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The map label for this gene is ycnB [H]

Identifier: 23098494

GI number: 23098494

Start: 1079307

End: 1080719

Strand: Direct

Name: ycnB [H]

Synonym: OB1039

Alternate gene names: 23098494

Gene position: 1079307-1080719 (Clockwise)

Preceding gene: 23098493

Following gene: 23098497

Centisome position: 29.73

GC content: 38.22

Gene sequence:

>1413_bases
ATGAGTGAGAGCCATGTAGGTGGGTCTACAGAGAAAATGAGTCGTGTACCAATATTAGTGGTATTGTTATCGGGTGCGTT
TGTTGCAATTTTGAATCAAACTTTACTTGGAACAGCATTACCTCATATAATGAGTGACCTGGAATTAGAAGCTAATACTG
CACAATGGTTGCAGTCTGCGTTTATGCTTGTGAATGGTATTATGATTCCAATTACTGCGTTCCTTATAGGAACATTTACC
ACGCGCAGTTTATTTCTAGCCGCTATGTCATCGTTTGCCATAGGAACATTAATATGCGGAATTGCTCCTAATTTCGAATT
GCTTTTAACAGGTAGGATCCTACAAGCTGCAGGAGCTGGTATTATCATGCCTTTAATGCAAACAATTATGATGTTAATTT
ATCCTAGAGAGCAAAGAGGTAGCGCAATGGGGATGTTCGGACTCATCATTTCATTTGCACCTGCCATCGGTCCGTCACTA
TCTGGTTATATTGTGGAACATTCCCCTTGGAGAACCTTATTCTTTATGGTTCTACCTATTGCAATCATAAATATTGGAAT
AGCCTATTTCCTACTAAAAAATGTAACAAAGCGTACATTTCCACAATTGGATAAGTTATCCATTATTTTATCTACATTAG
GTTTCGGTGGATTGTTGTACGGATTTAGTATTGCTGGCAGCGCTGGATGGTTAAGCAATCAAGTAATTATATCGATGATT
GTAGGAATTATAGCGCTGGCTTGGTTTATATTGAGACAATTAAATTTAAAAACACCAATTTTAGAATTTCGTGTATTTCA
ATACAAAATATTTACGATCACAACCATATTAGGAATGGTCACTTTCATGACGATGATAGGTGCTGCGGTAATTCTTCCGT
TATATATGCAGGATATGTTAGGATTTTCTGCATTTGAATCAGGACTTGCACTACTAGCTGGTGCTGTCTTGCAAGGGATA
ATGAACCCGGTCACTGGAAGATTATTTGATAGATATGGCTCACGTTATTTAGCTATTATTGGACTTGGTCTAATAGTGGT
AACCACCTTTATGTTTGGAATGCTGACAGCCGAAACAAGCTTCACATATATTGCAACGATACATGCGATACGTATGTTAG
GTGTCGCAATGGCAATGATGCCTGTAACTACTGCTGGTTTAAATTCTTTGCCCGATGAGTTTATAGCTCATGGAACAGCA
GTAAATAACACATTAAGGCAGGTTTCCGGTGCTATTGGAACGGCATTGCCAATTACGATCATGTCAACTGCAGCAATTCC
TAGCGAGGGATTGCAAGGGTTAATACACGGAGTGAATGTTTCCTTTATTGTTACGGCTATTATCTCTATTGTGGGACTAA
TCCTTGCATTTTTCATTCATGACGAAAAGAAAAAAAGAATTTCATCACGTTAA

Upstream 100 bases:

>100_bases
TTGTATTATATCTAAATAAAAATTTATTGAATAATACGTAATGACATGCTAAAATTGTTTATTTGCTAAAATTTTATAGT
TACAAGAAAGAAGGATTATT

Downstream 100 bases:

>100_bases
CTAAAAAAGCTTGGACACGCTGTCCAAGCTTTTTTTACGATCTATGAAAATTTTGCATCCGTGAATAGACGTACTAAATT
ATTCGCTTACGTTTTGTTCC

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSESHVGGSTEKMSRVPILVVLLSGAFVAILNQTLLGTALPHIMSDLELEANTAQWLQSAFMLVNGIMIPITAFLIGTFT
TRSLFLAAMSSFAIGTLICGIAPNFELLLTGRILQAAGAGIIMPLMQTIMMLIYPREQRGSAMGMFGLIISFAPAIGPSL
SGYIVEHSPWRTLFFMVLPIAIINIGIAYFLLKNVTKRTFPQLDKLSIILSTLGFGGLLYGFSIAGSAGWLSNQVIISMI
VGIIALAWFILRQLNLKTPILEFRVFQYKIFTITTILGMVTFMTMIGAAVILPLYMQDMLGFSAFESGLALLAGAVLQGI
MNPVTGRLFDRYGSRYLAIIGLGLIVVTTFMFGMLTAETSFTYIATIHAIRMLGVAMAMMPVTTAGLNSLPDEFIAHGTA
VNNTLRQVSGAIGTALPITIMSTAAIPSEGLQGLIHGVNVSFIVTAIISIVGLILAFFIHDEKKKRISSR

Sequences:

>Translated_470_residues
MSESHVGGSTEKMSRVPILVVLLSGAFVAILNQTLLGTALPHIMSDLELEANTAQWLQSAFMLVNGIMIPITAFLIGTFT
TRSLFLAAMSSFAIGTLICGIAPNFELLLTGRILQAAGAGIIMPLMQTIMMLIYPREQRGSAMGMFGLIISFAPAIGPSL
SGYIVEHSPWRTLFFMVLPIAIINIGIAYFLLKNVTKRTFPQLDKLSIILSTLGFGGLLYGFSIAGSAGWLSNQVIISMI
VGIIALAWFILRQLNLKTPILEFRVFQYKIFTITTILGMVTFMTMIGAAVILPLYMQDMLGFSAFESGLALLAGAVLQGI
MNPVTGRLFDRYGSRYLAIIGLGLIVVTTFMFGMLTAETSFTYIATIHAIRMLGVAMAMMPVTTAGLNSLPDEFIAHGTA
VNNTLRQVSGAIGTALPITIMSTAAIPSEGLQGLIHGVNVSFIVTAIISIVGLILAFFIHDEKKKRISSR
>Mature_469_residues
SESHVGGSTEKMSRVPILVVLLSGAFVAILNQTLLGTALPHIMSDLELEANTAQWLQSAFMLVNGIMIPITAFLIGTFTT
RSLFLAAMSSFAIGTLICGIAPNFELLLTGRILQAAGAGIIMPLMQTIMMLIYPREQRGSAMGMFGLIISFAPAIGPSLS
GYIVEHSPWRTLFFMVLPIAIINIGIAYFLLKNVTKRTFPQLDKLSIILSTLGFGGLLYGFSIAGSAGWLSNQVIISMIV
GIIALAWFILRQLNLKTPILEFRVFQYKIFTITTILGMVTFMTMIGAAVILPLYMQDMLGFSAFESGLALLAGAVLQGIM
NPVTGRLFDRYGSRYLAIIGLGLIVVTTFMFGMLTAETSFTYIATIHAIRMLGVAMAMMPVTTAGLNSLPDEFIAHGTAV
NNTLRQVSGAIGTALPITIMSTAAIPSEGLQGLIHGVNVSFIVTAIISIVGLILAFFIHDEKKKRISSR

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=416, Percent_Identity=27.8846153846154, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788710, Length=405, Percent_Identity=28.1481481481481, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI87081983, Length=398, Percent_Identity=26.6331658291457, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1790195, Length=439, Percent_Identity=25.5125284738041, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI1788392, Length=395, Percent_Identity=26.0759493670886, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323735, Length=326, Percent_Identity=23.3128834355828, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50608; Mature: 50476

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESHVGGSTEKMSRVPILVVLLSGAFVAILNQTLLGTALPHIMSDLELEANTAQWLQSA
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FMLVNGIMIPITAFLIGTFTTRSLFLAAMSSFAIGTLICGIAPNFELLLTGRILQAAGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCH
IIMPLMQTIMMLIYPREQRGSAMGMFGLIISFAPAIGPSLSGYIVEHSPWRTLFFMVLPI
HHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
AIINIGIAYFLLKNVTKRTFPQLDKLSIILSTLGFGGLLYGFSIAGSAGWLSNQVIISMI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VGIIALAWFILRQLNLKTPILEFRVFQYKIFTITTILGMVTFMTMIGAAVILPLYMQDML
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFSAFESGLALLAGAVLQGIMNPVTGRLFDRYGSRYLAIIGLGLIVVTTFMFGMLTAETS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
FTYIATIHAIRMLGVAMAMMPVTTAGLNSLPDEFIAHGTAVNNTLRQVSGAIGTALPITI
HHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
MSTAAIPSEGLQGLIHGVNVSFIVTAIISIVGLILAFFIHDEKKKRISSR
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC
>Mature Secondary Structure 
SESHVGGSTEKMSRVPILVVLLSGAFVAILNQTLLGTALPHIMSDLELEANTAQWLQSA
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FMLVNGIMIPITAFLIGTFTTRSLFLAAMSSFAIGTLICGIAPNFELLLTGRILQAAGAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCH
IIMPLMQTIMMLIYPREQRGSAMGMFGLIISFAPAIGPSLSGYIVEHSPWRTLFFMVLPI
HHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHH
AIINIGIAYFLLKNVTKRTFPQLDKLSIILSTLGFGGLLYGFSIAGSAGWLSNQVIISMI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VGIIALAWFILRQLNLKTPILEFRVFQYKIFTITTILGMVTFMTMIGAAVILPLYMQDML
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GFSAFESGLALLAGAVLQGIMNPVTGRLFDRYGSRYLAIIGLGLIVVTTFMFGMLTAETS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
FTYIATIHAIRMLGVAMAMMPVTTAGLNSLPDEFIAHGTAVNNTLRQVSGAIGTALPITI
HHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
MSTAAIPSEGLQGLIHGVNVSFIVTAIISIVGLILAFFIHDEKKKRISSR
HHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]