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The map label for this gene is ribBA [H]

Identifier: 23097879

GI number: 23097879

Start: 450658

End: 451413

Strand: Reverse

Name: ribBA [H]

Synonym: OB0424

Alternate gene names: 23097879

Gene position: 451413-450658 (Counterclockwise)

Preceding gene: 23097882

Following gene: 23097878

Centisome position: 12.43

GC content: 37.83

Gene sequence:

>756_bases
ATGTTAAATACGAAACTAGAATCAGAGGCTTTTGCCCTTTTAAAAGATAAAATTCAACTTATTCAACAAAATGATCATGC
TATATATTTGGTTGGACCAATCCAACTTCCCATAAATTTAGATGGAGAGACAACAGTGTTTCAATGGTATTGTTGGTTAA
ATTTTGATGAGATAACAGAAGACTATGAAAATATGATTGAAAAGTTATCCTCAGCAAACCTGGCTGAATATCAACAATCT
AGTGTCTTGGTATATGGAGATTTTGCTCATGCAGAAGAAGCACTTATTCGTATGCATTCGATTTGCCACACTGGTGACAT
ATTTGGTAGCAAACGTTGTGACTGTGGTTTTCAATTAAAGGAATCCATGAAGAAAATTAGAGAACATGGCACTGGAGCCT
TATTCTATTTAGCAAATCACGAAGGACGTGGCATAGGATTATTCAGTAAAGCGATGGCCTATGTACTGCAAGAGAATGGC
TATGACACCGTGGAGGCAAATGAAAGTCTTGGATACGTAAATGATGCTAGAGATTATGAAGATGCAATCTCCGTTTTACG
TACACTTCGCAGCAAACCCGTTACCCTGATCACAAATAATCCTTTGAAAGTAGATGCGCTTGAAAATGCCGGACTACAGC
TTTCTGGAAGAACCCCACTATGGGGAGATCGCTCAGAATATAACAAAAAATATCTAGACACGAAGGTGATAAAATCTGGT
CACTTACGAGAGGATGGTAAATGCAGTAATGACTGA

Upstream 100 bases:

>100_bases
AGGAAACAATAGTTATAAGCCCTTATCAGCCAGAGTTGGAACAATTGATTTGATAACAGTAATACACTATACTATGAATC
AATTGAAAGGAGTCTTTCCG

Downstream 100 bases:

>100_bases
TGATAAGCACTATATGAAACTTGCCATAGAGAACGCAAAAGCGATGAAAGGTCAAACAGACCCGAACCCTTTAGTCGGTG
CAGTTATTGTTAATCATAAT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MLNTKLESEAFALLKDKIQLIQQNDHAIYLVGPIQLPINLDGETTVFQWYCWLNFDEITEDYENMIEKLSSANLAEYQQS
SVLVYGDFAHAEEALIRMHSICHTGDIFGSKRCDCGFQLKESMKKIREHGTGALFYLANHEGRGIGLFSKAMAYVLQENG
YDTVEANESLGYVNDARDYEDAISVLRTLRSKPVTLITNNPLKVDALENAGLQLSGRTPLWGDRSEYNKKYLDTKVIKSG
HLREDGKCSND

Sequences:

>Translated_251_residues
MLNTKLESEAFALLKDKIQLIQQNDHAIYLVGPIQLPINLDGETTVFQWYCWLNFDEITEDYENMIEKLSSANLAEYQQS
SVLVYGDFAHAEEALIRMHSICHTGDIFGSKRCDCGFQLKESMKKIREHGTGALFYLANHEGRGIGLFSKAMAYVLQENG
YDTVEANESLGYVNDARDYEDAISVLRTLRSKPVTLITNNPLKVDALENAGLQLSGRTPLWGDRSEYNKKYLDTKVIKSG
HLREDGKCSND
>Mature_251_residues
MLNTKLESEAFALLKDKIQLIQQNDHAIYLVGPIQLPINLDGETTVFQWYCWLNFDEITEDYENMIEKLSSANLAEYQQS
SVLVYGDFAHAEEALIRMHSICHTGDIFGSKRCDCGFQLKESMKKIREHGTGALFYLANHEGRGIGLFSKAMAYVLQENG
YDTVEANESLGYVNDARDYEDAISVLRTLRSKPVTLITNNPLKVDALENAGLQLSGRTPLWGDRSEYNKKYLDTKVIKSG
HLREDGKCSND

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=169, Percent_Identity=47.3372781065089, Blast_Score=149, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=38.5964912280702, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 28385; Mature: 28385

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTKLESEAFALLKDKIQLIQQNDHAIYLVGPIQLPINLDGETTVFQWYCWLNFDEITE
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCEEEEEEEEECCHHHHHH
DYENMIEKLSSANLAEYQQSSVLVYGDFAHAEEALIRMHSICHTGDIFGSKRCDCGFQLK
HHHHHHHHHHCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
ESMKKIREHGTGALFYLANHEGRGIGLFSKAMAYVLQENGYDTVEANESLGYVNDARDYE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHH
DAISVLRTLRSKPVTLITNNPLKVDALENAGLQLSGRTPLWGDRSEYNKKYLDTKVIKSG
HHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC
HLREDGKCSND
CCCCCCCCCCC
>Mature Secondary Structure
MLNTKLESEAFALLKDKIQLIQQNDHAIYLVGPIQLPINLDGETTVFQWYCWLNFDEITE
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCEEEEEEEEECCHHHHHH
DYENMIEKLSSANLAEYQQSSVLVYGDFAHAEEALIRMHSICHTGDIFGSKRCDCGFQLK
HHHHHHHHHHCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
ESMKKIREHGTGALFYLANHEGRGIGLFSKAMAYVLQENGYDTVEANESLGYVNDARDYE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCHH
DAISVLRTLRSKPVTLITNNPLKVDALENAGLQLSGRTPLWGDRSEYNKKYLDTKVIKSG
HHHHHHHHHHCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCC
HLREDGKCSND
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA