGFIDVDQIVGKVDITYWPLTGKVNE
CCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHCEEEEEEECCCCCCCC
>Mature Secondary Structure
MKKFNIRRVLLLLLFLVGIAVILRTTLFANYVVDGKSMEPTLFDGNLLMVNKFVYELSDV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCEEEHHHHHHHHCCC
NRFDVIVFRASKEEDYVKRVIGTPGDKIEYKHDKLYINGEFMEERFLETYKEASSVEKFT
CEEEEEEEECCCCHHHHHHHHCCCCCCEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHH
NDFSLQQLTGEREVPDGKLFVLGDNRQDSLDSRSFGFIDVDQIVGKVDITYWPLTGKVNE
CCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEHHHHHCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8801417 [H]