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The map label for this gene is pbpE [H]

Identifier: 23097740

GI number: 23097740

Start: 319478

End: 320488

Strand: Direct

Name: pbpE [H]

Synonym: OB0285

Alternate gene names: 23097740

Gene position: 319478-320488 (Clockwise)

Preceding gene: 23097739

Following gene: 23097741

Centisome position: 8.8

GC content: 35.81

Gene sequence:

>1011_bases
ATGAATAAAAAGATGGAGTATGTTGATAAAGTTGCGAATGATATTCAATTTTCAGGAACGTTTCATGTGAAAAATTCTGA
AGGAATAACAACGAAAAATTATGGTTATTCCAATTATGCAGAAAGAATTAAAAACCAAACCAATACTCGTTATGGGATTG
CCTCTGGGTGTAAAATATTTACATCTATTGCCGTTTGCCAATTAATTGAAGCAGGAAAATTATCTTTTGACACTACATTA
AATCAATGCTTGGATTATGATTTTCCGTATTTTGATAAGGATATCACTGTTCATGATTTATTAACCCACACATCAGGCAT
TCCTGATTATTTCGATGAAGACGAGATGGATGATTATGAAGAACTGTGGGCGTCCATACCAATGTATCATATGCGGAGTC
TAAAGGATTTTTTGCCGTTATTTAAAGGTATGAAGATGAAAGGAAAAGTCGGAAACGCATTTTCATACAATAATGCTGGT
TATATTCTGCTAGGATTAATTGTCGAGAAGGTCTCTGGATATGTATTTGGTGATTATATCGAGAAGTATATATTTCAAAA
GGCGGGAATGGAAGACTCTGGGTATTTTGAGATGGATGATTTACCAGGACGAACTGCATTGGGTTATATCGAAAAGCCAG
ACGGGGCTTGGAAGACAAATATATATTCTCTTCCAGTCAAATCTGCTTCTGATGGTGGTGCATATGTGACAGCTAGAGAT
ATGGCTTTATTCTGGGATGCGCTAACACAGGCCCGACTTTTATCAAGAAACATGACAGACCTTCTATTAAAGCCTATAGT
CCGCGTGGATGATGATATTTACTATGGCTATGCTGGTTATATGCAAGTAATCGAAGACAAAACAATTAAGCATATTCTGA
TGGGGTATGATCCAGGAGTTAATTTTCGATTTGTACAGTATCCTGACACATCGTTAATAATTGTCGTGTGTTCGAATAAA
TCAGAAGGTGCATATGAGATTCTAAACAAGATAGAGGATCTATTGGTATAA

Upstream 100 bases:

>100_bases
GGAGATCTCCATGTGTAGATTCCAAGTGTGAACATCCTAACTAAATGATCCTTACCATACGTTTTTAAAAATACTAAAGG
ACATTTAGGAGGATATAATG

Downstream 100 bases:

>100_bases
GTGTAAGGAGAGGCTGGGCATACAATTGTCCAGCCCTTTTAAAATTAACAAATTCTTGGGTAGGAGGAAGGCAATTTGAC
ACCAACTAACGTAAAATGGG

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP 4*; PBP 4A; Penicillin-binding protein E [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MNKKMEYVDKVANDIQFSGTFHVKNSEGITTKNYGYSNYAERIKNQTNTRYGIASGCKIFTSIAVCQLIEAGKLSFDTTL
NQCLDYDFPYFDKDITVHDLLTHTSGIPDYFDEDEMDDYEELWASIPMYHMRSLKDFLPLFKGMKMKGKVGNAFSYNNAG
YILLGLIVEKVSGYVFGDYIEKYIFQKAGMEDSGYFEMDDLPGRTALGYIEKPDGAWKTNIYSLPVKSASDGGAYVTARD
MALFWDALTQARLLSRNMTDLLLKPIVRVDDDIYYGYAGYMQVIEDKTIKHILMGYDPGVNFRFVQYPDTSLIIVVCSNK
SEGAYEILNKIEDLLV

Sequences:

>Translated_336_residues
MNKKMEYVDKVANDIQFSGTFHVKNSEGITTKNYGYSNYAERIKNQTNTRYGIASGCKIFTSIAVCQLIEAGKLSFDTTL
NQCLDYDFPYFDKDITVHDLLTHTSGIPDYFDEDEMDDYEELWASIPMYHMRSLKDFLPLFKGMKMKGKVGNAFSYNNAG
YILLGLIVEKVSGYVFGDYIEKYIFQKAGMEDSGYFEMDDLPGRTALGYIEKPDGAWKTNIYSLPVKSASDGGAYVTARD
MALFWDALTQARLLSRNMTDLLLKPIVRVDDDIYYGYAGYMQVIEDKTIKHILMGYDPGVNFRFVQYPDTSLIIVVCSNK
SEGAYEILNKIEDLLV
>Mature_336_residues
MNKKMEYVDKVANDIQFSGTFHVKNSEGITTKNYGYSNYAERIKNQTNTRYGIASGCKIFTSIAVCQLIEAGKLSFDTTL
NQCLDYDFPYFDKDITVHDLLTHTSGIPDYFDEDEMDDYEELWASIPMYHMRSLKDFLPLFKGMKMKGKVGNAFSYNNAG
YILLGLIVEKVSGYVFGDYIEKYIFQKAGMEDSGYFEMDDLPGRTALGYIEKPDGAWKTNIYSLPVKSASDGGAYVTARD
MALFWDALTQARLLSRNMTDLLLKPIVRVDDDIYYGYAGYMQVIEDKTIKHILMGYDPGVNFRFVQYPDTSLIIVVCSNK
SEGAYEILNKIEDLLV

Specific function: Probably involved in peptidoglycan modification during cortex synthesis [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR021860 [H]

Pfam domain/function: PF00144 Beta-lactamase; PF11954 DUF3471 [H]

EC number: NA

Molecular weight: Translated: 38247; Mature: 38247

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKMEYVDKVANDIQFSGTFHVKNSEGITTKNYGYSNYAERIKNQTNTRYGIASGCKIF
CCCHHHHHHHHHHCEEECEEEEEECCCCCEECCCCCHHHHHHHHHCCCCCCCHHHHHHHH
TSIAVCQLIEAGKLSFDTTLNQCLDYDFPYFDKDITVHDLLTHTSGIPDYFDEDEMDDYE
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
ELWASIPMYHMRSLKDFLPLFKGMKMKGKVGNAFSYNNAGYILLGLIVEKVSGYVFGDYI
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHH
EKYIFQKAGMEDSGYFEMDDLPGRTALGYIEKPDGAWKTNIYSLPVKSASDGGAYVTARD
HHHHHHHCCCCCCCCEEECCCCCCCEECCEECCCCCCCCCEEEECCCCCCCCCCEEEEHH
MALFWDALTQARLLSRNMTDLLLKPIVRVDDDIYYGYAGYMQVIEDKTIKHILMGYDPGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCC
NFRFVQYPDTSLIIVVCSNKSEGAYEILNKIEDLLV
CEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKMEYVDKVANDIQFSGTFHVKNSEGITTKNYGYSNYAERIKNQTNTRYGIASGCKIF
CCCHHHHHHHHHHCEEECEEEEEECCCCCEECCCCCHHHHHHHHHCCCCCCCHHHHHHHH
TSIAVCQLIEAGKLSFDTTLNQCLDYDFPYFDKDITVHDLLTHTSGIPDYFDEDEMDDYE
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
ELWASIPMYHMRSLKDFLPLFKGMKMKGKVGNAFSYNNAGYILLGLIVEKVSGYVFGDYI
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHHCCCCHHHHH
EKYIFQKAGMEDSGYFEMDDLPGRTALGYIEKPDGAWKTNIYSLPVKSASDGGAYVTARD
HHHHHHHCCCCCCCCEEECCCCCCCEECCEECCCCCCCCCEEEECCCCCCCCCCEEEEHH
MALFWDALTQARLLSRNMTDLLLKPIVRVDDDIYYGYAGYMQVIEDKTIKHILMGYDPGV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCC
NFRFVQYPDTSLIIVVCSNKSEGAYEILNKIEDLLV
CEEEEEECCCEEEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8491712; 9384377 [H]