Click here to switch to the map view.

The map label for this gene is msrA [H]

Identifier: 23097904

GI number: 23097904

Start: 474640

End: 476235

Strand: Reverse

Name: msrA [H]

Synonym: OB0449

Alternate gene names: 23097904

Gene position: 476235-474640 (Counterclockwise)

Preceding gene: 23097905

Following gene: 23097903

Centisome position: 13.12

GC content: 34.77

Gene sequence:

>1596_bases
ATGAGGATATTGGAAATCAATCATGTTCAGTATGCGATAAAAGATCGAACACTAATAAACATTGATCAGCTATCTATTTC
AGAAAATGACCGAATTGGATTAGTTGGCCCTAATGGAACTGGAAAATCAACACTTTTAGAATTATTAGCTACAAAGCGAA
ATCCTGATTCCGGGAGCATAAAAACGTATACTCAAGTTGAGCTCTTACCTCAACTAAAAAGAAAAGATACTACAAAAAGT
GGCGGCGAGGTAACCCAAGAATATATTACTAATTCCTTAAAATCCAAGGCAGGACTTCTATTAGCAGATGAACCAACAAC
GAATCTTGATACCAAGCATATTGAATGGGTGGAGAAAAAATTATCCAATTGGCAAGGTGCGTTAATTATTGTTTCACATG
ACCGATTTTTCTTAGATAAGCTTTGCACGAGCATTTGGGAGTTAGAAGATAGTAAAGTGAATATCTACAAAGGAAATTAT
TCTGACTATCGAGAACAAAAAGATCTTGAGATACAACAGCAACAACAAGCGTACGAACACTATCAACAGAAGAAACAACA
ACTCGAAAACGCAATCGAAAAGAAAGAGCAACGGGCACAAAGAGCTACCAAAAAACCTAAACAAGTAAGCCGCTCTGAAG
CTAAAATTACAGGTGCAAAACCTTACTTTGCGAAGAAGCAAAAGAAATTACAAAAAACAGCAAAAGCATTGGAAAAACGG
TTAGAACATCTAGATAAAGTAGAAAAAGTAAATGATAGCCCTCCTATAAAAATGACTTTGCCGATGCAAGATAAAGTAAC
AGGAAAAATAATTATACGAATGGAAGATGTAGAAGGAAAAGTACCTGAAAAACGATTGTGGGAACCCGTAAGTCTCTATG
TTAAAGGCGGAGATAAAGTAGCAATAATTGGAGAAAATGGAACCGGAAAAACAACTCTAGTGAAGAAAATTATTAACCGT
AATCATAAAGGGATTACCATTAATCCTTCCGTTAAGATTGGTTATTTCAGTCAAAACTTATCCGTGCTTAATGCAAATAA
ATCAATTCTTGAAAATGTTCAAGAAACATCGAAACAACAGGAATCACTCATTCGCACCGTTTTAGCTCGACTACACTTTT
TCGATGAAGATGTGTATAAACCGGTACATGTATTAAGCGGTGGAGAACAAGTCAAAGTAGCTTTTGCAAAACTGTTTGTG
AGTGATATTAATATACTTATCCTCGATGAACCGACGAACTTTCTCGATATAGAAGCAGTTGAGGCACTAGAAGGTTTATT
ACAAGGGTATGTTGGAACAATCCTTTTTGTATCCCATGATCGCCATTTTATTAATCAAGTGGCTAACCGAATAGTGGAAA
TTAAAGACAAACAACTTCATATTTTTGATGGTAGTTATCAGGCATATCAACAAGTTCAATCGAAAACCCATGAACAAGAA
GATTCTCTTGAACAGCAGAAGTTGATAATCGAAAATAAAATCACTGAAGTATTAGGTAAACTTAGCCTTAACCCATCTGA
AGAATTAGATCAACACTTTCAAGAACTACTCAAAGAGAAAAAAATAATTATGGAGCAAATCAATAATAAAATGTAA

Upstream 100 bases:

>100_bases
TAGCTCTATTTTCCGTTGCCAATACCCGGTGCTATCCCCTTGTTCTGGAAAAGAACGGGGGCTTTTTTGTCTCCAAAAAT
ATATAAACGGAGATGATCAT

Downstream 100 bases:

