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The map label for this gene is ghrB [H]

Identifier: 23098299

GI number: 23098299

Start: 897207

End: 898160

Strand: Direct

Name: ghrB [H]

Synonym: OB0844

Alternate gene names: 23098299

Gene position: 897207-898160 (Clockwise)

Preceding gene: 23098296

Following gene: 23098300

Centisome position: 24.71

GC content: 34.7

Gene sequence:

>954_bases
ATGACAAAGAAATCAATTGCAATTAATTTAGATTTAGATGAAAAAAACGTACAAGCAATTCAGGAAGTGGCTCCAGACTG
GGAAATTTTTACTGGGAAAGACTTAGAAGAGGAGAAATTAAATCAAGCAGAGATACTGTTACATTGGCGTGAATCACAAG
CAAAAAAATATAGGAAGAGTGACAATTTAAAGTGGGTTCAATCCTGGAGTGCTGGAGTAGATTATTTGGACCTGGATTAT
TTAAAAAAGAACGATATACATTTAACTAGTGCAAACGGAGTTCATGCATATCCGATCTCTGAAACGATATTTGCATATAT
GTTAGGTTTTACACGATTAATACATACATATATTAGACAACAACAAGAGAAAAAATGGCATCATGCAAATTTAAAAGCAG
AAATTCATGAGAAAACAATTGGAATTATTGGAGTAGGAGAAATTGGCAAGGAAACGGCTAAAATCGCTCAAGCATTTGGC
ATGAAAGTACTAGGAGTACGTCATTCAGGAAGACCTCTTGAATATGTGGATGAAATGTATACACCAGCTGATTTATCACT
TGTTTTAGAACAAAGTGATTTTGTAGTGGTCACGCTACCTTTAACAAAAGACACACATCATATGTTTGGTAAAGAACAAT
TTGCACAGATGAAAAATAGTGCATTCTTTATCAATATCGGAAGAGGGCCTATTGTTGATGAAAGTGCATTAATTTCTGCG
TTGCAGCAAAAAGAAATAGCGGGAGCAGGACTTGATGTTTTTGAAACAGAACCACTTCAATCGGATAGCCCATTGTGGGA
GATGGAAAACGTAATTATCACACCACATTCTGCAGGTGCCACAGAATATTACACAAATCGAGTCATACATGATATTTTTA
TTCCTAATTTAAAAAGCTATCTTGATAAAGGAGAACCTACTATTAATGTGTTTCAGCATAAACTAGGATACTAA

Upstream 100 bases:

>100_bases
TTTAACTGGAAGGTTGATAAGATAATTAATAGTTAGATTTTTTGGAAAACCTATTTTTATAAAGGATGTCCTTCGTGTGG
ACTTCTAGACTGGAGGAACT

Downstream 100 bases:

>100_bases
ATGATTATCAGTAGTTTCTACAGAACAAGCACGGATCTAAAATCCAAGGTAAAGTTAATTTTACTCGCCGGATTTTAGAC
CCGTGTTTTTTTGGTTAGTA

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTKKSIAINLDLDEKNVQAIQEVAPDWEIFTGKDLEEEKLNQAEILLHWRESQAKKYRKSDNLKWVQSWSAGVDYLDLDY
LKKNDIHLTSANGVHAYPISETIFAYMLGFTRLIHTYIRQQQEKKWHHANLKAEIHEKTIGIIGVGEIGKETAKIAQAFG
MKVLGVRHSGRPLEYVDEMYTPADLSLVLEQSDFVVVTLPLTKDTHHMFGKEQFAQMKNSAFFINIGRGPIVDESALISA
LQQKEIAGAGLDVFETEPLQSDSPLWEMENVIITPHSAGATEYYTNRVIHDIFIPNLKSYLDKGEPTINVFQHKLGY

Sequences:

>Translated_317_residues
MTKKSIAINLDLDEKNVQAIQEVAPDWEIFTGKDLEEEKLNQAEILLHWRESQAKKYRKSDNLKWVQSWSAGVDYLDLDY
LKKNDIHLTSANGVHAYPISETIFAYMLGFTRLIHTYIRQQQEKKWHHANLKAEIHEKTIGIIGVGEIGKETAKIAQAFG
MKVLGVRHSGRPLEYVDEMYTPADLSLVLEQSDFVVVTLPLTKDTHHMFGKEQFAQMKNSAFFINIGRGPIVDESALISA
LQQKEIAGAGLDVFETEPLQSDSPLWEMENVIITPHSAGATEYYTNRVIHDIFIPNLKSYLDKGEPTINVFQHKLGY
>Mature_316_residues
TKKSIAINLDLDEKNVQAIQEVAPDWEIFTGKDLEEEKLNQAEILLHWRESQAKKYRKSDNLKWVQSWSAGVDYLDLDYL
KKNDIHLTSANGVHAYPISETIFAYMLGFTRLIHTYIRQQQEKKWHHANLKAEIHEKTIGIIGVGEIGKETAKIAQAFGM
KVLGVRHSGRPLEYVDEMYTPADLSLVLEQSDFVVVTLPLTKDTHHMFGKEQFAQMKNSAFFINIGRGPIVDESALISAL
QQKEIAGAGLDVFETEPLQSDSPLWEMENVIITPHSAGATEYYTNRVIHDIFIPNLKSYLDKGEPTINVFQHKLGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=253, Percent_Identity=33.201581027668, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=29.1970802919708, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4557497, Length=258, Percent_Identity=29.0697674418605, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI61743967, Length=258, Percent_Identity=29.0697674418605, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=29.0566037735849, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI145580575, Length=269, Percent_Identity=28.996282527881, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87082289, Length=248, Percent_Identity=41.5322580645161, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789279, Length=229, Percent_Identity=31.0043668122271, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787645, Length=268, Percent_Identity=29.1044776119403, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI87081824, Length=226, Percent_Identity=28.7610619469027, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532191, Length=239, Percent_Identity=30.9623430962343, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=266, Percent_Identity=22.1804511278195, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=241, Percent_Identity=30.2904564315353, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=248, Percent_Identity=29.0322580645161, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=333, Percent_Identity=26.7267267267267, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324964, Length=227, Percent_Identity=25.5506607929515, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=144, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=152, Percent_Identity=26.9736842105263, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28574286, Length=226, Percent_Identity=32.7433628318584, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI45552429, Length=226, Percent_Identity=32.7433628318584, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24585514, Length=226, Percent_Identity=32.7433628318584, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28574282, Length=226, Percent_Identity=32.7433628318584, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI45551003, Length=226, Percent_Identity=32.7433628318584, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=226, Percent_Identity=32.7433628318584, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585516, Length=229, Percent_Identity=30.5676855895196, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28571528, Length=244, Percent_Identity=30.7377049180328, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19921140, Length=241, Percent_Identity=26.5560165975104, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646446, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646448, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646452, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646450, Length=264, Percent_Identity=28.7878787878788, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=28.6792452830189, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 36085; Mature: 35953

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKSIAINLDLDEKNVQAIQEVAPDWEIFTGKDLEEEKLNQAEILLHWRESQAKKYRKS
CCCCEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCHHHCCCCCEEEEEHHHHHHHHHHC
DNLKWVQSWSAGVDYLDLDYLKKNDIHLTSANGVHAYPISETIFAYMLGFTRLIHTYIRQ
CCCCEEHHHCCCCCEEEHHHHCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
QQEKKWHHANLKAEIHEKTIGIIGVGEIGKETAKIAQAFGMKVLGVRHSGRPLEYVDEMY
HHHHHHHHCCCEEEEHHCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHC
TPADLSLVLEQSDFVVVTLPLTKDTHHMFGKEQFAQMKNSAFFINIGRGPIVDESALISA
CCCCEEEEEECCCEEEEEEECCCCHHHHHCHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
LQQKEIAGAGLDVFETEPLQSDSPLWEMENVIITPHSAGATEYYTNRVIHDIFIPNLKSY
HHHHHHCCCCCCCEECCCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LDKGEPTINVFQHKLGY
HHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TKKSIAINLDLDEKNVQAIQEVAPDWEIFTGKDLEEEKLNQAEILLHWRESQAKKYRKS
CCCEEEEEECCCHHHHHHHHHHCCCCEEECCCCCCHHHCCCCCEEEEEHHHHHHHHHHC
DNLKWVQSWSAGVDYLDLDYLKKNDIHLTSANGVHAYPISETIFAYMLGFTRLIHTYIRQ
CCCCEEHHHCCCCCEEEHHHHCCCCEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHH
QQEKKWHHANLKAEIHEKTIGIIGVGEIGKETAKIAQAFGMKVLGVRHSGRPLEYVDEMY
HHHHHHHHCCCEEEEHHCEEEEEECCCCCHHHHHHHHHHCCEEEEEECCCCCHHHHHHHC
TPADLSLVLEQSDFVVVTLPLTKDTHHMFGKEQFAQMKNSAFFINIGRGPIVDESALISA
CCCCEEEEEECCCEEEEEEECCCCHHHHHCHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
LQQKEIAGAGLDVFETEPLQSDSPLWEMENVIITPHSAGATEYYTNRVIHDIFIPNLKSY
HHHHHHCCCCCCCEECCCCCCCCCCEECCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
LDKGEPTINVFQHKLGY
HHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA