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The map label for this gene is proA

Identifier: 23098508

GI number: 23098508

Start: 1095417

End: 1096664

Strand: Direct

Name: proA

Synonym: OB1053

Alternate gene names: 23098508

Gene position: 1095417-1096664 (Clockwise)

Preceding gene: 23098507

Following gene: 23098510

Centisome position: 30.17

GC content: 35.5

Gene sequence:

>1248_bases
ATGAGTGAAGTAATAGAGAAAGCGAAGCGTGCAAAACAAGCAAGTTTTAAAATGGCTCTATCTACAACGGACGACAAGAA
TGAAGCATTGCAATTAATATCACAAGCAATTATAAATCACAAGCAAGAAATATTAACTGCAAATGCTTTAGATATAGAAG
AAGGGAAGAAAAAAGGGTTATCTGAAGCGGTTATCGATCGAATAAGATTGAATGAGGAAAGGTTACAAGATATAGCTGAT
GCAATTTTACAGGTAACTATATTAACTGATCCGATTGGAGAAGCTCTAGAAATAATAGAGAAAGATAATGGCTTATTTAT
TACCAAAAAGCGTGTTCCAATTGGTGTTATTGGTATGGTTTATGAAGCTAGACCGAATGTCACTGTAGATGCAGCTTCTC
TTGCAATAAAAACAGGGAACTCAGTAGTTTTGCGTGGTAGTTCTTCAGCCATAGAGTCTAATAAAGCGCTTATTCAAGTT
ATTCATCAGTCATTGGCTTCCAGCTCTATACCAAAAGAAGCTGTGCAATTAATTGAGGATACTAGAAGAGAAGTAGCGAA
TCAATTTTTTCAATTAAATGAATATCTAGATGTTTTAATACCAAGAGGAGGTAAACAATTAATAGATACAGTGATAAAAC
AATCAACTGTACCTGTAATTGAAACTGGTGCAGGAAATTGCCATGTTTATCTAGATGAATCTGCTAAAGTAGAGATGGCA
ACGGAAATTGTTTTGAATGCAAAACTTCAGCGTCCATCTGTGTGTAATGCAATTGAGTCATTAATTATTCATAGACAGTG
GTTTGAGGATCATGGTTTAGAATTATTAAAAACAATGCAATCTCATGATATCAAAATTCACGGTGATTCAGTCGTTATGG
AAAAATTTCCACCAGCAATAAAAGCAGTGGAAAGGGACTGGGAAAAGGAATATTTATCAAGTGAAATAAGTGTAAAAATA
GTTGATTCAGTATCAGAAGCTATCGATCACATCAATCGCTATGGTACACGTCATTCGGAAGCGATTATAACGGAAAACAA
GATGAATGCTGAACAATTTCAGCTTCAAGTTGATGCTGCAGCAGTTTATCACAACGCTTCAACTAGATTTACAGATGGAT
TTGAATTCGGATATGGTGCAGAAATAGGAATTAGTACACAAAAATTACATGCTCGTGGTCCGATGGGGCTGGAGGCATTA
ACGTCGACTAAATTTGTGATTTCAGGATCAGGACAAATTCGCGAATAA

Upstream 100 bases:

>100_bases
ACACATTAAAAAAAGCAAAACAGATGACGCAAATCCCTGCTATTGAGGTGATTCACAGAGATTCATGGGTTATGGTTGAT
CAAATAAAGGAGGAGTTCCA

Downstream 100 bases:

>100_bases
AAAAACACCAAACTACTTCTAGATTATATCGGAAGTAGTTTGGTGTTTTTATAGGTTTTAGAAGCTTATTCCCAAATCTC
TTTGGAAAGCTCTACAATAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSEVIEKAKRAKQASFKMALSTTDDKNEALQLISQAIINHKQEILTANALDIEEGKKKGLSEAVIDRIRLNEERLQDIAD
AILQVTILTDPIGEALEIIEKDNGLFITKKRVPIGVIGMVYEARPNVTVDAASLAIKTGNSVVLRGSSSAIESNKALIQV
IHQSLASSSIPKEAVQLIEDTRREVANQFFQLNEYLDVLIPRGGKQLIDTVIKQSTVPVIETGAGNCHVYLDESAKVEMA
TEIVLNAKLQRPSVCNAIESLIIHRQWFEDHGLELLKTMQSHDIKIHGDSVVMEKFPPAIKAVERDWEKEYLSSEISVKI
VDSVSEAIDHINRYGTRHSEAIITENKMNAEQFQLQVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLEAL
TSTKFVISGSGQIRE

Sequences:

>Translated_415_residues
MSEVIEKAKRAKQASFKMALSTTDDKNEALQLISQAIINHKQEILTANALDIEEGKKKGLSEAVIDRIRLNEERLQDIAD
AILQVTILTDPIGEALEIIEKDNGLFITKKRVPIGVIGMVYEARPNVTVDAASLAIKTGNSVVLRGSSSAIESNKALIQV
IHQSLASSSIPKEAVQLIEDTRREVANQFFQLNEYLDVLIPRGGKQLIDTVIKQSTVPVIETGAGNCHVYLDESAKVEMA
TEIVLNAKLQRPSVCNAIESLIIHRQWFEDHGLELLKTMQSHDIKIHGDSVVMEKFPPAIKAVERDWEKEYLSSEISVKI
VDSVSEAIDHINRYGTRHSEAIITENKMNAEQFQLQVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLEAL
TSTKFVISGSGQIRE
>Mature_414_residues
SEVIEKAKRAKQASFKMALSTTDDKNEALQLISQAIINHKQEILTANALDIEEGKKKGLSEAVIDRIRLNEERLQDIADA
ILQVTILTDPIGEALEIIEKDNGLFITKKRVPIGVIGMVYEARPNVTVDAASLAIKTGNSVVLRGSSSAIESNKALIQVI
HQSLASSSIPKEAVQLIEDTRREVANQFFQLNEYLDVLIPRGGKQLIDTVIKQSTVPVIETGAGNCHVYLDESAKVEMAT
EIVLNAKLQRPSVCNAIESLIIHRQWFEDHGLELLKTMQSHDIKIHGDSVVMEKFPPAIKAVERDWEKEYLSSEISVKIV
DSVSEAIDHINRYGTRHSEAIITENKMNAEQFQLQVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLEALT
STKFVISGSGQIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=417, Percent_Identity=34.2925659472422, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI62912457, Length=417, Percent_Identity=34.2925659472422, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1786438, Length=408, Percent_Identity=44.8529411764706, Blast_Score=367, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17569967, Length=418, Percent_Identity=34.4497607655502, Blast_Score=265, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17569969, Length=418, Percent_Identity=34.4497607655502, Blast_Score=265, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=439, Percent_Identity=34.624145785877, Blast_Score=269, Evalue=8e-73,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=34.5588235294118, Blast_Score=264, Evalue=7e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_OCEIH (Q8CUQ4)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691974.1
- ProteinModelPortal:   Q8CUQ4
- SMR:   Q8CUQ4
- GeneID:   1016931
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1053
- NMPDR:   fig|221109.1.peg.1055
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- BioCyc:   OIHE221109:OB1053-MONOMER
- BRENDA:   1.2.1.41
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45852; Mature: 45721

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVIEKAKRAKQASFKMALSTTDDKNEALQLISQAIINHKQEILTANALDIEEGKKKGL
CHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCH
SEAVIDRIRLNEERLQDIADAILQVTILTDPIGEALEIIEKDNGLFITKKRVPIGVIGMV
HHHHHHHHHCCHHHHHHHHHHHHEEHEECCCHHHHHHHHHCCCCEEEEECCCCEEEEEEE
YEARPNVTVDAASLAIKTGNSVVLRGSSSAIESNKALIQVIHQSLASSSIPKEAVQLIED
EECCCCCEEEHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TRREVANQFFQLNEYLDVLIPRGGKQLIDTVIKQSTVPVIETGAGNCHVYLDESAKVEMA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHH
TEIVLNAKLQRPSVCNAIESLIIHRQWFEDHGLELLKTMQSHDIKIHGDSVVMEKFPPAI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEHHHCCHHH
KAVERDWEKEYLSSEISVKIVDSVSEAIDHINRYGTRHSEAIITENKMNAEQFQLQVDAA
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHEEEEEHH
AVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLEALTSTKFVISGSGQIRE
HEEECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCEEEEECCCCCCC
>Mature Secondary Structure 
SEVIEKAKRAKQASFKMALSTTDDKNEALQLISQAIINHKQEILTANALDIEEGKKKGL
HHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHCCH
SEAVIDRIRLNEERLQDIADAILQVTILTDPIGEALEIIEKDNGLFITKKRVPIGVIGMV
HHHHHHHHHCCHHHHHHHHHHHHEEHEECCCHHHHHHHHHCCCCEEEEECCCCEEEEEEE
YEARPNVTVDAASLAIKTGNSVVLRGSSSAIESNKALIQVIHQSLASSSIPKEAVQLIED
EECCCCCEEEHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
TRREVANQFFQLNEYLDVLIPRGGKQLIDTVIKQSTVPVIETGAGNCHVYLDESAKVEMA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCHHHH
TEIVLNAKLQRPSVCNAIESLIIHRQWFEDHGLELLKTMQSHDIKIHGDSVVMEKFPPAI
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEHHHCCHHH
KAVERDWEKEYLSSEISVKIVDSVSEAIDHINRYGTRHSEAIITENKMNAEQFQLQVDAA
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHEEEEEHH
AVYHNASTRFTDGFEFGYGAEIGISTQKLHARGPMGLEALTSTKFVISGSGQIRE
HEEECCCCCCCCCCCCCCCCEECCCHHHHHCCCCCCHHHHCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376