>100_bases
TATCTGGGAGGTTGGGACAGAAGTATTAAACATAACAGATAAATCCGTATGTTTTGCTTGCTAGAATAAGCGGACGAAAT
ATACGGGAGTCATCAGCCGC

Product: ABC transporter ATP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MRILEINHVQYAIKDRTLINIDQLSISENDRIGLVGPNGTGKSTLLELLATKRNPDSGSIKTYTQVELLPQLKRKDTTKS
GGEVTQEYITNSLKSKAGLLLADEPTTNLDTKHIEWVEKKLSNWQGALIIVSHDRFFLDKLCTSIWELEDSKVNIYKGNY
SDYREQKDLEIQQQQQAYEHYQQKKQQLENAIEKKEQRAQRATKKPKQVSRSEAKITGAKPYFAKKQKKLQKTAKALEKR
LEHLDKVEKVNDSPPIKMTLPMQDKVTGKIIIRMEDVEGKVPEKRLWEPVSLYVKGGDKVAIIGENGTGKTTLVKKIINR
NHKGITINPSVKIGYFSQNLSVLNANKSILENVQETSKQQESLIRTVLARLHFFDEDVYKPVHVLSGGEQVKVAFAKLFV
SDINILILDEPTNFLDIEAVEALEGLLQGYVGTILFVSHDRHFINQVANRIVEIKDKQLHIFDGSYQAYQQVQSKTHEQE
DSLEQQKLIIENKITEVLGKLSLNPSEELDQHFQELLKEKKIIMEQINNKM

Sequences:

>Translated_531_residues
MRILEINHVQYAIKDRTLINIDQLSISENDRIGLVGPNGTGKSTLLELLATKRNPDSGSIKTYTQVELLPQLKRKDTTKS
GGEVTQEYITNSLKSKAGLLLADEPTTNLDTKHIEWVEKKLSNWQGALIIVSHDRFFLDKLCTSIWELEDSKVNIYKGNY
SDYREQKDLEIQQQQQAYEHYQQKKQQLENAIEKKEQRAQRATKKPKQVSRSEAKITGAKPYFAKKQKKLQKTAKALEKR
LEHLDKVEKVNDSPPIKMTLPMQDKVTGKIIIRMEDVEGKVPEKRLWEPVSLYVKGGDKVAIIGENGTGKTTLVKKIINR
NHKGITINPSVKIGYFSQNLSVLNANKSILENVQETSKQQESLIRTVLARLHFFDEDVYKPVHVLSGGEQVKVAFAKLFV
SDINILILDEPTNFLDIEAVEALEGLLQGYVGTILFVSHDRHFINQVANRIVEIKDKQLHIFDGSYQAYQQVQSKTHEQE
DSLEQQKLIIENKITEVLGKLSLNPSEELDQHFQELLKEKKIIMEQINNKM
>Mature_531_residues
MRILEINHVQYAIKDRTLINIDQLSISENDRIGLVGPNGTGKSTLLELLATKRNPDSGSIKTYTQVELLPQLKRKDTTKS
GGEVTQEYITNSLKSKAGLLLADEPTTNLDTKHIEWVEKKLSNWQGALIIVSHDRFFLDKLCTSIWELEDSKVNIYKGNY
SDYREQKDLEIQQQQQAYEHYQQKKQQLENAIEKKEQRAQRATKKPKQVSRSEAKITGAKPYFAKKQKKLQKTAKALEKR
LEHLDKVEKVNDSPPIKMTLPMQDKVTGKIIIRMEDVEGKVPEKRLWEPVSLYVKGGDKVAIIGENGTGKTTLVKKIINR
NHKGITINPSVKIGYFSQNLSVLNANKSILENVQETSKQQESLIRTVLARLHFFDEDVYKPVHVLSGGEQVKVAFAKLFV
SDINILILDEPTNFLDIEAVEALEGLLQGYVGTILFVSHDRHFINQVANRIVEIKDKQLHIFDGSYQAYQQVQSKTHEQE
DSLEQQKLIIENKITEVLGKLSLNPSEELDQHFQELLKEKKIIMEQINNKM

