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The map label for this gene is uvrA [H]

Identifier: 23097736

GI number: 23097736

Start: 313174

End: 315603

Strand: Direct

Name: uvrA [H]

Synonym: OB0281

Alternate gene names: 23097736

Gene position: 313174-315603 (Clockwise)

Preceding gene: 23097735

Following gene: 23097737

Centisome position: 8.63

GC content: 36.01

Gene sequence:

>2430_bases
ATGTCAGAATGGATTTATATTGACAATGCGAACGAGCATAATCTAAAGGGTATTAGTTTACGTATCCCCAAACGTAAATT
TACCGTGATCACGGGAGTCTCGGGTTCAGGAAAATCTACACTTGCACACGATATTCTATTTAATGAGTCACAGCGCCAAT
ATTTAGAGGCGATGGGGATGCAAGGAATTGAAAAGCCCAAGGTAAACCATATTAGTGGTGTATCCCCAGCAATCAGTATT
AAGCAACAAGAGACATCATCCAACCCTCGTTCCACTGTTGGTACAAAAACAGCGATGTATACAAGTTTAAGAATGATCTA
TGAAAAACTAGGCATCCGAAACTGCCCGAACTGTCAAAAAGAAGTTAACCCCACAAAAGCAATTGAAGAAACCGAGCATG
TAGATGGAGAATTTACTGTTTATCAAATTTGTCCCCACTGTACACATAAGTATAAAAAACTTACACGAAGTCATTTTTCA
TATAATACTATTGAAGGAGCATGTCAGACATGTAAAGGAATCGGAGAAGTTATCCAAATTAATATGGATACGTTATTTGA
TATGGAATCCTCCATAGAGAATGGAGCTGTAGCATTATGGACAGGCCAATATCTTGATTACCAATTATCAAATATTAAGA
CCACCATGGATTACTACGGAGTTCCTCTGGAAGAACAAACGCCACTCCAAGAATTTAATGAATTGCAATTTGCTCTACTC
TGTCATGGGACGAGTAGTGAAGAAGTTCTAGCTCTTACAAACATAAAAGAACCAAAAACAGTTTCAGCTGGAAAATTTCA
AGGTGTGTTGACAAATCTTTGGCAAAAATACCAATATAAACAAGGTGATATGGGTAAAGAATCTATCTTCTTTTATAGTG
ACACATGTTCGGATTGTCATGGTACAAAATTGAATAAACAAAGTAGAACAGTAAGCGTCATGAATCGTTCTATCACTGAT
ATAGCAACATTAGACTTAGATCAATTATTGGATTGGGTGGAAGAGTGTTATGAAGAGCTTCCTGATACAGAAACGAATGC
TGTAAATGTGTATTTACAAGATATTAAAATAAAACTCACAAGAATAAAACGCTTGGGGCTAGGGTATCTCACCTTAGAAC
GTGGAACAAGCACTTTATCTGGTGGAGAAAGTCAACGGATAAGATTATCAGCAATTTTAGATTCAGACTTAACGGATGTT
GTTTATATTATAGATGAGCCTACAGCTAGTCTACATGCGAAAGATACAGAGGGAATTATCACTATACTTAAACAGCTAAA
AGAAAAAGGAAATACGGTTATTGTTATTGAACATAATACAGATCTAATGCGAGAAGCAGATTATCTAGTTGAAATTGGTC
CAAAGGCAGGTCGCTTTGGAGGGGAATTAATTGGCCAAGGGTCAATAGAAAGTCTAAATAATACTGAAAGATCCTTGTTA
AAAAACTATCTTGAAAATAAAAGTGAGCCGAAACAAGATGTTAGAAAAACAGACACGTATATTGGGGTAGATAAAGTAAC
ACATCATAATCTGAATTCGGTTAGTGTAAATATCCCTACAAACATGCTGGTTAGTGTTACAGGTGTGTCAGGTTCCGGAA
AGTCTTCACTTATCTTTGATGTAGTAGGAGAGAAGAATTCCAAAGTACAAGGGGTAGACCAGTTTGATGAGGTAATAACC
ATTAATCAAACAACTATTTCAAAGATGAAACGATCTAATGTGGCTACCTATACGAACGTATACACGGATATACGAAATGT
ATTTGCGAAGCTGGAAGATAGTAAAGCGCAAGGATTTACTTCAAAACACTTTTCTTTTAATACAAATGGCGGAAGATGTG
AGACTTGTGAGGGATTAGGGTATGTAATGAGTAATATGCTATTTTTTAATGATATGGAAGTAATATGCCCAACTTGTAAA
GGAAAGAGATTTAAAGAAGAAATTCTGCGTATTACGTATGAAAATCATAGTATTAGTGATTGCCTAGATCTGTCAGTGGA
AGAAGCTTTTGAAGTATTTAAAGGGGAAGCTAAGATTGTAAAAGTACTACAGTTATTAACAGAAATTGGCTTAGGATATC
TGAAGCTTGGACAATCCTTAACAACATTATCAGGTGGTGAAGGACAGCGGCTAAAGCTATCAACTTCCTTAATGAAGAAA
TCGAAGCAGAACACATTATTTTTATTAGATGAACCATCCACAGGCCTTCATCCCTACGATATACAATACTTGTTAGAACT
GTTTAACCGGTTAATTGATAAGGGAAACTCTGTCATTATGGTTGAACATAATATTCGTATGATCCAGGCCAGTGATTGGA
TTATTGACCTTGGTCCAGAAGGTGGAATTAAGGGTGGACGTATAATGGCAGAAGGGACTCCAAAAGAAATTAAACAAAAT
CCTTTATCTATAACAGGGAAATATCTATAA

