Click here to switch to the map view.

The map label for this gene is yfhQ [H]

Identifier: 23098351

GI number: 23098351

Start: 947503

End: 948567

Strand: Direct

Name: yfhQ [H]

Synonym: OB0896

Alternate gene names: 23098351

Gene position: 947503-948567 (Clockwise)

Preceding gene: 23098349

Following gene: 23098353

Centisome position: 26.1

GC content: 32.3

Gene sequence:

>1065_bases
ATGAATAAAAGGTTACAAAGTATTAACATTCCAGTTTTTCAAACGGATTTGCTGGAATGGTATTATTTGAATAAACGTGA
TCTTCCTTGGCGAAGAGAACCAAACCCTTACAAAACATGGGTATCAGAAATTATGCTACAACAAACAAAGGTAGATACGG
TTATACCTTATTTTAATCGCTTTATGGAGAAATATCCAACCGTTTATGATTTAGCTAAAGCAGACGAACAAGATGTATTA
AAATCTTGGGAGGGTTTAGGTTACTATTCCCGTGCAAGAAATTTACAAACCGCAGTTCGAGAAGTTGTAGATACATATAA
TGGTGAAATACCTAATAACGAAAAGGAATTGGCAAGTTTAAAAGGAATTGGCCCGTATACAAAGGGAGCAATATTATCGA
TTGCTTTTAATCAACCTGTTCCTGCAGTAGATGGAAATGTTCTTAGAGTGTTTTCTAGGATTTTACAAATAGAAGATGAT
ATTGCAAAACAATCAACAAAGAAAGAAATAGAGCAATATGTTGGAGAAATTATATCTCATCAAGATCCTTCTTCATTTAA
TCAAGCCATTATGGATTTAGGTGCAACTATCTGTACACCCAAAAAACCAACGTGTATGTTTTGTCCGGTAATGGAACACT
GTCAAGCTTTTCAACATGGAATCCAAGAGCAATTACCAATTAAGAAAAAAGCAAAGAAGCAAAAAATAAAGCAGTATGTT
GTTTTACTTATTAGAAATGATCAAGGAGAATATGTAATTGAAAAACGCAGTGATCAAGGATTACTAGCAAATTTATGGCA
GTTCCCGATGGTTCCTCTTGATGAAGTAGGTATAGATCAAATTGAACAATGGATGTATGATAAATGTGGTATTGATTTAC
AAATGGAATCAGATTGTGACAATTTAAAGCATACTTTTAGTCATATTATATGGGAAATGGACATAAAAAAAGCAAGTACC
TCTCAAAATTTCTTAAATAAAGATTCATTAATGTTTATTGCGAAAGAAGAAATTGATAATTTCCCATTCCCTGTGTCCCA
TCAAAAAATGATGAAATTTTTATAA

Upstream 100 bases:

>100_bases
ATATGCGTACCAGTGTCCATATAAGATTATCCTCCTTAATAATTACCAGTAAATAAAGTCAAACCAGTCGCTATTGTAAC
ATAAAGGACGTGGAATTAAG

Downstream 100 bases:

>100_bases
AAAAAATCAGGATTTATCCTAATGGATGTCCTGATTTTTTTTCTATGCGTTGGAACATTTCTTTATTTATCTCATGAAGA
ACGGAAAGTCCTTCAGAGTT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNKRLQSINIPVFQTDLLEWYYLNKRDLPWRREPNPYKTWVSEIMLQQTKVDTVIPYFNRFMEKYPTVYDLAKADEQDVL
KSWEGLGYYSRARNLQTAVREVVDTYNGEIPNNEKELASLKGIGPYTKGAILSIAFNQPVPAVDGNVLRVFSRILQIEDD
IAKQSTKKEIEQYVGEIISHQDPSSFNQAIMDLGATICTPKKPTCMFCPVMEHCQAFQHGIQEQLPIKKKAKKQKIKQYV
VLLIRNDQGEYVIEKRSDQGLLANLWQFPMVPLDEVGIDQIEQWMYDKCGIDLQMESDCDNLKHTFSHIIWEMDIKKAST
SQNFLNKDSLMFIAKEEIDNFPFPVSHQKMMKFL

Sequences:

