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The map label for this gene is thlA [H]

Identifier: 23098131

GI number: 23098131

Start: 714001

End: 715176

Strand: Direct

Name: thlA [H]

Synonym: OB0676

Alternate gene names: 23098131

Gene position: 714001-715176 (Clockwise)

Preceding gene: 23098130

Following gene: 23098132

Centisome position: 19.67

GC content: 42.35

Gene sequence:

>1176_bases
ATGAATAGAGGTAGAGATGCGGTAATTGTTTCTGCTGTCCGAACAGCGATTGCCAGGCAAGGAGGAGCATTAGCGACGGT
GCCTGCACATGTGTTTGGGGCAGAAGTAATCAAAGAATCAGTGAAGCGAGCAAAGGTAGATCCAGAGCTAATCGATGATG
TCATTATGGGGAATGTATTAAGCGGTGGGGGAAATATCGCTAGATTAGCAGCTTTACAAGCAGATTTATCCTTACATTTA
CCAGGACTAACTATTGATCGTCAGTGTGGCTCGGGAATCAATGCCATTGTTCTTGCGCAGCAGGCTATTCAGTCAGGAAT
GGGAGACATTTATGTCGCTGGAGGTATGGAAAGTATGAGCCGTGCTCCATATTTGATGGATCGGCCAGATAAAGCGTTTA
GTCCTGTGCCGCCAACGATTCGTAAATCCAAACTCTCTCCAGAGCACATAGGCGATCCACCGATGGGAATAACGGCTGAA
AACCTTGCAAAAAAATATAATATTTCTAGAGAAGAACAAGATGAATATGCGCTTTCAAGTCAACAACGAATGGAAGAAGC
AATGAGAGAAGGGCGATTTAAAGAACAAATTGTACCAATTTCAGTTCCTCTACGAAAAGAAGCAGCCATTGTTTTCGATA
CTGACGAGCATCCACGTCCAAACTCGACTATGGAAGGATTAAAGAAATTACCACCTGCTTTTGTTAAAGAGGGAACAGTG
ACTGCTGGTAGTAGTTCTGGATTAAATGACGCGGCATCTGCTCTTGTGATTATGTCGAGAGAAAAAGCAGAAGAATTAAA
TTTAACACCATTGGCAATTGTTAGAAATGCTGCAGTGGCAGGTGTGGACCCAAATGTGATGGGGATCGGTCCTGTTCCAG
CTACACAAAAACTACTCAGAAAAGCAAATTTAAGCTTAAGAGATATTGATCTTATCGAATTAAATGAAGCATTTGCAGCA
CAAGTTATAGCCTGTGATCGTGAGCTTGCATTTAATCGAAACAAATTAAATGTAAATGGCGGCGCAATTGCTCATGGACA
CCCACTTGGAGCAACAGGAGCTATTTTAATAACAAAAATGGTGTATGAGTTACAGCGAATCGGTGGCAACTATGGACTTG
TAACAGCGTGTATTGGTGGTGGGCAAGGAATTTCTGCATTAATTGAAAGAGAATAG

Upstream 100 bases:

>100_bases
TCTTCGGCATCTGACTTTGTTACAGGAGAAACCATAGTAGTAGATGGAGGATCTGCTGCAATGTAGCATCATACTTTATG
AAAATGGATGTGAATAAATG

Downstream 100 bases:

>100_bases
TAGTGAGGTGTAATCGAGGCTTATAACATTTGTGTGGATTATGTATGCTATAATATAACCCACAAAAATGAGAGGAACAT
AGATTATGAGAGATAAAATT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNRGRDAVIVSAVRTAIARQGGALATVPAHVFGAEVIKESVKRAKVDPELIDDVIMGNVLSGGGNIARLAALQADLSLHL
PGLTIDRQCGSGINAIVLAQQAIQSGMGDIYVAGGMESMSRAPYLMDRPDKAFSPVPPTIRKSKLSPEHIGDPPMGITAE
NLAKKYNISREEQDEYALSSQQRMEEAMREGRFKEQIVPISVPLRKEAAIVFDTDEHPRPNSTMEGLKKLPPAFVKEGTV
TAGSSSGLNDAASALVIMSREKAEELNLTPLAIVRNAAVAGVDPNVMGIGPVPATQKLLRKANLSLRDIDLIELNEAFAA
QVIACDRELAFNRNKLNVNGGAIAHGHPLGATGAILITKMVYELQRIGGNYGLVTACIGGGQGISALIERE

Sequences:

>Translated_391_residues
MNRGRDAVIVSAVRTAIARQGGALATVPAHVFGAEVIKESVKRAKVDPELIDDVIMGNVLSGGGNIARLAALQADLSLHL
PGLTIDRQCGSGINAIVLAQQAIQSGMGDIYVAGGMESMSRAPYLMDRPDKAFSPVPPTIRKSKLSPEHIGDPPMGITAE
NLAKKYNISREEQDEYALSSQQRMEEAMREGRFKEQIVPISVPLRKEAAIVFDTDEHPRPNSTMEGLKKLPPAFVKEGTV
TAGSSSGLNDAASALVIMSREKAEELNLTPLAIVRNAAVAGVDPNVMGIGPVPATQKLLRKANLSLRDIDLIELNEAFAA
QVIACDRELAFNRNKLNVNGGAIAHGHPLGATGAILITKMVYELQRIGGNYGLVTACIGGGQGISALIERE
>Mature_391_residues
MNRGRDAVIVSAVRTAIARQGGALATVPAHVFGAEVIKESVKRAKVDPELIDDVIMGNVLSGGGNIARLAALQADLSLHL
PGLTIDRQCGSGINAIVLAQQAIQSGMGDIYVAGGMESMSRAPYLMDRPDKAFSPVPPTIRKSKLSPEHIGDPPMGITAE
NLAKKYNISREEQDEYALSSQQRMEEAMREGRFKEQIVPISVPLRKEAAIVFDTDEHPRPNSTMEGLKKLPPAFVKEGTV
TAGSSSGLNDAASALVIMSREKAEELNLTPLAIVRNAAVAGVDPNVMGIGPVPATQKLLRKANLSLRDIDLIELNEAFAA
QVIACDRELAFNRNKLNVNGGAIAHGHPLGATGAILITKMVYELQRIGGNYGLVTACIGGGQGISALIERE

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=399, Percent_Identity=44.8621553884712, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=44.529262086514, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=41.7721518987342, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI4557237, Length=391, Percent_Identity=39.1304347826087, Blast_Score=253, Evalue=3e-67,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=35.2941176470588, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI194353979, Length=246, Percent_Identity=33.739837398374, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=50, Blast_Score=339, Evalue=2e-94,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=44.8362720403023, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=45.3634085213033, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI48994986, Length=393, Percent_Identity=40.2035623409669, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1788683, Length=419, Percent_Identity=33.890214797136, Blast_Score=211, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI133906874, Length=394, Percent_Identity=41.8781725888325, Blast_Score=286, Evalue=9e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=35.0383631713555, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=34.2710997442455, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=34.6698113207547, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=28.498727735369, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=37.27959697733, Blast_Score=229, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=36, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24655093, Length=390, Percent_Identity=45.1282051282051, Blast_Score=320, Evalue=7e-88,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=42.4623115577889, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=36.3867684478371, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=36.3849765258216, Blast_Score=214, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41519; Mature: 41519

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRGRDAVIVSAVRTAIARQGGALATVPAHVFGAEVIKESVKRAKVDPELIDDVIMGNVL
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SGGGNIARLAALQADLSLHLPGLTIDRQCGSGINAIVLAQQAIQSGMGDIYVAGGMESMS
CCCCCCHHHHHHHHCCEEECCCCEEEHHHCCCCCHHHHHHHHHHCCCCCEEEECCHHHHH
RAPYLMDRPDKAFSPVPPTIRKSKLSPEHIGDPPMGITAENLAKKYNISREEQDEYALSS
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
QQRMEEAMREGRFKEQIVPISVPLRKEAAIVFDTDEHPRPNSTMEGLKKLPPAFVKEGTV
HHHHHHHHHCCCHHHCEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCCE
TAGSSSGLNDAASALVIMSREKAEELNLTPLAIVRNAAVAGVDPNVMGIGPVPATQKLLR
ECCCCCCCCHHHHEEEEEEHHHHHHCCCCHHHHHHCCEEECCCCCEEECCCCCHHHHHHH
KANLSLRDIDLIELNEAFAAQVIACDRELAFNRNKLNVNGGAIAHGHPLGATGAILITKM
HHCCCEECEEEEECCHHHHHHHHHHCHHHHCCCCEEECCCCEEECCCCCCCHHHHHHHHH
VYELQRIGGNYGLVTACIGGGQGISALIERE
HHHHHHHCCCCCEEEEEECCCCCHHHHCCCC
>Mature Secondary Structure
MNRGRDAVIVSAVRTAIARQGGALATVPAHVFGAEVIKESVKRAKVDPELIDDVIMGNVL
CCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SGGGNIARLAALQADLSLHLPGLTIDRQCGSGINAIVLAQQAIQSGMGDIYVAGGMESMS
CCCCCCHHHHHHHHCCEEECCCCEEEHHHCCCCCHHHHHHHHHHCCCCCEEEECCHHHHH
RAPYLMDRPDKAFSPVPPTIRKSKLSPEHIGDPPMGITAENLAKKYNISREEQDEYALSS
CCCCCCCCCCCCCCCCCCCHHHCCCCHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHH
QQRMEEAMREGRFKEQIVPISVPLRKEAAIVFDTDEHPRPNSTMEGLKKLPPAFVKEGTV
HHHHHHHHHCCCHHHCEEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCHHHHCCCCE
TAGSSSGLNDAASALVIMSREKAEELNLTPLAIVRNAAVAGVDPNVMGIGPVPATQKLLR
ECCCCCCCCHHHHEEEEEEHHHHHHCCCCHHHHHHCCEEECCCCCEEECCCCCHHHHHHH
KANLSLRDIDLIELNEAFAAQVIACDRELAFNRNKLNVNGGAIAHGHPLGATGAILITKM
HHCCCEECEEEEECCHHHHHHHHHHCHHHHCCCCEEECCCCEEECCCCCCCHHHHHHHHH
VYELQRIGGNYGLVTACIGGGQGISALIERE
HHHHHHHCCCCCEEEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]