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The map label for this gene is ykoH [H]

Identifier: 23098050

GI number: 23098050

Start: 621752

End: 623143

Strand: Direct

Name: ykoH [H]

Synonym: OB0595

Alternate gene names: 23098050

Gene position: 621752-623143 (Clockwise)

Preceding gene: 23098049

Following gene: 23098051

Centisome position: 17.13

GC content: 34.7

Gene sequence:

>1392_bases
ATGATATTTCGAAAGCTAATTAACTTTTTTTCTTCTATAACATTACGAAAAAAAATTATCTTCTTCTCAACCTTTTTTAT
GTTGATTTTAATATTAATTGTAAACACCGCTATTTATTTCCTGTTTTATCAATCAGCTTCAGAGGGAGAATTGGATCAAT
TAACCACTCATACAGATACGTTGGTGGAGAAAATTGGGGAAAATTCGTCCGTTTCTCTAGAAGAGATGAAAGATTTATTA
ACGGCGTATTTACCAACAAATGGAATGATTCGAGTTATTGATGCGAATGAGAACAAACTAATAGATCAAAAGAAGCCAGA
ATACACTGAAGTGCCTATAGAGTATACGACAACGGAACGAAGAGAAGTTATATCTAGTGATCAAGCAGATGTTGCTATGG
TGTCGAAACCAATTATTTGGCAAAATGGAGAAATTGTAACCATTCAAGTCTCCGATCATTTAATTCATATGAGTGAAACG
ATGCAAATTTTAAGGTATGTGCTATTTTTCTCGAGTGCGATTATATTAATTCCCACTATTATTGCAAGCATTCTTTTAAG
TCGCTTTTTATTAAACCCGATTCAAAAATTAAAAGAAACGATGCAGACAAATATTTCAAAAAGAGATTGGAAAAAAATAG
ATATTGAAAACAGATCAAAAGATGAGCTCTATGAAATGGAAGTAACATTTAATGAAATGATCGATTCGTTGAAAGAAAAT
TATGAGAAGCAGGAGATTTTTGTATCAAACGCATCCCATGAATTGAAAACACCTATTCAGATTATCAAAAGCTATGCACA
GTTATTAAGTCGACGTGGAGAAGGTAATCCTGAATTGCTGCAAGAGTCTACGGAAGCCATCGATTCGGAAGCGGACCGAA
TGCAGAATTTAGTCGAGCAAATGTTAGCATTAGCTAAGAATCAACAGGAACAAGTTGTTGAAACAGTGGATATGAAAGAA
CTCTTGCAACAAGTTGCGGACACATTCCAAAAAGCGTATGCTCCAAGAGAGATTATTTTATTCACGGATGAGAAAACCAA
GTATATGTGGCAAGGAAATCCTGATCAAATCAAACAAGTTATTTATATATTATTAACCAATGCGCTAAAATACAGTGAGA
AAGAAGTAAATATCCGCTTACAACAAAAAAGCGATGAAATGATAGTATCAGTTCAAGACTTTGGAGAAGGATTGGCGGAG
CAGGATCAGCAACATATTTTTGAAAGGTTTTATCGAGTAGACCGTGCAAGAAACAGAGAAACTGGTGGTACGGGACTTGG
ATTAGCAATTGCTAAGGTTATAGTGGAAACCTATCAAGGAGAAATAACTGTCCAAAGCAAGCTAGGTGAAGGCTCGATAT
TCCATATTCATCTTCCTAACATGGACCAATAA

Upstream 100 bases:

>100_bases
TTTATATTCGTTATTTACGCCAGAAAGTAGATAAAAACTTTGAGATACCGATAATTCAAACTGTACGTGGTGTAGGTTAT
ACAATTAAGGAAGATAAACA

Downstream 100 bases:

>100_bases
GCTAACAGATTCTCATCAAATTCTAATCTTTTTATTGGTATTTTGTGATGATTGGTATGATAAAGTTTGCATGTAGAGGT
GAAGCATATGAATAAACGTA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MIFRKLINFFSSITLRKKIIFFSTFFMLILILIVNTAIYFLFYQSASEGELDQLTTHTDTLVEKIGENSSVSLEEMKDLL
TAYLPTNGMIRVIDANENKLIDQKKPEYTEVPIEYTTTERREVISSDQADVAMVSKPIIWQNGEIVTIQVSDHLIHMSET
MQILRYVLFFSSAIILIPTIIASILLSRFLLNPIQKLKETMQTNISKRDWKKIDIENRSKDELYEMEVTFNEMIDSLKEN
YEKQEIFVSNASHELKTPIQIIKSYAQLLSRRGEGNPELLQESTEAIDSEADRMQNLVEQMLALAKNQQEQVVETVDMKE
LLQQVADTFQKAYAPREIILFTDEKTKYMWQGNPDQIKQVIYILLTNALKYSEKEVNIRLQQKSDEMIVSVQDFGEGLAE
QDQQHIFERFYRVDRARNRETGGTGLGLAIAKVIVETYQGEITVQSKLGEGSIFHIHLPNMDQ

Sequences:

>Translated_463_residues
MIFRKLINFFSSITLRKKIIFFSTFFMLILILIVNTAIYFLFYQSASEGELDQLTTHTDTLVEKIGENSSVSLEEMKDLL
TAYLPTNGMIRVIDANENKLIDQKKPEYTEVPIEYTTTERREVISSDQADVAMVSKPIIWQNGEIVTIQVSDHLIHMSET
MQILRYVLFFSSAIILIPTIIASILLSRFLLNPIQKLKETMQTNISKRDWKKIDIENRSKDELYEMEVTFNEMIDSLKEN
YEKQEIFVSNASHELKTPIQIIKSYAQLLSRRGEGNPELLQESTEAIDSEADRMQNLVEQMLALAKNQQEQVVETVDMKE
LLQQVADTFQKAYAPREIILFTDEKTKYMWQGNPDQIKQVIYILLTNALKYSEKEVNIRLQQKSDEMIVSVQDFGEGLAE
QDQQHIFERFYRVDRARNRETGGTGLGLAIAKVIVETYQGEITVQSKLGEGSIFHIHLPNMDQ
>Mature_463_residues
MIFRKLINFFSSITLRKKIIFFSTFFMLILILIVNTAIYFLFYQSASEGELDQLTTHTDTLVEKIGENSSVSLEEMKDLL
TAYLPTNGMIRVIDANENKLIDQKKPEYTEVPIEYTTTERREVISSDQADVAMVSKPIIWQNGEIVTIQVSDHLIHMSET
MQILRYVLFFSSAIILIPTIIASILLSRFLLNPIQKLKETMQTNISKRDWKKIDIENRSKDELYEMEVTFNEMIDSLKEN
YEKQEIFVSNASHELKTPIQIIKSYAQLLSRRGEGNPELLQESTEAIDSEADRMQNLVEQMLALAKNQQEQVVETVDMKE
LLQQVADTFQKAYAPREIILFTDEKTKYMWQGNPDQIKQVIYILLTNALKYSEKEVNIRLQQKSDEMIVSVQDFGEGLAE
QDQQHIFERFYRVDRARNRETGGTGLGLAIAKVIVETYQGEITVQSKLGEGSIFHIHLPNMDQ

Specific function: Probable member of the two-component regulatory system ykoH/ykoG. Potentially phosphorylates ykoG [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=243, Percent_Identity=31.2757201646091, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=31.8181818181818, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=27.7580071174377, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786783, Length=309, Percent_Identity=27.831715210356, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790861, Length=378, Percent_Identity=25.1322751322751, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693157, Length=253, Percent_Identity=24.901185770751, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1788713, Length=265, Percent_Identity=28.6792452830189, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787894, Length=244, Percent_Identity=28.2786885245902, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=29.1666666666667, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789808, Length=334, Percent_Identity=24.5508982035928, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789149, Length=278, Percent_Identity=26.2589928057554, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=23.8255033557047, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=285, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=28.4403669724771, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787374, Length=311, Percent_Identity=24.7588424437299, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=26.1224489795918, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=257, Percent_Identity=23.3463035019455, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=217, Percent_Identity=28.110599078341, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=302, Percent_Identity=24.8344370860927, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789403, Length=265, Percent_Identity=25.2830188679245, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 53527; Mature: 53527

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFRKLINFFSSITLRKKIIFFSTFFMLILILIVNTAIYFLFYQSASEGELDQLTTHTDT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LVEKIGENSSVSLEEMKDLLTAYLPTNGMIRVIDANENKLIDQKKPEYTEVPIEYTTTER
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHH
REVISSDQADVAMVSKPIIWQNGEIVTIQVSDHLIHMSETMQILRYVLFFSSAIILIPTI
HHHHCCCCCCHHHHCCCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASILLSRFLLNPIQKLKETMQTNISKRDWKKIDIENRSKDELYEMEVTFNEMIDSLKEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHC
YEKQEIFVSNASHELKTPIQIIKSYAQLLSRRGEGNPELLQESTEAIDSEADRMQNLVEQ
CCHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MLALAKNQQEQVVETVDMKELLQQVADTFQKAYAPREIILFTDEKTKYMWQGNPDQIKQV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHH
IYILLTNALKYSEKEVNIRLQQKSDEMIVSVQDFGEGLAEQDQQHIFERFYRVDRARNRE
HHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
TGGTGLGLAIAKVIVETYQGEITVQSKLGEGSIFHIHLPNMDQ
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MIFRKLINFFSSITLRKKIIFFSTFFMLILILIVNTAIYFLFYQSASEGELDQLTTHTDT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LVEKIGENSSVSLEEMKDLLTAYLPTNGMIRVIDANENKLIDQKKPEYTEVPIEYTTTER
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHH
REVISSDQADVAMVSKPIIWQNGEIVTIQVSDHLIHMSETMQILRYVLFFSSAIILIPTI
HHHHCCCCCCHHHHCCCEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IASILLSRFLLNPIQKLKETMQTNISKRDWKKIDIENRSKDELYEMEVTFNEMIDSLKEN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEHHHHHHHHHHHHHHC
YEKQEIFVSNASHELKTPIQIIKSYAQLLSRRGEGNPELLQESTEAIDSEADRMQNLVEQ
CCHHHHEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MLALAKNQQEQVVETVDMKELLQQVADTFQKAYAPREIILFTDEKTKYMWQGNPDQIKQV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHHHH
IYILLTNALKYSEKEVNIRLQQKSDEMIVSVQDFGEGLAEQDQQHIFERFYRVDRARNRE
HHHHHHHHHHCCCCCEEEEEEECCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
TGGTGLGLAIAKVIVETYQGEITVQSKLGEGSIFHIHLPNMDQ
CCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]