>Translated_354_residues
MNKRLQSINIPVFQTDLLEWYYLNKRDLPWRREPNPYKTWVSEIMLQQTKVDTVIPYFNRFMEKYPTVYDLAKADEQDVL
KSWEGLGYYSRARNLQTAVREVVDTYNGEIPNNEKELASLKGIGPYTKGAILSIAFNQPVPAVDGNVLRVFSRILQIEDD
IAKQSTKKEIEQYVGEIISHQDPSSFNQAIMDLGATICTPKKPTCMFCPVMEHCQAFQHGIQEQLPIKKKAKKQKIKQYV
VLLIRNDQGEYVIEKRSDQGLLANLWQFPMVPLDEVGIDQIEQWMYDKCGIDLQMESDCDNLKHTFSHIIWEMDIKKAST
SQNFLNKDSLMFIAKEEIDNFPFPVSHQKMMKFL
>Mature_354_residues
MNKRLQSINIPVFQTDLLEWYYLNKRDLPWRREPNPYKTWVSEIMLQQTKVDTVIPYFNRFMEKYPTVYDLAKADEQDVL
KSWEGLGYYSRARNLQTAVREVVDTYNGEIPNNEKELASLKGIGPYTKGAILSIAFNQPVPAVDGNVLRVFSRILQIEDD
IAKQSTKKEIEQYVGEIISHQDPSSFNQAIMDLGATICTPKKPTCMFCPVMEHCQAFQHGIQEQLPIKKKAKKQKIKQYV
VLLIRNDQGEYVIEKRSDQGLLANLWQFPMVPLDEVGIDQIEQWMYDKCGIDLQMESDCDNLKHTFSHIIWEMDIKKAST
SQNFLNKDSLMFIAKEEIDNFPFPVSHQKMMKFL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI6912520, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI115298648, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI190358497, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298654, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298652, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI115298650, Length=360, Percent_Identity=34.4444444444444, Blast_Score=208, Evalue=7e-54,
Organism=Escherichia coli, GI1789331, Length=310, Percent_Identity=37.741935483871, Blast_Score=213, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 41236; Mature: 41236

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRLQSINIPVFQTDLLEWYYLNKRDLPWRREPNPYKTWVSEIMLQQTKVDTVIPYFNR
CCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMEKYPTVYDLAKADEQDVLKSWEGLGYYSRARNLQTAVREVVDTYNGEIPNNEKELASL
HHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KGIGPYTKGAILSIAFNQPVPAVDGNVLRVFSRILQIEDDIAKQSTKKEIEQYVGEIISH
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDPSSFNQAIMDLGATICTPKKPTCMFCPVMEHCQAFQHGIQEQLPIKKKAKKQKIKQYV
CCCHHHHHHHHHCCCHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VLLIRNDQGEYVIEKRSDQGLLANLWQFPMVPLDEVGIDQIEQWMYDKCGIDLQMESDCD
EEEEECCCCCEEEEECCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEEECCCHH
NLKHTFSHIIWEMDIKKASTSQNFLNKDSLMFIAKEEIDNFPFPVSHQKMMKFL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEHHHCCCCCCCCCHHHHHHCC
>Mature Secondary Structure
MNKRLQSINIPVFQTDLLEWYYLNKRDLPWRREPNPYKTWVSEIMLQQTKVDTVIPYFNR
CCCCCCCCCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FMEKYPTVYDLAKADEQDVLKSWEGLGYYSRARNLQTAVREVVDTYNGEIPNNEKELASL
HHHHCCCHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KGIGPYTKGAILSIAFNQPVPAVDGNVLRVFSRILQIEDDIAKQSTKKEIEQYVGEIISH
CCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QDPSSFNQAIMDLGATICTPKKPTCMFCPVMEHCQAFQHGIQEQLPIKKKAKKQKIKQYV
CCCHHHHHHHHHCCCHHCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VLLIRNDQGEYVIEKRSDQGLLANLWQFPMVPLDEVGIDQIEQWMYDKCGIDLQMESDCD
EEEEECCCCCEEEEECCCCCHHHHHHHCCCCCHHHCCHHHHHHHHHHHCCCCEEECCCHH
NLKHTFSHIIWEMDIKKASTSQNFLNKDSLMFIAKEEIDNFPFPVSHQKMMKFL
HHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEHHHCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]