Upstream 100 bases:

>100_bases
ACTTATAGTACAAATTAGAAGATAGCCCCCACACCATACTTGCATCGCTTGATTTTTAAATATATAATGATTTTTCTGCA
ATAGAAAAGGAGGTAAGTCA

Downstream 100 bases:

>100_bases
ATCTTTATGAAAAAACCATCTACTCTAAAACTAAGTAGATGGTTTTTTGTGCATTAATTTACAAAATTAACCATATTTTA
ATCTATTTCTAAGAAAGCCT

Product: excinuclease ABC subunit A

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MSEWIYIDNANEHNLKGISLRIPKRKFTVITGVSGSGKSTLAHDILFNESQRQYLEAMGMQGIEKPKVNHISGVSPAISI
KQQETSSNPRSTVGTKTAMYTSLRMIYEKLGIRNCPNCQKEVNPTKAIEETEHVDGEFTVYQICPHCTHKYKKLTRSHFS
YNTIEGACQTCKGIGEVIQINMDTLFDMESSIENGAVALWTGQYLDYQLSNIKTTMDYYGVPLEEQTPLQEFNELQFALL
CHGTSSEEVLALTNIKEPKTVSAGKFQGVLTNLWQKYQYKQGDMGKESIFFYSDTCSDCHGTKLNKQSRTVSVMNRSITD
IATLDLDQLLDWVEECYEELPDTETNAVNVYLQDIKIKLTRIKRLGLGYLTLERGTSTLSGGESQRIRLSAILDSDLTDV
VYIIDEPTASLHAKDTEGIITILKQLKEKGNTVIVIEHNTDLMREADYLVEIGPKAGRFGGELIGQGSIESLNNTERSLL
KNYLENKSEPKQDVRKTDTYIGVDKVTHHNLNSVSVNIPTNMLVSVTGVSGSGKSSLIFDVVGEKNSKVQGVDQFDEVIT
INQTTISKMKRSNVATYTNVYTDIRNVFAKLEDSKAQGFTSKHFSFNTNGGRCETCEGLGYVMSNMLFFNDMEVICPTCK
GKRFKEEILRITYENHSISDCLDLSVEEAFEVFKGEAKIVKVLQLLTEIGLGYLKLGQSLTTLSGGEGQRLKLSTSLMKK
SKQNTLFLLDEPSTGLHPYDIQYLLELFNRLIDKGNSVIMVEHNIRMIQASDWIIDLGPEGGIKGGRIMAEGTPKEIKQN
PLSITGKYL

Sequences:

>Translated_809_residues
MSEWIYIDNANEHNLKGISLRIPKRKFTVITGVSGSGKSTLAHDILFNESQRQYLEAMGMQGIEKPKVNHISGVSPAISI
KQQETSSNPRSTVGTKTAMYTSLRMIYEKLGIRNCPNCQKEVNPTKAIEETEHVDGEFTVYQICPHCTHKYKKLTRSHFS
YNTIEGACQTCKGIGEVIQINMDTLFDMESSIENGAVALWTGQYLDYQLSNIKTTMDYYGVPLEEQTPLQEFNELQFALL
CHGTSSEEVLALTNIKEPKTVSAGKFQGVLTNLWQKYQYKQGDMGKESIFFYSDTCSDCHGTKLNKQSRTVSVMNRSITD
IATLDLDQLLDWVEECYEELPDTETNAVNVYLQDIKIKLTRIKRLGLGYLTLERGTSTLSGGESQRIRLSAILDSDLTDV
VYIIDEPTASLHAKDTEGIITILKQLKEKGNTVIVIEHNTDLMREADYLVEIGPKAGRFGGELIGQGSIESLNNTERSLL
KNYLENKSEPKQDVRKTDTYIGVDKVTHHNLNSVSVNIPTNMLVSVTGVSGSGKSSLIFDVVGEKNSKVQGVDQFDEVIT
INQTTISKMKRSNVATYTNVYTDIRNVFAKLEDSKAQGFTSKHFSFNTNGGRCETCEGLGYVMSNMLFFNDMEVICPTCK
GKRFKEEILRITYENHSISDCLDLSVEEAFEVFKGEAKIVKVLQLLTEIGLGYLKLGQSLTTLSGGEGQRLKLSTSLMKK
SKQNTLFLLDEPSTGLHPYDIQYLLELFNRLIDKGNSVIMVEHNIRMIQASDWIIDLGPEGGIKGGRIMAEGTPKEIKQN
PLSITGKYL
>Mature_808_residues
SEWIYIDNANEHNLKGISLRIPKRKFTVITGVSGSGKSTLAHDILFNESQRQYLEAMGMQGIEKPKVNHISGVSPAISIK
QQETSSNPRSTVGTKTAMYTSLRMIYEKLGIRNCPNCQKEVNPTKAIEETEHVDGEFTVYQICPHCTHKYKKLTRSHFSY
NTIEGACQTCKGIGEVIQINMDTLFDMESSIENGAVALWTGQYLDYQLSNIKTTMDYYGVPLEEQTPLQEFNELQFALLC
HGTSSEEVLALTNIKEPKTVSAGKFQGVLTNLWQKYQYKQGDMGKESIFFYSDTCSDCHGTKLNKQSRTVSVMNRSITDI
ATLDLDQLLDWVEECYEELPDTETNAVNVYLQDIKIKLTRIKRLGLGYLTLERGTSTLSGGESQRIRLSAILDSDLTDVV
YIIDEPTASLHAKDTEGIITILKQLKEKGNTVIVIEHNTDLMREADYLVEIGPKAGRFGGELIGQGSIESLNNTERSLLK
NYLENKSEPKQDVRKTDTYIGVDKVTHHNLNSVSVNIPTNMLVSVTGVSGSGKSSLIFDVVGEKNSKVQGVDQFDEVITI
NQTTISKMKRSNVATYTNVYTDIRNVFAKLEDSKAQGFTSKHFSFNTNGGRCETCEGLGYVMSNMLFFNDMEVICPTCKG
KRFKEEILRITYENHSISDCLDLSVEEAFEVFKGEAKIVKVLQLLTEIGLGYLKLGQSLTTLSGGEGQRLKLSTSLMKKS
KQNTLFLLDEPSTGLHPYDIQYLLELFNRLIDKGNSVIMVEHNIRMIQASDWIIDLGPEGGIKGGRIMAEGTPKEIKQNP
LSITGKYL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=695, Percent_Identity=36.1151079136691, Blast_Score=462, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 90477; Mature: 90346