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=445, Percent_Identity=28.314606741573, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI10947135, Length=407, Percent_Identity=26.5356265356265, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI69354671, Length=407, Percent_Identity=26.5356265356265, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI27881506, Length=432, Percent_Identity=26.8518518518519, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI10947137, Length=432, Percent_Identity=26.8518518518519, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1787041, Length=388, Percent_Identity=32.2164948453608, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789751, Length=416, Percent_Identity=28.6057692307692, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI2367384, Length=429, Percent_Identity=29.1375291375291, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1787182, Length=401, Percent_Identity=32.6683291770574, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI1787758, Length=224, Percent_Identity=24.5535714285714, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI48995001, Length=213, Percent_Identity=28.169014084507, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17553372, Length=407, Percent_Identity=30.958230958231, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17559834, Length=408, Percent_Identity=27.9411764705882, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555318, Length=402, Percent_Identity=24.1293532338308, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321121, Length=398, Percent_Identity=27.6381909547739, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320874, Length=411, Percent_Identity=26.7639902676399, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324314, Length=180, Percent_Identity=31.1111111111111, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323278, Length=178, Percent_Identity=29.7752808988764, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6325030, Length=190, Percent_Identity=29.4736842105263, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666836, Length=403, Percent_Identity=29.0322580645161, Blast_Score=169, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24641342, Length=404, Percent_Identity=26.980198019802, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24642252, Length=384, Percent_Identity=27.34375, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI18859989, Length=384, Percent_Identity=27.34375, Blast_Score=139, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 60744; Mature: 60744

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILEINHVQYAIKDRTLINIDQLSISENDRIGLVGPNGTGKSTLLELLATKRNPDSGSI
CEEEEECCEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
KTYTQVELLPQLKRKDTTKSGGEVTQEYITNSLKSKAGLLLADEPTTNLDTKHIEWVEKK
EEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHH
LSNWQGALIIVSHDRFFLDKLCTSIWELEDSKVNIYKGNYSDYREQKDLEIQQQQQAYEH
HCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHH
YQQKKQQLENAIEKKEQRAQRATKKPKQVSRSEAKITGAKPYFAKKQKKLQKTAKALEKR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHH
LEHLDKVEKVNDSPPIKMTLPMQDKVTGKIIIRMEDVEGKVPEKRLWEPVSLYVKGGDKV
HHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCHHHCCCCEEEEEECCCEE
AIIGENGTGKTTLVKKIINRNHKGITINPSVKIGYFSQNLSVLNANKSILENVQETSKQQ
EEEECCCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCEEEECCHHHHHHHHHHHHHH
ESLIRTVLARLHFFDEDVYKPVHVLSGGEQVKVAFAKLFVSDINILILDEPTNFLDIEAV
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
EALEGLLQGYVGTILFVSHDRHFINQVANRIVEIKDKQLHIFDGSYQAYQQVQSKTHEQE
HHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCHHH
DSLEQQKLIIENKITEVLGKLSLNPSEELDQHFQELLKEKKIIMEQINNKM
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRILEINHVQYAIKDRTLINIDQLSISENDRIGLVGPNGTGKSTLLELLATKRNPDSGSI
CEEEEECCEEEEECCCEEEEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCE
KTYTQVELLPQLKRKDTTKSGGEVTQEYITNSLKSKAGLLLADEPTTNLDTKHIEWVEKK
EEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHH
LSNWQGALIIVSHDRFFLDKLCTSIWELEDSKVNIYKGNYSDYREQKDLEIQQQQQAYEH
HCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCHHHHHHHHHHH
YQQKKQQLENAIEKKEQRAQRATKKPKQVSRSEAKITGAKPYFAKKQKKLQKTAKALEKR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHH
LEHLDKVEKVNDSPPIKMTLPMQDKVTGKIIIRMEDVEGKVPEKRLWEPVSLYVKGGDKV
HHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEECCCCCCCHHHCCCCEEEEEECCCEE
AIIGENGTGKTTLVKKIINRNHKGITINPSVKIGYFSQNLSVLNANKSILENVQETSKQQ
EEEECCCCCHHHHHHHHHCCCCCCEEECCCEEEEEEECCCEEEECCHHHHHHHHHHHHHH
ESLIRTVLARLHFFDEDVYKPVHVLSGGEQVKVAFAKLFVSDINILILDEPTNFLDIEAV
HHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHH
EALEGLLQGYVGTILFVSHDRHFINQVANRIVEIKDKQLHIFDGSYQAYQQVQSKTHEQE
HHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCHHH
DSLEQQKLIIENKITEVLGKLSLNPSEELDQHFQELLKEKKIIMEQINNKM
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]