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The map label for this gene is gpo [H]

Identifier: 23098025

GI number: 23098025

Start: 599592

End: 600068

Strand: Reverse

Name: gpo [H]

Synonym: OB0570

Alternate gene names: 23098025

Gene position: 600068-599592 (Counterclockwise)

Preceding gene: 23098027

Following gene: 23098017

Centisome position: 16.53

GC content: 33.54

Gene sequence:

>477_bases
ATGAGTGTACATGATTTTACAGTAACTACCATTGAAGGGGAAGAAAAAAGACTTTCCGATTATAAAGGTAAAGTGATATT
AATTGTGAATACTGCAAGTCAATGTGGCTTTACCCCACAGTTAGAAGATCTCCAAAAACTATATAAACAATATCAAGATA
ATGATTTTGAAATATTAGGGTTTCCGTGTAACCAGTTTGGTAATCAAGATCCTGGAGCATCAGAGGAAATTTCAGCATTC
TGTCAAAAGAACTATGGAGTAACTTTTCAAATGTTTAAAAAAGTTGATGTGAAAGGTAAAGAAGCCCATCCGCTCTATAA
GCACCTAACCGAAGAGAAGAAAGGAATACTAGGTGGACAAATCAAATGGAATTTCACGAAGTTCCTTATTGATCAAAATG
GAAATGTTATAGAACGTTTTTCTCCCCAAAAGAACCCCAATACGTTAAATAAAGATATTGAAGTTTTGTTACGATAA

Upstream 100 bases:

>100_bases
GTGCCATCTCGTAATACATGTTGCATAATAATCTAACCTTTCTATTTTGACCTCTATAAGGGGCGTTGTTATAATCTTTT
ACATAGGAGGGATTTTTTCT

Downstream 100 bases:

>100_bases
AAAGAGATCCGGTGAGTCAACGACTGCTTTTTAGCAAATCGCAGACTCACCGAGCTTTTTTTAAAATCAAACTGTATTGT
CTACCCCACGTGCTTTATTT

Product: gluthatione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MSVHDFTVTTIEGEEKRLSDYKGKVILIVNTASQCGFTPQLEDLQKLYKQYQDNDFEILGFPCNQFGNQDPGASEEISAF
CQKNYGVTFQMFKKVDVKGKEAHPLYKHLTEEKKGILGGQIKWNFTKFLIDQNGNVIERFSPQKNPNTLNKDIEVLLR

Sequences:

>Translated_158_residues
MSVHDFTVTTIEGEEKRLSDYKGKVILIVNTASQCGFTPQLEDLQKLYKQYQDNDFEILGFPCNQFGNQDPGASEEISAF
CQKNYGVTFQMFKKVDVKGKEAHPLYKHLTEEKKGILGGQIKWNFTKFLIDQNGNVIERFSPQKNPNTLNKDIEVLLR
>Mature_157_residues
SVHDFTVTTIEGEEKRLSDYKGKVILIVNTASQCGFTPQLEDLQKLYKQYQDNDFEILGFPCNQFGNQDPGASEEISAFC
QKNYGVTFQMFKKVDVKGKEAHPLYKHLTEEKKGILGGQIKWNFTKFLIDQNGNVIERFSPQKNPNTLNKDIEVLLR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=155, Percent_Identity=45.8064516129032, Blast_Score=140, Evalue=6e-34,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=45.8064516129032, Blast_Score=139, Evalue=1e-33,
Organism=Homo sapiens, GI15618997, Length=156, Percent_Identity=38.4615384615385, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI192455698, Length=158, Percent_Identity=37.3417721518987, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=46.1538461538462, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI4557629, Length=178, Percent_Identity=31.4606741573034, Blast_Score=88, Evalue=3e-18,
Organism=Homo sapiens, GI6006001, Length=178, Percent_Identity=32.5842696629214, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI41406084, Length=182, Percent_Identity=30.7692307692308, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI33186887, Length=178, Percent_Identity=28.6516853932584, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI32967607, Length=185, Percent_Identity=29.1891891891892, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788003, Length=165, Percent_Identity=41.8181818181818, Blast_Score=139, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17535473, Length=158, Percent_Identity=46.8354430379747, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17506887, Length=157, Percent_Identity=44.5859872611465, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=36.3057324840764, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=37.2670807453416, Blast_Score=115, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17550320, Length=163, Percent_Identity=36.1963190184049, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193209493, Length=163, Percent_Identity=35.5828220858896, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=42.1052631578947, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17507603, Length=105, Percent_Identity=35.2380952380952, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319721, Length=157, Percent_Identity=53.5031847133758, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322228, Length=138, Percent_Identity=57.9710144927536, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322826, Length=155, Percent_Identity=42.5806451612903, Blast_Score=129, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24656772, Length=158, Percent_Identity=44.9367088607595, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24656767, Length=158, Percent_Identity=44.9367088607595, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24656777, Length=158, Percent_Identity=44.9367088607595, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI85726443, Length=159, Percent_Identity=40.251572327044, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18127; Mature: 17996

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1 ; PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVHDFTVTTIEGEEKRLSDYKGKVILIVNTASQCGFTPQLEDLQKLYKQYQDNDFEILG
CCCCCEEEEEECCCHHHHHHCCCCEEEEEECHHHCCCCCCHHHHHHHHHHHCCCCEEEEE
FPCNQFGNQDPGASEEISAFCQKNYGVTFQMFKKVDVKGKEAHPLYKHLTEEKKGILGGQ
ECHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCE
IKWNFTKFLIDQNGNVIERFSPQKNPNTLNKDIEVLLR
EEEEEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHCC
>Mature Secondary Structure 
SVHDFTVTTIEGEEKRLSDYKGKVILIVNTASQCGFTPQLEDLQKLYKQYQDNDFEILG
CCCCEEEEEECCCHHHHHHCCCCEEEEEECHHHCCCCCCHHHHHHHHHHHCCCCEEEEE
FPCNQFGNQDPGASEEISAFCQKNYGVTFQMFKKVDVKGKEAHPLYKHLTEEKKGILGGQ
ECHHHCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCE
IKWNFTKFLIDQNGNVIERFSPQKNPNTLNKDIEVLLR
EEEEEEEEEEECCCCEEECCCCCCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]