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEWIYIDNANEHNLKGISLRIPKRKFTVITGVSGSGKSTLAHDILFNESQRQYLEAMGM
CCCEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHCC
QGIEKPKVNHISGVSPAISIKQQETSSNPRSTVGTKTAMYTSLRMIYEKLGIRNCPNCQK
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
EVNPTKAIEETEHVDGEFTVYQICPHCTHKYKKLTRSHFSYNTIEGACQTCKGIGEVIQI
HCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEE
NMDTLFDMESSIENGAVALWTGQYLDYQLSNIKTTMDYYGVPLEEQTPLQEFNELQFALL
CHHHHHCCHHCCCCCEEEEEECCCCCEEHHHHEEEHHHCCCCCCCCCCHHHHCCCEEEEE
CHGTSSEEVLALTNIKEPKTVSAGKFQGVLTNLWQKYQYKQGDMGKESIFFYSDTCSDCH
EECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
GTKLNKQSRTVSVMNRSITDIATLDLDQLLDWVEECYEELPDTETNAVNVYLQDIKIKLT
CCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEE
RIKRLGLGYLTLERGTSTLSGGESQRIRLSAILDSDLTDVVYIIDEPTASLHAKDTEGII
HHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHH
TILKQLKEKGNTVIVIEHNTDLMREADYLVEIGPKAGRFGGELIGQGSIESLNNTERSLL
HHHHHHHHCCCEEEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHCCHHHHHHH
KNYLENKSEPKQDVRKTDTYIGVDKVTHHNLNSVSVNIPTNMLVSVTGVSGSGKSSLIFD
HHHHHCCCCCHHHHHHHCCEEECHHHCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEE
VVGEKNSKVQGVDQFDEVITINQTTISKMKRSNVATYTNVYTDIRNVFAKLEDSKAQGFT
EECCCCCCCCCCCHHHHEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SKHFSFNTNGGRCETCEGLGYVMSNMLFFNDMEVICPTCKGKRFKEEILRITYENHSISD
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHEEEECCCCHHH
CLDLSVEEAFEVFKGEAKIVKVLQLLTEIGLGYLKLGQSLTTLSGGEGQRLKLSTSLMKK
HHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCEECCCCCCCEEEEHHHHHHC
SKQNTLFLLDEPSTGLHPYDIQYLLELFNRLIDKGNSVIMVEHNIRMIQASDWIIDLGPE
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCEEEEECCC
GGIKGGRIMAEGTPKEIKQNPLSITGKYL
CCCCCCEEEECCCHHHHHCCCCCEECCCC
>Mature Secondary Structure 
SEWIYIDNANEHNLKGISLRIPKRKFTVITGVSGSGKSTLAHDILFNESQRQYLEAMGM
CCEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHHHHHCCHHHHHHHHHCC
QGIEKPKVNHISGVSPAISIKQQETSSNPRSTVGTKTAMYTSLRMIYEKLGIRNCPNCQK
CCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCHH
EVNPTKAIEETEHVDGEFTVYQICPHCTHKYKKLTRSHFSYNTIEGACQTCKGIGEVIQI
HCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEE
NMDTLFDMESSIENGAVALWTGQYLDYQLSNIKTTMDYYGVPLEEQTPLQEFNELQFALL
CHHHHHCCHHCCCCCEEEEEECCCCCEEHHHHEEEHHHCCCCCCCCCCHHHHCCCEEEEE
CHGTSSEEVLALTNIKEPKTVSAGKFQGVLTNLWQKYQYKQGDMGKESIFFYSDTCSDCH
EECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
GTKLNKQSRTVSVMNRSITDIATLDLDQLLDWVEECYEELPDTETNAVNVYLQDIKIKLT
CCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEE
RIKRLGLGYLTLERGTSTLSGGESQRIRLSAILDSDLTDVVYIIDEPTASLHAKDTEGII
HHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHH
TILKQLKEKGNTVIVIEHNTDLMREADYLVEIGPKAGRFGGELIGQGSIESLNNTERSLL
HHHHHHHHCCCEEEEEECCCHHHHCCCEEEEECCCCCCCCCCCCCCCCCHHCCHHHHHHH
KNYLENKSEPKQDVRKTDTYIGVDKVTHHNLNSVSVNIPTNMLVSVTGVSGSGKSSLIFD
HHHHHCCCCCHHHHHHHCCEEECHHHCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEE
VVGEKNSKVQGVDQFDEVITINQTTISKMKRSNVATYTNVYTDIRNVFAKLEDSKAQGFT
EECCCCCCCCCCCHHHHEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
SKHFSFNTNGGRCETCEGLGYVMSNMLFFNDMEVICPTCKGKRFKEEILRITYENHSISD
CCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHEEEECCCCHHH
CLDLSVEEAFEVFKGEAKIVKVLQLLTEIGLGYLKLGQSLTTLSGGEGQRLKLSTSLMKK
HHHCCHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHCCCCEECCCCCCCEEEEHHHHHHC
SKQNTLFLLDEPSTGLHPYDIQYLLELFNRLIDKGNSVIMVEHNIRMIQASDWIIDLGPE
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCEEEEECCC
GGIKGGRIMAEGTPKEIKQNPLSITGKYL
CCCCCCEEEECCCHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]